DK100685A - Antipsykotiske 1-fluorphenylbutyl-4-(2-pyrimidinyl)-piperazinderivater - Google Patents

Antipsykotiske 1-fluorphenylbutyl-4-(2-pyrimidinyl)-piperazinderivater Download PDF

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Publication number
DK100685A
DK100685A DK100685A DK100685A DK100685A DK 100685 A DK100685 A DK 100685A DK 100685 A DK100685 A DK 100685A DK 100685 A DK100685 A DK 100685A DK 100685 A DK100685 A DK 100685A
Authority
DK
Denmark
Prior art keywords
antipsycotic
fluorphenyl
pyrimidinyl
butyl
piperazine derivatives
Prior art date
Application number
DK100685A
Other languages
English (en)
Other versions
DK166149B (da
DK100685D0 (da
DK166149C (da
Inventor
Joseph P Yevich
Jr Walter G Lobeck
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of DK100685D0 publication Critical patent/DK100685D0/da
Publication of DK100685A publication Critical patent/DK100685A/da
Publication of DK166149B publication Critical patent/DK166149B/da
Application granted granted Critical
Publication of DK166149C publication Critical patent/DK166149C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Legs For Furniture In General (AREA)
DK100685A 1984-03-06 1985-03-05 Antipsykotiske 1-fluorphenylbutyl-4-(2-pyrimidinyl)-piperazinderivater, farmaceutiske praeparater indeholdende saadanne derivater samt fremgangsmaade til fremstilling af derivaterne DK166149C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58658084A 1984-03-06 1984-03-06
US58658084 1984-03-06
US06/683,309 US4605655A (en) 1984-03-06 1984-12-18 Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives
US68330984 1984-12-18

Publications (4)

Publication Number Publication Date
DK100685D0 DK100685D0 (da) 1985-03-05
DK100685A true DK100685A (da) 1985-09-07
DK166149B DK166149B (da) 1993-03-15
DK166149C DK166149C (da) 1993-08-09

Family

ID=27079753

Family Applications (1)

Application Number Title Priority Date Filing Date
DK100685A DK166149C (da) 1984-03-06 1985-03-05 Antipsykotiske 1-fluorphenylbutyl-4-(2-pyrimidinyl)-piperazinderivater, farmaceutiske praeparater indeholdende saadanne derivater samt fremgangsmaade til fremstilling af derivaterne

Country Status (27)

Country Link
US (1) US4605655A (da)
KR (3) KR920005113B1 (da)
AT (1) AT390951B (da)
AU (1) AU576555B2 (da)
BE (1) BE901880A (da)
CA (1) CA1256871A (da)
CH (1) CH663022A5 (da)
CY (1) CY1545A (da)
DE (1) DE3507983A1 (da)
DK (1) DK166149C (da)
ES (1) ES8607254A1 (da)
FI (1) FI84478C (da)
FR (1) FR2560878B1 (da)
GB (1) GB2155925B (da)
GR (1) GR850561B (da)
HK (1) HK82890A (da)
HU (1) HU193949B (da)
IE (1) IE58338B1 (da)
IT (1) IT1183483B (da)
LU (1) LU85796A1 (da)
MX (1) MX9203177A (da)
MY (1) MY102240A (da)
NL (1) NL8500628A (da)
PT (1) PT80058B (da)
SE (1) SE462429B (da)
SG (1) SG35590G (da)
ZA (1) ZA851486B (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668687A (en) * 1984-07-23 1987-05-26 Bristol-Myers Company Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
US4677104A (en) * 1985-05-06 1987-06-30 Bristol-Myers Company Antipsychotic fused-ring pyridinylpiperazine derivatives
US4766215A (en) * 1987-02-27 1988-08-23 American Home Products Corporation Histamine H1 -receptor antagonists
SE8701375D0 (sv) * 1987-04-02 1987-04-02 Leo Ab Novel pyridyl- and pyrimidyl derivatives
US4826844A (en) * 1987-09-30 1989-05-02 American Home Products Corporation Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols
HU206109B (en) * 1987-10-26 1992-08-28 Pfizer Process for producing heterocyclic carbonylpropyl pyrimidinyl piperazine derivatives and pharmaceutical compositions comprising same
US4882432A (en) * 1989-01-09 1989-11-21 American Home Products Corporation Polycyclic-carbamic acid piperazinoalkyl esters and amides
GB8909209D0 (en) * 1989-04-22 1989-06-07 Wyeth John & Brother Ltd Piperazine derivatives
NZ233398A (en) * 1989-04-22 1991-12-23 American Home Prod Aryl- or heteroaryl-substituted piperazine derivatives and pharmaceutical compositions
US5055470A (en) * 1989-06-01 1991-10-08 Bristol-Myers Squibb Co. Method of treatment of ischemia in brain
US4994460A (en) * 1989-06-01 1991-02-19 Bristol-Myers Squibb Co. Agents for treatment of brain ischemia
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
US5633377A (en) * 1990-12-28 1997-05-27 Neurogen Corporation 4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands
US5681956A (en) * 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5512584A (en) * 1991-04-16 1996-04-30 Basf Aktiengesellschaft 1,3,4-trisubstituted piperidine derivatives, the preparation and use thereof
EP0538693A3 (en) * 1991-10-23 1994-08-17 Squibb & Sons Inc Stereoselective preparation of halophenyl alcohols
TW217382B (da) * 1991-10-24 1993-12-11 Bristol Myers Squibb Co
SE9201239D0 (sv) * 1992-04-21 1992-04-21 Kabi Pharmacia Ab Agents for treating substance abuse disorders
US5324662A (en) * 1992-05-15 1994-06-28 E. R. Squibb & Sons, Inc. Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
DE4243287A1 (de) * 1992-06-19 1993-12-23 Basf Ag N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
DE4219973A1 (de) * 1992-06-19 1993-12-23 Basf Ag N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
RU2124511C1 (ru) * 1993-05-14 1999-01-10 Фармасьютикал Ко., Лтд Производные пиперазина
ES2074946B1 (es) * 1993-07-19 1996-06-16 Ferrer Int Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida.
DE4341403A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
WO1995028390A1 (en) * 1994-04-18 1995-10-26 Asahi Kasei Kogyo Kabushiki Kaisha Adamantane derivative, process for producing the same, and use thereof
US5607936A (en) * 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
ES2104509B1 (es) * 1995-06-13 1998-07-01 Ferrer Int Nuevos compuestos derivados de 2-(3,4-disustituido-1-piperazinil)-5-fluoropirimidina.
US6166205A (en) * 1998-09-02 2000-12-26 Neurogen Corporation 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands
AU2008251259B2 (en) 2007-05-14 2013-02-14 Sk Biopharmaceuticals Co., Ltd. Novel carbamoyloxy arylalkanoyl arylpiperazine compound, pharmaceutical compositions comprising the compound and method for treating pain, anxiety and depression by administering the compound
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
WO2021236879A1 (en) 2020-05-20 2021-11-25 The Board Of Trustees Of The University Of Illinois Method for treating lysosomal storage diseases with histatin peptides

