DK1082437T3 - Xenobiotisk inducering af genekspression af cytochrom P450 CYP3A4 - Google Patents

Xenobiotisk inducering af genekspression af cytochrom P450 CYP3A4

Info

Publication number: DK1082437T3
Authority: DK; Denmark
Prior art keywords: cyp3a4; seq; cytochrome; gene expression; nucleotide sequence
Prior art date: 1998-05-21

Application number

DK99923306.7T

Other languages

English (en)

Inventor

Christopher Liddle

Bryan James Goodwin

Original Assignee

Univ Sydney

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-21

Filing date

1999-05-20

Publication date

2010-04-12

1999-05-20 Application filed by Univ Sydney filed Critical Univ Sydney

2010-04-12 Application granted granted Critical

2010-04-12 Publication of DK1082437T3 publication Critical patent/DK1082437T3/da

Links

102000004328 Cytochrome P-450 CYP3A Human genes 0.000 title abstract 3
108010081668 Cytochrome P-450 CYP3A Proteins 0.000 title abstract 3
230000014509 gene expression Effects 0.000 title abstract 2
230000006698 induction Effects 0.000 title 1
239000002676 xenobiotic agent Substances 0.000 title 1
230000002034 xenobiotic effect Effects 0.000 title 1
230000002068 genetic effect Effects 0.000 abstract 2
239000002773 nucleotide Substances 0.000 abstract 2
125000003729 nucleotide group Chemical group 0.000 abstract 2
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
108020005029 5' Flanking Region Proteins 0.000 abstract 1
108091027981 Response element Proteins 0.000 abstract 1
239000003623 enhancer Substances 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
230000002103 transcriptional effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

DK99923306.7T 1998-05-21 1999-05-20 Xenobiotisk inducering af genekspression af cytochrom P450 CYP3A4 DK1082437T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AUPP3628A AUPP362898A0 (en)	1998-05-21	1998-05-21	Xenobiotic induction of gene expression
PCT/AU1999/000381 WO1999061622A1 (en)	1998-05-21	1999-05-20	Xenobiotic related induction of gene expression

Publications (1)

Publication Number	Publication Date
DK1082437T3 true DK1082437T3 (da)	2010-04-12

Family

ID=3807879

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK09177085.9T DK2154250T3 (da)	1998-05-21	1999-05-20	Ikke-humant transgent dyr til xenobiotisk relateret induktion af genudtryk af cytokrom CYP3A4
DK99923306.7T DK1082437T3 (da)	1998-05-21	1999-05-20	Xenobiotisk inducering af genekspression af cytochrom P450 CYP3A4

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK09177085.9T DK2154250T3 (da)	1998-05-21	1999-05-20	Ikke-humant transgent dyr til xenobiotisk relateret induktion af genudtryk af cytokrom CYP3A4

Country Status (10)

Country	Link
US (3)	US6984489B1 (da)
EP (2)	EP2154250B1 (da)
JP (1)	JP4446603B2 (da)
AT (1)	ATE452193T1 (da)
AU (2)	AUPP362898A0 (da)
CA (1)	CA2333016C (da)
DE (1)	DE69941813D1 (da)
DK (2)	DK2154250T3 (da)
ES (1)	ES2337967T3 (da)
WO (1)	WO1999061622A1 (da)

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US6984773B1 (en) *	1998-01-09	2006-01-10	The Salk Institute For Biological Studies	Transgenic mice expressing a human SXR receptor polypeptide
US6756491B2 (en)	1998-01-09	2004-06-29	The Salk Institute For Biological Studies	Steroid-activated nuclear receptors and uses therefor
AUPP362898A0 (en)	1998-05-21	1998-06-11	University Of Sydney, The	Xenobiotic induction of gene expression
AU2006200258B2 (en) *	1999-12-09	2009-04-09	The Salk Institute For Biological Studies	Novel steroid-activated nuclear receptors and uses therefor
AU2001253373A1 (en) *	2000-04-12	2001-10-30	Puracyp	Compositions and methods for induction of proteins involved in xenobiotic metabolism
WO2002008451A2 (en) *	2000-07-25	2002-01-31	Epidauros Biotechnologie Ag	Assay for screening compounds for inducing drug metabolizing enzymes
US20020137663A1 (en) *	2000-08-11	2002-09-26	Forman Barry M.	The anti-neoplastic agent ET-743 inhibits trans activation by SXR
SE0003393D0 (sv) *	2000-09-22	2000-09-22	Pharmacia & Upjohn Ab	Promoter sequences
AU2002213660A1 (en) *	2000-11-01	2002-05-15	The University Of Sydney	Transgenic animals for analysing CYP3A4 cytochrome P450 gene regulation
AUPR116100A0 (en)	2000-11-01	2000-11-23	University Of Sydney, The	P450 gene regulation
JP2005510205A (ja)	2001-04-12	2005-04-21	ゼノジェンコーポレイション	チトクロム発現に関連するマウスおよびヒト転写制御エレメントの単離および同定
AU2002253458A1 (en) *	2002-04-09	2003-10-20	Universitat Basel	Enhancer sequence of the 5-aminolevulinic synthase gene
WO2006064197A2 (en) *	2004-12-13	2006-06-22	Iti Scotland Limited	Transgenic animals for assessing drug metabolism and toxicity
CN108271422A (zh)	2015-06-25	2018-07-10	株式会社国际电气通信基础技术研究所	基于器官间串扰系统的预测装置及预测程序
EP4005598A1 (en)	2016-03-29	2022-06-01	Karydo Therapeutix, Inc.	Screening method for candidate substances for active component to prevent or treat at least one disease selected from the group consisting of renal hypofunction, chronic kidney disease and kidney failure
CN109414504B (zh)	2016-03-29	2022-04-08	无限生物制药公司	药物组合物或食品组合物及评价活性成分体内效果的方法

