DK0994854T3 - Fremgangsmåde til fremstilling af en substitueret perhydroisoindol - Google Patents

Fremgangsmåde til fremstilling af en substitueret perhydroisoindol

Info

Publication number: DK0994854T3
Authority: DK; Denmark
Prior art keywords: pct; insulin; sec; formula; preparation
Prior art date: 1997-07-03

Application number

DK98935072T

Other languages

English (en)

Inventor

Jean-Pierre Lecouve

Claude Fugier

Jean-Claude Souvie

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-03

Filing date

1998-07-01

Publication date

2002-12-30

1998-07-01 Application filed by Adir filed Critical Adir

2002-12-30 Application granted granted Critical

2002-12-30 Publication of DK0994854T3 publication Critical patent/DK0994854T3/da

Links

ODSNARDHJFFSRH-UHFFFAOYSA-N 2,3,3a,4,5,6,7,7a-octahydro-1h-isoindole Chemical class C1CCCC2CNCC21 ODSNARDHJFFSRH-UHFFFAOYSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK98935072T 1997-07-03 1998-07-01 Fremgangsmåde til fremstilling af en substitueret perhydroisoindol DK0994854T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9708431A FR2765578B1 (fr)	1997-07-03	1997-07-03	Procede de preparation d'un perhydroisoindole substitue
PCT/FR1998/001405 WO1999001430A1 (fr)	1997-07-03	1998-07-01	Procede de preparation d'un perhydroisoindole substitue

Publications (1)

Publication Number	Publication Date
DK0994854T3 true DK0994854T3 (da)	2002-12-30

Family

ID=9508815

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98935072T DK0994854T3 (da)	1997-07-03	1998-07-01	Fremgangsmåde til fremstilling af en substitueret perhydroisoindol

Country Status (21)

Country	Link
US (1)	US6133454A (da)
EP (1)	EP0994854B1 (da)
JP (1)	JP4056093B2 (da)
KR (1)	KR100421073B1 (da)
CN (1)	CN1108291C (da)
AT (1)	ATE224368T1 (da)
AU (1)	AU734398B2 (da)
BR (1)	BR9810657A (da)
CA (1)	CA2295992C (da)
DE (1)	DE69808092T2 (da)
DK (1)	DK0994854T3 (da)
EA (1)	EA002151B1 (da)
ES (1)	ES2184304T3 (da)
FR (1)	FR2765578B1 (da)
HU (1)	HUP0002778A3 (da)
NO (1)	NO313095B1 (da)
NZ (1)	NZ501835A (da)
PL (1)	PL190861B1 (da)
PT (1)	PT994854E (da)
WO (1)	WO1999001430A1 (da)
ZA (1)	ZA985882B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2793411B1 (fr) *	1999-05-11	2001-06-29	Synthelabo	Utilisation de derives de l'acide succinique pour obtenir un medicament destine au traitement de l'inflammation
FR2834892B1 (fr) *	2002-01-23	2004-02-27	Servier Lab	Composition pharmaceutique orodispersible de mitiglinide
US6684422B2 (en) *	2002-02-27	2004-02-03	Ginger Magnolia	Toy retention blanket and system
WO2004002474A1 (ja) *	2002-06-28	2004-01-08	Kissei Pharmaceutical Co., Ltd.	糖尿病性合併症の予防又は進展阻止用医薬組成物
WO2004002473A1 (ja) *	2002-06-28	2004-01-08	Kissei Pharmaceutical Co., Ltd.	血糖コントロール用医薬組成物
EP1541582A1 (en) *	2002-08-23	2005-06-15	Banyu Pharmaceutical Co., Ltd.	Process for producing indolopyrrolocarbazole derivative
FR2860231B1 (fr) *	2003-09-25	2005-11-18	Servier Lab	Nouveau procede de preparation du cis-octahydro-isoindole
US7230022B2 (en) *	2004-02-19	2007-06-12	Bristol-Myers Squibb Company	Substituted fused bicyclic amines as modulators of chemokine receptor activity
CN1634885B (zh) *	2004-11-09	2011-05-04	北京乐力健生物科技有限公司	米格列奈晶型及其制备方法
CN1324010C (zh) *	2005-01-12	2007-07-04	江苏省药物研究所	一种米格列奈的制备方法
JP4918257B2 (ja)	2005-12-27	2012-04-18	キッセイ薬品工業株式会社	不斉還元方法
WO2009047797A2 (en) *	2007-10-08	2009-04-16	Ind-Swift Laboratories Limited	Process for the preparation of perhydroisoindole derivative
CN102382033B (zh) *	2010-08-31	2013-04-03	凯瑞斯德生化(苏州)有限公司	一种光学活性米格列奈酯及米格列奈盐的制备方法
DK2717922T3 (da)	2011-06-10	2019-01-07	Bluebird Bio Inc	Genterapivektorer til adrenoleukodystrofi og adrenomyeloneuropati
KR101327866B1 (ko) *	2011-10-27	2013-11-11	주식회사 메디켐코리아	미티글리나이드 칼슘염의 개선된 제조방법
ES2546362B1 (es) *	2012-06-22	2016-07-07	Laboratorios Lesvi, S. L.	PROCEDIMIENTO DE OBTENCIÓN DEL ÁCIDO (S) -2 BENCIL 4 - ((3aR, 7aS) -HEXAHIDRO-1H-ISOINDOL-2 (3H) IL) -4-OXOBUTANOICO Y SUS SALES
CN103450069B (zh) *	2013-06-24	2015-04-15	山西大同大学	一种米格列奈钙的制备方法
CN103709092B (zh) *	2013-11-04	2016-07-06	河北科技大学	米格列奈钙的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU654331B2 (en) *	1991-03-30	1994-11-03	Kissei Pharmaceutical Co. Ltd.	Succinic acid compounds

