DK106191A - Mellemprodukter til fremstilling af penemer og carbapenemer - Google Patents
Mellemprodukter til fremstilling af penemer og carbapenemer Download PDFInfo
- Publication number
- DK106191A DK106191A DK106191A DK106191A DK106191A DK 106191 A DK106191 A DK 106191A DK 106191 A DK106191 A DK 106191A DK 106191 A DK106191 A DK 106191A DK 106191 A DK106191 A DK 106191A
- Authority
- DK
- Denmark
- Prior art keywords
- peneme
- carbapeneme
- intermediates
- manufacturing
- carbapeneme manufacturing
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- HHXMXAQDOUCLDN-RXMQYKEDSA-N penem Chemical compound S1C=CN2C(=O)C[C@H]21 HHXMXAQDOUCLDN-RXMQYKEDSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/279,751 US4876365A (en) | 1988-12-05 | 1988-12-05 | Intermediate compounds for preparing penems and carbapenems |
| PCT/US1989/005341 WO1990006316A1 (fr) | 1988-12-05 | 1989-12-01 | Procede d'obtention de composes intermediaires pour la preparation de penems et de carbapenems |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK106191D0 DK106191D0 (da) | 1991-06-04 |
| DK106191A true DK106191A (da) | 1991-07-03 |
Family
ID=23070295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK106191A DK106191A (da) | 1988-12-05 | 1991-06-04 | Mellemprodukter til fremstilling af penemer og carbapenemer |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4876365A (fr) |
| EP (2) | EP0447456A1 (fr) |
| JP (1) | JPH04500077A (fr) |
| AU (1) | AU4809790A (fr) |
| CA (1) | CA2004355A1 (fr) |
| DK (1) | DK106191A (fr) |
| IL (1) | IL92522A0 (fr) |
| WO (1) | WO1990006316A1 (fr) |
| ZA (1) | ZA899208B (fr) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4876365A (en) * | 1988-12-05 | 1989-10-24 | Schering Corporation | Intermediate compounds for preparing penems and carbapenems |
| US5342631A (en) * | 1992-12-29 | 1994-08-30 | Wm. Wrigley Jr. Company | Wax-free chewing gum including special oligosaccharide binders |
| WO1995001961A1 (fr) * | 1993-07-09 | 1995-01-19 | Schering Corporation | Procede de synthese d'azetidinones |
| US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| AR023463A1 (es) | 1999-04-16 | 2002-09-04 | Schering Corp | Uso de compuestos de azetidinona |
| US6584357B1 (en) * | 2000-10-17 | 2003-06-24 | Sony Corporation | Method and system for forming an acoustic signal from neural timing difference data |
| US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| PL364178A1 (en) * | 2001-01-26 | 2004-12-13 | Schering Corporation | Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions |
| DK1355644T3 (da) * | 2001-01-26 | 2006-10-23 | Schering Corp | Anvendelse af substituerede azetidinonforbindelser til behandling af sitosterolæmi |
| US20020183305A1 (en) * | 2001-01-26 | 2002-12-05 | Schering Corporation | Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications |
| AU2002241956A1 (en) * | 2001-01-26 | 2002-08-06 | Schering Corporation | Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
| IL156585A0 (en) * | 2001-01-26 | 2004-01-04 | Schering Corp | Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions |
| HU230253B1 (hu) * | 2001-01-26 | 2015-11-30 | Merck Sharp & Dohme Corp | Peroxiszóma proliferátor-aktivált receptor (PPAR) aktivátor(ok) és szterin-abszorpció inhibitor(ok) kombinációi és alkalmazásuk vaszkuláris indikációk kezelésére |
| US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| DK1373230T3 (da) | 2001-03-28 | 2005-11-07 | Schering Corp | Enantiselektiv syntese af azetidinon mellemprodukter |
| JP2004532868A (ja) * | 2001-05-25 | 2004-10-28 | シェーリング コーポレイション | アルツハイマー病の処置におけるアゼチジノン置換誘導体の使用 |
| US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| JP2005504091A (ja) * | 2001-09-21 | 2005-02-10 | シェーリング コーポレイション | ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置 |
| US20030119808A1 (en) * | 2001-09-21 | 2003-06-26 | Schering Corporation | Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects |
| AU2002335770B2 (en) * | 2001-09-21 | 2005-08-18 | Merck Sharp & Dohme Corp. | Methods for treating or preventing vascular inflammation using sterol absorption inhibitor(s) |
| US7053080B2 (en) * | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| US20030204096A1 (en) * | 2002-03-25 | 2003-10-30 | Schering Corporation | Enantioselective synthesis of azetidinone intermediate compounds |
| WO2004043457A1 (fr) * | 2002-11-06 | 2004-05-27 | Schering Corporation | Inhibiteurs d'absorption de cholesterol pour le traitement de troubles auto-immuns |
