DK1071702T3 - Fedtsyrederivater af galdesyre og galdesyrederivater - Google Patents

Fedtsyrederivater af galdesyre og galdesyrederivater

Info

Publication number: DK1071702T3
Authority: DK; Denmark
Prior art keywords: bile; acid; bile acid; acid derivatives; fatty acid
Prior art date: 1998-04-08

Application number

DK99912026T

Other languages

Danish (da)

English (en)

Inventor

Tuvia Gilat

Original Assignee

Galmed Int Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-08

Filing date

1999-03-25

Publication date

2002-12-30

1999-03-25 Application filed by Galmed Int Ltd filed Critical Galmed Int Ltd

2002-12-30 Application granted granted Critical

2002-12-30 Publication of DK1071702T3 publication Critical patent/DK1071702T3/da

Links

HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical class C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title abstract 6
229940053200 antiepileptics fatty acid derivative Drugs 0.000 title 1
239000003613 bile acid Substances 0.000 abstract 4
239000003833 bile salt Substances 0.000 abstract 4
235000014113 dietary fatty acids Nutrition 0.000 abstract 3
229930195729 fatty acid Natural products 0.000 abstract 3
239000000194 fatty acid Substances 0.000 abstract 3
150000004665 fatty acids Chemical class 0.000 abstract 3
206010003210 Arteriosclerosis Diseases 0.000 abstract 1
208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
210000000941 bile Anatomy 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
201000001883 cholelithiasis Diseases 0.000 abstract 1
230000021615 conjugation Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
150000004671 saturated fatty acids Chemical class 0.000 abstract 1
235000003441 saturated fatty acids Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Fats And Perfumes (AREA)

DK99912026T 1998-04-08 1999-03-25 Fedtsyrederivater af galdesyre og galdesyrederivater DK1071702T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IL12399898A IL123998A (en)	1998-04-08	1998-04-08	Conjugates of bile salts and pharmaceutical preparations containing them
PCT/IL1999/000173 WO1999052932A1 (en)	1998-04-08	1999-03-25	Fatty acid derivatives of bile acids and bile acid derivatives

Publications (1)

Publication Number	Publication Date
DK1071702T3 true DK1071702T3 (da)	2002-12-30

Family

ID=11071405

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99912026T DK1071702T3 (da)	1998-04-08	1999-03-25	Fedtsyrederivater af galdesyre og galdesyrederivater

Country Status (25)