1997
- 1997-07-03 FR FR9708431A patent/FR2765578B1/fr not_active Expired - Fee Related
1998
- 1998-07-01 ES ES98935072T patent/ES2184304T3/es not_active Expired - Lifetime
- 1998-07-01 NZ NZ501835A patent/NZ501835A/xx unknown
- 1998-07-01 HU HU0002778A patent/HUP0002778A3/hu unknown
- 1998-07-01 WO PCT/FR1998/001405 patent/WO1999001430A1/fr not_active Ceased
- 1998-07-01 DK DK98935072T patent/DK0994854T3/da active
- 1998-07-01 EA EA200000094A patent/EA002151B1/ru not_active IP Right Cessation
- 1998-07-01 AT AT98935072T patent/ATE224368T1/de not_active IP Right Cessation
- 1998-07-01 BR BR9810657-0A patent/BR9810657A/pt not_active Application Discontinuation
- 1998-07-01 DE DE69808092T patent/DE69808092T2/de not_active Expired - Lifetime
- 1998-07-01 AU AU84450/98A patent/AU734398B2/en not_active Ceased
- 1998-07-01 PT PT98935072T patent/PT994854E/pt unknown
- 1998-07-01 JP JP50653499A patent/JP4056093B2/ja not_active Expired - Fee Related
- 1998-07-01 EP EP98935072A patent/EP0994854B1/fr not_active Expired - Lifetime
- 1998-07-01 CA CA002295992A patent/CA2295992C/fr not_active Expired - Fee Related
- 1998-07-01 CN CN98806779A patent/CN1108291C/zh not_active Expired - Fee Related
- 1998-07-01 PL PL337728A patent/PL190861B1/pl not_active IP Right Cessation
- 1998-07-01 US US09/446,848 patent/US6133454A/en not_active Expired - Fee Related
- 1998-07-02 KR KR10-1998-0026520A patent/KR100421073B1/ko not_active Expired - Fee Related
- 1998-07-03 ZA ZA985882A patent/ZA985882B/xx unknown
1999
- 1999-12-30 NO NO19996577A patent/NO313095B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
HUP0002778A3 (en)	2001-12-28
PL190861B1 (pl)	2006-02-28
PL337728A1 (en)	2000-08-28
JP4056093B2 (ja)	2008-03-05
CA2295992C (fr)	2003-09-23
WO1999001430A1 (fr)	1999-01-14
FR2765578A1 (fr)	1999-01-08
HK1028610A1 (en)	2001-02-23
CN1108291C (zh)	2003-05-14
CA2295992A1 (fr)	1999-01-14
JP2002507222A (ja)	2002-03-05
EP0994854B1 (fr)	2002-09-18
KR100421073B1 (ko)	2004-06-11
FR2765578B1 (fr)	1999-09-10
ATE224368T1 (de)	2002-10-15
EA002151B1 (ru)	2001-12-24
ES2184304T3 (es)	2003-04-01
PT994854E (pt)	2002-12-31
DE69808092T2 (de)	2003-04-30
AU734398B2 (en)	2001-06-14
ZA985882B (en)	1999-01-26
DE69808092D1 (de)	2002-10-24
US6133454A (en)	2000-10-17
CN1261879A (zh)	2000-08-02
AU8445098A (en)	1999-01-25
KR19990013522A (ko)	1999-02-25
NO996577L (no)	2000-03-02
HU0002778D0 (en)	1998-07-01
NO313095B1 (no)	2002-08-12
NO996577D0 (no)	1999-12-30
NZ501835A (en)	2000-11-24
BR9810657A (pt)	2000-10-03
EA200000094A1 (ru)	2000-06-26
EP0994854A1 (fr)	2000-04-26
HUP0002778A2 (hu)	2001-01-29