Family Cites Families (20)

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US5851819A (en)	1987-06-16	1998-12-22	National Institutes Of Health	Vectors carrying MDR1 cDNA which confer multidrug resistance on transduced cells
US4997757A (en)	1987-12-23	1991-03-05	Genebiomed, Inc.	Process for detecting potential carcinogens
US5429948A (en) *	1988-03-02	1995-07-04	Gentest Corporation	Human cell line stably expressing 5cDNAS encoding procarcinogen-activating enzymes and related mutagenicity assays
GB9308271D0 (en)	1993-04-21	1993-06-02	Univ Edinburgh	Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method
CA2128399A1 (en)	1993-07-20	1995-01-21	Koji Hayashi	Method for safety evaluation of chemical compound using recombinant yeast expressing human cytochrome p450
US6432639B1 (en)	1997-09-10	2002-08-13	Dna Sciences Laboratories, Inc.	Isolated CYP3A4 nucleic acid molecules and detection methods
US6756491B2 (en)	1998-01-09	2004-06-29	The Salk Institute For Biological Studies	Steroid-activated nuclear receptors and uses therefor
EP1066320A4 (en)	1998-03-27	2005-03-16	Glaxo Group Ltd	ORPHAN NUCLEAR RECEPTOR
AUPP362898A0 (en)	1998-05-21	1998-06-11	University Of Sydney, The	Xenobiotic induction of gene expression
ATE341637T1 (de)	1998-12-17	2006-10-15	Xenogen Corp	Unblutige bestimmung einer physiologischen reaktion in einem säugetier
WO2001011951A1 (fr)	1999-08-13	2001-02-22	Kirin Beer Kabushiki Kaisha	Souris renfermant un cytochrome p450 humain
EP1088900A1 (en)	1999-09-10	2001-04-04	Epidauros Biotechnologie AG	Polymorphisms in the human CYP3A4, CYP3A7 and hPXR genes and their use in diagnostic and therapeutic applications
AU2001253373A1 (en)	2000-04-12	2001-10-30	Puracyp	Compositions and methods for induction of proteins involved in xenobiotic metabolism
WO2002008451A2 (en)	2000-07-25	2002-01-31	Epidauros Biotechnologie Ag	Assay for screening compounds for inducing drug metabolizing enzymes
WO2002025270A1 (en)	2000-09-21	2002-03-28	Baylor College Of Medicine	Screening systems and methods for identifying modulators of xenobiotic metabolism
US20020150915A1 (en)	2000-09-22	2002-10-17	Anders Berkenstam	Promoter sequences
AU2002213660A1 (en)	2000-11-01	2002-05-15	The University Of Sydney	Transgenic animals for analysing CYP3A4 cytochrome P450 gene regulation
US6734582B2 (en)	2001-04-10	2004-05-11	International Business Machines Corporation	Linear actuator using a rotating motor
JP2005510205A (ja)	2001-04-12	2005-04-21	ゼノジェンコーポレイション	チトクロム発現に関連するマウスおよびヒト転写制御エレメントの単離および同定
AUPR446701A0 (en)	2001-04-18	2001-05-17	Gene Stream Pty Ltd	Transgenic mammals for pharmacological and toxicological studies

