ATE301994T1 - Verfahren zur erleichterung von schmerzen durch eine kombination von tramadol und einen nmda- antagonist - Google Patents

Verfahren zur erleichterung von schmerzen durch eine kombination von tramadol und einen nmda- antagonist

Info

Publication number
ATE301994T1
ATE301994T1 AT97911024T AT97911024T ATE301994T1 AT E301994 T1 ATE301994 T1 AT E301994T1 AT 97911024 T AT97911024 T AT 97911024T AT 97911024 T AT97911024 T AT 97911024T AT E301994 T1 ATE301994 T1 AT E301994T1
Authority
AT
Austria
Prior art keywords
tramadol
combination
relieving pain
nmda antagonist
nmda receptor
Prior art date
Application number
AT97911024T
Other languages
English (en)
Inventor
Frank S Caruso
Original Assignee
Algos Pharm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Algos Pharm Corp filed Critical Algos Pharm Corp
Application granted granted Critical
Publication of ATE301994T1 publication Critical patent/ATE301994T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT97911024T 1996-10-24 1997-10-21 Verfahren zur erleichterung von schmerzen durch eine kombination von tramadol und einen nmda- antagonist ATE301994T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73636996A 1996-10-24 1996-10-24
US08/904,519 US5919826A (en) 1996-10-24 1997-08-01 Method of alleviating pain
PCT/US1997/019075 WO1998017268A2 (en) 1996-10-24 1997-10-21 Method of alleviating pain by means of combining tramadol with an nmda antagonist

Publications (1)

Publication Number Publication Date
ATE301994T1 true ATE301994T1 (de) 2005-09-15

Family

ID=27113033

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97911024T ATE301994T1 (de) 1996-10-24 1997-10-21 Verfahren zur erleichterung von schmerzen durch eine kombination von tramadol und einen nmda- antagonist

Country Status (9)

