DK1003494T3 - (d)-metadon, et ikke-opioidt analgetikum - Google Patents

(d)-metadon, et ikke-opioidt analgetikum

Info

Publication number: DK1003494T3
Authority: DK; Denmark
Prior art keywords: alpha; subject; methadone; normethadol; acetylmethadol
Prior art date: 1997-01-22

Application number

DK98904609T

Other languages

English (en)

Inventor

Charles E Inturrisi

Original Assignee

Cornell Res Foundation Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-22

Filing date

1998-01-21

Publication date

2007-07-16

1998-01-21 Application filed by Cornell Res Foundation Inc filed Critical Cornell Res Foundation Inc

2007-07-16 Application granted granted Critical

2007-07-16 Publication of DK1003494T3 publication Critical patent/DK1003494T3/da

Links

229960001797 methadone Drugs 0.000 title 1
229940121367 non-opioid analgesics Drugs 0.000 title 1
102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 2
108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 2
KYHAUJGXNUJCTC-LPHOPBHVSA-N (3s,6s)-6-(methylamino)-4,4-diphenylheptan-3-ol Chemical compound C=1C=CC=CC=1C(C[C@H](C)NC)([C@@H](O)CC)C1=CC=CC=C1 KYHAUJGXNUJCTC-LPHOPBHVSA-N 0.000 abstract 1
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 1
229950005506 acetylmethadol Drugs 0.000 abstract 1
-1 d-alpha-normethadol Chemical compound 0.000 abstract 1
USSIQXCVUWKGNF-KRWDZBQOSA-N dextromethadone Chemical compound C=1C=CC=CC=1C(C[C@H](C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-KRWDZBQOSA-N 0.000 abstract 1
229950004655 dimepheptanol Drugs 0.000 abstract 1
XBMIVRRWGCYBTQ-AVRDEDQJSA-N levacetylmethadol Chemical compound C=1C=CC=CC=1C(C[C@H](C)N(C)C)([C@@H](OC(C)=O)CC)C1=CC=CC=C1 XBMIVRRWGCYBTQ-AVRDEDQJSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Emergency Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK98904609T 1997-01-22 1998-01-21 (d)-metadon, et ikke-opioidt analgetikum DK1003494T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3530897P	1997-01-22	1997-01-22
PCT/US1998/001088 WO1998031358A1 (en)	1997-01-22	1998-01-21	d-METHADONE, A NONOPIOID ANALGESIC

Publications (1)

Publication Number	Publication Date
DK1003494T3 true DK1003494T3 (da)	2007-07-16

Family

ID=21881853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98904609T DK1003494T3 (da)	1997-01-22	1998-01-21	(d)-metadon, et ikke-opioidt analgetikum

Country Status (12)

Country	Link
US (1)	US6008258A (da)
EP (1)	EP1003494B1 (da)
JP (2)	JP4514241B2 (da)
AT (1)	ATE357226T1 (da)
AU (1)	AU6244898A (da)
CA (1)	CA2278422C (da)
DE (1)	DE69837387T2 (da)
DK (1)	DK1003494T3 (da)
ES (1)	ES2283049T3 (da)
MA (1)	MA24794A1 (da)
PT (1)	PT1003494E (da)
WO (1)	WO1998031358A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20070197651A1 (en) *	1998-03-09	2007-08-23	Tufts University	Treatment of stereotypic, self-injurious and compulsive behaviors in man and animals using antagonists of NMDA receptors
US20060167114A1 (en) *	1998-03-09	2006-07-27	Louis Shuster	Treatment of stereotypic, self-injurious and compulsive behaviors in man and animals using antagonists of NMDA receptors
EP1061924A1 (en) *	1998-03-09	2000-12-27	Trustees Of Tufts College	Treatment of compulsive behaviours in man and animals
BR9912827A (pt)	1998-07-16	2001-05-02	Sloan Kettering Inst Cancer	Composições tópicas compreendendo um analgésico opióide e um antagonista de nmda
US6897242B1 (en) *	1999-02-24	2005-05-24	Judson J. Somerville	Non-racemic mixtures of d- and l- methadone and method of treating pain
AU2001251374A1 (en) *	2000-04-07	2001-10-23	Ultramed International, Inc.	Maintaining abstinence after detoxification from opiate addiction
IL152473A0 (en)	2000-04-28	2003-05-29	Sloan Kettering Inst Cancer	Topical anesthetic/opioid formulations and uses thereof
US7820688B2 (en)	2001-04-27	2010-10-26	Memorial Sloan-Kettering Cancer Center	Topical anesthetic/opioid formulations and uses thereof
EP1471909A4 (en) *	2002-01-16	2007-07-25	Endo Pharmaceuticals Inc	PHARMACEUTICAL COMPOSITION AND METHOD FOR THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM
EP1476155A4 (en) *	2002-01-23	2009-10-28	Univ California	METHODS AND COMPOSITIONS FOR REDUCING THE DEVELOPMENT OF DRUG TOLERANCE AND / OR PHYSICAL DEPENDENCE
CA2486095A1 (en) *	2002-05-13	2004-05-21	Endo Pharmaceuticals Inc.	Abuse-resistant opioid dosage form
WO2004022002A2 (en) *	2002-09-09	2004-03-18	Endo Pharmaceuticals Inc.	Combined immediate release and extended release analgesic composition
US20040180915A1 (en) *	2003-03-14	2004-09-16	Xanodyne Pharmacal, Inc.	Methadone-containing compositions for parenteral administration and method of use thereof
US20040202717A1 (en)	2003-04-08	2004-10-14	Mehta Atul M.	Abuse-resistant oral dosage forms and method of use thereof
US20100010096A1 (en) *	2006-10-27	2010-01-14	John Charin Somberg	Methadone chiral isolate as an improved pharmaceutical
US20100048605A1 (en) *	2006-12-11	2010-02-25	University Of Kentucky Research Foundation	Synergistic effects of combinations of nornicotine and opioids for the treatment of pain
US9468611B2 (en) *	2012-09-27	2016-10-18	Relmada Therapeutics, Inc.	d-Methadone for the treatment of psychiatric symptoms
AU2018215056A1 (en)	2017-01-31	2019-08-08	Charles E. Inturrisi	D-methadone and its derivatives for use in the treatment of disorders of the nervous system
WO2018183320A1 (en) *	2017-03-31	2018-10-04	Depco, Inc.	Therapeutic putty having analgesics and/or counterirritants
EP3917619A4 (en) *	2019-01-30	2022-10-26	University of Padova	Structurally modified opioids for prevention and treatment of diseases and conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3895056A (en) *	1972-12-26	1975-07-15	Lilly Co Eli	Alpha-d1-4-acetoxy-1-methyl-3,3-diphenylhexylamine and salts
US5321012A (en) *	1993-01-28	1994-06-14	Virginia Commonwealth University Medical College	Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
CA2115792C (en) *	1993-03-05	2005-11-01	David J. Mayer	Method for the treatment of pain
US5352683A (en) *	1993-03-05	1994-10-04	Virginia Commonwealth University Medical College Of Virginia	Method for the treatment of chronic pain

1998
- 1998-01-21 DE DE69837387T patent/DE69837387T2/de not_active Expired - Lifetime
- 1998-01-21 PT PT98904609T patent/PT1003494E/pt unknown
- 1998-01-21 EP EP98904609A patent/EP1003494B1/en not_active Expired - Lifetime
- 1998-01-21 DK DK98904609T patent/DK1003494T3/da active
- 1998-01-21 AU AU62448/98A patent/AU6244898A/en not_active Abandoned
- 1998-01-21 WO PCT/US1998/001088 patent/WO1998031358A1/en not_active Ceased
- 1998-01-21 CA CA002278422A patent/CA2278422C/en not_active Expired - Lifetime
- 1998-01-21 ES ES98904609T patent/ES2283049T3/es not_active Expired - Lifetime
- 1998-01-21 JP JP53465698A patent/JP4514241B2/ja not_active Expired - Lifetime
- 1998-01-21 AT AT98904609T patent/ATE357226T1/de not_active IP Right Cessation
- 1998-01-21 US US09/010,239 patent/US6008258A/en not_active Expired - Lifetime
- 1998-01-22 MA MA24934A patent/MA24794A1/fr unknown
2009
- 2009-09-14 JP JP2009211687A patent/JP2010013477A/ja active Pending

Also Published As

Publication number	Publication date
US6008258A (en)	1999-12-28
CA2278422A1 (en)	1998-07-23
JP4514241B2 (ja)	2010-07-28
EP1003494A1 (en)	2000-05-31
JP2010013477A (ja)	2010-01-21
AU6244898A (en)	1998-08-07
DE69837387D1 (de)	2007-05-03
ES2283049T3 (es)	2007-10-16
PT1003494E (pt)	2007-06-06
DE69837387T2 (de)	2007-12-13
ATE357226T1 (de)	2007-04-15
MA24794A1 (fr)	1999-12-31
EP1003494B1 (en)	2007-03-21
EP1003494A4 (en)	2002-10-16
JP2001508797A (ja)	2001-07-03
WO1998031358A1 (en)	1998-07-23
CA2278422C (en)	2007-11-13

Publication	Publication Date	Title
DK1003494T3 (da)	2007-07-16	(d)-metadon, et ikke-opioidt analgetikum
IL128003A (en)	2003-06-24	MULTISPECIFIC BINDING MOLECULES COMPRISING A BINDING DETERMINANT WHICH BINDS AN FCalpha RECEPTOR
DE69733081D1 (de)	2005-05-25	Antikonvulsive mitteln enthaltende zubereitung zur behandlung von neuropathischen schmerzen
ATE301994T1 (de)	2005-09-15	Verfahren zur erleichterung von schmerzen durch eine kombination von tramadol und einen nmda- antagonist
BR9910180A (pt)	2001-01-09	Composição farmacêutica, processos para o tratamento de uma condição associada com a transmissão reduzida de nicotina, para identificação de um modulador positivo de um agonista receptor nicotìnico e para identificação de um composto, composto, e, uso de um modulador positivo de um agonista receptor nicotìnico
AU1718400A (en)	2000-06-05	Method for treating pain
FI965203A7 (fi)	1996-12-23	Morfiinia, polypyrrolidonia ja polyalkyleenioksidia sisältävä koostumus
FR12C0001I2 (fr)	2014-05-16	Anticorps se liant de maniere immunospecifique a un stimulateur de lymphocyte b
DE69629591D1 (de)	2003-09-25	Formulierung zur intranasalen verabreichung
CA2146973A1 (en)	1994-05-11	Uses of tgf-.beta. receptor fragment as a therapeutic agent
FI823112A7 (fi)	1983-03-09	Nalbufiini-narkoottinen analgeettikoostumus ja menetelmä kivuntunnon poistamiseksi.
DK1063995T3 (da)	2003-03-10	Kombination til behandling af alkoholafhængighed indeholdende en opiod-antagonist og en NMDA-receptorkompleks-modulator
MY118828A (en)	2005-01-31	Substituted amino compounds and their use as substances having an analgesic effect
BR0110208A (pt)	2003-01-28	Composições e terapias para distúrbios associados com hiperlipidemia
ATE221391T1 (de)	2002-08-15	Konjugat enthaltend dtpa und albumin zur individuellen dosierung von arzneimitteln
SE9603725D0 (sv)	1996-10-11	New teatment
DK0846173T3 (da)	2006-01-16	Anvendelse af et anti-interleukin-9-antistof til fremstilling af et lægemiddel til behandling af astma
BG103872A (en)	2000-07-31	Glycoconjugates of 20(s)-camptotecin
EA199800866A1 (ru)	1999-06-24	Способ снятия боли
MY133169A (en)	2007-10-31	Substituted heterocyclic benzocycloalkenes and the use thereof as substances having an analgesic effect
WO1998020835A3 (en)	1998-07-16	Method of treating hyperlipidemia in humans
CA2299400A1 (en)	1999-05-06	Method for treating disease-related or drug-induced dyskinesias
WO2000051632A3 (de)	2001-10-04	Kupferagonist, der an die amyloid precursorprotein (app) bindet und/oder eine hemmende wirkung auf die amyloid-a beta-peptids ausübt
EA199800535A1 (ru)	1998-12-24	Способ лечения боли
PT862454E (pt)	2002-11-29	Novas utilizacoes de ctla-8 de mamifero e reagentes relacionados