ES8801221A1 - Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina - Google Patents

Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina

Info

Publication number
ES8801221A1
ES8801221A1 ES557198A ES557198A ES8801221A1 ES 8801221 A1 ES8801221 A1 ES 8801221A1 ES 557198 A ES557198 A ES 557198A ES 557198 A ES557198 A ES 557198A ES 8801221 A1 ES8801221 A1 ES 8801221A1
Authority
ES
Spain
Prior art keywords
general formula
compound
group
preparation
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557198A
Other languages
English (en)
Other versions
ES557198A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Ube Corp
Original Assignee
Sankyo Co Ltd
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd, Ube Industries Ltd filed Critical Sankyo Co Ltd
Publication of ES8801221A1 publication Critical patent/ES8801221A1/es
Publication of ES557198A0 publication Critical patent/ES557198A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Dental Preparations (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Eyeglasses (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Soil Working Implements (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Luminescent Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE CICLOPENTADPIRIDINA, DE FORMULA GENERAL (I), Y SUS SALES ESTERES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R2 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO HIDROXIDO, UN GRUPO ALCOXI C1-4 O UN GRUPO ARILOXI; R3 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C1-4; Y R4 Y R5 REPRESENTAN GRUPOS ALQUILO C1-4, GRUPOS ALCOXI C1-4 O GRUPOS HIDROXI, CON TETRAACETATO DE PLOMO, PARA OBTENER UN COMPUESTO DE FORMULA GENERAL (III). EL COMPUESTO OBTENIDO DE FORMULA GENERAL (III), SE HIDROLIZA Y OPCIONALMENTE EL COMPUESTO HIDROLIZADO SE HACE REACCIONAR CON UN HALURO DE FORMULA: R7X, PARA OBTENER EL COMPUESTO DE FORMULA GENERAL BUSCADO. DE APLICACION EN EL TRATAMIENTO DE LA DEPRESION MENTAL.
ES557198A 1985-03-07 1986-11-14 Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina Expired ES8801221A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4362685 1985-03-07

Publications (2)

Publication Number Publication Date
ES8801221A1 true ES8801221A1 (es) 1988-01-01
ES557198A0 ES557198A0 (es) 1988-01-01

Family

ID=12669058

Family Applications (3)

Application Number Title Priority Date Filing Date
ES552796A Expired ES8704905A1 (es) 1985-03-07 1986-03-07 Un procedimiento para la preparacion de nuevos derivados de ciclopenta (d) pirimidina.
ES557198A Expired ES8801221A1 (es) 1985-03-07 1986-11-14 Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina
ES557199A Expired ES8801222A1 (es) 1985-03-07 1986-11-14 Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES552796A Expired ES8704905A1 (es) 1985-03-07 1986-03-07 Un procedimiento para la preparacion de nuevos derivados de ciclopenta (d) pirimidina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557199A Expired ES8801222A1 (es) 1985-03-07 1986-11-14 Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina

Country Status (15)

