DK1001944T3 - Pyrazinderivater, deres fremstilling samt medikamenter indeholdende disse forbindelser - Google Patents
Pyrazinderivater, deres fremstilling samt medikamenter indeholdende disse forbindelserInfo
- Publication number
- DK1001944T3 DK1001944T3 DK98939676T DK98939676T DK1001944T3 DK 1001944 T3 DK1001944 T3 DK 1001944T3 DK 98939676 T DK98939676 T DK 98939676T DK 98939676 T DK98939676 T DK 98939676T DK 1001944 T3 DK1001944 T3 DK 1001944T3
- Authority
- DK
- Denmark
- Prior art keywords
- ch2oh
- alk
- choh
- equal
- preparation
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 150000003216 pyrazines Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 10
- -1 alkyl radical Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9709058A FR2766187B1 (fr) | 1997-07-17 | 1997-07-17 | Derives de pyrazine, leur preparation et les medicaments les contenant |
| PCT/FR1998/001542 WO1999003844A1 (fr) | 1997-07-17 | 1998-07-15 | Derives de pyrazine, leur preparation et les medicaments les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1001944T3 true DK1001944T3 (da) | 2004-02-09 |
Family
ID=9509300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98939676T DK1001944T3 (da) | 1997-07-17 | 1998-07-15 | Pyrazinderivater, deres fremstilling samt medikamenter indeholdende disse forbindelser |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6399613B1 (da) |
| EP (1) | EP1001944B1 (da) |
| JP (1) | JP4443036B2 (da) |
| KR (1) | KR20010021901A (da) |
| CN (1) | CN1264371A (da) |
| AT (1) | ATE251144T1 (da) |
| AU (1) | AU747127B2 (da) |
| BR (1) | BR9810880A (da) |
| CA (1) | CA2296727C (da) |
| DE (1) | DE69818679T2 (da) |
| DK (1) | DK1001944T3 (da) |
| ES (1) | ES2205536T3 (da) |
| FR (1) | FR2766187B1 (da) |
| HU (1) | HUP0004602A3 (da) |
| IL (1) | IL134040A0 (da) |
| MX (1) | MXPA00000280A (da) |
| NO (1) | NO20000198D0 (da) |
| NZ (1) | NZ501906A (da) |
| PL (1) | PL338148A1 (da) |
| PT (1) | PT1001944E (da) |
| RU (1) | RU2194703C2 (da) |
| SK (1) | SK482000A3 (da) |
| WO (1) | WO1999003844A1 (da) |
| ZA (1) | ZA986337B (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9905771D0 (en) * | 1999-03-12 | 1999-05-05 | Isis Innovation | Compounds |
| US7598278B2 (en) * | 2002-04-11 | 2009-10-06 | L'oreal | Administration of pyridinedicarboxylic acid compounds for stimulating or inducing the growth of human keratinous fibers and/or arresting their loss |
| AU2005311534B2 (en) * | 2004-12-03 | 2011-02-17 | F. Hoffmann-La Roche Ag | 3-substituted pyridine derivatives as H3 antagonists |
| US20070270590A1 (en) * | 2006-04-20 | 2007-11-22 | Marioara Mendelovici | Methods for preparing eszopiclone crystalline form a, substantially pure eszopiclone and optically enriched eszopiclone |
| EP1904499A1 (en) * | 2006-06-26 | 2008-04-02 | Teva Pharmaceutical Industries Ltd | Process for the preparation of zopiclone |
| EP2032557A2 (en) * | 2007-01-31 | 2009-03-11 | Teva Pharmaceutical Industries Ltd. | Methods for preparing eszopiclone |
| CN101891679B (zh) * | 2009-05-19 | 2014-04-16 | 上海华明高技术（集团）有限公司 | 吡啶二甲酸与二氨基吡啶质子转移化合物的制备方法 |
| FR3030248B1 (fr) | 2014-12-22 | 2018-03-23 | L'oreal | Association derive d'acide pyridine-dicarboxylique/agent anti-oxydant particulier |
