DK1064284T3 - Hypnotiske beta-carbolinderivater, fremgangsmåde til fremstilling deraf og deres anvendelse som medicinske produkter - Google Patents

Hypnotiske beta-carbolinderivater, fremgangsmåde til fremstilling deraf og deres anvendelse som medicinske produkter

Info

Publication number: DK1064284T3
Authority: DK; Denmark
Prior art keywords: hypnotic; beta; processes; preparation; medical products
Prior art date: 1998-03-17

Application number

DK99939844T

Other languages

English (en)

Inventor

Jean-Bernard Fourtillan

Marianne Fourtillan

Jean-Claude Jacquesy

Marie-Paule Jouannetaud

Bruno Violeau

Omar Karam

Original Assignee

Besins Int Lab

Macef

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-17

Filing date

1999-03-17

Publication date

2002-07-22

1998-03-17 Priority claimed from US09/042,990 external-priority patent/US6048868A/en

1999-03-17 Application filed by Besins Int Lab, Macef filed Critical Besins Int Lab

2002-07-22 Application granted granted Critical

2002-07-22 Publication of DK1064284T3 publication Critical patent/DK1064284T3/da

Links

230000000147 hypnotic effect Effects 0.000 title 1
229940127554 medical product Drugs 0.000 title 1
AIFRHYZBTHREPW-UHFFFAOYSA-N β-carboline Chemical class N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

DK99939844T 1998-03-17 1999-03-17 Hypnotiske beta-carbolinderivater, fremgangsmåde til fremstilling deraf og deres anvendelse som medicinske produkter DK1064284T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/042,990 US6048868A (en)	1994-09-14	1998-03-17	Melatonin-antagonist β-carboline derivatives and analogues thereof containing naphthalenic structure, process for their preparation and their use as medicinal products
PCT/IB1999/000494 WO1999047521A1 (en)	1998-03-17	1999-03-17	HYPNOTIC β-CARBOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS

Publications (1)

Publication Number	Publication Date
DK1064284T3 true DK1064284T3 (da)	2002-07-22

Family

ID=21924862

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99939844T DK1064284T3 (da)	1998-03-17	1999-03-17	Hypnotiske beta-carbolinderivater, fremgangsmåde til fremstilling deraf og deres anvendelse som medicinske produkter

Country Status (24)

Country	Link
EP (1)	EP1064284B1 (da)
JP (1)	JP4333036B2 (da)
CN (1)	CN1115342C (da)
AR (1)	AR018767A1 (da)
AT (1)	ATE215087T1 (da)
AU (1)	AU752364B2 (da)
BG (1)	BG63973B1 (da)
BR (1)	BR9908833A (da)
CA (1)	CA2324270A1 (da)
DE (1)	DE69901098T2 (da)
DK (1)	DK1064284T3 (da)
ES (1)	ES2174632T3 (da)
HU (1)	HUP0101234A3 (da)
IL (1)	IL138442A (da)
IS (1)	IS2199B (da)
NO (1)	NO317296B1 (da)
NZ (1)	NZ506913A (da)
PL (1)	PL193450B1 (da)
PT (1)	PT1064284E (da)
RU (1)	RU2210571C2 (da)
SK (1)	SK284387B6 (da)
TR (1)	TR200003596T2 (da)
UA (1)	UA71911C2 (da)
WO (1)	WO1999047521A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2824829B1 (fr) *	2001-05-16	2005-06-03	Macef	Nouveaux derives de dihydroimidazo [5,1-a]-beta-carboline, leur procede de preparation et leur application a titre de medicament
FR2904973A1 (fr) *	2006-08-18	2008-02-22	Fourtillan Snc	Derives de 1-methylidene-pyrido[3,4-b]indole et leur utilisation en therapeutique.
FR2916200A1 (fr) *	2007-05-18	2008-11-21	Fourtillan Snc	Nouveaux derives des 1,2,3,4,6,7,12,12a-octahydro pyrazino[1',2':1,6]pyrido[3,4-b]indoles, leur preparation et leur utilisation en therapeutique
CA2727055C (en)	2008-01-11	2016-12-20	Albany Molecular Research, Inc.	(1-azinone) -substituted pyridoindoles as mch antagonists
WO2011003005A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
US8629158B2 (en)	2009-07-01	2014-01-14	Albany Molecular Research, Inc.	Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
WO2011003021A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2012088124A2 (en)	2010-12-21	2012-06-28	Albany Molecular Research, Inc.	Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof
US8697700B2 (en)	2010-12-21	2014-04-15	Albany Molecular Research, Inc.	Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof
FI130627B (en) *	2021-03-31	2023-12-18	Equinorm Ltd	Novel heterocyclic compounds and their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5283343A (en) *	1987-08-17	1994-02-01	Whitby Research, Inc.	2-aryl substituted N-acetyltryptamines and process of preparing such
HU207070B (en) *	1990-10-31	1993-03-01	Richter Gedeon Vegyeszet	Process for producing 1beta-ethyl-1alpha-hydroxymethyl-1,2,3,4,6,712,12balpha-octahydroindolo(2,3-a) quinolizine
RU2067980C1 (ru) *	1992-06-30	1996-10-20	Глэксо Груп Лимитед	Производные лактама и фармацевтическая композиция, являющаяся антагонистом 5-окситраптамина /5-нт/ на 5- нт3 -рецепторах или их физиологически приемлемые соли и соловаты
RU2068847C1 (ru) *	1994-05-18	1996-11-10	Всероссийский научный центр по безопасности биологически активных веществ	ПРОИЗВОДНЫЕ 3,4-ДИГИДРО- ИЛИ 1,2,3,4-ТЕТРАГИДРО- β -КАРБОЛИНОВ ИЛИ ИХ СОЛИ С ОРГАНИЧЕСКИМИ ИЛИ НЕОРГАНИЧЕСКИМИ КИСЛОТАМИ, ПРОЯВЛЯЮЩИЕ АНТИМИКРОБНУЮ АКТИВНОСТЬ
FR2724384B1 (fr) *	1994-09-14	1999-04-16	Cemaf	Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament

1999
- 1999-03-17 BR BR9908833-9A patent/BR9908833A/pt not_active Application Discontinuation
- 1999-03-17 TR TR2000/03596T patent/TR200003596T2/xx unknown
- 1999-03-17 AU AU32707/99A patent/AU752364B2/en not_active Ceased
- 1999-03-17 PL PL99342929A patent/PL193450B1/pl not_active IP Right Cessation
- 1999-03-17 EP EP99939844A patent/EP1064284B1/en not_active Expired - Lifetime
- 1999-03-17 RU RU2000126288/04A patent/RU2210571C2/ru not_active IP Right Cessation
- 1999-03-17 ES ES99939844T patent/ES2174632T3/es not_active Expired - Lifetime
- 1999-03-17 IL IL138442A patent/IL138442A/en not_active IP Right Cessation
- 1999-03-17 NZ NZ506913A patent/NZ506913A/en unknown
- 1999-03-17 CN CN99805687A patent/CN1115342C/zh not_active Expired - Fee Related
- 1999-03-17 UA UA2000105839A patent/UA71911C2/uk unknown
- 1999-03-17 AT AT99939844T patent/ATE215087T1/de not_active IP Right Cessation
- 1999-03-17 DK DK99939844T patent/DK1064284T3/da active
- 1999-03-17 AR ARP990101166A patent/AR018767A1/es active IP Right Grant
- 1999-03-17 WO PCT/IB1999/000494 patent/WO1999047521A1/en not_active Ceased
- 1999-03-17 JP JP2000536716A patent/JP4333036B2/ja not_active Expired - Fee Related
- 1999-03-17 SK SK1385-2000A patent/SK284387B6/sk not_active IP Right Cessation
- 1999-03-17 DE DE69901098T patent/DE69901098T2/de not_active Expired - Lifetime
- 1999-03-17 PT PT99939844T patent/PT1064284E/pt unknown
- 1999-03-17 CA CA002324270A patent/CA2324270A1/en not_active Abandoned
- 1999-03-17 HU HU0101234A patent/HUP0101234A3/hu unknown
2000
- 2000-09-12 IS IS5627A patent/IS2199B/is unknown
- 2000-09-14 BG BG104768A patent/BG63973B1/bg unknown
- 2000-09-15 NO NO20004638A patent/NO317296B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1999047521A1 (en)	1999-09-23
DE69901098T2 (de)	2002-11-21
NO20004638D0 (no)	2000-09-15
JP4333036B2 (ja)	2009-09-16
CA2324270A1 (en)	1999-09-23
AU3270799A (en)	1999-10-11
DE69901098D1 (de)	2002-05-02
AR018767A1 (es)	2001-12-12
HUP0101234A3 (en)	2002-12-28
PT1064284E (pt)	2002-09-30
IS2199B (is)	2007-02-15
IS5627A (is)	2000-09-12
UA71911C2 (en)	2005-01-17
JP2002506867A (ja)	2002-03-05
PL193450B1 (pl)	2007-02-28
NZ506913A (en)	2003-07-25
ES2174632T3 (es)	2002-11-01
CN1299361A (zh)	2001-06-13
BR9908833A (pt)	2000-11-21
IL138442A0 (en)	2001-10-31
NO317296B1 (no)	2004-10-04
SK284387B6 (sk)	2005-02-04
IL138442A (en)	2006-12-10
TR200003596T2 (tr)	2001-04-20
PL342929A1 (en)	2001-07-16
EP1064284B1 (en)	2002-03-27
SK13852000A3 (sk)	2001-09-11
HUP0101234A2 (hu)	2001-12-28
AU752364B2 (en)	2002-09-19
NO20004638L (no)	2000-11-16
CN1115342C (zh)	2003-07-23
BG63973B1 (bg)	2003-08-29
EP1064284A1 (en)	2001-01-03
RU2210571C2 (ru)	2003-08-20
ATE215087T1 (de)	2002-04-15
BG104768A (en)	2001-05-31

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