SE8501067L - Antipsykotiska 1-fluorfenylbutyl-4-(2-pyrimidimyl)-piperazin-derivat - Google Patents

Antipsykotiska 1-fluorfenylbutyl-4-(2-pyrimidimyl)-piperazin-derivat

Info

Publication number: SE8501067L
Authority: SE; Sweden
Prior art keywords: pyrimidimyl; antipsycotic; fluorphenyl; butyl; ring
Prior art date: 1984-03-06

Application number

SE8501067A

Other languages

English (en)

Other versions

SE8501067D0 (sv

SE462429B (sv

Inventor

J P Yevich

Jr W G Lobeck

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-03-06

Filing date

1985-03-05

Publication date

1985-09-07

1985-03-05 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1985-03-05 Publication of SE8501067D0 publication Critical patent/SE8501067D0/sv

1985-09-07 Publication of SE8501067L publication Critical patent/SE8501067L/sv

1990-06-25 Publication of SE462429B publication Critical patent/SE462429B/sv

Links

-1 1-FLUORPHENYL Chemical class 0.000 title 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 2
239000000164 antipsychotic agent Substances 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 abstract 1
208000016285 Movement disease Diseases 0.000 abstract 1
230000000561 anti-psychotic effect Effects 0.000 abstract 1
239000003693 atypical antipsychotic agent Substances 0.000 abstract 1
229940127236 atypical antipsychotics Drugs 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
230000000506 psychotropic effect Effects 0.000 abstract 1
125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000383 tetramethylene group Chemical class [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Legs For Furniture In General (AREA)
Plural Heterocyclic Compounds (AREA)

SE8501067A 1984-03-06 1985-03-05 Antipsykotiska 1-fluorfenylbutyl-4-(2-pyrimidinyl)-piperazinderivat, foerfarande foer framstaellning av dessa och en farmaceutisk komposition SE462429B (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US58658084A	1984-03-06	1984-03-06
US06/683,309 US4605655A (en)	1984-03-06	1984-12-18	Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives

Publications (3)

Publication Number	Publication Date
SE8501067D0 SE8501067D0 (sv)	1985-03-05
SE8501067L true SE8501067L (sv)	1985-09-07
SE462429B SE462429B (sv)	1990-06-25

Family

ID=27079753

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8501067A SE462429B (sv)	1984-03-06	1985-03-05	Antipsykotiska 1-fluorfenylbutyl-4-(2-pyrimidinyl)-piperazinderivat, foerfarande foer framstaellning av dessa och en farmaceutisk komposition

Country Status (27)

Country	Link
US (1)	US4605655A (sv)
KR (3)	KR920005113B1 (sv)
AT (1)	AT390951B (sv)
AU (1)	AU576555B2 (sv)
BE (1)	BE901880A (sv)
CA (1)	CA1256871A (sv)
CH (1)	CH663022A5 (sv)
CY (1)	CY1545A (sv)
DE (1)	DE3507983A1 (sv)
DK (1)	DK166149C (sv)
ES (1)	ES8607254A1 (sv)
FI (1)	FI84478C (sv)
FR (1)	FR2560878B1 (sv)
GB (1)	GB2155925B (sv)
GR (1)	GR850561B (sv)
HK (1)	HK82890A (sv)
HU (1)	HU193949B (sv)
IE (1)	IE58338B1 (sv)
IT (1)	IT1183483B (sv)
LU (1)	LU85796A1 (sv)
MX (1)	MX9203177A (sv)
MY (1)	MY102240A (sv)
NL (1)	NL8500628A (sv)
PT (1)	PT80058B (sv)
SE (1)	SE462429B (sv)
SG (1)	SG35590G (sv)
ZA (1)	ZA851486B (sv)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4668687A (en) *	1984-07-23	1987-05-26	Bristol-Myers Company	Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
US4677104A (en) *	1985-05-06	1987-06-30	Bristol-Myers Company	Antipsychotic fused-ring pyridinylpiperazine derivatives
US4766215A (en) *	1987-02-27	1988-08-23	American Home Products Corporation	Histamine H1 -receptor antagonists
SE8701375D0 (sv) *	1987-04-02	1987-04-02	Leo Ab	Novel pyridyl- and pyrimidyl derivatives
US4826844A (en) *	1987-09-30	1989-05-02	American Home Products Corporation	Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols
US4994455A (en) *	1987-10-26	1991-02-19	Pfizer Inc.	Anti-anxiety agents
US4882432A (en) *	1989-01-09	1989-11-21	American Home Products Corporation	Polycyclic-carbamic acid piperazinoalkyl esters and amides
GB8909209D0 (en) *	1989-04-22	1989-06-07	Wyeth John & Brother Ltd	Piperazine derivatives
EP0955296A3 (en) *	1989-04-22	2000-01-19	American Home Products Corporation	Tertiary alkyl functionalized piperazine derivatives
US5055470A (en) *	1989-06-01	1991-10-08	Bristol-Myers Squibb Co.	Method of treatment of ischemia in brain
US4994460A (en) *	1989-06-01	1991-02-19	Bristol-Myers Squibb Co.	Agents for treatment of brain ischemia
FR2672052B1 (fr) *	1991-01-28	1995-05-24	Esteve Labor Dr	Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
US5633377A (en) *	1990-12-28	1997-05-27	Neurogen Corporation	4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands
US5681956A (en) *	1990-12-28	1997-10-28	Neurogen Corporation	4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5512584A (en) *	1991-04-16	1996-04-30	Basf Aktiengesellschaft	1,3,4-trisubstituted piperidine derivatives, the preparation and use thereof
EP0538693A3 (en) *	1991-10-23	1994-08-17	Squibb & Sons Inc	Stereoselective preparation of halophenyl alcohols
TW217382B (sv) *	1991-10-24	1993-12-11	Bristol Myers Squibb Co
SE9201239D0 (sv) *	1992-04-21	1992-04-21	Kabi Pharmacia Ab	Agents for treating substance abuse disorders
US5324662A (en) *	1992-05-15	1994-06-28	E. R. Squibb & Sons, Inc.	Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
DE4243287A1 (de) *	1992-06-19	1993-12-23	Basf Ag	N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
DE4219973A1 (de) *	1992-06-19	1993-12-23	Basf Ag	N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
RU2124511C1 (ru) *	1993-05-14	1999-01-10	Фармасьютикал Ко., Лтд	Производные пиперазина
ES2074946B1 (es) *	1993-07-19	1996-06-16	Ferrer Int	Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida.
DE4341403A1 (de) *	1993-12-04	1995-06-08	Basf Ag	N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
CA2187542C (en) *	1994-04-18	2000-02-01	Nobuyuki Takahashi	Adamantane derivative, process for producing the same, and use thereof
US5607936A (en) *	1994-09-30	1997-03-04	Merck & Co., Inc.	Substituted aryl piperazines as neurokinin antagonists
ES2104509B1 (es) *	1995-06-13	1998-07-01	Ferrer Int	Nuevos compuestos derivados de 2-(3,4-disustituido-1-piperazinil)-5-fluoropirimidina.
US6166205A (en) *	1998-09-02	2000-12-26	Neurogen Corporation	2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands
CA2686926C (en)	2007-05-14	2016-01-05	Sk Holdings Co., Ltd.	Novel carbamoyloxy arylalkanoyl arylpiperazine compound, pharmaceutical compositions comprising the compound and method for treating pain, anxiety and depression by administering the compound
US10154988B2 (en)	2012-11-14	2018-12-18	The Johns Hopkins University	Methods and compositions for treating schizophrenia
IL298323B2 (en)	2020-05-20	2023-10-01	Univ Illinois	A method for treating lysosomal storage disease using histatin peptides

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE589092A (sv) *	1959-03-26
US2973360A (en) *	1959-10-12	1961-02-28	Paul A J Janssen	Certain 1-(2-theonyl lower alkyl)-4-(heterocyclic substituted)-piperazines
US2985657A (en) *	1959-10-12	1961-05-23	Paul A J Janssen	1-(aroylalkyl)-4-heterocyclylpiperazines
US2979508A (en) *	1959-10-12	1961-04-11	Paul A J Janssen	Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols
NL127996C (sv) *	1963-11-19
GB1259685A (en) *	1969-04-03	1972-01-12	Soc D Etudes Prod Chimique	Amino-pyrimidine derivatives
BE758380A (fr) *	1969-11-04	1971-04-16	Sumitomo Chemical Co	Procede de preparation de derives d'aryl-cetones
GB1307256A (en) *	1970-09-15	1973-02-14	Science Union & Cie	Piperazine derivatives and a process for their preparation
BE882836A (fr) *	1979-05-15	1980-08-18	Soc D Etudes Prod Chimique	Nouveaux derives halogenes de l'isopropylamino pyrimidine, leur preparation et leur utilisaton therapeutique
US4316899A (en) *	1979-08-24	1982-02-23	Beecham Group Limited	Chromanone derivatives, a process for their preparation and compositions containing them
DE3321969A1 (de) *	1983-06-18	1984-12-20	Troponwerke GmbH & Co KG, 5000 Köln	2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

