DK103687A - 7-(1-pyrrolidinyl)-quinoloncarboxylsyrederivater, fremgangsmaader til deres fremstilling og deres anvendelse i laegemidler - Google Patents
7-(1-pyrrolidinyl)-quinoloncarboxylsyrederivater, fremgangsmaader til deres fremstilling og deres anvendelse i laegemidlerInfo
- Publication number
- DK103687A DK103687A DK103687A DK103687A DK103687A DK 103687 A DK103687 A DK 103687A DK 103687 A DK103687 A DK 103687A DK 103687 A DK103687 A DK 103687A DK 103687 A DK103687 A DK 103687A
- Authority
- DK
- Denmark
- Prior art keywords
- pyrrolidinyl
- acid derivatives
- pharmaceuticals
- procedures
- preparation
- Prior art date
Links
- VLRVZPBUWJJETB-UHFFFAOYSA-N 2-oxo-7-pyrrolidin-1-yl-1h-quinoline-3-carboxylic acid Chemical class C1=C2NC(=O)C(C(=O)O)=CC2=CC=C1N1CCCC1 VLRVZPBUWJJETB-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- -1 (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl Chemical group 0.000 abstract 1
- XSLKSUTUIARGHW-UHFFFAOYSA-N 3-oxo-7-pyrrolidin-1-yl-2h-quinoline-2-carboxylic acid Chemical class C1=CC2=CC(=O)C(C(=O)O)N=C2C=C1N1CCCC1 XSLKSUTUIARGHW-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3606698 | 1986-03-01 | ||
| DE19863606698 DE3606698A1 (de) | 1986-03-01 | 1986-03-01 | 7-(1-pyrrolidinyl)-chinoloncarbonsaeure -derivate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK103687D0 DK103687D0 (da) | 1987-02-27 |
| DK103687A true DK103687A (da) | 1987-09-02 |
| DK169334B1 DK169334B1 (da) | 1994-10-10 |
Family
ID=6295255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK103687A DK169334B1 (da) | 1986-03-01 | 1987-02-27 | 7-(1-Pyrrolidinyl)-3-quinoloncarboxylsyrederivater, fremgangsmåder til deres fremstilling og deres anvendelse i lægemidler og dyrefodertilsætninger |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4820716A (da) |
| EP (1) | EP0235676B1 (da) |
| JP (1) | JPH0784458B2 (da) |
| KR (1) | KR950007590B1 (da) |
| AT (1) | ATE53582T1 (da) |
| CA (1) | CA1337564C (da) |
| DE (2) | DE3606698A1 (da) |
| DK (1) | DK169334B1 (da) |
| ES (1) | ES2017651B3 (da) |
| GR (1) | GR3000560T3 (da) |
| HU (1) | HU208129B (da) |
| IL (1) | IL81702A (da) |
| ZA (1) | ZA871431B (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5153204A (en) * | 1986-03-01 | 1992-10-06 | Bayer Aktiengesellschaft | 7-(1-Pyrrolidinyl)-quinolonecarboxylic acid derivatives |
| JPH0262875A (ja) * | 1988-05-23 | 1990-03-02 | Wakunaga Pharmaceut Co Ltd | 新規イソインドリン誘導体 |
| KR910003630B1 (ko) * | 1988-06-17 | 1991-06-07 | 한국과학기술원 | 벤조일 아세틱 에스테르 유도체 및 그 제조방법 |
| EP0366189A3 (en) * | 1988-10-24 | 1992-01-02 | Norwich Eaton Pharmaceuticals, Inc. | Novel antimicrobial lactam-quinolones |
| CA2001203C (en) * | 1988-10-24 | 2001-02-13 | Thomas P. Demuth, Jr. | Novel antimicrobial dithiocarbamoyl quinolones |
| FR2673426B1 (fr) * | 1991-03-01 | 1993-07-16 | Bouchara Sa | Nouvelles quinolones, leur procede de preparation et les compositions en refermant. |
| FR2674247B1 (fr) * | 1991-03-19 | 1993-07-16 | Bouchara Sa | Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant. |
| US5330992A (en) * | 1992-10-23 | 1994-07-19 | Sterling Winthrop Inc. | 1-cyclopropyl-4-pyridyl-quinolinones |
| CN111087409B (zh) * | 2018-10-24 | 2021-06-08 | 江阴安博生物医药有限公司 | 一种喹诺酮类化合物及其制备方法和应用 |
| CN116606279A (zh) * | 2023-03-13 | 2023-08-18 | 广东工业大学 | 一种氟喹诺酮类化合物及其制备方法和应用 |