1998
- 1998-05-21 AU AUPP3628A patent/AUPP362898A0/en not_active Abandoned
1999
- 1999-05-20 DE DE69941813T patent/DE69941813D1/de not_active Expired - Lifetime
- 1999-05-20 AT AT99923306T patent/ATE452193T1/de active
- 1999-05-20 CA CA2333016A patent/CA2333016C/en not_active Expired - Fee Related
- 1999-05-20 US US09/700,991 patent/US6984489B1/en not_active Expired - Fee Related
- 1999-05-20 DK DK09177085.9T patent/DK2154250T3/da active
- 1999-05-20 JP JP2000551006A patent/JP4446603B2/ja not_active Expired - Lifetime
- 1999-05-20 EP EP09177085A patent/EP2154250B1/en not_active Expired - Lifetime
- 1999-05-20 AU AU40232/99A patent/AU758087B2/en not_active Ceased
- 1999-05-20 EP EP99923306A patent/EP1082437B1/en not_active Expired - Lifetime
- 1999-05-20 DK DK99923306.7T patent/DK1082437T3/da active
- 1999-05-20 ES ES99923306T patent/ES2337967T3/es not_active Expired - Lifetime
- 1999-05-20 WO PCT/AU1999/000381 patent/WO1999061622A1/en not_active Ceased
2006
- 2006-01-04 US US11/324,921 patent/US7638614B2/en not_active Expired - Fee Related
2009
- 2009-12-02 US US12/629,186 patent/US9029336B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1082437A4 (en)	2003-03-19
US6984489B1 (en)	2006-01-10
ES2337967T3 (es)	2010-04-30
AUPP362898A0 (en)	1998-06-11
JP4446603B2 (ja)	2010-04-07
EP2154250A1 (en)	2010-02-17
AU758087B2 (en)	2003-03-13
US20100146652A1 (en)	2010-06-10
CA2333016C (en)	2011-08-09
EP1082437B1 (en)	2009-12-16
WO1999061622A1 (en)	1999-12-02
ATE452193T1 (de)	2010-01-15
US7638614B2 (en)	2009-12-29
US9029336B2 (en)	2015-05-12
AU4023299A (en)	1999-12-13
CA2333016A1 (en)	1999-12-02
EP2154250B1 (en)	2013-03-20
JP2002516107A (ja)	2002-06-04
DK2154250T3 (da)	2013-06-17
DE69941813D1 (de)	2010-01-28
EP1082437A1 (en)	2001-03-14
US20060105385A1 (en)	2006-05-18

Publication	Publication Date	Title
EP1082437A4 (en)	2003-03-19	XENOBIOTIC INDUCTION OF GENE EXPRESSION
DE69231745D1 (de)	2001-04-26	Gensequenzen kodierend für Flavonoid-Stoffwechselwegenzyme und deren Verwendung
DK1334200T3 (da)	2011-07-18	Multipelt inducerbart genreguleringssystem
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DK0581848T3 (da)	2003-10-27	Lukkede antisense- og sense-oligonukleotider og deres anvendelser
DE69020151D1 (de)	1995-07-20	Genetisch geformte neue pflanzenphenotypen.
ATE195554T1 (de)	2000-09-15	Rekombinanter promoter zur genexpression in monokotylen
ATE188507T1 (de)	2000-01-15	Polyphenol oxidase gene
NZ508439A (en)	2004-02-27	Novel endometriosis-associated gene
ATE164396T1 (de)	1998-04-15	Hefepromoter und seine verwendung
ATE342366T1 (de)	2006-11-15	Rekombinantes konstrukt für eine erhöhte expression von genen in pflanzen.
DK0486067T3 (da)	1996-02-26	Peroxidasegen af mikrobiel oprindelse
DE69434830D1 (de)	2006-10-05	Zur verleihung viraler resistenz an pflanzen geeignetes polyribozym und dieses polyribozym produzierende resistente pflanzen
ATE339508T1 (de)	2006-10-15	Mites-ähnliches element und an trankriptionsaktivierung beteiligtes element
DE69739936D1 (de)	2010-08-26	Genexpressionsregulator-dna, expressionskassette, expressionsvektor und transgene pflanze
EP1364025A4 (en)	2004-05-19	A NEW MAPPING OF GENE BN01 TO CHROMOSOME 16Q24.3
ATE390484T1 (de)	2008-04-15	An der herstellung von homo-glutaminsäure beteiligtes gen und dessen verwendung
DE60123787D1 (de)	2006-11-23	Neuartige, aliphatische acyltransferase-gene
Holton et al.	1997	Genetic sequences encoding flavonoid pathway enzymes and uses therefor
DK0874054T3 (da)	2003-12-08	Vektor til ekspression af immunglobulin-cytokin-fusionsproteiner i maligne B-celler