ATE171445T1 - Perhydroisoindolderivate als substanz p antagonisten - Google Patents

Perhydroisoindolderivate als substanz p antagonisten

Info

Publication number
ATE171445T1
ATE171445T1 AT94923755T AT94923755T ATE171445T1 AT E171445 T1 ATE171445 T1 AT E171445T1 AT 94923755 T AT94923755 T AT 94923755T AT 94923755 T AT94923755 T AT 94923755T AT E171445 T1 ATE171445 T1 AT E171445T1
Authority
AT
Austria
Prior art keywords
antagonists
substance
pct
derivatives
perhydroisoindole derivatives
Prior art date
Application number
AT94923755T
Other languages
English (en)
Inventor
Daniel Achard
Serge Grisoni
Evelyne James-Surcouf
Jean-Luc Malleron
Anne Morgat
Jean-Francois Peyronel
Jean-Francois Sabuco
Michel Tabart
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9309400A external-priority patent/FR2709752B1/fr
Priority claimed from FR9311946A external-priority patent/FR2710913B1/fr
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of ATE171445T1 publication Critical patent/ATE171445T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT94923755T 1993-07-30 1994-07-28 Perhydroisoindolderivate als substanz p antagonisten ATE171445T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9309400A FR2709752B1 (fr) 1993-07-30 1993-07-30 Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR9311946A FR2710913B1 (fr) 1993-10-07 1993-10-07 Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ATE171445T1 true ATE171445T1 (de) 1998-10-15

Family

ID=26230522

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94923755T ATE171445T1 (de) 1993-07-30 1994-07-28 Perhydroisoindolderivate als substanz p antagonisten

Country Status (19)

Country Link
US (1) US5624950A (de)
EP (1) EP0711280B1 (de)
JP (1) JPH09500893A (de)
KR (1) KR960703858A (de)
AT (1) ATE171445T1 (de)
AU (1) AU7386594A (de)
CA (1) CA2168233A1 (de)
CZ (1) CZ26396A3 (de)
DE (1) DE69413542T2 (de)
DK (1) DK0711280T3 (de)
ES (1) ES2123149T3 (de)
FI (1) FI960399A7 (de)
HU (1) HUT75304A (de)
IL (1) IL110494A0 (de)
NO (1) NO960365D0 (de)
PL (1) PL312739A1 (de)
SK (1) SK13096A3 (de)
TW (1) TW365603B (de)
WO (1) WO1995004040A1 (de)

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NZ552397A (en) 2004-07-15 2011-04-29 Amr Technology Inc Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
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US7265247B1 (en) 2006-07-28 2007-09-04 Im&T Research, Inc. Substituted phenylsulfur trifluoride and other like fluorinating agents
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JP5319518B2 (ja) 2007-04-02 2013-10-16 Ｍｓｄ株式会社 インドールジオン誘導体
AU2008269154B2 (en) 2007-06-27 2014-06-12 Merck Sharp & Dohme Llc 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US8030516B2 (en) 2007-10-19 2011-10-04 Ube Industries, Ltd. Methods for producing perfluoroalkanedi(sulfonyl chloride)
AU2009222122A1 (en) 2008-03-03 2009-09-11 Tiger Pharmatech Tyrosine kinase inhibitors
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UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
CN102224147B (zh) 2008-09-22 2015-03-18 宇部兴产株式会社 制备多(五氟硫烷基)芳香化合物的方法
WO2010081014A1 (en) 2009-01-09 2010-07-15 Im&T Research, Inc. Novel 4-fluoropyrrolidine-2-carbonyl fluoride compounds and their preparative methods
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AU2010247735B2 (en) 2009-05-12 2015-07-16 Albany Molecular Research, Inc. Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydroisoquinoline and use thereof
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US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
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EP2770987B1 (de) 2011-10-27 2018-04-04 Merck Sharp & Dohme Corp. Neue verbindungen als erk-hemmer
US20150299696A1 (en) 2012-05-02 2015-10-22 Sirna Therapeutics, Inc. SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
RU2660429C2 (ru) 2012-09-28 2018-07-06 Мерк Шарп И Доум Корп. Новые соединения, которые являются ингибиторами erk
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KR102196882B1 (ko) 2012-12-20 2020-12-30 머크 샤프 앤드 돔 코포레이션 Hdm2 억제제로서의 치환된 이미다조피리딘
WO2014120748A1 (en) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
WO2015034925A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Circular polynucleotides
EP3525785B1 (de) 2016-10-12 2025-08-27 Merck Sharp & Dohme LLC Kdm5-inhibitoren
EP3706747B1 (de) 2017-11-08 2025-09-03 Merck Sharp & Dohme LLC Prmt5-inhibitoren
US10947234B2 (en) 2017-11-08 2021-03-16 Merck Sharp & Dohme Corp. PRMT5 inhibitors
US11981701B2 (en) 2018-08-07 2024-05-14 Merck Sharp & Dohme Llc PRMT5 inhibitors
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Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2654726B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone et leur preparation.
FR2654725B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2676443B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole et leur preparation.
FR2676442B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2689888B1 (fr) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2689889B1 (fr) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, et leur preparation.

Also Published As

Publication number Publication date
SK13096A3 (en) 1996-09-04
PL312739A1 (en) 1996-05-13
DE69413542D1 (de) 1998-10-29
KR960703858A (ko) 1996-08-31
AU7386594A (en) 1995-02-28
CZ26396A3 (en) 1996-05-15
EP0711280B1 (de) 1998-09-23
NO960365L (no) 1996-01-29
EP0711280A1 (de) 1996-05-15
ES2123149T3 (es) 1999-01-01
FI960399A0 (fi) 1996-01-29
CA2168233A1 (fr) 1995-02-09
DK0711280T3 (da) 1999-06-14
NO960365D0 (no) 1996-01-29
IL110494A0 (en) 1994-10-21
WO1995004040A1 (fr) 1995-02-09
DE69413542T2 (de) 1999-03-25
TW365603B (en) 1999-08-01
JPH09500893A (ja) 1997-01-28
US5624950A (en) 1997-04-29
HU9503986D0 (en) 1996-03-28
HUT75304A (en) 1997-05-28
FI960399A7 (fi) 1996-01-29

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee