DK1007527T3 - Optisk rene camptothecinanaloger, optisk rene syntesemellemprodukter og fremgangsmåde til fremstilling heraf - Google Patents

Optisk rene camptothecinanaloger, optisk rene syntesemellemprodukter og fremgangsmåde til fremstilling heraf

Info

Publication number
DK1007527T3
DK1007527T3 DK98941567T DK98941567T DK1007527T3 DK 1007527 T3 DK1007527 T3 DK 1007527T3 DK 98941567 T DK98941567 T DK 98941567T DK 98941567 T DK98941567 T DK 98941567T DK 1007527 T3 DK1007527 T3 DK 1007527T3
Authority
DK
Denmark
Prior art keywords
optically pure
preparation
synthetic intermediates
camptothecin analogs
pure synthetic
Prior art date
Application number
DK98941567T
Other languages
Danish (da)
English (en)
Inventor
Eric Manginot
Jean-Bernard Cazaux
Olivier Lavergne
Breton Christine Le
Dennis Bigg
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Application granted granted Critical
Publication of DK1007527T3 publication Critical patent/DK1007527T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK98941567T 1997-08-29 1998-08-07 Optisk rene camptothecinanaloger, optisk rene syntesemellemprodukter og fremgangsmåde til fremstilling heraf DK1007527T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9710785A FR2768431B1 (fr) 1997-08-29 1997-08-29 Nouveaux analogues optiquement purs de la camptothecine, nouvel intermediaire de synthese optiquement pur et son procede de preparation
PCT/FR1998/001768 WO1999011646A1 (fr) 1997-08-29 1998-08-07 Analogues optiquement purs de la camptothecine, intermediaire de synthese optiquement pur et son procede de preparation

Publications (1)

Publication Number Publication Date
DK1007527T3 true DK1007527T3 (da) 2004-03-08

Family

ID=9510590

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98941567T DK1007527T3 (da) 1997-08-29 1998-08-07 Optisk rene camptothecinanaloger, optisk rene syntesemellemprodukter og fremgangsmåde til fremstilling heraf

Country Status (25)

Country Link
EP (2) EP1007527B1 (cs)
JP (1) JP2001514261A (cs)
KR (1) KR100570254B1 (cs)
CN (3) CN1104434C (cs)
AR (1) AR016856A1 (cs)
AT (1) ATE253069T1 (cs)
AU (1) AU760863B2 (cs)
BR (1) BR9811405A (cs)
CA (1) CA2301739C (cs)
CZ (1) CZ297896B6 (cs)
DE (1) DE69819340T2 (cs)
DK (1) DK1007527T3 (cs)
ES (1) ES2209196T3 (cs)
FR (1) FR2768431B1 (cs)
HR (1) HRP20000110A2 (cs)
HU (1) HUP0003429A3 (cs)
IL (2) IL134437A0 (cs)
NO (1) NO324882B1 (cs)
NZ (1) NZ502862A (cs)
PL (1) PL195289B1 (cs)
PT (1) PT1007527E (cs)
RU (1) RU2233283C2 (cs)
TW (1) TW419479B (cs)
WO (1) WO1999011646A1 (cs)
ZA (1) ZA987445B (cs)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790261B1 (fr) 1999-02-26 2004-09-10 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6372906B1 (en) 2001-04-12 2002-04-16 University Of Pittsburgh Synthesis of silyl camptothecins and silyl homocamptothecins
US6723853B2 (en) 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
CN100408582C (zh) * 2004-02-12 2008-08-06 中国人民解放军第二军医大学 高喜树碱类化合物及其制备方法和用途
JP2008513437A (ja) * 2004-09-21 2008-05-01 ソシエテ ド コンセイユ ド ルシェルシェ エ ダアップリカーション シャンティフィック（エス．セー．エール．アー．エス．） 有用な中間体の新規製造方法
CN100465175C (zh) * 2005-11-29 2009-03-04 中国人民解放军第二军医大学 7-位取代高喜树碱类化合物及作为药物的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3008226B2 (ja) * 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
US5459269A (en) * 1992-06-18 1995-10-17 North Carolina State University 14-halo-camptothecins
FR2757514B1 (fr) * 1996-12-20 1999-02-12 Sod Conseils Rech Applic Nouveaux analogues de la camptothecine, des procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
DE69635560T2 (de) * 1995-06-21 2006-08-17 Société de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.) Camptothecinanaloge, Verfahren zur ihrer Herstellung, ihre Verwendung als Arzneimittel und diese enthaltende pharmazeutische Zusammensetzungen

Also Published As

Publication number Publication date
KR100570254B1 (ko) 2006-04-12
AU760863B2 (en) 2003-05-22
ES2209196T3 (es) 2004-06-16
AU8989698A (en) 1999-03-22
DE69819340T2 (de) 2004-08-19
HRP20000110A2 (en) 2001-02-28
IL134437A0 (en) 2001-04-30
BR9811405A (pt) 2000-08-29
CZ297896B6 (cs) 2007-04-25
NO324882B1 (no) 2007-12-27
DE69819340D1 (de) 2003-12-04
NO20000995D0 (no) 2000-02-28
IL134437A (en) 2006-08-01
HUP0003429A3 (en) 2002-11-28
AR016856A1 (es) 2001-08-01
HK1031732A1 (en) 2001-06-22
EP1007527B1 (fr) 2003-10-29
CN1440973A (zh) 2003-09-10
CZ2000711A3 (cs) 2000-08-16
TW419479B (en) 2001-01-21
ATE253069T1 (de) 2003-11-15
NZ502862A (en) 2002-10-25
CN1195758C (zh) 2005-04-06
EP1378512A1 (fr) 2004-01-07
HUP0003429A1 (hu) 2001-07-30
RU2233283C2 (ru) 2004-07-27
FR2768431A1 (fr) 1999-03-19
PL195289B1 (pl) 2007-08-31
WO1999011646A1 (fr) 1999-03-11
CN1268948A (zh) 2000-10-04
CA2301739A1 (fr) 1999-03-11
PT1007527E (pt) 2004-03-31
PL338835A1 (en) 2000-11-20
JP2001514261A (ja) 2001-09-11
CA2301739C (fr) 2009-11-17
EP1007527A1 (fr) 2000-06-14
NO20000995L (no) 2000-02-28
FR2768431B1 (fr) 2000-03-24
CN1440972A (zh) 2003-09-10
KR20010023394A (ko) 2001-03-26
CN1104434C (zh) 2003-04-02
HK1058665A1 (en) 2004-05-28
ZA987445B (en) 1999-02-17

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