Publication	Publication Date	Title
NO996577L (no)	2000-03-02	Fremgangsmåte ved fremstilling av perhydroisoindol
ATE171445T1 (de)	1998-10-15	Perhydroisoindolderivate als substanz p antagonisten
BR9713126A (pt)	2000-04-11	Compostos derivados da piridin-2-il-metilamina, processo para sua preparação, compostos intermediários de sìntese, medicamento inédito, e, composição farmacêutica
DK0696281T3 (da)	1999-11-01	Hidtil ukendte 5-pyrrolyl-2-pyridylmethylsulfinylbenzimidazolderivater
ATE172968T1 (de)	1998-11-15	Substituierte azadioxacycloalkene und ihre verwendung als fungizide
ES2194202T3 (es)	2003-11-16	Compuestos polimorfos.
DE69433984D1 (de)	2004-10-14	Arylpiperazinderivate von indol als liganden der rezeptoren 5 ht1-like, 5 ht1b und 5 ht1d
DK0766696T3 (da)	1999-02-15	Thiazolidinderivater, fremstilling af disse forbindelser og lægemidler indeholdende disse forbindelser
DK0748314T3 (da)	2002-08-26	Tetrasubstituerede imidazolderivater, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler og farmaceutiske præparater med indhold deraf
DE59304311D1 (de)	1996-11-28	N-substituierte 3-azabicyclo[3.2.0]heptan-derivate als neuroleptika
BR9610175A (pt)	1998-08-11	Composto processo de preparação do composto composição farmacêutica e utilização do composto
DK0678088T3 (da)	1996-11-18	N-acylpyrrolidiner og lægemidler til behandling og forebyggelse af cholecystokinin- og gastrinrelaterede sygdomme
BR0116721A (pt)	2003-12-23	Processo para a preparação de (±)-trans-4-p-fluorofenil-3-hidroximetil-1-metilpiperi dina
NO20010907L (no)	2001-04-25	Medikament inneholdende platinakompleksforbindelser og anvendelse derav
DK0766695T3 (da)	1999-02-15	Pyrrolidinderivater til behandling af CCK- og gastrinrelaterede sygdomme
DE69528902D1 (de)	2003-01-02	Neue verwendung und neue derivate von imidazol, ihrer herstellung, zwischenprodukte, und verwendung als arzneimittel
FR2757161B1 (fr)	1999-03-12	Diphenylalkyl-tetrahydropyridines
ATE146467T1 (de)	1997-01-15	Substituierte 3-azabicyclo(3.2.0>heptan-derivate als zwischenprodukte
MA27264A1 (fr)	2005-03-01	Acutumine et dérivés d'acutumine, synthèse et utilisation
ES2164665T3 (es)	2002-03-01	Inhibidores de proteasas retrovirales.