DK1053746T3 - Anvendelse af bionedbrydelige mikrokugler, som frigiver et anticancermiddel, til behandling af glioblastomer - Google Patents

Anvendelse af bionedbrydelige mikrokugler, som frigiver et anticancermiddel, til behandling af glioblastomer

Info

Publication number
DK1053746T3
DK1053746T3 DK00401344T DK00401344T DK1053746T3 DK 1053746 T3 DK1053746 T3 DK 1053746T3 DK 00401344 T DK00401344 T DK 00401344T DK 00401344 T DK00401344 T DK 00401344T DK 1053746 T3 DK1053746 T3 DK 1053746T3
Authority
DK
Denmark
Prior art keywords
glioblastomas
treatment
anticancer agent
biodegradable microspheres
microspheres releasing
Prior art date
Application number
DK00401344T
Other languages
English (en)
Inventor
Nathalie Faisant
Jean-Pierre Benoit
Philippe Menei
Original Assignee
Ethypharm Lab Prod Ethiques
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm Lab Prod Ethiques filed Critical Ethypharm Lab Prod Ethiques
Application granted granted Critical
Publication of DK1053746T3 publication Critical patent/DK1053746T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK00401344T 1999-05-17 2000-05-17 Anvendelse af bionedbrydelige mikrokugler, som frigiver et anticancermiddel, til behandling af glioblastomer DK1053746T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9906207A FR2793684B1 (fr) 1999-05-17 1999-05-17 Utilisation de microspheres biodegradables liberant un agent anticancereux pour le traitement du glioblastome, procede de preparation de ces microspheres et suspension les contenant

Publications (1)

Publication Number Publication Date
DK1053746T3 true DK1053746T3 (da) 2003-03-31

Family

ID=9545636

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00401344T DK1053746T3 (da) 1999-05-17 2000-05-17 Anvendelse af bionedbrydelige mikrokugler, som frigiver et anticancermiddel, til behandling af glioblastomer

Country Status (30)

