DK1092437T3 - Anvendelse af epidermal vækstfaktor som et gastrointestinalt terapeutisk middel - Google Patents

Anvendelse af epidermal vækstfaktor som et gastrointestinalt terapeutisk middel

Info

Publication number: DK1092437T3
Authority: DK; Denmark
Prior art keywords: growth factor; epidermal growth; egf; therapeutic agent; animal
Prior art date: 1995-05-10

Application number

DK00123426T

Other languages

Danish (da)

English (en)

Inventor

Andre G Buret

James A Hardin

Merle E Olson

Grant D Gall

Original Assignee

Univ Technologies Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-10

Filing date

1996-05-09

Publication date

2005-01-31

1996-05-09 Application filed by Univ Technologies Int filed Critical Univ Technologies Int

2005-01-31 Application granted granted Critical

2005-01-31 Publication of DK1092437T3 publication Critical patent/DK1092437T3/da

Links

VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 title abstract 4
102000009024 Epidermal Growth Factor Human genes 0.000 title abstract 3
101800003838 Epidermal growth factor Proteins 0.000 title abstract 3
229940116977 epidermal growth factor Drugs 0.000 title abstract 3
239000003814 drug Substances 0.000 title abstract 2
230000002496 gastric effect Effects 0.000 title 1
229940124597 therapeutic agent Drugs 0.000 title 1
239000003795 chemical substances by application Substances 0.000 abstract 2
208000000103 Anorexia Nervosa Diseases 0.000 abstract 1
239000000654 additive Substances 0.000 abstract 1
230000000996 additive effect Effects 0.000 abstract 1
238000009360 aquaculture Methods 0.000 abstract 1
244000144974 aquaculture Species 0.000 abstract 1
239000003651 drinking water Substances 0.000 abstract 1
235000020188 drinking water Nutrition 0.000 abstract 1
239000002778 food additive Substances 0.000 abstract 1
235000013373 food additive Nutrition 0.000 abstract 1
208000015380 nutritional deficiency disease Diseases 0.000 abstract 1
230000004584 weight gain Effects 0.000 abstract 1
235000019786 weight gain Nutrition 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/168—Steroids
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/184—Hormones
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Polymers & Plastics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Husbandry (AREA)
Food Science & Technology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Birds (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Tropical Medicine & Parasitology (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Oncology (AREA)
Obesity (AREA)
Communicable Diseases (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Fodder In General (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK00123426T 1995-05-10 1996-05-09 Anvendelse af epidermal vækstfaktor som et gastrointestinalt terapeutisk middel DK1092437T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/438,901 US5753622A (en)	1995-05-10	1995-05-10	Use of epidermal growth factor as a gastrointestinal therapeutic agent
EP96913397A EP0824357B1 (de)	1995-05-10	1996-05-09	Verwendung des epidermalen wachstumsfaktors als magen-darm therapeutikum

Publications (1)

Publication Number	Publication Date
DK1092437T3 true DK1092437T3 (da)	2005-01-31

Family

ID=23742496

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK00123426T DK1092437T3 (da)	1995-05-10	1996-05-09	Anvendelse af epidermal vækstfaktor som et gastrointestinalt terapeutisk middel
DK04019831T DK1479394T3 (da)	1995-05-10	1996-05-09	Anvendelse af epidermal vækstfaktor (EGF) til ögning af vækstforögelse hos et dyr
DK96913397T DK0824357T3 (da)	1995-05-10	1996-05-09	Anvendelsen af epidermal vækstfaktor som et gastrointestinalt terapeutisk middel

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DK04019831T DK1479394T3 (da)	1995-05-10	1996-05-09	Anvendelse af epidermal vækstfaktor (EGF) til ögning af vækstforögelse hos et dyr
DK96913397T DK0824357T3 (da)	1995-05-10	1996-05-09	Anvendelsen af epidermal vækstfaktor som et gastrointestinalt terapeutisk middel

Country Status (12)

