DK1087992T3 - Antithrombotiske forbindelser - Google Patents

Antithrombotiske forbindelser

Info

Publication number
DK1087992T3
DK1087992T3 DK99927976T DK99927976T DK1087992T3 DK 1087992 T3 DK1087992 T3 DK 1087992T3 DK 99927976 T DK99927976 T DK 99927976T DK 99927976 T DK99927976 T DK 99927976T DK 1087992 T3 DK1087992 T3 DK 1087992T3
Authority
DK
Denmark
Prior art keywords
antithrombotic compounds
antithrombotic
compounds
Prior art date
Application number
DK99927976T
Other languages
English (en)
Inventor
Boeckel Constant Adriaan Anton Van
Johannes Egbertus Maria Basten
Rogier Christian Buijsman
Cornelia Maria Dreef-Tromp
Original Assignee
Organon Nv
Univ Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv, Univ Leiden filed Critical Organon Nv
Application granted granted Critical
Publication of DK1087992T3 publication Critical patent/DK1087992T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK99927976T 1998-06-17 1999-06-11 Antithrombotiske forbindelser DK1087992T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98202037 1998-06-17
PCT/EP1999/004100 WO1999065934A1 (en) 1998-06-17 1999-06-11 Antithrombotic compounds

Publications (1)

Publication Number Publication Date
DK1087992T3 true DK1087992T3 (da) 2008-11-24

Family

ID=8233825

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99927976T DK1087992T3 (da) 1998-06-17 1999-06-11 Antithrombotiske forbindelser

Country Status (30)

Country Link
US (1) US6486129B1 (da)
EP (1) EP1087992B1 (da)
JP (1) JP4369052B2 (da)
KR (1) KR100790910B1 (da)
CN (1) CN1261450C (da)
AR (1) AR019674A1 (da)
AT (1) ATE405580T1 (da)
AU (1) AU756493B2 (da)
BR (1) BR9911300A (da)
CA (1) CA2334863C (da)
CO (1) CO5080750A1 (da)
CY (1) CY1108567T1 (da)
CZ (1) CZ299382B6 (da)
DE (1) DE69939378D1 (da)
DK (1) DK1087992T3 (da)
ES (1) ES2312210T3 (da)
HU (1) HU229088B1 (da)
ID (1) ID26614A (da)
IL (2) IL139955A0 (da)
NO (1) NO326057B1 (da)
NZ (1) NZ508623A (da)
PE (1) PE20000700A1 (da)
PL (1) PL199433B1 (da)
PT (1) PT1087992E (da)
RU (1) RU2225869C2 (da)
SK (1) SK286755B6 (da)
TR (1) TR200003710T2 (da)
TW (1) TWI221156B (da)
WO (1) WO1999065934A1 (da)
ZA (1) ZA200007075B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999065934A1 (en) * 1998-06-17 1999-12-23 Akzo Nobel N.V. Antithrombotic compounds
TWI289566B (en) * 1999-12-07 2007-11-11 N.V.Organon Antithrombotic compound
DE10049937A1 (de) * 2000-10-06 2002-04-11 Knoll Ag Niedermolekulare Inhibitoren von Serinproteasen mit Polyhydroxyalkyl- und Polyhydroxycycloalkylresten
WO2003064440A1 (de) * 2002-01-31 2003-08-07 Morphochem Aktiengesellschaft für kombinatorische Chemie Verbindungen, die faktor xa-aktivät inhibieren
DE10300049A1 (de) * 2003-01-03 2004-07-15 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen, die Faktor VIIa inhibieren
DE10330900B4 (de) * 2003-07-01 2006-09-14 Leibniz-Institut Für Polymerforschung Dresden E.V. Biomaterial mit einem modularen Beschichtungssystem zur Anwendung in Medizinprodukten mit direktem Blutkontakt
EP1574516A1 (en) * 2004-03-05 2005-09-14 Sanofi-Aventis Antithrombotic compound
TW200621794A (en) * 2004-10-06 2006-07-01 Akzo Nobel Nv Pulmonary administration of an antithrombotic compound
TWI403334B (zh) * 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
TWI376234B (en) * 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
ES2362011T3 (es) * 2005-10-10 2011-06-27 N.V. Organon Inhibidores duales antitrombóticos anticoagulantes que comprenden una marca de biotina.
CA2624867A1 (en) * 2005-10-10 2007-04-19 N.V. Organon Antithrombotic compound
MY145269A (en) * 2005-10-10 2012-01-13 Organon Nv Antithrombotic dual inhibitors comprising a biotin label
US8597632B2 (en) 2008-10-03 2013-12-03 Glycan Biosciences Llc Anionic oligosaccharide conjugates
BR112021026410A2 (pt) 2019-07-01 2022-02-08 Tonix Pharma Ltd Anticorpos anti-cd154 e usos dos mesmos
JP2024503625A (ja) 2021-01-06 2024-01-26 トニックス ファーマ リミテッド 改変された抗ｃｄ１５４抗体により免疫寛容を誘導する方法
WO2025248134A1 (en) 2024-05-31 2025-12-04 Tonix Pharma Limited Treatment methods comprising administration of modified cd154 antibodies

