DK1087934T3 - Aminocyclohexyletherforbindelser og anvendelser deraf - Google Patents

Aminocyclohexyletherforbindelser og anvendelser deraf

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Publication number
DK1087934T3
DK1087934T3 DK99911550T DK99911550T DK1087934T3 DK 1087934 T3 DK1087934 T3 DK 1087934T3 DK 99911550 T DK99911550 T DK 99911550T DK 99911550 T DK99911550 T DK 99911550T DK 1087934 T3 DK1087934 T3 DK 1087934T3
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Prior art keywords
ether compounds
compounds
aminocyclohexyl ether
compositions
formula
Prior art date
Application number
DK99911550T
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Danish (da)
English (en)
Inventor
Allen I Bain
Gregory N Beatch
Cindy J Longley
Bertrand M C Plouvier
Tao Sheng
Michael J A Walker
Richard A Wall
Sandro L Yong
Jiqun Zhu
Alexander B Zolotoy
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Cardiome Pharma Corp
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Publication of DK1087934T3 publication Critical patent/DK1087934T3/da

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DK99911550T 1998-04-01 1999-04-01 Aminocyclohexyletherforbindelser og anvendelser deraf DK1087934T3 (da)

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Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1422217A3 (fr) 1998-04-01 2004-06-16 Cardiome Pharma Corp. Composés aminocyclohexyle ether et leur utilisation
US7507545B2 (en) 1999-03-31 2009-03-24 Cardiome Pharma Corp. Ion channel modulating activity method
DE10049481A1 (de) 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte C-Cyclohexylmethylamin-Derivate
US7524879B2 (en) * 2000-10-06 2009-04-28 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US7057053B2 (en) 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
DE10213051B4 (de) * 2002-03-23 2013-03-07 Grünenthal GmbH Substituierte 4-Aminocyclohexanole
AU2003248647A1 (en) * 2002-06-14 2003-12-31 Johnson Matthey Pharmaceutical Materials, Inc. Stereoselective synthesis of 1,2-disubstituted cycloalkyls
KR101059379B1 (ko) * 2003-05-02 2011-08-26 카디오메 파마 코포레이션 아미노사이클로헥실 에테르 화합물, 이의 제조방법 및 이를 포함하는 약제학적 조성물
US20080063707A1 (en) * 2003-05-02 2008-03-13 Cardiome Pharma Corp. Controlled release tablet formulations for the prevention of arrhythmias
CN100441568C (zh) * 2003-05-02 2008-12-10 卡迪欧梅制药公司 氨基环己基醚化合物和它们的用途
US20090041841A1 (en) * 2003-05-02 2009-02-12 Cardiome Pharma Corp. Controlled release tablet formulations for the prevention of arrhythmias
US7345086B2 (en) 2003-05-02 2008-03-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
WO2005016242A2 (fr) * 2003-06-04 2005-02-24 Cardiome Pharma Corp. Methode de synthese pour composes de trans-aminocyclohexyl ether
US7674820B2 (en) 2003-08-07 2010-03-09 Cardiome Pharma Corp. Ion channel modulating activity I
US7345087B2 (en) 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
JP4954864B2 (ja) * 2004-04-01 2012-06-20 カーディオム ファーマ コーポレイション イオンチャネル調節化合物のプロドラッグおよびその使用
US7977373B2 (en) 2004-04-01 2011-07-12 Cardiome Pharma Corp. Prodrugs of ion channel modulating compounds and uses thereof
