DK1086124T3 - Nye cyclosporiner - Google Patents

Nye cyclosporiner

Info

Publication number
DK1086124T3
DK1086124T3 DK99932697T DK99932697T DK1086124T3 DK 1086124 T3 DK1086124 T3 DK 1086124T3 DK 99932697 T DK99932697 T DK 99932697T DK 99932697 T DK99932697 T DK 99932697T DK 1086124 T3 DK1086124 T3 DK 1086124T3
Authority
DK
Denmark
Prior art keywords
cyclosporins
new
novel cyclosporins
new cyclosporins
pharmaceuticals
Prior art date
Application number
DK99932697T
Other languages
Danish (da)
English (en)
Inventor
Ernst Ellmerer-Mueller
Dagmar Broessner
Najib Maslouh
Horst-Dieter Ambrosi
Gerhard Jas
Gunter Fischer
Original Assignee
Chem Ag C
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ag C filed Critical Chem Ag C
Application granted granted Critical
Publication of DK1086124T3 publication Critical patent/DK1086124T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK99932697T 1998-06-12 1999-06-10 Nye cyclosporiner DK1086124T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98110761 1998-06-12
PCT/EP1999/004012 WO1999065933A1 (fr) 1998-06-12 1999-06-10 Nouvelles cyclosporines

Publications (1)

Publication Number Publication Date
DK1086124T3 true DK1086124T3 (da) 2004-03-29

Family

ID=8232110

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99932697T DK1086124T3 (da) 1998-06-12 1999-06-10 Nye cyclosporiner

Country Status (19)

