ATE254460T1 - Anhydrovinblastin zur behandlung von krebs - Google Patents

Anhydrovinblastin zur behandlung von krebs

Info

Publication number: ATE254460T1
Authority: AT; Austria
Prior art keywords: cancer; treatment; anhydrovinblastin; vinblastine; present
Prior art date: 1997-03-04

Application number

AT98909249T

Other languages

English (en)

Inventor

Bruce Schmidt

James Kutney

Lawrence Mayer

Original Assignee

Univ British Columbia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-04

Filing date

1998-03-04

Publication date

2003-12-15

1997-03-04 Priority claimed from CA 2199065 external-priority patent/CA2199065A1/en

1997-05-14 Priority claimed from CA 2205314 external-priority patent/CA2205314A1/en

1998-03-04 Application filed by Univ British Columbia filed Critical Univ British Columbia

2003-12-15 Application granted granted Critical

2003-12-15 Publication of ATE254460T1 publication Critical patent/ATE254460T1/de

Links

206010028980 Neoplasm Diseases 0.000 title abstract 2
201000011510 cancer Diseases 0.000 title abstract 2
FFRFGVHNKJYNOV-UHFFFAOYSA-N ac1l8myg Chemical compound C1C(CC)=CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 FFRFGVHNKJYNOV-UHFFFAOYSA-N 0.000 title 1
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical class C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 abstract 2
FFRFGVHNKJYNOV-DOVUUNBWSA-N 3',4'-Anhydrovinblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C=C(C2)CC)N2CCC2=C1NC1=CC=CC=C21 FFRFGVHNKJYNOV-DOVUUNBWSA-N 0.000 abstract 1
JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 abstract 1
229940034982 antineoplastic agent Drugs 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
229960003048 vinblastine Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT98909249T 1997-03-04 1998-03-04 Anhydrovinblastin zur behandlung von krebs ATE254460T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
CA 2199065 CA2199065A1 (en)	1997-03-04	1997-03-04	Anhydrovinblastine for the treatment of cancer
CA 2205314 CA2205314A1 (en)	1997-03-04	1997-05-14	Anhydrovinblastine for the treatment of cervical and lung cancer
CA002219095A CA2219095A1 (en)	1997-03-04	1997-10-24	Anhydrovinblastine for the treatment of cervical and lung cancer
PCT/CA1998/000195 WO1998039004A1 (en)	1997-03-04	1998-03-04	Anhydrovinblastine for the treatment of cervical and lung cancer

Publications (1)

Publication Number	Publication Date
ATE254460T1 true ATE254460T1 (de)	2003-12-15

Family

ID=27170289

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98909249T ATE254460T1 (de)	1997-03-04	1998-03-04	Anhydrovinblastin zur behandlung von krebs

Country Status (10)

Country	Link
US (2)	US6326376B1 (de)
EP (1)	EP0969839B1 (de)
AT (1)	ATE254460T1 (de)
AU (1)	AU6388598A (de)
CA (1)	CA2219095A1 (de)
DE (1)	DE69819875T2 (de)
DK (1)	DK0969839T3 (de)
ES (1)	ES2212272T3 (de)
NZ (1)	NZ337752A (de)
WO (1)	WO1998039004A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003088969A1 (en) *	2002-04-16	2003-10-30	Access Oncology, Inc.	Anhydrovinblastine for the treatment of cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4279817A (en)	1975-05-30	1981-07-21	The United States Of America As Represented By The Department Of Health & Human Services	Method for producing dimer alkaloids
US4029663A (en)	1975-07-10	1977-06-14	Eli Lilly And Company	Dimeric anhydro-vinca derivatives
US4307100A (en)	1978-08-24	1981-12-22	Agence Nationale De Valorisation De La Recherche (Anvar)	Nor bis-indole compounds usable as medicaments
US4778885A (en) *	1986-09-18	1988-10-18	Allelix Inc.	Production of alkaloid dimers using ferric ion
US5037977A (en) *	1988-08-11	1991-08-06	Mitsui Petrochemical Industries Ltd.	Method for production of dimeric alkaloids
US6011041A (en)	1995-07-28	2000-01-04	University Of British Columbia	Use of anhydrovinblastine

1997
- 1997-10-24 CA CA002219095A patent/CA2219095A1/en not_active Abandoned
1998
- 1998-03-04 NZ NZ337752A patent/NZ337752A/xx unknown
- 1998-03-04 DE DE69819875T patent/DE69819875T2/de not_active Expired - Fee Related
- 1998-03-04 AU AU63885/98A patent/AU6388598A/en not_active Abandoned
- 1998-03-04 US US09/380,540 patent/US6326376B1/en not_active Expired - Fee Related
- 1998-03-04 ES ES98909249T patent/ES2212272T3/es not_active Expired - Lifetime
- 1998-03-04 EP EP98909249A patent/EP0969839B1/de not_active Expired - Lifetime
- 1998-03-04 DK DK98909249T patent/DK0969839T3/da active
- 1998-03-04 WO PCT/CA1998/000195 patent/WO1998039004A1/en not_active Ceased
- 1998-03-04 AT AT98909249T patent/ATE254460T1/de not_active IP Right Cessation
2001
- 2001-09-04 US US09/946,149 patent/US20020103218A1/en not_active Abandoned

Also Published As

Publication number	Publication date
NZ337752A (en)	2001-08-31
DE69819875D1 (de)	2003-12-24
ES2212272T3 (es)	2004-07-16
DE69819875T2 (de)	2004-11-11
CA2219095A1 (en)	1998-09-04
DK0969839T3 (da)	2004-03-29
EP0969839A1 (de)	2000-01-12
WO1998039004A1 (en)	1998-09-11
US6326376B1 (en)	2001-12-04
AU6388598A (en)	1998-09-22
US20020103218A1 (en)	2002-08-01
EP0969839B1 (de)	2003-11-19
HK1026610A1 (en)	2000-12-22

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Legal Events

Date

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Title

Description

2004-07-15

UEP

Publication of translation of european patent specification

Ref document number: 0969839

Country of ref document: EP

2006-12-15

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Ceased due to non-payment of the annual fee