Country	Link
US (2)	US5753622A (de)
EP (3)	EP0824357B1 (de)
JP (1)	JP3549541B2 (de)
AT (3)	ATE357927T1 (de)
AU (1)	AU704675B2 (de)
CA (2)	CA2220434C (de)
DE (3)	DE69637002T2 (de)
DK (3)	DK1092437T3 (de)
ES (2)	ES2285320T3 (de)
NZ (2)	NZ307134A (de)
PT (1)	PT1479394E (de)
WO (1)	WO1996035445A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5753622A (en) *	1995-05-10	1998-05-19	University Technologies International, Inc.	Use of epidermal growth factor as a gastrointestinal therapeutic agent
US5929051A (en) *	1998-05-13	1999-07-27	Carrington Laboratories, Inc.	Aloe pectins
US7022683B1 (en) *	1998-05-13	2006-04-04	Carrington Laboratories, Inc.	Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
US6313103B1 (en)	1998-05-13	2001-11-06	Carrington Laboratories, Inc.	Pectic substance as a growth factor stabilizer
US20060014684A1 (en) *	2000-03-03	2006-01-19	University Technologies International Inc.	Novel uses of EGF
US7494669B2 (en)	2001-02-28	2009-02-24	Carrington Laboratories, Inc.	Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
NZ529806A (en) *	2001-05-18	2005-08-26	Ca Minister Agriculture & Food	Nucleic acid and protein sequences of bovine epidermal growth factor
EP1441754A1 (de) *	2001-10-26	2004-08-04	University Technologies International Inc.	Verwendung von egf zur behandlung von pathogeninfektionen des urogenitalstraktes
CA2427190A1 (en) *	2002-04-30	2003-10-30	Alberta Research Council Inc.	Production of recombinant epidermal growth factor in plants
WO2004001020A2 (en) *	2002-06-19	2003-12-31	Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw	Methods and means to promote gut absorption
EP1812042A1 (de) *	2004-09-30	2007-08-01	University Technologies International Inc.	Rehydrierende zusammensetzungen mit epidermalem wachstumsfaktor
WO2007011702A2 (en) *	2005-07-15	2007-01-25	The University Of North Carolina At Chapel Hill	Use of egfr inhibitors to prevent or treat obesity
DK2119450T3 (da)	2005-11-29	2013-05-06	Actogenix Nv	Induktion af mucosal tolerance over for pankreatisk ø-beta-celle-autoantigener
CN103933563B (zh)	2007-01-25	2016-09-28	英特瑞克斯顿阿克图比奥帝克斯有限公司	使用遗传修饰的乳杆菌通过抗原的粘膜递送治疗免疫疾病
US20110275566A1 (en) *	2008-10-10	2011-11-10	Nationwide Children's Hospital Inc.	Methods of treating necrotizing enterocolitis using heparin binding epidermal growth factor (hb-egf)
CN102696887B (zh) *	2012-06-20	2013-07-31	湖南海谷生物技术有限公司	一种具有营养保健促生长功能的饲料活性蛋粉及其生产方法
US11241480B2 (en) *	2017-01-26	2022-02-08	Washington University	Methods for modulation of dietary and microbial exposure with compositions comprising an EGFR ligand
CN113813369B (zh) *	2021-11-09	2023-09-22	浙江省农业科学院	用于预防/治疗仔猪肠道损伤的egf/mmt复合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8409960D0 (en) *	1984-04-17	1984-05-31	Searle & Co	Therapeutic method
AU620797B2 (en) *	1986-12-11	1992-02-27	British Technology Group Limited	Improvements in or relating to the use of epidermal growth factor
ES2111625T3 (es) *	1992-07-06	1998-03-16	Nestle Sa	Agente antigastritis.
US5753622A (en) *	1995-05-10	1998-05-19	University Technologies International, Inc.	Use of epidermal growth factor as a gastrointestinal therapeutic agent

1995
- 1995-05-10 US US08/438,901 patent/US5753622A/en not_active Expired - Lifetime
1996
- 1996-05-09 ES ES04019831T patent/ES2285320T3/es not_active Expired - Lifetime
- 1996-05-09 DE DE69637002T patent/DE69637002T2/de not_active Expired - Fee Related
- 1996-05-09 DK DK00123426T patent/DK1092437T3/da active
- 1996-05-09 DE DE69614377T patent/DE69614377T2/de not_active Expired - Fee Related
- 1996-05-09 EP EP96913397A patent/EP0824357B1/de not_active Expired - Lifetime
- 1996-05-09 WO PCT/CA1996/000291 patent/WO1996035445A1/en not_active Ceased
- 1996-05-09 EP EP00123426A patent/EP1092437B1/de not_active Expired - Lifetime
- 1996-05-09 DE DE69633583T patent/DE69633583T2/de not_active Expired - Fee Related
- 1996-05-09 NZ NZ307134A patent/NZ307134A/en not_active IP Right Cessation
- 1996-05-09 AU AU56411/96A patent/AU704675B2/en not_active Ceased
- 1996-05-09 CA CA002220434A patent/CA2220434C/en not_active Expired - Fee Related
- 1996-05-09 AT AT04019831T patent/ATE357927T1/de not_active IP Right Cessation
- 1996-05-09 CA CA2492724A patent/CA2492724C/en not_active Expired - Fee Related
- 1996-05-09 DK DK04019831T patent/DK1479394T3/da active
- 1996-05-09 EP EP04019831A patent/EP1479394B1/de not_active Expired - Lifetime
- 1996-05-09 NZ NZ501482A patent/NZ501482A/xx not_active IP Right Cessation
- 1996-05-09 PT PT04019831T patent/PT1479394E/pt unknown
- 1996-05-09 JP JP53362496A patent/JP3549541B2/ja not_active Expired - Fee Related
- 1996-05-09 ES ES00123426T patent/ES2226681T3/es not_active Expired - Lifetime
- 1996-05-09 AT AT00123426T patent/ATE278415T1/de not_active IP Right Cessation
- 1996-05-09 DK DK96913397T patent/DK0824357T3/da active
- 1996-05-09 AT AT96913397T patent/ATE203912T1/de not_active IP Right Cessation
2000
- 2000-03-03 US US09/518,135 patent/US6656907B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2492724C (en)	2010-08-03
CA2220434C (en)	2005-02-22
EP0824357A1 (de)	1998-02-25
DE69614377D1 (de)	2001-09-13
CA2492724A1 (en)	1996-11-14
WO1996035445A1 (en)	1996-11-14
CA2220434A1 (en)	1996-11-14
AU5641196A (en)	1996-11-29
JP3549541B2 (ja)	2004-08-04
EP1092437A1 (de)	2001-04-18
EP0824357B1 (de)	2001-08-08
DK0824357T3 (da)	2001-10-08
US6656907B1 (en)	2003-12-02
DE69633583T2 (de)	2006-02-23
PT1479394E (pt)	2007-04-30
EP1479394B1 (de)	2007-03-28
US5753622A (en)	1998-05-19
ATE278415T1 (de)	2004-10-15
ES2226681T3 (es)	2005-04-01
EP1479394A1 (de)	2004-11-24
NZ307134A (en)	2000-02-28
HK1072894A1 (en)	2005-09-16
NZ501482A (en)	2004-12-24
ATE203912T1 (de)	2001-08-15
DE69614377T2 (de)	2002-05-23
EP1092437B1 (de)	2004-10-06
DE69637002T2 (de)	2007-08-16
DE69637002D1 (de)	2007-05-10
ATE357927T1 (de)	2007-04-15
JPH11505528A (ja)	1999-05-21
AU704675B2 (en)	1999-04-29
DK1479394T3 (da)	2007-06-11
ES2285320T3 (es)	2007-11-16
DE69633583D1 (de)	2004-11-11