WO2006138673A2 (fr) 2005-06-15 2006-12-28 Cardiome Pharma Corp. Procedes synthetiques de preparation de composes d'ether aminocyclohexyle
US7705036B2 (en) 2004-04-01 2010-04-27 Cardiome Pharma Corp. Deuterated aminocyclohexyl ether compounds and processes for preparing same
US8058304B2 (en) 2004-04-01 2011-11-15 Cardiome Pharma Corp. Merged ion channel modulating compounds and uses thereof
WO2005097203A2 (fr) * 2004-04-01 2005-10-20 Cardiome Pharma Corp. Conjugues de proteine serique de composes de modulation du canal ionique, utilisations de ces derniers
WO2005097869A1 (fr) * 2004-04-01 2005-10-20 Cardiome Pharma Corp. Polymeres comprenant des composes modulateurs de canaux ioniques et utilisations de ceux-ci
US8263638B2 (en) * 2004-11-08 2012-09-11 Cardiome Pharma Corp. Dosing regimens for ion channel modulating compounds
JP5159314B2 (ja) * 2004-11-18 2013-03-06 カーディオム ファーマ コーポレイション アミノシクロヘキシルエーテル化合物の合成方法
MY145694A (en) * 2005-04-11 2012-03-30 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
AR056968A1 (es) 2005-04-11 2007-11-07 Xenon Pharmaceuticals Inc Compuestos espiro-oxindol y composiciones farmacéuticas
GB0510164D0 (en) * 2005-04-28 2005-06-22 Paradigm Therapeutics Ltd Ion channel
JPWO2007055180A1 (ja) * 2005-11-09 2009-04-30 東レ・ファインケミカル株式会社 光学活性トランス−2−アミノシクロヘキサノールおよびその誘導体の製造方法
AR063280A1 (es) 2006-10-12 2009-01-21 Xenon Pharmaceuticals Inc Uso de compuestos de espiro-oxindol como agentes terapeuticos
WO2008046087A2 (fr) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Composés spiro et leurs utilisations en tant qu'agents thérapeutiques
JP2010526102A (ja) * 2007-05-04 2010-07-29 カーディオム ファーマ コーポレイション イオンチャネル調節化合物の制御放出経口製剤および不整脈を予防するための関連する方法
CN105218565A (zh) 2008-10-17 2016-01-06 泽农医药公司 螺羟吲哚化合物及其作为治疗剂的用途
WO2010045197A1 (fr) 2008-10-17 2010-04-22 Xenon Pharmaceuticals, Inc. Composés spiro-oxindole et leur utilisation comme agents thérapeutiques
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
CN102753556B (zh) 2009-10-14 2015-05-13 泽农医药公司 螺-羟吲哚化合物的合成方法
NZ601667A (en) 2010-02-26 2014-10-31 Xenon Pharmaceuticals Inc Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
EP2605772B1 (fr) 2010-08-16 2016-06-22 Cardiome International AG Procédé de préparation de composés d'éther d'aminocyclohexyle
US9681836B2 (en) 2012-04-23 2017-06-20 Cyberonics, Inc. Methods, systems and apparatuses for detecting seizure and non-seizure states
TW201636017A (zh) 2015-02-05 2016-10-16 梯瓦製藥國際有限責任公司 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法
TWI841592B (zh) 2018-09-03 2024-05-11 瑞士商赫孚孟拉羅股份公司 雙環雜芳基衍生物
LT3894411T (lt) 2018-12-13 2024-08-26 F. Hoffmann-La Roche Ag 7-fenoksi-n-(3-azabiciklo[3.2.1]oktan-8-il)-6,7-dihidro-5h-pirolo [1,2-b][1,2,4]triazol-2-amino dariniai ir susiję junginiai kaip gama sekretazės moduliatoriai alzheimerio ligai gydyti
CN114031535B (zh) * 2021-11-30 2023-08-25 上海旭东海普药业有限公司 一种改进的盐酸维纳卡兰的合成方法

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2954380A (en) * 1958-11-26 1960-09-27 Us Vitamin Pharm Corp Piperazinocyclohexyl esters
US3218328A (en) * 1963-02-18 1965-11-16 U S Vitamin & Pharmacentical C Heterocyclic amino phenoxyacetic acids, acid addition salts and quaternary ammonium salts thereof
