DK1025253T3 - Positiv-negativ-selektion ved den homologe rekombination - Google Patents

Positiv-negativ-selektion ved den homologe rekombination

Info

Publication number
DK1025253T3
DK1025253T3 DK98955483T DK98955483T DK1025253T3 DK 1025253 T3 DK1025253 T3 DK 1025253T3 DK 98955483 T DK98955483 T DK 98955483T DK 98955483 T DK98955483 T DK 98955483T DK 1025253 T3 DK1025253 T3 DK 1025253T3
Authority
DK
Denmark
Prior art keywords
positive
homologous recombination
negative selection
negative
selection
Prior art date
Application number
DK98955483T
Other languages
English (en)
Other versions
DK1025253T4 (da
Inventor
Johannes Auer
Raimund Sprenger
Konrad Honold
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8227499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1025253(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of DK1025253T3 publication Critical patent/DK1025253T3/da
Application granted granted Critical
Publication of DK1025253T4 publication Critical patent/DK1025253T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK98955483T 1997-10-20 1998-10-20 Positiv-negativ-selektion ved den homologe rekombination DK1025253T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97118175 1997-10-20
PCT/EP1998/006616 WO1999020780A1 (de) 1997-10-20 1998-10-20 Positiv-negativ-selektion bei der homologen rekombination

Publications (2)

Publication Number Publication Date
DK1025253T3 true DK1025253T3 (da) 2004-07-12
DK1025253T4 DK1025253T4 (da) 2009-08-31

Family

ID=8227499

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98955483T DK1025253T4 (da) 1997-10-20 1998-10-20 Positiv-negativ-selektion ved den homologe rekombination

Country Status (17)