Country Link
US (2) US6803052B2 (da)
EP (2) EP1228755A1 (da)
JP (1) JP5230045B2 (da)
KR (1) KR100649948B1 (da)
CN (1) CN1210020C (da)
AR (1) AR024008A1 (da)
AT (1) ATE228353T1 (da)
AU (1) AU775320B2 (da)
BG (1) BG64936B1 (da)
BR (1) BR0010648A (da)
CA (1) CA2388656C (da)
CZ (1) CZ20014137A3 (da)
DE (1) DE60000842T2 (da)
DK (1) DK1053746T3 (da)
EA (1) EA004943B1 (da)
ES (1) ES2185544T3 (da)
FR (1) FR2793684B1 (da)
HK (1) HK1047044B (da)
HU (1) HUP0201224A3 (da)
IL (2) IL146467A0 (da)
MX (1) MXPA01011919A (da)
NO (1) NO331686B1 (da)
NZ (1) NZ515515A (da)
PL (1) PL201614B1 (da)
PT (1) PT1053746E (da)
SI (1) SI1053746T1 (da)
SK (1) SK16342001A3 (da)
TW (1) TWI229608B (da)
WO (1) WO2000069413A1 (da)
ZA (1) ZA200109415B (da)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1210139B1 (de) 1999-08-05 2006-10-11 MAP Medizin-Technologie GmbH Vorrichtung zur zufuhr eines atemgases und befeuchtungsvorrichtung
AUPR098300A0 (en) 2000-10-25 2000-11-16 Sirtex Medical Limited Polymer based radionuclide containing microspheres
JP2002154963A (ja) * 2000-11-14 2002-05-28 Yakult Honsha Co Ltd 徐放性抗腫瘍剤
US20020081339A1 (en) * 2000-12-22 2002-06-27 Philippe Menei Treatment of inoperable tumors by stereotactic injection of microspheres
ES2427930T3 (es) 2001-05-23 2013-11-04 Mitsubishi Tanabe Pharma Corporation Composición terapéutica para el tratamiento regenerativo de enfermedades de los cartílagos
KR20040007596A (ko) 2001-05-23 2004-01-24 다나베 세이야꾸 가부시키가이샤 골절 치료 촉진용 조성물
MXPA04000156A (es) 2001-06-29 2005-06-06 Medgraft Microtech Inc Implantes inyectables biodegradables y metodos relacionados de fabricacion y uso.
UA77999C2 (en) * 2001-12-10 2007-02-15 Thymosin-alpha 1 for treatment of malignant glioblastoma
US20050069549A1 (en) 2002-01-14 2005-03-31 William Herman Targeted ligands
US8986737B2 (en) 2002-09-05 2015-03-24 Wm. Marsh Rice University Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth
CN105194774B (zh) 2003-06-20 2018-06-01 瑞思迈有限公司 带有加湿器的可吸入气体设备
WO2005023293A1 (en) * 2003-09-09 2005-03-17 Pohang University Of Science And Technology Vaccine composition comprising il-12 adjuvant encapsulated in controlled-release microsphere
WO2005089398A2 (en) * 2004-03-18 2005-09-29 St. Luke's Hospital Method for the delivery of sustained release agents
EP1763321A4 (en) 2004-04-16 2010-02-17 Critical Care Innovations Inc SYSTEMS AND METHOD FOR ENHANCING ABLATION OF IMAGE-GUIDED FABRIC
US8088413B2 (en) * 2004-04-16 2012-01-03 Nuvue Therapeutics, Inc. Methods for improved cryo-chemotherapy tissue ablation
US20070275991A1 (en) 2004-09-07 2007-11-29 Biocompatibles Uk Limited Drug Delivery From Embolic Agents
US8702580B2 (en) * 2004-10-06 2014-04-22 Brainlab Ag Method and device for assisting in a tissue treatment
CN100386115C (zh) * 2004-10-14 2008-05-07 孔庆忠 一种抗癌药物组合物
CN1299685C (zh) * 2005-01-26 2007-02-14 上海大学 氟尿嘧啶载药微球及其制备方法
CN100340297C (zh) * 2005-02-03 2007-10-03 山东蓝金生物工程有限公司 抗癌体内植入剂
CN100464785C (zh) * 2005-08-30 2009-03-04 孔庆忠 一种抗癌药物缓释注射剂及其应用
CN1923281B (zh) * 2005-08-30 2010-05-05 孔庆忠 一种含植物生物碱的抗癌缓释注射剂
CN1923282B (zh) * 2005-08-30 2010-05-05 孔庆忠 一种含激素类药物的抗癌缓释注射剂
CN100500214C (zh) * 2006-01-09 2009-06-17 济南帅华医药科技有限公司 抗癌药物缓释注射剂
CN100563711C (zh) * 2006-01-18 2009-12-02 济南帅华医药科技有限公司 一种抗癌缓释注射剂
CN100531715C (zh) * 2006-01-23 2009-08-26 济南帅华医药科技有限公司 氨甲喋呤缓释注射剂
CN100531717C (zh) * 2006-01-23 2009-08-26 济南帅华医药科技有限公司 含氨甲喋呤增效剂的抗癌缓释剂
CN100500215C (zh) * 2006-01-23 2009-06-17 济南帅华医药科技有限公司 含氨甲喋呤及其增效剂的缓释注射剂
CN1923173B (zh) * 2006-02-24 2010-05-19 济南康泉医药科技有限公司 一种同载抗癌抗生素及其增效剂的抗癌药物缓释剂
CN100486560C (zh) * 2006-03-06 2009-05-13 济南康泉医药科技有限公司 一种含血管抑制剂的复方抗癌缓释注射剂
WO2007105218A2 (en) * 2006-03-14 2007-09-20 Yeda Research And Development Co. Ltd. Composition and method for brain tumor therapy
CN100464736C (zh) * 2006-03-17 2009-03-04 山东蓝金生物工程有限公司 同载抗代谢药物及其增效剂的抗癌缓释注射剂
EP1985286A1 (en) * 2007-04-24 2008-10-29 Biocompatibles UK Limited Microspheres for treatment of brain tumours
CA2858315C (en) 2011-12-13 2020-05-12 Engeneic Molecular Delivery Pty Ltd Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors
US10342769B2 (en) 2014-11-14 2019-07-09 Navinta Iii Inc Carmustine pharmaceutical composition
US20170128424A1 (en) * 2015-11-11 2017-05-11 Qrono, Inc. Sustained release pharmaceutical compositions and methods of use
HRP20240485T1 (hr) 2017-08-24 2024-07-05 Novo Nordisk A/S Pripravci glp-1 i njihova upotreba
CA3160922A1 (en) 2019-12-05 2021-06-10 Brock A. LINDSEY Protein-loaded plga nanospheres
PE20230819A1 (es) 2020-02-18 2023-05-19 Novo Nordisk As Composiciones y usos de glp-1

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2693905B1 (fr) * 1992-07-27 1994-09-02 Rhone Merieux Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues.
NZ260909A (en) * 1993-07-05 1995-04-27 Takeda Chemical Industries Ltd Production of sustained release preparation by allowing a water-soluble polypeptide to permeate into a biodegradable matrix in an aqueous solution
US5626862A (en) * 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
AU733394B2 (en) * 1996-10-16 2001-05-10 Regeneron Pharmaceuticals, Inc. Method of enhancing the delivery of growth factors
DE69839508D1 (de) * 1997-03-31 2008-07-03 Toray Industries Chinolinmorphinan-derivate und ihre medizinische anwendung
JP2001519400A (ja) * 1997-10-14 2001-10-23 ケンブリッジ ニューロサイエンス インク． ニューレグリン使用を含む治療法