DE2259260A1 (de) 1972-12-04 1974-06-06 Merck Patent Gmbh Neue amine
US4145435A (en) * 1976-11-12 1979-03-20 The Upjohn Company 2-aminocycloaliphatic amide compounds
US4179501A (en) * 1976-11-12 1979-12-18 The Upjohn Company Analgesic N-(2-aminocycloaliphatic)azidobenzamides
DE2658401A1 (de) 1976-12-23 1978-07-06 Merck Patent Gmbh Cyclopentan-1-amine, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
US4656182A (en) 1983-12-06 1987-04-07 Warner-Lambert Company Substituted trans-1,2-diaminocyclohexyl amide compounds
US4598087A (en) 1983-12-06 1986-07-01 Warner-Lambert Company Substituted trans-1,2-diaminocyclohexyl amide compounds
GB2159816B (en) * 1984-05-18 1989-05-24 Glaxo Group Ltd Aminocyclopentyl ethers and their preparation and pharmaceutical formulation
US4663343A (en) * 1985-07-19 1987-05-05 Warner-Lambert Company Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compounds
DE3668268D1 (de) 1985-10-25 1990-02-22 Upjohn Co Verwendung von cis-n-(2-aminocycloaliphatische) benzen acetamid und benzamid zur herstellung von antikrampfmittel.
US5059620A (en) * 1985-12-27 1991-10-22 The Du Pont Merck Pharmaceutical Company Aryl substituted aminomethyl benzene derivatives
US4855316A (en) * 1988-02-18 1989-08-08 Warner-Lambert Company 1,2-diamino-4,5-dimethoxycyclohexyl amide analgesic compounds
AU626949B2 (en) 1988-12-06 1992-08-13 Warner-Lambert Company 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics
US5051428A (en) * 1988-12-06 1991-09-24 Warner-Lambert Company 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics
US4906655A (en) * 1989-01-24 1990-03-06 Warner-Lambert Company Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents
JPH02270864A (ja) 1989-04-12 1990-11-05 Asahi Glass Co Ltd フルオロカルバサイクリックヌクレオシドおよびその製造法
EP0524439A1 (fr) * 1991-07-24 1993-01-27 F.Hoffmann-La Roche & Co. Aktiengesellschaft Dérivés du cyclohexane et du tétrahydropyranne et compositions antifongiques contenant ces dérivés
ZA929008B (en) 1991-12-13 1993-05-21 Bristol Myers Squibb Co Piperazinyl- and piperidinyl-cyclohexanols.
CA2058502A1 (fr) 1991-12-27 1993-06-28 David C. Horwell 2-aminomonomethoxycyclohexanecarboxamides, utiles comme analgesiques
EP0552386A1 (fr) 1992-01-13 1993-07-28 Warner-Lambert Company Dérivés 2-amino-3 ou 6-méthoxy cyclohexyl-amides
US5506257A (en) * 1992-03-26 1996-04-09 University Of British Columbia Aminocyclohexylamides for antiarrhythmic and anaesthetic uses
DE69311896T2 (de) 1992-03-26 1997-10-16 University Of British Columbia, Vancouver, British Columbia Aminocyclohexylamide für antiarrhythmische und anästhetische verwendungen
GB9220286D0 (en) 1992-09-25 1992-11-11 Merck Sharp & Dohme Therapeutic agents
US5451596A (en) * 1992-12-29 1995-09-19 Rhone Poulenc Rorer Pharmaceuticals Inc. Cycloalkyl amine bis-aryl squalene synthase inhibitors
US5747278A (en) * 1993-05-21 1998-05-05 California Institute Of Technology DNA encoding inward rectifier, G-protein activated, mammalian, potassium KGA channel and uses thereof
