DK1084145T3 - Antistoffer imod ED-B-domænet i fibronectin, konjugater indeholdende disse og anvendelse deraf til diagnosticering og behandling af tumorer og sygdomme forbundet med angiogenese - Google Patents

Antistoffer imod ED-B-domænet i fibronectin, konjugater indeholdende disse og anvendelse deraf til diagnosticering og behandling af tumorer og sygdomme forbundet med angiogenese

Info

Publication number
DK1084145T3
DK1084145T3 DK99923571T DK99923571T DK1084145T3 DK 1084145 T3 DK1084145 T3 DK 1084145T3 DK 99923571 T DK99923571 T DK 99923571T DK 99923571 T DK99923571 T DK 99923571T DK 1084145 T3 DK1084145 T3 DK 1084145T3
Authority
DK
Denmark
Prior art keywords
fibronectin
angiogenesis
domain
antibodies
tumors
Prior art date
Application number
DK99923571T
Other languages
Danish (da)
English (en)
Inventor
Dario Neri
Lorenzo Tarli
Francesca Viti
Manfred Birchler
Original Assignee
Eidgenoess Tech Hochschule
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/300,425 external-priority patent/US20030045681A1/en
Application filed by Eidgenoess Tech Hochschule filed Critical Eidgenoess Tech Hochschule
Application granted granted Critical
Publication of DK1084145T3 publication Critical patent/DK1084145T3/da

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1018Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6843Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK99923571T 1998-05-11 1999-05-11 Antistoffer imod ED-B-domænet i fibronectin, konjugater indeholdende disse og anvendelse deraf til diagnosticering og behandling af tumorer og sygdomme forbundet med angiogenese DK1084145T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7533898A 1998-05-11 1998-05-11
US09/300,425 US20030045681A1 (en) 1998-05-11 1999-04-28 Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis
PCT/EP1999/003210 WO1999058570A2 (en) 1998-05-11 1999-05-11 Antibodies to the ed-b domain of fibronectin, conjugates containing them and use therefor for diagnosis and therapy of tumors and diseases associated with angiogenesis

Publications (1)

Publication Number Publication Date
DK1084145T3 true DK1084145T3 (da) 2005-12-19

Family

ID=26756726

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99923571T DK1084145T3 (da) 1998-05-11 1999-05-11 Antistoffer imod ED-B-domænet i fibronectin, konjugater indeholdende disse og anvendelse deraf til diagnosticering og behandling af tumorer og sygdomme forbundet med angiogenese

Country Status (24)

Country Link
US (1) US20070189963A1 (pt)
EP (1) EP1084145B1 (pt)
JP (1) JP2002514405A (pt)
CN (1) CN1250571C (pt)
AT (1) ATE301676T1 (pt)
AU (1) AU759207B2 (pt)
BR (1) BRPI9910394B8 (pt)
CA (1) CA2333833C (pt)
CZ (1) CZ300495B6 (pt)
DE (1) DE69926630T2 (pt)
DK (1) DK1084145T3 (pt)
EA (1) EA005685B1 (pt)
EE (1) EE05435B1 (pt)
ES (1) ES2247802T3 (pt)
HU (1) HU225675B1 (pt)
IL (1) IL139452A0 (pt)
IS (1) IS2522B (pt)
NO (1) NO327732B1 (pt)
NZ (1) NZ508600A (pt)
PL (1) PL199353B1 (pt)
SK (1) SK286822B6 (pt)
TR (1) TR200003317T2 (pt)
TW (1) TWI259837B (pt)
WO (1) WO1999058570A2 (pt)

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Also Published As

Publication number Publication date
SK286822B6 (sk) 2009-06-05
TWI259837B (en) 2006-08-11
SK16792000A3 (sk) 2001-05-10
PL345845A1 (en) 2002-01-14
CA2333833A1 (en) 1999-11-18
CZ300495B6 (cs) 2009-06-03
EA200001169A1 (ru) 2001-04-23
CZ20004216A3 (en) 2001-05-16
CN1250571C (zh) 2006-04-12
CA2333833C (en) 2011-01-25
AU759207B2 (en) 2003-04-10
AU4039899A (en) 1999-11-29
BRPI9910394B1 (pt) 2013-07-02
HU225675B1 (en) 2007-06-28
JP2002514405A (ja) 2002-05-21
HUP0102992A2 (hu) 2001-11-28
PL199353B1 (pl) 2008-09-30
ES2247802T3 (es) 2006-03-01
NO20005694D0 (no) 2000-11-10
EP1084145B1 (en) 2005-08-10
EP1084145A2 (en) 2001-03-21
DE69926630T2 (de) 2006-05-24
WO1999058570A3 (en) 2000-03-16
BRPI9910394B8 (pt) 2021-07-06
EA005685B1 (ru) 2005-04-28
IL139452A0 (en) 2001-11-25
HUP0102992A3 (en) 2003-09-29
EE200000802A (et) 2002-06-17
IS5708A (is) 2000-11-10
IS2522B (is) 2009-07-15
CN1303393A (zh) 2001-07-11
NO327732B1 (no) 2009-09-14
WO1999058570A2 (en) 1999-11-18
BRPI9910394A (pt) 2001-01-09
EE05435B1 (et) 2011-06-15
NZ508600A (en) 2003-03-28
TR200003317T2 (tr) 2001-07-23
DE69926630D1 (de) 2005-09-15
US20070189963A1 (en) 2007-08-16
NO20005694L (no) 2001-01-10
ATE301676T1 (de) 2005-08-15

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