DK1109021T3 - Snail, en ny tumoral progressionsmarkör og et targetprotein for nye antitumorale forbindelser - Google Patents

Snail, en ny tumoral progressionsmarkör og et targetprotein for nye antitumorale forbindelser

Info

Publication number
DK1109021T3
DK1109021T3 DK00938837T DK00938837T DK1109021T3 DK 1109021 T3 DK1109021 T3 DK 1109021T3 DK 00938837 T DK00938837 T DK 00938837T DK 00938837 T DK00938837 T DK 00938837T DK 1109021 T3 DK1109021 T3 DK 1109021T3
Authority
DK
Denmark
Prior art keywords
snail
target protein
tumor progression
antitumoral compounds
new tumor
Prior art date
Application number
DK00938837T
Other languages
English (en)
Inventor
Garcia Amparo Cano
Toledano Maria Angela Nieto
Castro Maria Isabel Rodrigo
Annamaria Locascio
Del Barrio Marta Garcia
Fernandez De Valderrama Blanco
Perez Francisco Portillo
Moreno Mirna Alicia Perez
Original Assignee
Consejo Superior Investigacion
Univ Madrid Autonoma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8309058&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1109021(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Consejo Superior Investigacion, Univ Madrid Autonoma filed Critical Consejo Superior Investigacion
Application granted granted Critical
Publication of DK1109021T3 publication Critical patent/DK1109021T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK00938837T 1999-07-01 2000-06-27 Snail, en ny tumoral progressionsmarkör og et targetprotein for nye antitumorale forbindelser DK1109021T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES009901466A ES2161612B1 (es) 1999-07-01 1999-07-01 Procedimiento para identificar un compuesto que inhiba la funcion represora de snail.
PCT/ES2000/000226 WO2001002860A1 (es) 1999-07-01 2000-06-27 Snail, nuevo marcador de progresion tumoral y proteina diana de nuevos compuestos antitumorales
EP00938837A EP1109021B1 (en) 1999-07-01 2000-06-27 Snail, new tumoral progression marker and target protein of new antitumoral compounds

Publications (1)

Publication Number Publication Date
DK1109021T3 true DK1109021T3 (da) 2005-03-29

Family

ID=8309058

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00938837T DK1109021T3 (da) 1999-07-01 2000-06-27 Snail, en ny tumoral progressionsmarkör og et targetprotein for nye antitumorale forbindelser

Country Status (10)