Country	Link
US (3)	US6395722B1 (de)
EP (1)	EP1071702B1 (de)
JP (1)	JP5031942B2 (de)
KR (1)	KR100615560B1 (de)
CN (1)	CN100386339C (de)
AT (1)	ATE222923T1 (de)
AU (1)	AU742944B2 (de)
BR (1)	BRPI9909908B8 (de)
CA (1)	CA2325933C (de)
CZ (1)	CZ300824B6 (de)
DE (1)	DE69902647T2 (de)
DK (1)	DK1071702T3 (de)
EA (1)	EA003392B1 (de)
ES (1)	ES2183526T3 (de)
HU (1)	HU229513B1 (de)
ID (1)	ID26042A (de)
IL (1)	IL123998A (de)
NO (1)	NO316875B1 (de)
NZ (1)	NZ507309A (de)
PL (1)	PL199271B1 (de)
PT (1)	PT1071702E (de)
SI (1)	SI1071702T1 (de)
TR (1)	TR200002876T2 (de)
UA (1)	UA70318C2 (de)
WO (1)	WO1999052932A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL123998A (en) *	1998-04-08	2004-09-27	Galmed Int Ltd	Conjugates of bile salts and pharmaceutical preparations containing them
IL142650A (en) *	1998-04-08	2007-06-03	Galmed Int Ltd	Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes
US20030083231A1 (en) *	1998-11-24	2003-05-01	Ahlem Clarence N.	Blood cell deficiency treatment method
US8975246B2 (en)	2001-04-17	2015-03-10	Galmed Research And Development Ltd.	Bile acid or bile salt fatty acid conjugates
US7053076B2 (en)	2001-08-29	2006-05-30	Xenoport, Inc.	Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
ITMI20021025A1 (it) *	2002-05-14	2003-11-14	Nicox Sa	Farmaci per il trattamento acuto di disfunzioni del circolo venoso epatico e portale
US20080026077A1 (en) *	2002-11-12	2008-01-31	John Hilfinger	Methods and compositions of gene delivery agents for systemic and local therapy
US7906137B2 (en) *	2004-05-21	2011-03-15	Mediplex Corporation, Korea	Delivery agents for enhancing mucosal absorption of therapeutic agents
US8304383B2 (en) *	2005-11-22	2012-11-06	Atheronova Operations, Inc.	Dissolution of arterial plaque
US20090035348A1 (en) *	2005-11-22	2009-02-05	Z & Z Medical Holdings, Inc.	Dissolution of arterial plaque
WO2007084549A2 (en) *	2006-01-20	2007-07-26	Filiberto Zadini	Drug-eluting stent with atherosclerotic plaques dissolving pharmacological preparation
US20070212470A1 (en) *	2006-03-13	2007-09-13	Nutracea	Therapeutic uses of an anti-cancer composition derived from rice bran
US20080038385A1 (en) *	2006-03-13	2008-02-14	Nutracea	Therapeutic uses of an anti-cancer composition derived from rice bran
US20090305943A1 (en) *	2006-07-18	2009-12-10	Sven Siegel	Cyclodextrin blends with crystal growth inhibitors
CA2685127C (en)	2007-04-23	2019-01-08	Alnylam Pharmaceuticals, Inc.	Glycoconjugates of rna interference agents
US20080287429A1 (en) *	2007-05-15	2008-11-20	Z & Z Medical Holdings, Inc.	Dissolution of Arterial Cholesterol Plaques by Pharmacologically Induced Elevation of Endogenous Bile Salts
SI2182954T1 (sl) *	2007-07-25	2019-04-30	Medizinische Universitat Graz	Uporaba nor-žolčnih kislin pri zdravljenju arterioskleroze
CN101367859B (zh) *	2007-08-17	2011-05-11	中国人民解放军军事医学科学院毒物药物研究所	脂肪酸胆汁酸偶合物及其医药用途
CZ301037B6 (cs) *	2007-09-06	2009-10-21	Vysoká škola chemicko-technologická v Praze	Amidové konjugáty steroidních a žlucových kyselin s D-glukosaminem a zpusob jejich prípravy
EP2231194B1 (de)	2007-12-04	2017-02-22	Alnylam Pharmaceuticals Inc.	Folat-irna-konjugate
WO2009082607A2 (en)	2007-12-04	2009-07-02	Alnylam Pharmaceuticals, Inc.	Targeting lipids
US20100021538A1 (en) *	2008-02-29	2010-01-28	Youngro Byun	Pharmaceutical compositions containing heparin derivatives
WO2009126933A2 (en)	2008-04-11	2009-10-15	Alnylam Pharmaceuticals, Inc.	Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
JP5620392B2 (ja) *	2008-11-03	2014-11-05	タフツユニヴァーシティーＴｕｆｔｓＵｎｉｖｅｒｓｉｔｙ	クロストリジウム・ディフィシレ胞子の発芽および伸長を阻害するための方法および組成物
US20120157419A1 (en) *	2009-02-02	2012-06-21	Tuvia Gilat	Methods and compositions for treating alzheimer's disease
GB2480632A (en)	2010-05-25	2011-11-30	Kythera Biopharmaceuticals Inc	Preparation of 12-keto and 12-alpha-hydroxy steroids
CN102115486B (zh) *	2009-12-30	2015-06-03	上海特化医药科技有限公司	一种3-β-花生酰胺基-7α,12α,5β-胆烷-24-羧酸的制备方法
EP2721047B1 (de) *	2011-06-16	2016-11-16	Kythera Biopharmaceuticals, Inc.	Verfahren zur synthese und reinigung von deoxycholsäure
US20160175324A1 (en) *	2013-08-08	2016-06-23	Galderm Therapeutics Ltd.	Anti-acne compositions comprising bile acid-fatty acid conjugates
SI3077047T1 (sl) *	2013-12-04	2019-09-30	Galmed Research & Development Ltd.	Soli aramchola
US11571431B2 (en)	2013-12-04	2023-02-07	Galmed Research And Development Ltd	Aramchol salts
JP2017519726A (ja) *	2014-06-01	2017-07-20	ガルメッドリサーチアンドディベロップメントリミテッド．	リポジストロフィー治療用脂肪酸胆汁酸複合体
TWI710633B (zh)	2014-11-10	2020-11-21	美商阿尼拉製藥公司	Ｂ型肝炎病毒（ＨＢＶ）ｉＲＮＡ組成物及其用途方法
US10849911B2 (en)	2015-06-10	2020-12-01	Galmed Research And Development Ltd.	Low dose compositions of Aramachol salts
IL243707A0 (en)	2016-01-20	2016-05-01	Galmed Res And Dev Ltd	Treatment to regulate the microbiota in the intestine
CN106496300B (zh) *	2016-10-19	2018-05-18	上海博志研新药物技术有限公司	花生胆酸及其中间体的制备方法
US11197870B2 (en)	2016-11-10	2021-12-14	Galmed Research And Development Ltd	Treatment for hepatic fibrosis
MA46786A (fr) *	2016-11-10	2019-09-18	Galmed Res And Development Ltd	Inhibition de la fibrose chez des patients atteints d'une stéatose hépatique non alcoolique
US11324820B2 (en)	2017-04-18	2022-05-10	Alnylam Pharmaceuticals, Inc.	Methods for the treatment of subjects having a hepatitis b virus (HBV) infection
US11136347B2 (en)	2017-06-07	2021-10-05	Crystal Pharmaceutical (Suzhou) Co., Ltd.	Crystalline forms of a fatty acid bile acid conjugate, preparation method thereof and use thereof
CA3106701A1 (en)	2018-08-13	2020-02-20	Alnylam Pharmaceuticals, Inc.	Hepatitis b virus (hbv) dsrna agent compositions and methods of use thereof
IT202000000328A1 (it)	2020-01-10	2021-07-10	Ice S P A	Metodo di preparazione dell'aramchol
CN114524857B (zh) *	2022-02-22	2023-06-30	中国科学院微生物研究所	胆酸衍生物及其应用
CN116687850A (zh)	2022-02-24	2023-09-05	甘莱制药有限公司	包含环状膦酸酯化合物的药物组合物及其制备方法与用途
WO2023227723A1 (en) *	2022-05-26	2023-11-30	Pharmazell Gmbh	An improved process for the preparation of aramchol and salts thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3856953A (en) *	1973-05-15	1974-12-24	Intellectual Property Dev Corp	Method of treating fatty liver
IT1167478B (it) *	1981-07-24	1987-05-13	Carlo Scolastico	Derivati dell'acido ursodesossicolico
IT1167479B (it) *	1981-07-24	1987-05-13	Carlo Scolastico	Derivati dell'acido chenodesossicolico
DE3930696A1 (de) *	1989-09-14	1991-03-28	Hoechst Ag	Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel
IL123998A (en) *	1998-04-08	2004-09-27	Galmed Int Ltd	Conjugates of bile salts and pharmaceutical preparations containing them
DE19824123A1 (de) *	1998-05-29	1999-12-02	Hoechst Marion Roussel De Gmbh	Gallensäurederivat, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung

1998
- 1998-04-08 IL IL12399898A patent/IL123998A/en not_active IP Right Cessation
1999
- 1999-03-25 JP JP2000543488A patent/JP5031942B2/ja not_active Expired - Lifetime
- 1999-03-25 WO PCT/IL1999/000173 patent/WO1999052932A1/en not_active Ceased
- 1999-03-25 ES ES99912026T patent/ES2183526T3/es not_active Expired - Lifetime
- 1999-03-25 PT PT99912026T patent/PT1071702E/pt unknown
- 1999-03-25 TR TR2000/02876T patent/TR200002876T2/xx unknown
- 1999-03-25 ID IDW20001998A patent/ID26042A/id unknown
- 1999-03-25 DK DK99912026T patent/DK1071702T3/da active
- 1999-03-25 BR BRPI9909908A patent/BRPI9909908B8/pt not_active IP Right Cessation
- 1999-03-25 SI SI9930142T patent/SI1071702T1/xx unknown
- 1999-03-25 AU AU30515/99A patent/AU742944B2/en not_active Expired
- 1999-03-25 CA CA002325933A patent/CA2325933C/en not_active Expired - Lifetime
- 1999-03-25 DE DE69902647T patent/DE69902647T2/de not_active Expired - Lifetime
- 1999-03-25 PL PL343360A patent/PL199271B1/pl unknown
- 1999-03-25 HU HU0101653A patent/HU229513B1/hu unknown
- 1999-03-25 CZ CZ20003625A patent/CZ300824B6/cs not_active IP Right Cessation
- 1999-03-25 AT AT99912026T patent/ATE222923T1/de active
- 1999-03-25 CN CNB998049034A patent/CN100386339C/zh not_active Expired - Lifetime
- 1999-03-25 KR KR1020007010903A patent/KR100615560B1/ko not_active Expired - Lifetime
- 1999-03-25 EA EA200000888A patent/EA003392B1/ru not_active IP Right Cessation
- 1999-03-25 NZ NZ507309A patent/NZ507309A/xx not_active IP Right Cessation
- 1999-03-25 EP EP99912026A patent/EP1071702B1/de not_active Expired - Lifetime
- 1999-03-25 UA UA2000095546A patent/UA70318C2/uk unknown
2000
- 2000-09-29 US US09/675,656 patent/US6395722B1/en not_active Expired - Lifetime
- 2000-10-04 NO NO20004998A patent/NO316875B1/no not_active IP Right Cessation
- 2000-10-23 US US09/693,928 patent/US6384024B1/en not_active Expired - Lifetime
2002
- 2002-02-21 US US10/078,671 patent/US6589946B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CN1296492A (zh)	2001-05-23
NO20004998L (no)	2000-12-06
KR20010042342A (ko)	2001-05-25
NO316875B1 (no)	2004-06-07
CA2325933C (en)	2008-06-10
AU742944B2 (en)	2002-01-17
NO20004998D0 (no)	2000-10-04
CZ300824B6 (cs)	2009-08-19
JP5031942B2 (ja)	2012-09-26
BR9909908B1 (pt)	2014-03-18
BRPI9909908B8 (pt)	2021-05-25
EA200000888A1 (ru)	2001-04-23
HUP0101653A2 (hu)	2001-12-28
EP1071702A1 (de)	2001-01-31
PT1071702E (pt)	2003-01-31
US6395722B1 (en)	2002-05-28
US6589946B2 (en)	2003-07-08
AU3051599A (en)	1999-11-01
HUP0101653A3 (en)	2002-02-28
WO1999052932A1 (en)	1999-10-21
BR9909908A (pt)	2000-12-26
SI1071702T1 (en)	2003-04-30
UA70318C2 (uk)	2004-10-15
CZ20003625A3 (cs)	2001-01-17
NZ507309A (en)	2003-06-30
EP1071702B1 (de)	2002-08-28
ID26042A (id)	2000-11-16
ATE222923T1 (de)	2002-09-15
IL123998A (en)	2004-09-27
TR200002876T2 (tr)	2000-12-21
ES2183526T3 (es)	2003-03-16
US6384024B1 (en)	2002-05-07
CA2325933A1 (en)	1999-10-21
DE69902647T2 (de)	2003-04-24
PL343360A1 (en)	2001-08-13
US20020091111A1 (en)	2002-07-11
HU229513B1 (en)	2014-01-28
KR100615560B1 (ko)	2006-08-25
DE69902647D1 (de)	2002-10-02
CN100386339C (zh)	2008-05-07
JP2002511482A (ja)	2002-04-16
EA003392B1 (ru)	2003-04-24
PL199271B1 (pl)	2008-09-30