1984
- 1984-12-18 US US06/683,309 patent/US4605655A/en not_active Expired - Lifetime
1985
- 1985-02-27 ZA ZA851486A patent/ZA851486B/xx unknown
- 1985-03-01 FI FI850850A patent/FI84478C/sv not_active IP Right Cessation
- 1985-03-04 ES ES540901A patent/ES8607254A1/es not_active Expired
- 1985-03-04 AU AU39449/85A patent/AU576555B2/en not_active Expired
- 1985-03-05 IT IT19773/85A patent/IT1183483B/it active
- 1985-03-05 BE BE0/214607A patent/BE901880A/fr not_active IP Right Cessation
- 1985-03-05 HU HU85831A patent/HU193949B/hu unknown
- 1985-03-05 SE SE8501067A patent/SE462429B/sv not_active IP Right Cessation
- 1985-03-05 GR GR850561A patent/GR850561B/el not_active IP Right Cessation
- 1985-03-05 LU LU85796A patent/LU85796A1/fr unknown
- 1985-03-05 IE IE54685A patent/IE58338B1/en not_active IP Right Cessation
- 1985-03-05 PT PT80058A patent/PT80058B/pt unknown
- 1985-03-05 DK DK100685A patent/DK166149C/da not_active IP Right Cessation
- 1985-03-05 AT AT0064985A patent/AT390951B/de not_active IP Right Cessation
- 1985-03-05 CH CH991/85A patent/CH663022A5/de not_active IP Right Cessation
- 1985-03-05 FR FR8503220A patent/FR2560878B1/fr not_active Expired
- 1985-03-05 GB GB08505662A patent/GB2155925B/en not_active Expired
- 1985-03-06 NL NL8500628A patent/NL8500628A/nl active Search and Examination
- 1985-03-06 CA CA000475878A patent/CA1256871A/en not_active Expired
- 1985-03-06 DE DE19853507983 patent/DE3507983A1/de not_active Ceased
- 1985-03-06 KR KR1019850001414A patent/KR920005113B1/ko not_active Expired
1987
- 1987-10-01 MY MYPI87002690A patent/MY102240A/en unknown
1990
- 1990-05-19 SG SG355/90A patent/SG35590G/en unknown
- 1990-10-11 HK HK828/90A patent/HK82890A/xx not_active IP Right Cessation
1991
- 1991-03-22 CY CY1545A patent/CY1545A/en unknown
1992
- 1992-05-09 KR KR1019920007855A patent/KR920005694B1/ko not_active Expired
- 1992-05-09 KR KR1019920007854A patent/KR920005114B1/ko not_active Expired
- 1992-06-23 MX MX9203177A patent/MX9203177A/es unknown