US5492825A (en) * 1993-08-06 1996-02-20 The Regents Of The University Of California Mammalian inward rectifier potassium channel cDNA, IRK1, corresponding vectors, and transformed cells
CA2172513C (fr) * 1993-09-24 2008-01-08 Bernard A. Macleod Aminocyclohexylesters et leurs utilisations
GB9406043D0 (en) * 1994-03-26 1994-05-18 Smithkline Beecham Plc Compounds
US5441946A (en) 1994-04-14 1995-08-15 Rhone-Poulenc-Rorer Pharmaceuticals, Inc. Phosphonate derivatives of lipophilic amines
ATE212860T1 (de) * 1994-09-19 2002-02-15 Fujisawa Pharmaceutical Co Eine neuartige medizinische verwendung eines 5ht 3-antagonisten
US5556990A (en) 1994-12-16 1996-09-17 Rhone-Poulenc Rorer Pharmaceuticals Inc. Polyarylcarbamoylaza- and -carbamoylalkanedioic acids
JP3789938B2 (ja) 1995-02-03 2006-06-28 ビーエーエスエフ アクチェンゲゼルシャフト 酵素触媒作用アシル化による1級及び2級のヘテロ原子置換アミンのラセミ体分割
PL328199A1 (en) 1996-01-25 1999-01-18 Schering Ag Improved concentrated intravascular injection and infusion solutions
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5646151A (en) 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
PL330850A1 (en) 1996-06-27 1999-06-07 Smithkline Beecham Corp Antagonists of il-8 receptors
US5935945A (en) * 1996-10-31 1999-08-10 Merck & Co., Inc. Methods of treating or preventing cardiac arrhythmia
US6180632B1 (en) * 1997-05-28 2001-01-30 Aventis Pharmaceuticals Products Inc. Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
US6399618B1 (en) 1997-07-09 2002-06-04 Cardiome Pharma Corp Compositions and methods for modulating sexual activity
TW536401B (en) 1997-09-03 2003-06-11 Cardiome Pharma Corp A pharmaceutical composition of N,N-bis(phenylcarbamoylmethyl)dimethylammomum chloride and derivatives for the treatment of pain
AU9248698A (en) 1997-09-26 1999-04-23 Nortran Pharmaceuticals Inc. Mixtures of enantiomers of aminocyclohexylamides to produce simultaneous analgesia with local anaesthesia or antiarrhythmia
JP3773644B2 (ja) * 1998-01-06 2006-05-10 芝府エンジニアリング株式会社 接点材料
US6013830A (en) 1998-03-30 2000-01-11 Sepracor Inc. Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols
EP1422217A3 (fr) * 1998-04-01 2004-06-16 Cardiome Pharma Corp. Composés aminocyclohexyle ether et leur utilisation
GB9819466D0 (en) * 1998-09-08 1998-10-28 Boudriau Pierre Automated turning module for rudderless for personal watercraft
US6979685B1 (en) 1999-02-12 2005-12-27 Cardiome Pharma Corp. Cycloalkyl amine compounds and uses thereof
AU2528900A (en) 1999-02-12 2000-08-29 Nortran Pharmaceuticals Inc. Cycloalkyl amine compounds and uses thereof
US7053087B1 (en) 1999-03-04 2006-05-30 Cardiome Pharma Corp. Aminocycloalkyl cinnamide compounds for arrhythmia and analgesics and anesthetics
US7507545B2 (en) * 1999-03-31 2009-03-24 Cardiome Pharma Corp. Ion channel modulating activity method
CA2268590A1 (fr) 1999-04-12 2000-10-12 Nortran Pharmaceuticals Inc. Composes de regulation des canaux ioniques et utilisations de ces produits
CA2404464C (fr) * 2000-04-20 2008-03-11 F. Hoffmann-La Roche Ag Derives de la pyrrolidine et de la piperidine et leur utilisation pour le traitement de maladies neurodegeneratives
CA2311483A1 (fr) 2000-06-12 2001-12-12 Gregory N Beatch Ethers imidazo [1,2-a] pyridiniques et leurs utilisations
