DK1047771T3 - Fremgangsmåde til genfoldning af angiostatin - Google Patents
Fremgangsmåde til genfoldning af angiostatinInfo
- Publication number
- DK1047771T3 DK1047771T3 DK99901279T DK99901279T DK1047771T3 DK 1047771 T3 DK1047771 T3 DK 1047771T3 DK 99901279 T DK99901279 T DK 99901279T DK 99901279 T DK99901279 T DK 99901279T DK 1047771 T3 DK1047771 T3 DK 1047771T3
- Authority
- DK
- Denmark
- Prior art keywords
- angiostatin
- refolding
- disclosed
- subfragments
- solubilizing
- Prior art date
Links
- 102000012936 Angiostatins Human genes 0.000 title abstract 3
- 108010079709 Angiostatins Proteins 0.000 title abstract 3
- FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 title abstract 3
- 241000894006 Bacteria Species 0.000 abstract 1
- 210000003000 inclusion body Anatomy 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000003381 solubilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7124798P | 1998-01-12 | 1998-01-12 | |
| PCT/US1999/000048 WO1999035248A2 (en) | 1998-01-12 | 1999-01-11 | Method of refolding angiostatin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1047771T3 true DK1047771T3 (da) | 2003-08-11 |
Family
ID=22100170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99901279T DK1047771T3 (da) | 1998-01-12 | 1999-01-11 | Fremgangsmåde til genfoldning af angiostatin |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1047771B1 (da) |
| AT (1) | ATE238414T1 (da) |
| AU (1) | AU2101599A (da) |
| DE (1) | DE69907139T2 (da) |
| DK (1) | DK1047771T3 (da) |
| ES (1) | ES2198879T3 (da) |
| PT (1) | PT1047771E (da) |
| WO (1) | WO1999035248A2 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL140729A0 (en) * | 1998-07-14 | 2002-02-10 | Bristol Myers Squibb Co | Lysine binding fragments of angiostatin, pharmaceutical compositions containing the same and processes for the preparation thereof |
| EP1218495A2 (en) * | 1999-12-03 | 2002-07-03 | EntreMed, Inc. | METHOD OF PRODUCING AND PURIFYING ANGIOSTATIN$m(3) PROTEIN |
| US6723536B2 (en) | 1999-12-03 | 2004-04-20 | Entremed, Inc. | Method of producing and purifying angiostatin |
| IL152804A0 (en) | 2000-05-16 | 2003-06-24 | Bolder Biotechnology Inc | Methods for refolding proteins containing free cysteine residues |
| AU8591901A (en) | 2000-09-05 | 2002-03-22 | Karolinska Innovations Ab | Materials and methods relating to endothelial cell growth inhibitors |
| US20100144622A1 (en) * | 2006-09-29 | 2010-06-10 | Xinli Lin | Methods for production of recombinant plasminogen and plasmin polypeptides |
| WO2008076933A2 (en) | 2006-12-14 | 2008-06-26 | Bolder Biotechnology, Inc. | Long acting proteins and peptides and methods of making and using the same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2047063A1 (en) * | 1991-07-15 | 1993-01-16 | Warren C. Mackellar | Method for folding tissue plasminogen activators and erivatives thereof |
| US6057122A (en) * | 1996-05-03 | 2000-05-02 | Abbott Laboratories | Antiangiogenic peptides polynucleotides encoding same and methods for inhibiting angiogenesis |
-
1999
- 1999-01-11 ES ES99901279T patent/ES2198879T3/es not_active Expired - Lifetime
- 1999-01-11 DK DK99901279T patent/DK1047771T3/da active
- 1999-01-11 PT PT99901279T patent/PT1047771E/pt unknown
- 1999-01-11 EP EP99901279A patent/EP1047771B1/en not_active Expired - Lifetime
- 1999-01-11 DE DE69907139T patent/DE69907139T2/de not_active Expired - Fee Related
- 1999-01-11 AU AU21015/99A patent/AU2101599A/en not_active Abandoned
- 1999-01-11 WO PCT/US1999/000048 patent/WO1999035248A2/en not_active Ceased
- 1999-01-11 AT AT99901279T patent/ATE238414T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999035248A3 (en) | 1999-11-11 |
| PT1047771E (pt) | 2003-08-29 |
| DE69907139D1 (de) | 2003-05-28 |
| AU2101599A (en) | 1999-07-26 |
| EP1047771A2 (en) | 2000-11-02 |
| WO1999035248A2 (en) | 1999-07-15 |
| ES2198879T3 (es) | 2004-02-01 |
| ATE238414T1 (de) | 2003-05-15 |
| DE69907139T2 (de) | 2004-01-29 |
| EP1047771B1 (en) | 2003-04-23 |
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