| CA2517571C (fr) | 2003-03-07 | 2011-07-05 | Schering Corporation | Azetidinones substituees , procedes pour leur preparation, formulations et utilisations de celles-ci |
| JP2006519869A (ja) | 2003-03-07 | 2006-08-31 | シェーリング コーポレイション | 置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用 |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| JP4589919B2 (ja) | 2003-03-07 | 2010-12-01 | シェーリング コーポレイション | 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用 |
| EP1680189A2 (fr) * | 2003-11-05 | 2006-07-19 | Schering Corporation | Combinaisons de modulateurs lipidiques et d'azetidinones substituees et traitements d'affections vasculaires |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4301074A (en) * | 1977-11-17 | 1981-11-17 | Merck & Co., Inc. | 6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid |
| EP0042026B1 (fr) * | 1978-02-02 | 1986-01-08 | Ciba-Geigy Ag | Dérivés d'azétidin-2-one 3,4-disubstitués et procédé de préparation |
| IL59081A0 (en) * | 1979-01-10 | 1980-05-30 | Schering Corp | 2-penem compounds and a method for preparing them |
| US4378314A (en) * | 1979-09-21 | 1983-03-29 | Bristol Myers Company | Antibacterial agents and metal containing azetidinone intermediates therefore |
| EP0035689B1 (fr) * | 1980-02-28 | 1984-12-19 | Fujisawa Pharmaceutical Co., Ltd. | Dérivés de 2-oxoazétidine substituée en position 4, procédés pour leur préparation et leur utilisation pour la synthèse d'antibiotiques |
| EP0046363B1 (fr) * | 1980-08-16 | 1984-11-14 | Beecham Group Plc | Procédé de préparation de dérivés de 2-thio penème et les intermédiaires |
| CA1190236A (fr) * | 1981-10-23 | 1985-07-09 | Edward J.J. Grabowski | Synthese d'un antibiotique |
| US4388310A (en) * | 1982-03-01 | 1983-06-14 | Merck & Co., Inc. | 6-Amido-2-S-oxides of substituted 2-organothio-pen-2-em-3-carboxylic acids |
| US4530793A (en) * | 1982-11-29 | 1985-07-23 | Schering Corporation | Processes for the production of penems |
| US4675317A (en) * | 1983-01-25 | 1987-06-23 | Merck & Co., Inc. | 2-unsaturated alkylthio-pen-2-em-3-carboxylic acids |
| US4614614A (en) * | 1983-03-28 | 1986-09-30 | Ciba-Geigy Corporation | Process for the manufacture of optically active azetidinones |
| US4504485A (en) * | 1983-04-04 | 1985-03-12 | Schering Corporation | 5R,6S,8R-6-(1-Hydroxyethyl)-2-(2-carbamoyloxyethylthio)-penem-3-carboxylic acid |
| CA1283906C (fr) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | COMPOSE DE .beta.-LACTAM ET PROCEDE DE PRODUCTION |
| GB8321004D0 (en) * | 1983-08-04 | 1983-09-07 | Erba Farmitalia | Azetidinones |
| US4584133A (en) * | 1983-11-07 | 1986-04-22 | Schering Corporation | Process for the production of penems |
| US4596677A (en) * | 1984-04-06 | 1986-06-24 | Bristol-Myers Company | Anhydropenicillin intermediates |
| GB8416652D0 (en) * | 1984-06-29 | 1984-08-01 | Erba Farmitalia | Penem derivatives |
| US4663451A (en) * | 1985-05-09 | 1987-05-05 | Farmitalia Carlo Erba S.P.A. | Process for the synthesis of penems and penams |
| DE3587546D1 (de) * | 1984-10-01 | 1993-09-30 | Ciba Geigy | Verfahren zur Herstellung von optisch aktiven Acyloxyazetidinonen. |
| US4740595A (en) * | 1986-03-13 | 1988-04-26 | Schering Corporation | Preparation of azetidinones via N-protected oxirancecarboxamide intermediates |
| GB8702139D0 (en) * | 1987-01-30 | 1987-03-04 | Ici Plc | Process |
| US4876365A (en) * | 1988-12-05 | 1989-10-24 | Schering Corporation | Intermediate compounds for preparing penems and carbapenems |
-
1988
- 1988-12-05 US US07/279,751 patent/US4876365A/en not_active Expired - Fee Related
-
1989
- 1989-12-01 AU AU48097/90A patent/AU4809790A/en not_active Abandoned
- 1989-12-01 JP JP2501321A patent/JPH04500077A/ja active Pending
- 1989-12-01 CA CA002004355A patent/CA2004355A1/fr not_active Abandoned
- 1989-12-01 EP EP90900652A patent/EP0447456A1/fr active Pending
- 1989-12-01 EP EP89122213A patent/EP0373448A1/fr not_active Withdrawn
- 1989-12-01 ZA ZA899208A patent/ZA899208B/xx unknown
- 1989-12-01 WO PCT/US1989/005341 patent/WO1990006316A1/fr not_active Ceased
- 1989-12-01 IL IL92522A patent/IL92522A0/xx unknown
-
1991
- 1991-06-04 DK DK106191A patent/DK106191A/da unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU4809790A (en) | 1990-06-26 |
| JPH04500077A (ja) | 1992-01-09 |
| CA2004355A1 (fr) | 1990-06-05 |
| EP0373448A1 (fr) | 1990-06-20 |
| WO1990006316A1 (fr) | 1990-06-14 |
| IL92522A0 (en) | 1990-08-31 |
| US4876365A (en) | 1989-10-24 |
| DK106191D0 (da) | 1991-06-04 |
| EP0447456A1 (fr) | 1991-09-25 |
| ZA899208B (en) | 1990-09-26 |
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