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT84170B (pt) * 1986-01-24 1989-03-30 Sanofi Sa Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas
DE4115468A1 (de) 1991-05-11 1992-11-12 Behringwerke Ag Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
DE4206858A1 (de) * 1992-03-05 1993-09-09 Behringwerke Ag Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
DK0649854T3 (da) * 1993-09-01 2000-07-03 Akzo Nobel Nv Biskonjugater omfattende to saccharider og en spacer
IL120722A (en) * 1996-05-08 1999-07-14 Akzo Nobel Nv Polysulfated tetrasaccharide derivatives and pharmaceutical compositions containing them
WO1999065934A1 (en) * 1998-06-17 1999-12-23 Akzo Nobel N.V. Antithrombotic compounds

Also Published As

Publication number Publication date
IL139955A (en) 2006-08-20
AU4512999A (en) 2000-01-05
AU756493B2 (en) 2003-01-16
PT1087992E (pt) 2008-10-17
CA2334863C (en) 2011-02-15
US6486129B1 (en) 2002-11-26
CN1305494A (zh) 2001-07-25
DE69939378D1 (de) 2008-10-02
HK1034266A1 (en) 2001-10-19
CZ299382B6 (cs) 2008-07-09
NO20006317D0 (no) 2000-12-12
PL345238A1 (en) 2001-12-03
ZA200007075B (en) 2002-02-28
SK19222000A3 (sk) 2001-07-10
HUP0102764A2 (hu) 2001-12-28
KR100790910B1 (ko) 2008-01-03
KR20010052943A (ko) 2001-06-25
JP2002518407A (ja) 2002-06-25
PE20000700A1 (es) 2000-08-14
NO326057B1 (no) 2008-09-08
EP1087992B1 (en) 2008-08-20
NO20006317L (no) 2001-02-14
AR019674A1 (es) 2002-03-13
PL199433B1 (pl) 2008-09-30
CA2334863A1 (en) 1999-12-23
CO5080750A1 (es) 2001-09-25
TWI221156B (en) 2004-09-21
NZ508623A (en) 2002-11-26
RU2225869C2 (ru) 2004-03-20
CN1261450C (zh) 2006-06-28
SK286755B6 (sk) 2009-05-07
CZ20004735A3 (cs) 2001-08-15
ATE405580T1 (de) 2008-09-15
ES2312210T3 (es) 2009-02-16
TR200003710T2 (tr) 2001-04-20
HU229088B1 (en) 2013-07-29
JP4369052B2 (ja) 2009-11-18
BR9911300A (pt) 2001-04-03
IL139955A0 (en) 2002-02-10
CY1108567T1 (el) 2014-04-09
WO1999065934A1 (en) 1999-12-23
HUP0102764A3 (en) 2003-11-28
EP1087992A1 (en) 2001-04-04
ID26614A (id) 2001-01-25

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