Country Link
US (1) US6583265B1 (fr)
EP (1) EP1086124B1 (fr)
JP (1) JP4477777B2 (fr)
KR (1) KR20010052766A (fr)
CN (1) CN1205220C (fr)
AT (1) ATE254630T1 (fr)
AU (1) AU760168B2 (fr)
BR (1) BR9911160A (fr)
CA (1) CA2334730C (fr)
DE (1) DE69912952T2 (fr)
DK (1) DK1086124T3 (fr)
ES (1) ES2212583T3 (fr)
HU (1) HUP0102833A3 (fr)
IL (1) IL139825A0 (fr)
MX (1) MXPA00012218A (fr)
NO (1) NO20006282L (fr)
PL (1) PL344599A1 (fr)
PT (1) PT1086124E (fr)
WO (1) WO1999065933A1 (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001058469A1 (fr) * 2000-02-08 2001-08-16 Wax Martin B Methodes de traitement du glaucome
US6784156B2 (en) 2001-03-05 2004-08-31 Enanta Pharmaceuticals, Inc. Cyclosporins for the treatment of respiratory diseases
KR100465012B1 (ko) * 2001-05-11 2005-01-13 주식회사 엘지생활건강 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
US20030087813A1 (en) 2001-10-12 2003-05-08 Or Yat Sun Cyclosporin analogs for the treatment of lung diseases
KR20040039622A (ko) * 2002-11-04 2004-05-12 주식회사 엘지생활건강 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
US7012065B2 (en) 2003-02-07 2006-03-14 Enanta Pharmaceuticals, Inc. Cyclosporins for the treatment of immune disorders
JP2006524232A (ja) 2003-03-17 2006-10-26 アルバニー モレキュラー リサーチ インコーポレーティッド 新規サイクロスポリン
EP1742652A2 (fr) * 2004-04-08 2007-01-17 Novartis AG Nim811 utilise dansla prevention ou le traitement de l'ischemie cerebrale et de lesions cerebrales et de la moelle epiniere
JP2008514701A (ja) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキン類似体およびそれらの薬学的使用
EP1804823A4 (fr) 2004-09-29 2010-06-09 Amr Technology Inc Nouveaux analogues de la cyclosporine et leurs utilisations pharmaceutiques
JP5139065B2 (ja) * 2004-10-01 2013-02-06 スシネキス インク Ｃ型肝炎感染の治療及び予防のための３−エーテル及び３−チオエーテル置換シクロスポリン誘導体
US7196161B2 (en) 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
US7361636B2 (en) 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
US8329658B2 (en) * 2005-09-30 2012-12-11 Scynexis, Inc. Arylalkyl and heteroarylalkyl derivatives of cyclosporine A for the treatment and prevention of viral infection
BRPI0616476A2 (pt) * 2005-09-30 2011-06-21 Scynexis Inc uso de uma quantidade terapeuticamente eficaz de um derivado de ciclosporina, e, composição farmacêutica
ATE502633T1 (de) * 2006-05-19 2011-04-15 Scynexis Inc Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
EP2027761A1 (fr) * 2006-06-02 2009-02-25 Claude Annie Perrichon Gestion des electrons actifs
US7576057B2 (en) 2006-11-20 2009-08-18 Scynexis, Inc. Cyclic peptides
US20080255038A1 (en) * 2007-04-11 2008-10-16 Samuel Earl Hopkins Pharmaceutical compositions
US20090306033A1 (en) * 2008-06-06 2009-12-10 Keqiang Li Novel cyclic peptides
US9090671B2 (en) 2008-06-06 2015-07-28 Scynexis, Inc. Macrocyclic peptides
AU2009268549B2 (en) 2008-07-10 2015-07-16 Allergan, Inc. Cyclosporin derivatives for treating ocular and dermal diseases and conditions
EP2376524B1 (fr) * 2008-12-31 2017-03-15 Cypralis Limited Dérivés de cyclosporine a
WO2010138422A1 (fr) * 2009-05-27 2010-12-02 Allergan, Inc. Dérivés de cyclosporine pour améliorer la pousse des cheveux
AU2010254316A1 (en) * 2009-05-27 2011-12-22 Allergan, Inc. Cyclosporin derivatives for treating inflammatory diseases and conditions
AU2010339460A1 (en) 2009-12-30 2012-07-19 Scynexis Inc. Cyclosporine analogues
WO2012009715A2 (fr) 2010-07-16 2012-01-19 S&T Global Inc. Nouveaux dérivés de la cyclosporine destinés à traiter et à prévenir une infection virale
WO2012021796A2 (fr) 2010-08-12 2012-02-16 S&T Global, Inc. Nouveaux dérivés de cyclosporine destinés à la prévention ou au traitement d'une infection virale
US9175042B2 (en) * 2010-10-12 2015-11-03 Allergan, Inc. Cyclosporin analogs
RU2013119869A (ru) * 2010-10-12 2014-11-20 Аллерган, Инк. Аналоги циклоспорина
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
JP6144627B2 (ja) 2010-12-15 2017-06-07 コントラヴィア ファーマシューティカルズ、インク． アミノ酸１および３で修飾されたシクロスポリン類似体分子
GB201711749D0 (en) * 2017-07-21 2017-09-06 Cypralis Ltd Cyclosporin analogues and uses thereof
CN111449050A (zh) * 2019-01-20 2020-07-28 睿诺医疗科技（上海）有限公司 环孢菌素类似物及其用途
AU2020363688A1 (en) * 2019-10-12 2022-04-21 Farsight Medical Technology (Shanghai) Co., Ltd. Treatment and prevention of nephrotoxin-induced kidney injuries
IL296586B1 (en) 2020-03-26 2026-04-01 Farsight Medical Tech Shanghai Co Ltd Cyclophilin inhibitors and their uses
CN113694177B (zh) * 2020-04-15 2022-06-17 睿诺医疗科技（上海）有限公司 器官损伤的预防和治疗
GB202207348D0 (en) 2022-05-19 2022-07-06 Cypralis Ltd Macrocyclic compounds and uses thereof
CN121219307A (zh) * 2023-06-02 2025-12-26 睿诺医疗科技（上海）有限公司 亲环蛋白抑制剂及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (fr) * 1985-03-11 1992-07-29 Sandoz Ag Cyclosporines
PL324531A1 (en) 1995-07-17 1998-06-08 Chem Ag C Derivatives of cyclosporin effective against hiv virus
FR2757520B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent
FR2757521B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757522B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
NO20006282D0 (no) 2000-12-11
CA2334730A1 (fr) 1999-12-23
AU760168B2 (en) 2003-05-08
DE69912952D1 (en) 2003-12-24
WO1999065933A1 (fr) 1999-12-23
JP2002518406A (ja) 2002-06-25
MXPA00012218A (es) 2002-04-24
IL139825A0 (en) 2002-02-10
HUP0102833A2 (hu) 2002-01-28
US6583265B1 (en) 2003-06-24
PL344599A1 (en) 2001-11-05
KR20010052766A (ko) 2001-06-25
EP1086124A1 (fr) 2001-03-28
NO20006282L (no) 2001-02-12
CA2334730C (fr) 2009-09-29
ES2212583T3 (es) 2004-07-16
DE69912952T2 (de) 2004-09-02
BR9911160A (pt) 2001-04-03
PT1086124E (pt) 2004-04-30
CN1205220C (zh) 2005-06-08
ATE254630T1 (de) 2003-12-15
JP4477777B2 (ja) 2010-06-09
CN1305493A (zh) 2001-07-25
AU4899399A (en) 2000-01-05
HUP0102833A3 (en) 2002-03-28
EP1086124B1 (fr) 2003-11-19

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