Country Link
US (1) US4749704A (es)
EP (1) EP0194161B1 (es)
JP (1) JPS6270A (es)
KR (1) KR890003839B1 (es)
AT (1) ATE106077T1 (es)
AU (1) AU580391B2 (es)
CA (1) CA1273632A (es)
DE (1) DE3689848T2 (es)
DK (1) DK165109C (es)
ES (3) ES8704905A1 (es)
FI (1) FI88717C (es)
HK (1) HK1005450A1 (es)
IE (1) IE64504B1 (es)
NO (1) NO168767C (es)
ZA (1) ZA861708B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5037980A (en) * 1988-04-18 1991-08-06 American Cyanamid Company Phenyl imidazo[1,2-a]pyrimidines
US5877178A (en) * 1991-04-08 1999-03-02 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
US5234936A (en) * 1991-10-24 1993-08-10 American Home Products Corporation Pyrimidocycloalkanes as a ii antagonists
CN100398524C (zh) * 2003-08-12 2008-07-02 弗·哈夫曼-拉罗切有限公司 作为crf拮抗剂的四氢喹唑啉衍生物
EP1942069A4 (en) 2005-10-26 2013-01-09 Mitsubishi Electric Corp LIFT GROUP MANAGEMENT AND CONTROL DEVICE
RU2481336C2 (ru) 2006-07-06 2013-05-10 Эррэй Биофарма Инк. Циклопента(d)пиримидины в качестве ингибиторов протеинкиназ акт
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
DE602007011628D1 (de) 2006-07-06 2011-02-10 Array Biopharma Inc Dihydrofuropyrimidine als akt-proteinkinaseinhibitoren
WO2008006039A1 (en) 2006-07-06 2008-01-10 Array Biopharma Inc. Dihydrothieno pyrimidines as akt protein kinase inhibitors
WO2008021456A2 (en) * 2006-08-16 2008-02-21 Cytovia, Inc. N-aryl-5,7-dihydrofuro[3,4-d]pyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
MX2009014013A (es) 2007-07-05 2010-01-28 Array Biopharma Inc Pirimidil ciclopentanos como inhibidores de la proteina cinasa akt.
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
CA2692502C (en) 2007-07-05 2016-03-01 Array Biopharma Inc. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
US8835434B2 (en) 2008-01-09 2014-09-16 Array Biopharma, Inc. Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
US8853216B2 (en) 2008-01-09 2014-10-07 Array Biopharma, Inc. Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor
WO2010047201A1 (ja) 2008-10-20 2010-04-29 三菱電機株式会社 エレベーター群管理装置
TR201815685T4 (tr) 2011-04-01 2018-11-21 Genentech Inc Kanser tedavisi için akt ve mek inhibe edici bileşiklerin kombinasyonları.
FI2694072T4 (fi) 2011-04-01 2024-09-30 Genentech Inc Akt-inhibiittoriyhdisteen ja abirateronin yhdistelmä käytettäväksi terapeuttisissa hoidoissa
GB201121127D0 (en) 2011-12-08 2012-01-18 Dow Corning Treatment of filler with silane
CN111303053B (zh) * 2020-03-16 2023-01-17 中国海洋大学 环戊并[d]嘧啶类化合物及其药学上可接受的盐、溶剂合物或者前药以及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470182A (en) * 1967-02-09 1969-09-30 Sandoz Ag 4-amino-substituted quinazolines
US3980650A (en) * 1972-05-05 1976-09-14 N.V. Koninklijke Pharmaceutische Fabrieken V/H Brocades-Stheeman En Pharmacia 4-Amino-pyrimidine derivatives
US3915976A (en) * 1972-09-01 1975-10-28 Sandoz Ag Substituted-4-phenyl-5h-cycloalkano(d)pyrimidines
PH20344A (en) * 1981-01-29 1986-12-04 Sankyo Co Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them
JPS57203072A (en) * 1981-06-05 1982-12-13 Sankyo Co Ltd 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient

Also Published As

Publication number Publication date
US4749704A (en) 1988-06-07
NO168767C (no) 1992-04-01
DE3689848T2 (de) 1995-01-12
HK1005450A1 (en) 1999-01-08
ES8801222A1 (es) 1988-01-01
DK165109B (da) 1992-10-12
AU5448186A (en) 1986-09-11
FI88717C (fi) 1993-06-28
KR890003839B1 (ko) 1989-10-05
IE860597L (en) 1986-09-07
DE3689848D1 (de) 1994-06-30
NO168767B (no) 1991-12-23
FI88717B (fi) 1993-03-15
FI860969L (fi) 1986-09-08
EP0194161A2 (en) 1986-09-10
JPS6270A (ja) 1987-01-06
ZA861708B (en) 1986-11-26
DK165109C (da) 1993-03-01
DK106586D0 (da) 1986-03-07
EP0194161B1 (en) 1994-05-25
AU580391B2 (en) 1989-01-12
NO860852L (no) 1986-09-08
CA1273632A (en) 1990-09-04
EP0194161A3 (en) 1987-09-02
ES557198A0 (es) 1988-01-01
ES8704905A1 (es) 1987-04-16
ES557199A0 (es) 1988-01-01
KR860007221A (ko) 1986-10-08
ATE106077T1 (de) 1994-06-15
FI860969A0 (fi) 1986-03-07
ES552796A0 (es) 1987-04-16
DK106586A (da) 1986-09-08
IE64504B1 (en) 1995-08-09

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