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL249827A (da) * 1959-03-26
US2979508A (en) * 1959-10-12 1961-04-11 Paul A J Janssen Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols
US2973360A (en) * 1959-10-12 1961-02-28 Paul A J Janssen Certain 1-(2-theonyl lower alkyl)-4-(heterocyclic substituted)-piperazines
US2985657A (en) * 1959-10-12 1961-05-23 Paul A J Janssen 1-(aroylalkyl)-4-heterocyclylpiperazines
NL127996C (da) * 1963-11-19
GB1259685A (en) * 1969-04-03 1972-01-12 Soc D Etudes Prod Chimique Amino-pyrimidine derivatives
BE758380A (fr) * 1969-11-04 1971-04-16 Sumitomo Chemical Co Procede de preparation de derives d'aryl-cetones
GB1307256A (en) * 1970-09-15 1973-02-14 Science Union & Cie Piperazine derivatives and a process for their preparation
BE882836A (fr) * 1979-05-15 1980-08-18 Soc D Etudes Prod Chimique Nouveaux derives halogenes de l'isopropylamino pyrimidine, leur preparation et leur utilisaton therapeutique
US4316899A (en) * 1979-08-24 1982-02-23 Beecham Group Limited Chromanone derivatives, a process for their preparation and compositions containing them
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
SE462429B (sv) 1990-06-25
IE58338B1 (en) 1993-09-08
MY102240A (en) 1992-05-15
CY1545A (en) 1991-03-22
HU193949B (en) 1987-12-28
SE8501067L (sv) 1985-09-07
SE8501067D0 (sv) 1985-03-05
SG35590G (en) 1990-07-13
GB8505662D0 (en) 1985-04-03
IE850546L (en) 1985-09-06
DK166149B (da) 1993-03-15
DK100685D0 (da) 1985-03-05
ATA64985A (de) 1990-01-15
CA1256871A (en) 1989-07-04
PT80058B (pt) 1987-10-20
HK82890A (en) 1990-10-19
FI850850L (fi) 1985-09-07
GB2155925B (en) 1987-11-25
ZA851486B (en) 1985-11-27
IT8519773A0 (it) 1985-03-05
PT80058A (en) 1985-04-01
LU85796A1 (fr) 1985-12-12
AT390951B (de) 1990-07-25
HUT37781A (en) 1986-02-28
FI84478C (fi) 1991-12-10
KR920005114B1 (ko) 1992-06-26
AU576555B2 (en) 1988-09-01
KR920005694B1 (ko) 1992-07-13
FR2560878A1 (fr) 1985-09-13
FI84478B (fi) 1991-08-30
ES540901A0 (es) 1986-05-16
ES8607254A1 (es) 1986-05-16
AU3944985A (en) 1985-09-12
GR850561B (da) 1985-07-03
IT1183483B (it) 1987-10-22
KR850006402A (ko) 1985-10-05
FI850850A0 (fi) 1985-03-01
BE901880A (fr) 1985-09-05
NL8500628A (nl) 1985-10-01
KR920005113B1 (ko) 1992-06-26
US4605655A (en) 1986-08-12
FR2560878B1 (fr) 1988-10-14
DE3507983A1 (de) 1985-09-12
GB2155925A (en) 1985-10-02
MX9203177A (es) 1992-07-01
DK166149C (da) 1993-08-09
CH663022A5 (de) 1987-11-13

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PUP Patent expired