Country Link
US (1) US5919826A (de)
EP (1) EP0938305B8 (de)
JP (1) JP3599750B2 (de)
AT (1) ATE301994T1 (de)
AU (1) AU4826197A (de)
CA (1) CA2269474C (de)
DE (1) DE69734006T2 (de)
ES (1) ES2245461T3 (de)
WO (1) WO1998017268A2 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413961B1 (en) * 1995-12-12 2002-07-02 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
US6098631A (en) * 1998-01-21 2000-08-08 The Regents Of The University Of Michigan Compositions and methods for treating autoimmune disease
US6376467B1 (en) 1998-10-09 2002-04-23 The Regents Of The University Of California Use of inhibitors of protein kinase C epsilon to treat pain
GB2339534A (en) * 1998-07-16 2000-02-02 Edko Trading Representation Epidural or intrathecal administration of NSAID's
CN1349423A (zh) * 1999-03-01 2002-05-15 奥索-麦克尼尔药品公司 包含曲马多物质和选择性cox－2抑制剂药物的组合物
DE19927689A1 (de) * 1999-06-17 2000-12-21 Gruenenthal Gmbh Orale Darreichungsformen zur Verabreichung einer fixen Kombination von Tramadol und Diclofenac
DE19940740A1 (de) * 1999-08-31 2001-03-01 Gruenenthal Gmbh Pharmazeutische Salze
EP1313460A2 (de) * 1999-11-09 2003-05-28 Darwin Discovery Limited Therapeutische verwendung und formulierungen von (-)-tramadol
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
US20040122090A1 (en) * 2001-12-07 2004-06-24 Lipton Stuart A. Methods for treating neuropsychiatric disorders with nmda receptor antagonists
EP1436258A4 (de) * 2001-03-08 2005-03-23 Univ Emory Ph-wert-abhängige nmda-rezeptorantagonisten
EP1397126B9 (de) 2001-03-16 2007-02-21 DMI Biosciences, Inc. Verwendung von Tramadol zur Verzögerung der Ejakulation
DE60143671D1 (de) * 2001-06-07 2011-01-27 Sang Christine Behandlung von neuropathischen schmerzen mittels eines n-methyl-d-aspartate (nmda)-rezeptor-antagonists
CA2368297C (en) * 2002-01-17 2011-04-12 Andritz Ab Multi-application wood working knife and clamping assembly
US8128957B1 (en) * 2002-02-21 2012-03-06 Valeant International (Barbados) Srl Modified release compositions of at least one form of tramadol
US20050182056A9 (en) * 2002-02-21 2005-08-18 Seth Pawan Modified release formulations of at least one form of tramadol
US7273889B2 (en) * 2002-09-25 2007-09-25 Innovative Drug Delivery Systems, Inc. NMDA receptor antagonist formulation with reduced neurotoxicity
MXPA02010828A (es) * 2002-11-04 2004-07-16 Leopoldo Espinosa Abdala Composicion farmaceutica en capsulas que comprende un antiinflamatorio no esteroideo y un analgesico opiaceo para el manejo del dolor.
WO2005072705A1 (en) * 2004-01-29 2005-08-11 Neuromolecular, Inc. Combination of a nmda receptor antagonist and a mao-inhibitor or a gadpf-inhibitor for the treatment of central nervous system-related conditions
EP1750677B1 (de) * 2004-05-28 2017-02-01 Imaginot Pty Ltd. Abgabesystem für eine orale therapeutische verbindung
EP1789028A2 (de) * 2004-08-24 2007-05-30 Neuromolecular Pharmaceuticals Inc Zusammensetzungen zur behandlung von nociceptiven schmerzen
US20080176873A1 (en) * 2004-11-10 2008-07-24 Trinity Laboratories, Inc. Novel Pharmaceutical Compositions for Treating Acquired Chronic Pain and Associated Dysphoria
EP1827385B1 (de) 2004-11-23 2013-03-27 Adamas Pharmaceuticals, Inc. Pharmazeutische zusammensetzung enthaltend memantin in verzögerter freisetzungs-form zur behandlung von dementia
US7619007B2 (en) * 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
US8389578B2 (en) 2004-11-24 2013-03-05 Adamas Pharmaceuticals, Inc Composition and method for treating neurological disease
JP5666087B2 (ja) 2005-04-06 2015-02-12 アダマス・ファーマシューティカルズ・インコーポレーテッド Ｃｎｓ関連疾患の治療のための方法及び組成物
CN101534808A (zh) 2005-06-27 2009-09-16 拜维尔实验室国际有限公司 丁氨苯丙酮盐的改良释放配制品
US8221792B2 (en) * 2005-07-07 2012-07-17 Farnam Companies, Inc. Sustained release pharmaceutical compositions for highly water soluble drugs
JP5528705B2 (ja) * 2005-12-13 2014-06-25 トリニティ ラボラトリーズ インコーポレイテッド ヒトにおける早漏を治療するための方法
US7645767B2 (en) 2006-08-31 2010-01-12 Trinity Laboratories, Inc. Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy
ES2573253T3 (es) 2006-09-20 2016-06-06 The Board Of Regents Of The University Of Texas System Métodos para el suministro de anestésicos volátiles para anestesia regional y/o alivio del dolor
WO2008131256A1 (en) * 2007-04-19 2008-10-30 Trinity Laboratories Inc. Improved treatments for premature ejaculation in humans
KR20100045983A (ko) 2007-06-29 2010-05-04 에모리 유니버시티 신경보호를 위한 ｎｍｄａ 수용체 길항물질
WO2009021058A2 (en) * 2007-08-06 2009-02-12 Trinity Labortories, Inc. Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy
EP3581169A1 (de) 2008-01-22 2019-12-18 The Board Of Regents Of The University Of Texas System Flüchtige anästhesiemittelzusammensetzungen mit extraktiven lösungsmitteln für lokale anästhesie und/oder schmerzlinderung
US20090246276A1 (en) 2008-01-28 2009-10-01 Graham Jackson Pharmaceutical Compositions
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
JP5864417B2 (ja) * 2009-07-16 2016-02-17 マリンクロッド エルエルシー トール様受容体９のアンタゴニストとしての（＋）−モルフィナンおよびその治療的使用
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
MX365650B (es) 2009-12-02 2019-06-10 Adamas Pharmaceuticals Inc Composiciones de amantadina y metodos para su uso.
US20110251239A1 (en) 2010-04-07 2011-10-13 Eisai Inc. Combination therapy for the treatment of dementia
WO2012008984A1 (en) * 2010-07-16 2012-01-19 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
US10154971B2 (en) 2013-06-17 2018-12-18 Adamas Pharma, Llc Methods of administering amantadine
PL3639828T3 (pl) 2013-12-24 2022-05-02 Virginia Commonwealth University Zastosowanie utlenowanych siarczanów cholesterolu (ocs) w leczeniu ostrej niewydolności wątroby
US9693949B1 (en) 2015-12-22 2017-07-04 Revogenex Ireland Ltd Intravenous administration of tramadol
US9980900B2 (en) 2015-12-22 2018-05-29 Revogenex Ireland Ltd Intravenous administration of tramadol
AU2018360383A1 (en) 2017-11-02 2020-05-21 Natureceuticals Sdn. Bhd. Extract of orthosiphon stamineus, formulations, and uses thereof
PH12022551856A1 (en) 2020-01-22 2024-01-03 Seelos Therapeutics Inc Reducing side effects of nmda antagonists
BR112022022243A2 (pt) 2020-05-01 2022-12-20 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Bloqueadores do canal de proteína e e inibidores de orf3 como agentes anti-covid-19.
WO2022113069A1 (en) 2020-11-24 2022-06-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. E protein channel blockers and orf3 inhibitors as anti-covid-19 agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
CA2095523C (en) * 1991-09-06 2004-06-22 Robert B. Raffa Composition comprising a tramadol material and acetaminophen and its use
US5516803A (en) * 1991-10-30 1996-05-14 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
WO1993017673A1 (en) * 1992-03-03 1993-09-16 Top Gold Pty., Limited Sustained release analgesics
CA2115792C (en) * 1993-03-05 2005-11-01 David J. Mayer Method for the treatment of pain
GB9417532D0 (en) * 1994-08-31 1994-10-19 Zeneca Ltd Aromatic compounds

Also Published As

Publication number Publication date
DE69734006D1 (de) 2005-09-22
DE69734006T2 (de) 2006-04-13
JP2002507962A (ja) 2002-03-12
JP3599750B2 (ja) 2004-12-08
US5919826A (en) 1999-07-06
WO1998017268A3 (en) 1998-06-25
EP0938305B8 (de) 2005-10-19
ES2245461T3 (es) 2006-01-01
WO1998017268A2 (en) 1998-04-30
EP0938305B1 (de) 2005-08-17
AU4826197A (en) 1998-05-15
EP0938305A2 (de) 1999-09-01
CA2269474A1 (en) 1998-04-30
CA2269474C (en) 2003-12-30

Similar Documents

Publication Publication Date Title
ATE301994T1 (de) Verfahren zur erleichterung von schmerzen durch eine kombination von tramadol und einen nmda- antagonist
ATE293458T1 (de) Antikonvulsive mitteln enthaltende zubereitung zur behandlung von neuropathischen schmerzen
MX9602818A (es) Un metodo de tratamiento de infeccion parasitaria usando antagonistas ige.
WO1998015275A3 (en) Method and potentiated composition for treating migraine
DE69724451D1 (de) Kombinationtherapie mit einem tnf-bindendem protein zür behandlung von durch tnf verursachten erkrangungen
DK0893992T3 (da) Hurtigt sönderdelende oral doseringsform
DE69634609D1 (de) Analgesiche synergie durch gleichzeitige verabreichung von subanalgesichen doseneines mu-opioidanagonisten und eines kappa - 2- opioidanagonisten
DK0760661T3 (da) Farmaceutiske sammensætninger omfattende en opiat-antagonist og calciumsalte, deres anvendelse til behandling af endorfin-m
DE60133029D1 (de) Mittel zur prävention oder behandlung von psoriasi
DK0662005T3 (da) Mikropartikelpræparater af biologisk nedbrydelige copolymerer
DK0415613T3 (da) Anvendelse af sertralin til behandling af præmatur ejakulation
DK0710479T3 (da) Anvendelse af en serotoninagonist sammen med en tachykininreceptorantagonist til fremstilling af et medikament til behandli
DK1003494T3 (da) (d)-metadon, et ikke-opioidt analgetikum
BR9508671A (pt) Método de alívio da dor e composição terapêutica
DK0799618T3 (da) Anvendelse af alpha1-adrenoreceptor-antagonister i fremstillingen af et medikament til forebyggelsen og behandlingen af cancer
PL312198A1 (en) Application of procaine in obtaining a pharmaceutical preparation of analgesic activity with minimum motorial blocking effect
BR0010373A (pt) Uso de um agonista de cobre e método para identificação de um agonista de cobre
DE69732133D1 (de) Verfahren und vorrichtung zur kompensation von durch chrominanzsignalverarbeitung verursachten luminanzstörungen
DE69730515D1 (de) Die verwendung von nk-1 rezeptor antagonisten für die behandlungen von stress störungen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties