ES8801221A1 - Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina - Google Patents

Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina

Info

Publication number
ES8801221A1
ES8801221A1 ES557198A ES557198A ES8801221A1 ES 8801221 A1 ES8801221 A1 ES 8801221A1 ES 557198 A ES557198 A ES 557198A ES 557198 A ES557198 A ES 557198A ES 8801221 A1 ES8801221 A1 ES 8801221A1
Authority
ES
Spain
Prior art keywords
general formula
compound
group
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557198A
Other languages
English (en)
Other versions
ES557198A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Ube Corp
Original Assignee
Sankyo Co Ltd
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd, Ube Industries Ltd filed Critical Sankyo Co Ltd
Publication of ES557198A0 publication Critical patent/ES557198A0/es
Publication of ES8801221A1 publication Critical patent/ES8801221A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Dental Preparations (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Luminescent Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Soil Working Implements (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Eyeglasses (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE CICLOPENTADPIRIDINA, DE FORMULA GENERAL (I), Y SUS SALES ESTERES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R2 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO HIDROXIDO, UN GRUPO ALCOXI C1-4 O UN GRUPO ARILOXI; R3 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C1-4; Y R4 Y R5 REPRESENTAN GRUPOS ALQUILO C1-4, GRUPOS ALCOXI C1-4 O GRUPOS HIDROXI, CON TETRAACETATO DE PLOMO, PARA OBTENER UN COMPUESTO DE FORMULA GENERAL (III). EL COMPUESTO OBTENIDO DE FORMULA GENERAL (III), SE HIDROLIZA Y OPCIONALMENTE EL COMPUESTO HIDROLIZADO SE HACE REACCIONAR CON UN HALURO DE FORMULA: R7X, PARA OBTENER EL COMPUESTO DE FORMULA GENERAL BUSCADO. DE APLICACION EN EL TRATAMIENTO DE LA DEPRESION MENTAL.
ES557198A 1985-03-07 1986-11-14 Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina Expired ES8801221A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4362685 1985-03-07

Publications (2)

Publication Number Publication Date
ES557198A0 ES557198A0 (es) 1988-01-01
ES8801221A1 true ES8801221A1 (es) 1988-01-01

Family

ID=12669058

Family Applications (3)

Application Number Title Priority Date Filing Date
ES552796A Expired ES8704905A1 (es) 1985-03-07 1986-03-07 Un procedimiento para la preparacion de nuevos derivados de ciclopenta (d) pirimidina.
ES557198A Expired ES8801221A1 (es) 1985-03-07 1986-11-14 Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina
ES557199A Expired ES8801222A1 (es) 1985-03-07 1986-11-14 Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES552796A Expired ES8704905A1 (es) 1985-03-07 1986-03-07 Un procedimiento para la preparacion de nuevos derivados de ciclopenta (d) pirimidina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557199A Expired ES8801222A1 (es) 1985-03-07 1986-11-14 Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina

Country Status (14)