Also Published As

Publication number Publication date
US6803052B2 (en) 2004-10-12
EA200101206A1 (ru) 2002-04-25
BG106106A (en) 2002-05-31
JP5230045B2 (ja) 2013-07-10
AU775320B2 (en) 2004-07-29
MXPA01011919A (es) 2002-05-06
EP1228755A1 (fr) 2002-08-07
WO2000069413A1 (fr) 2000-11-23
CN1356892A (zh) 2002-07-03
NO331686B1 (no) 2012-02-20
FR2793684B1 (fr) 2001-08-10
US20030175356A1 (en) 2003-09-18
CA2388656A1 (fr) 2000-11-23
ATE228353T1 (de) 2002-12-15
CZ20014137A3 (cs) 2002-06-12
AR024008A1 (es) 2002-09-04
EA004943B1 (ru) 2004-10-28
DE60000842D1 (de) 2003-01-09
PL352372A1 (en) 2003-08-25
DE60000842T2 (de) 2003-08-28
IL146467A0 (en) 2002-07-25
HUP0201224A3 (en) 2004-05-28
ZA200109415B (en) 2003-01-29
EP1053746B1 (fr) 2002-11-27
HK1047044A1 (en) 2003-02-07
IL146467A (en) 2006-06-11
HUP0201224A2 (hu) 2002-11-28
NO20015501D0 (no) 2001-11-09
NZ515515A (en) 2004-02-27
US20020051749A1 (en) 2002-05-02
ES2185544T3 (es) 2003-05-01
CN1210020C (zh) 2005-07-13
TWI229608B (en) 2005-03-21
KR100649948B1 (ko) 2006-11-24
CA2388656C (fr) 2011-04-26
BR0010648A (pt) 2002-02-19
SI1053746T1 (en) 2003-04-30
FR2793684A1 (fr) 2000-11-24
HK1047044B (zh) 2005-12-23
AU4764100A (en) 2000-12-05
NO20015501L (no) 2002-01-09
PT1053746E (pt) 2003-04-30
JP2002544219A (ja) 2002-12-24
US7041241B2 (en) 2006-05-09
EP1053746A1 (fr) 2000-11-22
PL201614B1 (pl) 2009-04-30
BG64936B1 (bg) 2006-10-31
SK16342001A3 (sk) 2002-08-06
KR20020000178A (ko) 2002-01-04

Similar Documents

Publication Publication Date Title
DK1053746T3 (da) Anvendelse af bionedbrydelige mikrokugler, som frigiver et anticancermiddel, til behandling af glioblastomer
DK1208095T3 (da) Dibenzopyraner som glucocorticoidreceptorantagonister til behandling af diabetes
DK1459749T3 (da) (S,S)-reboxetin til behandling af inkontinens
NL300343I1 (nl) 6-alfa, 9-alfa-difluor-17-alfa-(2-furanylcarboxyl)oxy-11-beta-hydroxy-16-alfa-methyl-3-oxo-androst-1, 4-dieen-17-carbothionzuur-s-fluormethylester alseen ontstekingremmend middel
NO20032181D0 (no) Anvendelse av CCI-779 som et antineoplastisk middel
NL1018939A1 (nl) Maandverband.
DE60013812D1 (de) Schnellkupplung
BR0110624B1 (pt) dispositivo fixador anular.
NO20026195D0 (no) Substituerte-triazolopyrimidiner som anticancer midler
NO20013671D0 (no) Substituerte bicycliske derivater nyttige som anticancer midler
DE60038784D1 (de) Schnellkupplung
AR028162A1 (es) Disponibilidad controlada de compuestos de formulacion, composiciones y metodos para el lavado que utilizan los mismos.
FI19992312L (fi) Laite palon sammuttamiseksi
DK1221952T3 (da) Anvendelse af en antagonist til centrale cannaboidreceptorer med henblik på fremstilling af lægemidler
DK1200073T3 (da) Selektive iGluR5-receptorantagonister til behandling af migræne
ECSP055888A (es) Derivados de aril-quinazolin/aril-2-amino-fenil metanona que promueven la liberación de la hormona paratiroides.
IT1305301B1 (it) Raccordo per anastomosi vascolari.
NO20044132L (no) Legemidler som inneholder aktive ingredienser som senker kolesterolnivaet med tidsforsinket frigjoring av det aktive middelet
NO20011402L (no) Tricykliske <delta>3-piperidiner som farmasöytiske midler
ATE349571T1 (de) Schnell entfaltbare, zweilagige vorübergehende bodenkonstruktion
NO20032415D0 (no) Forbindelser som er aktive på glukokortikoidreseptor II
DK1157987T3 (da) S-nitrosothioler som midler til behandling af kredsløbsforstyrrelser
RU2002117643A (ru) Люплатекс, обладающий противолучевыми свойствами
ES1043646Y (es) Anclaje para clavijas de pared.
ES1048303Y (es) Estructura perfeccionada para el soporte de aplacados.