| CN116606280A (zh) * | 2023-03-13 | 2023-08-18 | 广东工业大学 | 一种氟喹诺酮类化合物及其在制备抗菌药物中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5746986A (en) * | 1980-09-02 | 1982-03-17 | Dai Ichi Seiyaku Co Ltd | Pyrido(1,2,3-de)(1,4)benzoxazine derivative |
| US4670444B1 (en) * | 1980-09-03 | 1999-02-09 | Bayer Ag | and-naphthyridine-3-carboxylic acids and antibacte7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-rial agents containing these compounds |
| US4620007A (en) * | 1980-09-03 | 1986-10-28 | Bayer Aktiengesellschaft | 6-fluoro-7-chloro-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid |
| US4499091A (en) * | 1982-03-31 | 1985-02-12 | Sterling Drug Inc. | 1-Amino (or substituted amino)-1,4-dihydro-4-oxo-6-fluoro-7-heterylquinoline-3-carboxylic acids and their use as antibacterial agents |
| DE3248507A1 (de) * | 1982-12-29 | 1984-07-05 | Bayer Ag, 5090 Leverkusen | Mikrobizide mittel auf chinoloncarbonsaeure basis |
| DE3318145A1 (de) * | 1983-05-18 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| NZ208470A (en) * | 1983-07-18 | 1988-06-30 | Abbott Lab | 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such |
| NZ210847A (en) * | 1984-01-26 | 1988-02-29 | Abbott Lab | Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions |
| DE3574380D1 (en) * | 1984-02-17 | 1989-12-28 | Daiichi Seiyaku Co | 1,8-naphthyridine derivatives |
| CA1285279C (en) * | 1984-02-17 | 1991-06-25 | Joseph P. Sanchez | 7-amine derivatives of 1-cyclopropyl-6,8-difluoro-1,4- dihydro-4-oxo-3-quinolinecarboxylic acids and 1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine- 3-carboxylic acidsas antibacterial agents |
| US4571396A (en) * | 1984-04-16 | 1986-02-18 | Warner-Lambert Company | Antibacterial agents |
| DE3420743A1 (de) * | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| US4623650A (en) * | 1984-12-06 | 1986-11-18 | Pfizer Inc. | Antibiotic derivatives of 7-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids |
| FR2574404B1 (fr) * | 1984-12-12 | 1987-04-24 | Provesan Sa | Derives 1-substitues de l'acide 6-fluoro-7-(pyrrol-1-yl)-1,4-dihydro-4-oxoquinoleine-3-carboxylique, leur preparation et leur application en tant que medicaments |
| DE3517535A1 (de) * | 1985-05-15 | 1986-11-20 | Bayer Ag, 5090 Leverkusen | 1-aryl-4-chinolon-3-carbonsaeuren |
-
1986
- 1986-03-01 DE DE19863606698 patent/DE3606698A1/de not_active Withdrawn
-
1987
- 1987-02-12 US US07/013,744 patent/US4820716A/en not_active Expired - Fee Related
- 1987-02-18 DE DE8787102290T patent/DE3763192D1/de not_active Expired - Lifetime
- 1987-02-18 ES ES87102290T patent/ES2017651B3/es not_active Expired - Lifetime
- 1987-02-18 EP EP87102290A patent/EP0235676B1/de not_active Expired - Lifetime
- 1987-02-18 AT AT87102290T patent/ATE53582T1/de active
- 1987-02-27 ZA ZA871431A patent/ZA871431B/xx unknown
- 1987-02-27 CA CA000530762A patent/CA1337564C/en not_active Expired - Fee Related
- 1987-02-27 DK DK103687A patent/DK169334B1/da not_active IP Right Cessation
- 1987-02-27 HU HU87818A patent/HU208129B/hu not_active IP Right Cessation
- 1987-02-27 IL IL81702A patent/IL81702A/xx not_active IP Right Cessation
- 1987-02-28 KR KR1019870001788A patent/KR950007590B1/ko not_active Expired - Fee Related
- 1987-02-28 JP JP62044163A patent/JPH0784458B2/ja not_active Expired - Lifetime
-
1990
- 1990-06-14 GR GR90400330T patent/GR3000560T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE3763192D1 (de) | 1990-07-19 |