Country Link
US (1) US4749704A (es)
EP (1) EP0194161B1 (es)
JP (1) JPS6270A (es)
KR (1) KR890003839B1 (es)
AT (1) ATE106077T1 (es)
AU (1) AU580391B2 (es)
CA (1) CA1273632A (es)
DE (1) DE3689848T2 (es)
DK (1) DK165109C (es)
ES (3) ES8704905A1 (es)
FI (1) FI88717C (es)
IE (1) IE64504B1 (es)
NO (1) NO168767C (es)
ZA (1) ZA861708B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5037980A (en) * 1988-04-18 1991-08-06 American Cyanamid Company Phenyl imidazo[1,2-a]pyrimidines
US5877178A (en) * 1991-04-08 1999-03-02 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
US5234936A (en) * 1991-10-24 1993-08-10 American Home Products Corporation Pyrimidocycloalkanes as a ii antagonists
JP2007501821A (ja) * 2003-08-12 2007-02-01 エフ．ホフマン−ラ　ロシュ　アーゲー Ｃｆｒアンタゴニストとしてのテトラヒドロキナゾリン誘導体
WO2007049342A1 (ja) 2005-10-26 2007-05-03 Mitsubishi Denki Kabushiki Kaisha エレベーター群管理制御装置
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
WO2008006032A1 (en) 2006-07-06 2008-01-10 Array Biopharma Inc. Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
CN101511842B (zh) 2006-07-06 2012-10-31 阵列生物制药公司 作为akt蛋白激酶抑制剂的二氢呋喃并嘧啶
ATE532789T1 (de) 2006-07-06 2011-11-15 Array Biopharma Inc Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren
WO2008021456A2 (en) * 2006-08-16 2008-02-21 Cytovia, Inc. N-aryl-5,7-dihydrofuro[3,4-d]pyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
SI2173723T1 (sl) 2007-07-05 2011-12-30 Array Biopharma Inc Pirimidil ciklopentani kot inhibitorji AKT-protein-kinaze
US8618097B2 (en) 2007-07-05 2013-12-31 Array Biopharma, Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
EP2240455B1 (en) 2008-01-09 2012-12-26 Array Biopharma, Inc. Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor
JP5346345B2 (ja) 2008-01-09 2013-11-20 アレイ バイオファーマ、インコーポレイテッド Ａｋｔタンパク質キナーゼ阻害剤としての水酸化されたピリミジルシクロペンタン類
WO2010047201A1 (ja) 2008-10-20 2010-04-29 三菱電機株式会社 エレベーター群管理装置
KR20140022053A (ko) 2011-04-01 2014-02-21 제넨테크, 인크. Akt 및 mek 억제제 화합물의 조합물, 및 사용 방법
ES2620644T3 (es) 2011-04-01 2017-06-29 Genentech, Inc. Combinaciones de compuestos inhibidores de AKT y agentes quimioterapéuticos, y métodos de uso
GB201121127D0 (en) 2011-12-08 2012-01-18 Dow Corning Treatment of filler with silane
CN111303053B (zh) * 2020-03-16 2023-01-17 中国海洋大学 环戊并[d]嘧啶类化合物及其药学上可接受的盐、溶剂合物或者前药以及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470182A (en) * 1967-02-09 1969-09-30 Sandoz Ag 4-amino-substituted quinazolines
US3980650A (en) * 1972-05-05 1976-09-14 N.V. Koninklijke Pharmaceutische Fabrieken V/H Brocades-Stheeman En Pharmacia 4-Amino-pyrimidine derivatives
US3915976A (en) * 1972-09-01 1975-10-28 Sandoz Ag Substituted-4-phenyl-5h-cycloalkano(d)pyrimidines
PH20344A (en) * 1981-01-29 1986-12-04 Sankyo Co Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them
JPS57203072A (en) * 1981-06-05 1982-12-13 Sankyo Co Ltd 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient

Also Published As

Publication number Publication date
EP0194161A3 (en) 1987-09-02
AU580391B2 (en) 1989-01-12
IE860597L (en) 1986-09-07
CA1273632A (en) 1990-09-04
DE3689848T2 (de) 1995-01-12
NO168767C (no) 1992-04-01
ES8704905A1 (es) 1987-04-16
ES557198A0 (es) 1988-01-01
NO168767B (no) 1991-12-23
NO860852L (no) 1986-09-08
DK106586D0 (da) 1986-03-07
HK1005450A1 (en) 1999-01-08
DK165109C (da) 1993-03-01
KR860007221A (ko) 1986-10-08
ES8801222A1 (es) 1988-01-01
EP0194161B1 (en) 1994-05-25
KR890003839B1 (ko) 1989-10-05
ZA861708B (en) 1986-11-26
FI860969A0 (fi) 1986-03-07
ATE106077T1 (de) 1994-06-15
AU5448186A (en) 1986-09-11
ES557199A0 (es) 1988-01-01
JPS6270A (ja) 1987-01-06
US4749704A (en) 1988-06-07
DK106586A (da) 1986-09-08
IE64504B1 (en) 1995-08-09
FI88717C (fi) 1993-06-28
DK165109B (da) 1992-10-12
EP0194161A2 (en) 1986-09-10
DE3689848D1 (de) 1994-06-30
ES552796A0 (es) 1987-04-16
FI88717B (fi) 1993-03-15
FI860969L (fi) 1986-09-08

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