Also Published As

Publication number	Publication date
FR2560878A1 (fr)	1985-09-13
SG35590G (en)	1990-07-13
ES8607254A1 (es)	1986-05-16
DK100685D0 (da)	1985-03-05
HK82890A (en)	1990-10-19
FI850850L (fi)	1985-09-07
CY1545A (en)	1991-03-22
ZA851486B (en)	1985-11-27
LU85796A1 (fr)	1985-12-12
KR920005113B1 (ko)	1992-06-26
PT80058B (pt)	1987-10-20
FR2560878B1 (fr)	1988-10-14
IT8519773A0 (it)	1985-03-05
DE3507983A1 (de)	1985-09-12
MY102240A (en)	1992-05-15
DK166149B (da)	1993-03-15
IE58338B1 (en)	1993-09-08
KR920005114B1 (ko)	1992-06-26
FI84478B (fi)	1991-08-30
CA1256871A (en)	1989-07-04
FI84478C (sv)	1991-12-10
BE901880A (fr)	1985-09-05
ATA64985A (de)	1990-01-15
PT80058A (en)	1985-04-01
SE8501067D0 (sv)	1985-03-05
GB2155925B (en)	1987-11-25
HUT37781A (en)	1986-02-28
GB2155925A (en)	1985-10-02
HU193949B (en)	1987-12-28
SE462429B (sv)	1990-06-25
FI850850A0 (fi)	1985-03-01
MX9203177A (es)	1992-07-01
KR850006402A (ko)	1985-10-05
US4605655A (en)	1986-08-12
NL8500628A (nl)	1985-10-01
DK100685A (da)	1985-09-07
CH663022A5 (de)	1987-11-13
DK166149C (da)	1993-08-09
AU3944985A (en)	1985-09-12
IT1183483B (it)	1987-10-22
GB8505662D0 (en)	1985-04-03
KR920005694B1 (ko)	1992-07-13
AT390951B (de)	1990-07-25
AU576555B2 (en)	1988-09-01
ES540901A0 (es)	1986-05-16
GR850561B (sv)	1985-07-03
IE850546L (en)	1985-09-06

Legal Events

Date

Code

Title

Description

1995-01-31

NAL

Patent in force

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2005-05-03

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Patent has lapsed

Publication	Publication Date	Title
SE8501067D0 (sv)	1985-03-05	Antipsychotic 1-fluorophenylbutyl-4-(2-pyri-midinyl)piperazine derivatives
AU588015B2 (en)	1989-09-07	Heterocyclic piperazine derivatives
MX9102407A (es)	1994-05-31	4 arilpiperazinas y 4-arilpiperidinas novedosas.
DE69630214D1 (de)	2003-11-06	Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien
SE7713471L (sv)	1978-06-08	Nya organiska foreningar, deras framstellning och anvendning
DE3783988D1 (de)	1993-03-18	Zyklische enolderivate, herstellung und anwendung.
DE69721008D1 (de)	2003-05-22	Bicyclische pyrimidine derivate und ihre verwendung als antikoagulantien
OA09321A (en)	1992-09-15	Fused polycyclic compounds, compositions, methods of manufacture and their use as PAF antagonists, antihistamines and/or antiinflammatory agents.
ES2103287T3 (es)	1997-09-16	Nuevos derivados de tiazolidina.
MY102080A (en)	1992-03-31	Pharmacologically active substituted benzamides
NO20022976D0 (no)	2002-06-20	2-(1H-indol-3yl)-2-okso-acetamider med antitumoraktivitet
ES2087936T3 (es)	1996-08-01	Benceno, piridina y derivado de pirimidina.
FI851261A0 (fi)	1985-03-28	Substituerade bensopyraner, foerfarande foer deras framstaellning och deras anvaendning i laekemedel.
FR2390446A1 (fr)	1978-12-08	Nouvelles triazines 1,3,5-s-hexahydrotrisubstituees, leur preparation et leur application a la lutte contre le developpement microbien
PE52894A1 (es)	1995-01-06	Derivado de camptotecina soluble en agua
ES2059396T3 (es)	1994-11-16	Derivados de indeno y metodos.
FR2372839A1 (fr)	1978-06-30	Derives d'oxazolidinedione des alcaloides de vinca, a activite antitumorale
FR2389624A1 (sv)	1978-12-01
ES2042850T3 (es)	1993-12-16	Nuevo procedimiento para la preparacion de oxalil- y oxamil-hidracidas.
ATE131172T1 (de)	1995-12-15	Heterocyclische nmda antagonisten.
ES424545A1 (es)	1976-05-16	Procedimiento para la obtencion de derivados de imidazo he-terociclicos.
ATE7694T1 (de)	1984-06-15	Derivate von 2-methyl-5-thiazolmethylamin und carboxamid.
FI842041A0 (fi)	1984-05-22	Klass iii antiarrytmiskt foerfarande.
FR2400024A1 (fr)	1979-03-09	Nouveaux derives de penicilline
FI863079A0 (fi)	1986-07-28	Kontinuerligt frigoerande fenyletanolaminderivatkompositioner.