US6521619B2 (en) * 2000-06-29 2003-02-18 Icos Corporation Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents
US6498170B2 (en) * 2000-07-17 2002-12-24 Wyeth Cyclamine sulfonamides as β-3 adrenergic receptor agonists
US7057053B2 (en) 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
AU2003248647A1 (en) 2002-06-14 2003-12-31 Johnson Matthey Pharmaceutical Materials, Inc. Stereoselective synthesis of 1,2-disubstituted cycloalkyls
GB2407093A (en) 2002-07-12 2005-04-20 Cardiome Inc Mutations of voltage-gated potassium channels
US7345086B2 (en) * 2003-05-02 2008-03-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
KR101059379B1 (ko) 2003-05-02 2011-08-26 카디오메 파마 코포레이션 아미노사이클로헥실 에테르 화합물, 이의 제조방법 및 이를 포함하는 약제학적 조성물
WO2004098525A2 (fr) 2003-05-02 2004-11-18 Cardiome Pharma Corp. Utilisations de composes modulant les canaux ioniques
WO2005016242A2 (fr) * 2003-06-04 2005-02-24 Cardiome Pharma Corp. Methode de synthese pour composes de trans-aminocyclohexyl ether
US7674820B2 (en) * 2003-08-07 2010-03-09 Cardiome Pharma Corp. Ion channel modulating activity I
US20070197632A1 (en) 2003-10-31 2007-08-23 Cardiome Pharma Corp Aminocyclohexyl ether compounds and uses thereof
US7345087B2 (en) 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
US7789873B2 (en) * 2004-08-02 2010-09-07 Coloplast A/S Urinary catheter assembly

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US7534790B2 (en) 2009-05-19
US7875611B2 (en) 2011-01-25
PL197293B1 (pl) 2008-03-31
CZ20003485A3 (cs) 2001-03-14
US20050020481A1 (en) 2005-01-27
SK14372000A3 (sk) 2001-07-10
FR10C0057I2 (fr) 2011-11-25
NO2010023I1 (no) 2010-12-14
US20080070911A1 (en) 2008-03-20
IL138719A0 (en) 2001-10-31
EE04548B1 (et) 2005-10-17
FR10C0057I1 (fr) 2011-02-18
CN1217918C (zh) 2005-09-07
DE69915063T2 (de) 2004-10-14
RO121028B1 (ro) 2006-11-30
WO1999050225A1 (fr) 1999-10-07
PL343425A1 (en) 2001-08-13
ATE260240T1 (de) 2004-03-15
DE122010000052I1 (de) 2011-05-05
US20050192208A2 (en) 2005-09-01
EP1422217A2 (fr) 2004-05-26
IS5632A (is) 2000-09-20
EP1087934B1 (fr) 2004-02-25
CN1303364A (zh) 2001-07-11
ES2217742T3 (es) 2004-11-01
AU751772B2 (en) 2002-08-29
TR200002796T2 (tr) 2000-12-21
NO321130B1 (no) 2006-03-20
CA2326777C (fr) 2011-12-20
BE2011C002I2 (en) 2018-08-24
HUP0102613A2 (hu) 2002-04-29
KR100631299B1 (ko) 2006-10-09
EE200000583A (et) 2002-02-15
MXPA00009593A (es) 2004-03-10
KR20010042334A (ko) 2001-05-25
BRPI9909282A (pt) 2001-10-16
EP1087934A1 (fr) 2001-04-04
CA2326777A1 (fr) 1999-10-07
JP2006306878A (ja) 2006-11-09
US20070004718A1 (en) 2007-01-04
AU751772C (en) 2006-09-07
PT1087934E (pt) 2004-07-30
NZ507169A (en) 2004-02-27
US7101877B2 (en) 2006-09-05
NO2010023I2 (no) 2011-10-17
IS2648B (is) 2010-08-15
BRPI9909282B1 (pt) 2011-07-26
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RU2252933C2 (ru) 2005-05-27
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CY2010018I1 (el) 2012-01-25
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SK285908B6 (sk) 2007-10-04
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HU229993B1 (en) 2015-04-28
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