DK1018008T3 - Fremgangsmåde til identifikation af förerstrukturer eller aktive forbindelser - Google Patents
Fremgangsmåde til identifikation af förerstrukturer eller aktive forbindelserInfo
- Publication number
- DK1018008T3 DK1018008T3 DK98950081T DK98950081T DK1018008T3 DK 1018008 T3 DK1018008 T3 DK 1018008T3 DK 98950081 T DK98950081 T DK 98950081T DK 98950081 T DK98950081 T DK 98950081T DK 1018008 T3 DK1018008 T3 DK 1018008T3
- Authority
- DK
- Denmark
- Prior art keywords
- leads
- compounds
- active compounds
- driver structures
- identifying driver
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Physics & Mathematics (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Food Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97402239A EP0905512A1 (en) | 1997-09-25 | 1997-09-25 | Method of identification of leads or active compounds |
| EP98950081A EP1018008B1 (en) | 1997-09-25 | 1998-09-25 | Method of identification of leads or active compounds |
| PCT/EP1998/006105 WO1999015894A2 (en) | 1997-09-25 | 1998-09-25 | Method of identification of leads or active compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1018008T3 true DK1018008T3 (da) | 2005-06-20 |
Family
ID=8229857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98950081T DK1018008T3 (da) | 1997-09-25 | 1998-09-25 | Fremgangsmåde til identifikation af förerstrukturer eller aktive forbindelser |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP0905512A1 (da) |
| JP (1) | JP2003524144A (da) |
| AT (1) | ATE290691T1 (da) |
| AU (1) | AU751416B2 (da) |
| CA (1) | CA2304783A1 (da) |
| DE (1) | DE69829299T2 (da) |
| DK (1) | DK1018008T3 (da) |
| ES (1) | ES2236949T3 (da) |
| PT (1) | PT1018008E (da) |
| TW (1) | TW554170B (da) |
| WO (1) | WO1999015894A2 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1025256A2 (en) * | 1997-10-09 | 2000-08-09 | Ixsys, Incorporated | Method for identifying binding ligands to receptors |
| CA2465328C (en) * | 2001-11-01 | 2011-06-14 | Michael Francis Gross | Piperidines |
| US6853952B2 (en) | 2003-05-13 | 2005-02-08 | Pa Knowledge Limited | Method and systems of enhancing the effectiveness and success of research and development |
| EP1997805A1 (en) * | 2007-06-01 | 2008-12-03 | Commissariat à l'Energie Atomique | Compounds with antiparasitic activity, applications thereof to the treatment of infectious diseases caused by apicomplexans |
| GB0909743D0 (en) * | 2009-06-05 | 2009-07-22 | F2G Ltd | Antifungal targgt |
| CN114730397A (zh) * | 2019-10-03 | 2022-07-08 | 艾腾怀斯股份有限公司 | 用于通过计算机模拟筛选化合物的系统和方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2201061T3 (es) * | 1992-08-13 | 2004-03-16 | The Regents Of The University Of California | Genes de receptores opioides delta. |
| CA2189634A1 (en) * | 1994-05-06 | 1995-11-16 | John J. Baldwin | Combinatorial dihydrobenzopyran library |
| JPH11500419A (ja) * | 1995-01-11 | 1999-01-12 | パンラブス・インコーポレーテッド | 分類された大量の化学ライブラリの製造方法 |
| US6341256B1 (en) * | 1995-03-31 | 2002-01-22 | Curagen Corporation | Consensus configurational bias Monte Carlo method and system for pharmacophore structure determination |
| US5807754A (en) * | 1995-05-11 | 1998-09-15 | Arqule, Inc. | Combinatorial synthesis and high-throughput screening of a Rev-inhibiting arylidenediamide array |
| AU7457796A (en) * | 1995-10-23 | 1997-05-15 | Tularik Inc. | Rip: novel human protein involved in tumor necrosis factor signal transduction, and screening assays |
-
1997
- 1997-09-25 EP EP97402239A patent/EP0905512A1/en not_active Withdrawn
-
1998
- 1998-09-25 AT AT98950081T patent/ATE290691T1/de not_active IP Right Cessation
- 1998-09-25 TW TW087115977A patent/TW554170B/zh not_active IP Right Cessation
- 1998-09-25 ES ES98950081T patent/ES2236949T3/es not_active Expired - Lifetime
- 1998-09-25 WO PCT/EP1998/006105 patent/WO1999015894A2/en not_active Ceased
- 1998-09-25 CA CA002304783A patent/CA2304783A1/en not_active Abandoned
- 1998-09-25 AU AU96281/98A patent/AU751416B2/en not_active Ceased
- 1998-09-25 JP JP2000513141A patent/JP2003524144A/ja not_active Ceased
- 1998-09-25 PT PT98950081T patent/PT1018008E/pt unknown
- 1998-09-25 EP EP98950081A patent/EP1018008B1/en not_active Revoked
- 1998-09-25 DE DE69829299T patent/DE69829299T2/de not_active Revoked
- 1998-09-25 DK DK98950081T patent/DK1018008T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| PT1018008E (pt) | 2005-07-29 |
| DE69829299D1 (de) | 2005-04-14 |
| CA2304783A1 (en) | 1999-04-01 |
| AU9628198A (en) | 1999-04-12 |
| DE69829299T2 (de) | 2006-04-13 |
| JP2003524144A (ja) | 2003-08-12 |
| WO1999015894A2 (en) | 1999-04-01 |
| EP1018008B1 (en) | 2005-03-09 |
| EP1018008A2 (en) | 2000-07-12 |
| ATE290691T1 (de) | 2005-03-15 |
| AU751416B2 (en) | 2002-08-15 |
| TW554170B (en) | 2003-09-21 |
| EP0905512A1 (en) | 1999-03-31 |
| ES2236949T3 (es) | 2005-07-16 |
| WO1999015894A3 (en) | 1999-08-19 |
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