| CN120981230A (zh) * | 2023-03-31 | 2025-11-18 | 弗莱克斯塞思知识产权控股有限责任公司 | 杂芳基抗降解剂 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4220650A (en) * | 1978-10-18 | 1980-09-02 | Pfizer Inc. | Organic diamine therapeutic compositions and methods |
| DE3703959A1 (de) * | 1987-02-10 | 1988-08-18 | Hoechst Ag | Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen |
| JPH01117863A (ja) * | 1987-10-30 | 1989-05-10 | Toyobo Co Ltd | 新規なアミド化合物 |
| DE4020570A1 (de) * | 1990-06-28 | 1992-01-02 | Hoechst Ag | 2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung |
-
1997
- 1997-07-17 FR FR9709058A patent/FR2766187B1/fr not_active Expired - Fee Related
-
1998
- 1998-07-15 ES ES98939676T patent/ES2205536T3/es not_active Expired - Lifetime
- 1998-07-15 IL IL13404098A patent/IL134040A0/xx unknown
- 1998-07-15 KR KR1020007000465A patent/KR20010021901A/ko not_active Ceased
- 1998-07-15 PL PL98338148A patent/PL338148A1/xx unknown
- 1998-07-15 MX MXPA00000280A patent/MXPA00000280A/es unknown
- 1998-07-15 JP JP2000503069A patent/JP4443036B2/ja not_active Expired - Fee Related
- 1998-07-15 DK DK98939676T patent/DK1001944T3/da active
- 1998-07-15 AT AT98939676T patent/ATE251144T1/de not_active IP Right Cessation
- 1998-07-15 BR BR9810880-8A patent/BR9810880A/pt not_active IP Right Cessation
- 1998-07-15 AU AU88102/98A patent/AU747127B2/en not_active Ceased
- 1998-07-15 NZ NZ501906A patent/NZ501906A/en unknown
- 1998-07-15 HU HU0004602A patent/HUP0004602A3/hu unknown
- 1998-07-15 SK SK48-2000A patent/SK482000A3/sk unknown
- 1998-07-15 RU RU2000103449/04A patent/RU2194703C2/ru not_active IP Right Cessation
- 1998-07-15 PT PT98939676T patent/PT1001944E/pt unknown
- 1998-07-15 CA CA002296727A patent/CA2296727C/fr not_active Expired - Fee Related
- 1998-07-15 CN CN98807199A patent/CN1264371A/zh active Pending
- 1998-07-15 WO PCT/FR1998/001542 patent/WO1999003844A1/fr not_active Ceased
- 1998-07-15 DE DE69818679T patent/DE69818679T2/de not_active Expired - Lifetime
- 1998-07-15 EP EP98939676A patent/EP1001944B1/fr not_active Expired - Lifetime
- 1998-07-16 ZA ZA986337A patent/ZA986337B/xx unknown
-
2000
- 2000-01-14 US US09/483,984 patent/US6399613B1/en not_active Expired - Fee Related
- 2000-01-14 NO NO20000198A patent/NO20000198D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69818679T2 (de) | 2004-07-29 |
| AU8810298A (en) | 1999-02-10 |
| SK482000A3 (en) | 2000-06-12 |
| NO20000198L (no) | 2000-01-14 |
| NZ501906A (en) | 2002-04-26 |
| ZA986337B (en) | 1999-01-27 |
| MXPA00000280A (es) | 2002-04-17 |
| WO1999003844A1 (fr) | 1999-01-28 |
| CA2296727C (fr) | 2009-06-09 |
| KR20010021901A (ko) | 2001-03-15 |
| JP2001510188A (ja) | 2001-07-31 |
| PT1001944E (pt) | 2004-02-27 |
| DE69818679D1 (de) | 2003-11-06 |
| US6399613B1 (en) | 2002-06-04 |
| ATE251144T1 (de) | 2003-10-15 |
| AU747127B2 (en) | 2002-05-09 |
| HUP0004602A2 (hu) | 2001-11-28 |
| PL338148A1 (en) | 2000-09-25 |
| CN1264371A (zh) | 2000-08-23 |
| FR2766187A1 (fr) | 1999-01-22 |
| RU2194703C2 (ru) | 2002-12-20 |
| ES2205536T3 (es) | 2004-05-01 |
| NO20000198D0 (no) | 2000-01-14 |
| EP1001944A1 (fr) | 2000-05-24 |
| BR9810880A (pt) | 2002-05-21 |
| EP1001944B1 (fr) | 2003-10-01 |
| FR2766187B1 (fr) | 2000-06-02 |
| HUP0004602A3 (en) | 2001-12-28 |
| IL134040A0 (en) | 2001-04-30 |
| CA2296727A1 (fr) | 1999-01-28 |
| JP4443036B2 (ja) | 2010-03-31 |
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