Country Link
US (1) US6284541B1 (da)
EP (1) EP1025253B2 (da)
JP (1) JP4417549B2 (da)
KR (1) KR100566702B1 (da)
CN (1) CN1146666C (da)
AR (1) AR017368A1 (da)
AT (1) ATE260982T1 (da)
AU (1) AU730466B2 (da)
BR (1) BR9813099B1 (da)
CA (1) CA2306229C (da)
DE (1) DE59810925D1 (da)
DK (1) DK1025253T4 (da)
ES (1) ES2213925T5 (da)
PT (1) PT1025253E (da)
TR (1) TR200001046T2 (da)
WO (1) WO1999020780A1 (da)
ZA (1) ZA989497B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220221B2 (en) * 2000-05-03 2007-05-22 Nautilus, Inc. Exercise device with body extension mechanism
AU2001289104A1 (en) * 2000-09-15 2002-03-26 Deltagen, Inc. Methods of producing cells and animals comprising targeted gene modifications
WO2002055687A2 (en) * 2000-12-13 2002-07-18 Deltagen Inc Transgenic mice containing target gene disruptions
WO2003027261A2 (en) * 2001-09-27 2003-04-03 Functional Genetics, Inc. Methods and compositions for gene targeting by homologous recombination
ATE476503T1 (de) † 2001-10-01 2010-08-15 Deutsches Krebsforsch Verfahren zur herstellung von protein- bibliotheken und zur selektion von proteinen daraus
AU2002351233A1 (en) * 2001-12-04 2003-06-17 Genome Biosciences, Llc Gene targeting methods and vectors
CA2484360A1 (en) * 2002-05-02 2003-11-13 The University Of North Carolina At Chapel Hill In vitro mutagenesis, phenotyping, and gene mapping
FR2860517B1 (fr) * 2003-10-03 2006-02-10 Evologic Sa Procedes et outils pour la modification chromosomique de bacteries
CN101137752B (zh) 2005-03-08 2013-04-03 巴斯福植物科学有限公司 增强表达的内含子序列
ATE536374T1 (de) 2006-09-01 2011-12-15 Therapeutic Human Polyclonals Inc Erhöhte expression von humanem oder humanisiertem immunglobulin bei nicht-humanen transgenen tieren
UA100692C2 (ru) 2007-05-02 2013-01-25 Мериал Лимитед Днк-плазмиды, имеющие повышенную экспрессию и стабильность
EP2281048A4 (en) * 2008-04-21 2012-04-18 Unitargeting Res As GENETICALLY MODIFIED EUKARINOUS CELLS
CN102618453A (zh) * 2011-10-31 2012-08-01 四川农业大学 猪传染性胸膜肺炎放线杆菌Apx I C基因缺失突变株、构建方法、疫苗及应用
CN104053773A (zh) * 2011-12-13 2014-09-17 公立大学法人横滨市立大学 基因打靶载体及其利用方法
DE102014116334A1 (de) * 2014-11-10 2016-05-12 Eberhard Karls Universität Tübingen Medizinische Fakultät Herstellung von rekombinanten Expressionsvektoren
JP7585015B2 (ja) 2020-12-04 2024-11-18 株式会社東芝 核酸構築物のセット、キット、検出方法及び薬剤効果予測方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01203975A (ja) * 1988-02-09 1989-08-16 Konica Corp 流体試料中の特定成分の測定方法
DE3907679A1 (de) * 1989-03-09 1990-09-13 Max Planck Gesellschaft Verfahren zur gezielten veraenderung eines gens
US5464764A (en) * 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
ATE174058T1 (de) † 1989-11-06 1998-12-15 Cell Genesys Inc Herstellung von proteinen mittels homologer rekombination
CA2040099A1 (en) 1990-05-01 1991-11-02 Mariano Barbacid Tyrosine kinase negative trkb
JPH06503722A (ja) * 1990-11-30 1994-04-28 アボット・ラボラトリーズ 末端欠失神経成長因子受容体の検出に有用なイムノアッセイおよびモノクローナル抗体
NZ245015A (en) † 1991-11-05 1995-12-21 Transkaryotic Therapies Inc Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production
US5641670A (en) * 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
EP0700430B1 (en) * 1993-06-04 2005-04-20 The United States of America as Represented by the Secretary of the Navy Methods for selectively stimulating proliferation of t cells
IT1261847B (it) 1993-09-01 1996-06-03 San Romanello Centro Fond Metodo per marcare cellule eucariote.
US6066322A (en) * 1995-03-03 2000-05-23 Millennium Pharmaceuticals, Inc. Methods for the treatment of immune disorders
US5633161A (en) * 1995-03-29 1997-05-27 Millennium Pharmaceuticals, Inc. Murine gene fomy030 coding for tumor progression inhibitor
US6017754A (en) 1995-08-24 2000-01-25 Invitrogen Corporation System for isolating and identifying eukaryotic cells transfected with genes and vectors, host cells and methods thereof

Also Published As

Publication number Publication date
AR017368A1 (es) 2001-09-05
CN1276836A (zh) 2000-12-13
JP2001523442A (ja) 2001-11-27
KR100566702B1 (ko) 2006-04-03
CA2306229C (en) 2011-03-22
BR9813099B1 (pt) 2010-02-09
ES2213925T5 (es) 2009-11-11
JP4417549B2 (ja) 2010-02-17
BR9813099A (pt) 2000-08-22
AU1229399A (en) 1999-05-10
EP1025253B1 (de) 2004-03-03
US6284541B1 (en) 2001-09-04
ATE260982T1 (de) 2004-03-15
CA2306229A1 (en) 1999-04-29
ES2213925T3 (es) 2004-09-01
PT1025253E (pt) 2004-07-30
CN1146666C (zh) 2004-04-21
EP1025253A1 (de) 2000-08-09
KR20010031277A (ko) 2001-04-16
WO1999020780A1 (de) 1999-04-29
TR200001046T2 (tr) 2001-07-23
EP1025253B2 (de) 2009-07-29
ZA989497B (en) 2000-04-19
AU730466B2 (en) 2001-03-08
DK1025253T4 (da) 2009-08-31
DE59810925D1 (de) 2004-04-08

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