Publication	Publication Date	Title
DK1071702T3 (da)	2002-12-30	Fedtsyrederivater af galdesyre og galdesyrederivater
TR199801195T2 (xx)	1998-10-21	Tedavide yararl� kinolin ve kinozilin bile�ikleri.
EP1244455A4 (de)	2004-11-03	Verfahren zur behandlungvon gefässerkrankungen, die sich durch eine insuffizienz von stickstoffmonoxid auszeichnen
TR200103095T2 (tr)	2002-04-22	Renin engelleyiciler.
CY1106853T1 (el)	2012-05-23	Χρηση συζευγματων χολικου οξεος ή λιπαρου οξεος χολικου αλατος
BR9914044A (pt)	2001-12-04	ésteres tetrahidropirido
WO1997030677A3 (en)	1997-11-20	Pentafluorobenzenesulfonamides and analogs
CA2260777A1 (en)	1998-02-12	Pentafluorobenzenesulfonamides and analogs
IT1304501B1 (it)	2001-03-19	Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza
DE60121461D1 (de)	2006-08-24	Kondensierte pyridoindolderivate
TR199802384T2 (xx)	1999-03-22	N�rodejeneratif hastal�klar�n tedavisinde yararl� farmas�tik bile�imlerin haz�rlanmas� i�in P-Aminofenol t�revlerinin kullan�m�.
ATE389655T1 (de)	2008-04-15	Pyrimidinderivate
BR0008437A (pt)	2001-10-30	Inibidores esteróides de sulfatase e métodos parafabricação e uso dos mesmos
DK0613687T3 (da)	1999-12-06	Anvendelse af pregnanderivat til behandling af tumorer
MX9707046A (es)	1998-02-28	Composiciones que comprenden nicotinilalanina y un inhibidor de conjugacion de glicina o vitamina b6.
AP9400608A0 (en)	1995-07-12	"New nicotinic acid derivative".
ATE254460T1 (de)	2003-12-15	Anhydrovinblastin zur behandlung von krebs
CA2215319A1 (en)	1996-09-19	Compositions comprising nicotinylalanine and an inhibitor of glycine conjugation or vitamin b6