Publication	Publication Date	Title
DK1092437T3 (da)	2005-01-31	Anvendelse af epidermal vækstfaktor som et gastrointestinalt terapeutisk middel
AU1017088A (en)	1988-07-14	Sustained release growth hormone compositions for parenteral administration and their use
ATE136030T1 (de)	1996-04-15	Azaheterocyclylmethyl-chromane als wirkstoffe zur behandlung von erkrankungen des zentralnervensystems
JPS6470457A (en)	1989-03-15	Local remedy for skin damaged by beam
NZ251320A (en)	1999-08-30	Bis-aromatic alpha,beta-unsaturated ketones, preparation and use in pharmaceutical compositions
DE69109284D1 (de)	1995-06-01	Verwendung von fluorierten löslichen tensiden zur herstellung von aerosolarzneimitteln mit dosierter abgabe.
ATE234615T1 (de)	2003-04-15	Verwendung von acetylcystein zur herstellung eines arzneimittels zur behandlung von chronischen geschwüren
DE59208974D1 (de)	1997-11-20	Neue pyrazinderivative, ihre herstellung und verwendung
DE59712094D1 (de)	2004-12-30	Mittel zur herstellung von aquarien- und gartenteichwasser und verwendung davon
DE3681144D1 (de)	1991-10-02	Verwendung biologisch aktiver copolymere zur herstellung eines arzneimittels zur stimulierung des wachstums von tieren.
ATE137965T1 (de)	1996-06-15	Verwendung von tomoxetine zur behandlung von funktionsstörungen der niedrigen harnwege
DE69130497D1 (de)	1998-12-24	Neue Verwendung von 1-Alpha-hydroxylierten-19-nor-vitamin-D-Verbindungen zur Behandlung von Psoriasis
YU78092A (sh)	1995-10-03	Postupak za dobijanje derivata beta-fenilizoserina i njihova primena
ATE89728T1 (de)	1993-06-15	Verwendung von dihydroergotamin und seinen salzen zur lokalen behandlung trophischer stoerungen.
ATE83480T1 (de)	1993-01-15	Cyclisches peptid, seine herstellung und seine verwendung zur behandlung von cardiovasculaeren stoerungen.
DE68905657D1 (de)	1993-05-06	Verwendung von arginin-aspartat zur herstellung eines arzneimittels zur behandlung gewisser gedaechtnisstoerungen.
ATE107852T1 (de)	1994-07-15	Badezusatz und dessen verwendung.
ATE173921T1 (de)	1998-12-15	Verwendung von deoxyspergualin zur herstellung eines arzneimittels zur behandlung von entzündlich-hyperreaktiven erkrankungen
DE69313850D1 (de)	1997-10-16	Veterinaerprodukt zur rehydration
SU1522498A1 (ru)	1996-02-10	Дезинфицирующее средство
IT1247508B (it)	1994-12-17	Composizioni farmaceutiche contenenti l'estere 4-(2 metilamminoetil)- 1,2- fenilenicodell`acido 2-metilpropanoico per il trattamento della neurootticopatia glaucomatosa
CA2031825A1 (en)	1991-06-09	Bath additive and its use
IT1232818B (it)	1992-03-05	Impiego dell'acido piperazin carbossilico e suoi derivati per il trattamento di ridotto spirito di iniziativa e/o ritrosia sociale, disturbi di sonno o emicrania e simili
ATE124264T1 (de)	1995-07-15	Verwendung eines polypeptids mit humaner interleukin-2 aktivität zur herstellung pharmazeutischer zusammensetzungen zur behandlung von pneumothoraxen.
Potapchenko et al.	1989	Dosage-time dependency of effect of silver in water on pathogenic escherichia