| ZA871431B (en) | 1987-08-20 |
| DK169334B1 (da) | 1994-10-10 |
| GR3000560T3 (en) | 1991-07-31 |
| US4820716A (en) | 1989-04-11 |
| JPH0784458B2 (ja) | 1995-09-13 |
| EP0235676B1 (de) | 1990-06-13 |
| JPS62207269A (ja) | 1987-09-11 |
| HUT43581A (en) | 1987-11-30 |
| ES2017651B3 (es) | 1991-03-01 |
| KR950007590B1 (ko) | 1995-07-12 |
| HU208129B (en) | 1993-08-30 |
| KR870008867A (ko) | 1987-10-21 |
| IL81702A0 (en) | 1987-09-16 |
| DE3606698A1 (de) | 1987-09-03 |
| IL81702A (en) | 1991-05-12 |
| EP0235676A3 (en) | 1987-11-25 |
| CA1337564C (en) | 1995-11-14 |
| DK103687D0 (da) | 1987-02-27 |
| ATE53582T1 (de) | 1990-06-15 |
| EP0235676A2 (de) | 1987-09-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8607914A1 (es) | Un procedimiento de preparar un derivado de trans-1,2-diaminociclohexil-amida. | |
| NO905300D0 (no) | Pyrimidin-nukleosider og mellomprodukter. | |
| DK132789A (da) | 9-halogen-(z)-prostaglandinderivater, fremgangsmaade til deres fremstilling og deres anvendelse som laegemiddel | |
| ZA882618B (en) | New pyrazolo(3,4-d)pyrimidines and pharmaceutical compositions containing them | |
| DK103687D0 (da) | 7-(1-pyrrolidinyl)-quinoloncarboxylsyrederivater, fremgangsmaader til deres fremstilling og deres anvendelse i laegemidler | |
| PT90478A (pt) | Processo para a preparacao de derivados da purina e de composicoes farmaceuticas que os contem | |
| HUT39175A (en) | Process for producing 7-/3-aryl-1-piperazinyl/- and 7-/3-cyclohexyl-1-piperazinyl/-3-quinoline-carboxylic acids and pharmaceutical compositions containing them as active agents | |
| ES8503667A1 (es) | Un procedimiento para la preparacion de nuevos derivados de 2-oxo-imidazolina. | |
| DK499088A (da) | 1-oe(2-pyrimidinyl)-aminoalkylaapiperidinderivater, fremgangsmaade til fremstilling deraf og laegemiddel indeholdende saadanne derivater | |
| ES8801221A1 (es) | Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina | |
| SE8604950L (sv) | Demensforbettrande och terapeutiska medel | |
| DK373783A (da) | Thieno-thiazol-derivater, fremgangsmaade til deres fremstilling samt deres anvendelse | |
| ES454086A1 (es) | Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-norosimorfona nuevas. | |
| DK225985A (da) | Cephalosporiner eller farmaceutisk acceptable salte deraf, deres fremstilling og anvendelse som laegemidler | |
| ES2038600T3 (es) | Composiciones para uso terapeutico comprendiendo compuestos organo-siliceos. | |
| ES540260A0 (es) | Procedimiento para preparar derivados de 2-alcoxiaminosulfo-nilbencenosulfonilurea | |
| ES8606324A1 (es) | Procedimiento para preparar isocromanos y oxepinas, susti- tuidos | |
| KR890003741A (ko) | 7-(1-피롤리디닐)퀴놀론카르복실산 유도체 | |
| ES456755A1 (es) | Procedimiento para la preparacion de derivados de sandwici- na. | |
| DK583887D0 (da) | 4-hydroxy-4-(substitueret alkenyl)-cyclohexancarboxylsyrer og deres fremstilling | |
| SE8400451D0 (sv) | Bronchodilatory azepino /1,2-a/pyrimidine derivatives and acid addition salts thereof and pharmaceutical compositions containig same | |
| ES415404A1 (es) | Procedimiento para preparar derivados del acido amino-2 benzoico. | |
| ES442708A1 (es) | Un procedimiento para preparar nuevos derivados de piperazi-na. | |
| ES435453A1 (es) | Procedimiento para la preparacion de 2-tetrahidrofurfuril-6,7-benzomorfanos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |