DK1051420T3 - Nye cytotoksiske tris(oxazol)-holdige makrolider - Google Patents

Nye cytotoksiske tris(oxazol)-holdige makrolider

Info

Publication number: DK1051420T3
Authority: DK; Denmark
Prior art keywords: represents hydrogen; lower alkyl; macrolides; oxazole; hydrogen
Prior art date: 1998-01-27

Application number

DK99903797T

Other languages

Danish (da)

English (en)

Inventor

Tatsuo Instituto Biomar S Higa

Gravalos Dolores Instit Garcia

Jose Luis In Fernandez-Puentes

Original Assignee

Inst Biomar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-27

Filing date

1999-01-27

Publication date

2002-12-30

1999-01-27 Application filed by Inst Biomar Sa filed Critical Inst Biomar Sa

2002-12-30 Application granted granted Critical

2002-12-30 Publication of DK1051420T3 publication Critical patent/DK1051420T3/da

Links

239000003120 macrolide antibiotic agent Substances 0.000 title abstract 4
229940041033 macrolides Drugs 0.000 title abstract 4
ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 title abstract 2
239000007983 Tris buffer Substances 0.000 title abstract 2
231100000433 cytotoxic Toxicity 0.000 title abstract 2
230000001472 cytotoxic effect Effects 0.000 title abstract 2
239000001257 hydrogen Substances 0.000 abstract 8
229910052739 hydrogen Inorganic materials 0.000 abstract 8
150000002431 hydrogen Chemical group 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK99903797T 1998-01-27 1999-01-27 Nye cytotoksiske tris(oxazol)-holdige makrolider DK1051420T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9801741.1A GB9801741D0 (en)	1998-01-27	1998-01-27	New cytotoxic tris (oxazole)-containing macrolides
PCT/GB1999/000277 WO1999037653A1 (en)	1998-01-27	1999-01-27	New cytotoxic tris(oxazole)-containing macrolides

Publications (1)

Publication Number	Publication Date
DK1051420T3 true DK1051420T3 (da)	2002-12-30

Family

ID=10825984

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99903797T DK1051420T3 (da)	1998-01-27	1999-01-27	Nye cytotoksiske tris(oxazol)-holdige makrolider

Country Status (21)

Country	Link
US (1)	US6391900B1 (de)
EP (1)	EP1051420B1 (de)
JP (1)	JP4511027B2 (de)
KR (1)	KR20010034413A (de)
CN (1)	CN1131869C (de)
AT (1)	ATE229024T1 (de)
AU (1)	AU760184B2 (de)
BR (1)	BR9907748A (de)
CA (1)	CA2319032C (de)
CZ (1)	CZ291931B6 (de)
DE (1)	DE69904294T2 (de)
DK (1)	DK1051420T3 (de)
ES (1)	ES2186324T3 (de)
GB (1)	GB9801741D0 (de)
HU (1)	HUP0101321A3 (de)
IL (1)	IL137545A0 (de)
MX (1)	MXPA00007381A (de)
PL (1)	PL342040A1 (de)
PT (1)	PT1051420E (de)
RU (1)	RU2217433C2 (de)
WO (1)	WO1999037653A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100471727B1 (ko) *	2002-10-14	2005-02-21	학교법인 포항공과대학교	이속사졸린 고리와 불소를 포함하는 거대고리 화합물 및그의 제조방법
CN100360515C (zh) *	2004-04-09	2008-01-09	中国科学院上海药物研究所	抗肿瘤活性成份陵水醇、制备方法和用途
ES2276629B1 (es) *	2005-12-15	2009-04-01	Pharma Mar, S.A.	Compuestos antitumorales.
CA2729620A1 (en) *	2008-07-03	2010-01-07	Pharma Mar, S.A.	Antitumoral macrolides
KR102491180B1 (ko)	2017-04-27	2023-01-20	파르마 마르 에스.에이.	항종양 화합물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6256493A (ja) *	1985-09-06	1987-03-12	Yamanouchi Pharmaceut Co Ltd	カビラマイド類
FR2664600B1 (fr) *	1990-07-16	1994-09-02	Rhone Poulenc Sante	Nouveau sel derive de la dialcoylaminoalcoyl-sulfonyl-26 pristinamycine iib.
GB9315914D0 (en) *	1993-07-31	1993-09-15	Smithkline Beecham Plc	Novel compound
EP0729950A4 (de) *	1994-09-13	2001-02-07	Kyowa Hakko Kogyo Kk	Anti-hiv arzneimittel

1998
- 1998-01-27 GB GBGB9801741.1A patent/GB9801741D0/en not_active Ceased
1999
- 1999-01-27 AU AU24319/99A patent/AU760184B2/en not_active Ceased
- 1999-01-27 HU HU0101321A patent/HUP0101321A3/hu unknown
- 1999-01-27 EP EP99903797A patent/EP1051420B1/de not_active Expired - Lifetime
- 1999-01-27 JP JP2000528574A patent/JP4511027B2/ja not_active Expired - Fee Related
- 1999-01-27 CN CN998045632A patent/CN1131869C/zh not_active Expired - Fee Related
- 1999-01-27 CA CA002319032A patent/CA2319032C/en not_active Expired - Fee Related
- 1999-01-27 AT AT99903797T patent/ATE229024T1/de not_active IP Right Cessation
- 1999-01-27 US US09/601,146 patent/US6391900B1/en not_active Expired - Fee Related
- 1999-01-27 CZ CZ20002754A patent/CZ291931B6/cs not_active IP Right Cessation
- 1999-01-27 IL IL13754599A patent/IL137545A0/xx unknown
- 1999-01-27 KR KR1020007008182A patent/KR20010034413A/ko not_active Ceased
- 1999-01-27 ES ES99903797T patent/ES2186324T3/es not_active Expired - Lifetime
- 1999-01-27 MX MXPA00007381A patent/MXPA00007381A/es unknown
- 1999-01-27 BR BR9907748-5A patent/BR9907748A/pt not_active IP Right Cessation
- 1999-01-27 WO PCT/GB1999/000277 patent/WO1999037653A1/en not_active Ceased
- 1999-01-27 DE DE69904294T patent/DE69904294T2/de not_active Expired - Lifetime
- 1999-01-27 PT PT99903797T patent/PT1051420E/pt unknown
- 1999-01-27 DK DK99903797T patent/DK1051420T3/da active
- 1999-01-27 PL PL99342040A patent/PL342040A1/xx unknown
- 1999-01-27 RU RU2000122441/04A patent/RU2217433C2/ru not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2002501074A (ja)	2002-01-15
ES2186324T3 (es)	2003-05-01
CZ291931B6 (cs)	2003-06-18
AU760184B2 (en)	2003-05-08
DE69904294D1 (de)	2003-01-16
WO1999037653A1 (en)	1999-07-29
DE69904294T2 (de)	2003-08-21
KR20010034413A (ko)	2001-04-25
MXPA00007381A (es)	2002-06-04
CN1131869C (zh)	2003-12-24
IL137545A0 (en)	2001-07-24
CZ20002754A3 (cs)	2002-02-13
EP1051420A1 (de)	2000-11-15
PL342040A1 (en)	2001-05-21
RU2217433C2 (ru)	2003-11-27
CA2319032A1 (en)	1999-07-29
BR9907748A (pt)	2000-10-17
GB9801741D0 (en)	1998-03-25
PT1051420E (pt)	2003-02-28
HUP0101321A3 (en)	2002-06-28
AU2431999A (en)	1999-08-09
US6391900B1 (en)	2002-05-21
CA2319032C (en)	2009-09-08
HUP0101321A2 (hu)	2001-09-28
JP4511027B2 (ja)	2010-07-28
CN1320127A (zh)	2001-10-31
ATE229024T1 (de)	2002-12-15
EP1051420B1 (de)	2002-12-04

Publication	Publication Date	Title
NO20016401L (no)	2002-01-23	Th2 differensieringsinhibitorer
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MY138525A (en)	2009-06-30	Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
IL136249A0 (en)	2001-05-20	Suppository containing an acid-labile active compound
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DK1347984T3 (da)	2005-01-10	Fremgangsmåde til fremstilling af taxanderivater
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