Country Link
US (6) US6617121B1 (da)
EP (1) EP1109021B1 (da)
AT (1) ATE284537T1 (da)
AU (1) AU5408300A (da)
CA (1) CA2383943A1 (da)
DE (1) DE60016548T2 (da)
DK (1) DK1109021T3 (da)
ES (3) ES2161655B1 (da)
PT (1) PT1109021E (da)
WO (1) WO2001002860A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60238055D1 (de) * 2001-06-22 2010-12-02 Burkhard Jansen Verfahren zur diagnose einer person mit multipler sklerose
ES2195751B1 (es) * 2001-11-27 2005-04-01 Universidad De Salamanca (Otri) Mamiferos no humanos transgenicos como modelos para patologias humanas con origen en celulas stem.
US20050089896A1 (en) 2003-02-18 2005-04-28 Roy Frans V. Method to control tumor progression and invasiveness
DE60327056D1 (de) * 2002-02-20 2009-05-20 Vlaams Interuniv Inst Biotech Verfahren zur kontrolle der tumorprogression und invasivität
WO2004065602A1 (es) * 2003-01-17 2004-08-05 Universidad Autónoma de Madrid Procedimiento para identificar la transición epitelio-mesenquimal de células mesoteliales (temcm) e identificar compuestos moduladores de temcm, composiciones farmacéuticas y su uso en el diagnóstico y tratamiento de enfermedades que cursan con temcm
WO2004086038A2 (en) * 2003-03-28 2004-10-07 Institut Curie A method for screening compounds having the capacity to control tumor cell invasion or metastasis using constitutively active akt
US20060003956A1 (en) * 2004-03-03 2006-01-05 Casadome David O Materials and methods for the derepression of the E-cadherin promoter
ES2301268B1 (es) * 2004-10-25 2009-05-01 Centro De Investigacion Biomolecular Aplicada Salamanca, S.L. Empleo del gen slug, o de sus productos de replicacion, transcripcion o expresion, en la identificacion, diagnostico, prevencion o tratamiento de la diseminacion del cancer y/o desarrollo de metastasis.
WO2006101925A2 (en) * 2005-03-16 2006-09-28 Osi Pharmaceuticals, Inc. Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors
US8383357B2 (en) * 2005-03-16 2013-02-26 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors
WO2007012970A1 (en) * 2005-07-28 2007-02-01 Oncostem Pharma, S.L. Graded expression of snail as marker of cancer development and dna damage-based diseases
US8029989B2 (en) * 2005-08-26 2011-10-04 The Trustees Of The University Of Pennsylvania Method using snail transcriptional repressor
GB0602063D0 (en) 2006-02-02 2006-03-15 Univ Manchester Cell Culture
US8377636B2 (en) * 2007-04-13 2013-02-19 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to kinase inhibitors
AU2008307634A1 (en) * 2007-10-03 2009-04-09 Osi Pharmaceuticals, Inc. Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
US8048621B2 (en) * 2007-10-03 2011-11-01 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
US20110171124A1 (en) * 2009-02-26 2011-07-14 Osi Pharmaceuticals, Inc. In situ methods for monitoring the EMT status of tumor cells in vivo
AU2011223655A1 (en) * 2010-03-03 2012-06-28 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
JP2014519813A (ja) 2011-04-25 2014-08-21 オーエスアイ・ファーマシューティカルズ，エルエルシー 癌薬剤発見、診断、および治療におけるｅｍｔ遺伝子シグネチャーの使用
CN109984062B (zh) * 2018-12-29 2021-07-27 广西桂螺农业科技有限公司 一种厚壳田螺的繁育方法
WO2023126958A1 (en) * 2021-12-30 2023-07-06 Mestastop Solutions Private Limited Method for producing a spontaneous metastasis model

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4547432A (en) * 1984-07-31 1985-10-15 The United States Of America As Represented By The United States Department Of Energy Method of bonding silver to glass and mirrors produced according to this method
FR2656129B1 (fr) * 1989-12-20 1992-03-13 Gen Electric Cgr Procede de reconstruction multi-echelle de l'image de la structure d'un corps.
WO1996002002A1 (en) * 1994-07-08 1996-01-25 Schalken Jack A Assay for increased invasiveness of epithelial cells
DE19503510C2 (de) * 1995-02-03 1996-12-19 Sekurit Saint Gobain Deutsch Verfahren zur Herstellung einer IR-reflektierenden Verbundglasscheibe für Kraftfahrzeuge
AU9767998A (en) * 1997-10-17 1999-05-10 Te Whetu Whanau Trust Limited Germline mutations in the e-cadherin gene and method for detecting predispos ition to cancer
AU4742400A (en) * 1999-09-29 2001-04-30 Ip2H Ag Process for production of a dielectric multi-layered reflecting coating

Also Published As

Publication number Publication date
CA2383943A1 (en) 2001-01-11
PT1109021E (pt) 2005-04-29
US20070077590A1 (en) 2007-04-05
EP1109021A1 (en) 2001-06-20
EP1109021B1 (en) 2004-12-08
US20070054307A1 (en) 2007-03-08
US7794930B2 (en) 2010-09-14
WO2001002860A1 (es) 2001-01-11
ES2161655A1 (es) 2001-12-01
US7482126B2 (en) 2009-01-27
ES2161655B1 (es) 2002-06-01
US20070065450A1 (en) 2007-03-22
ES2234619T3 (es) 2005-07-01
ATE284537T1 (de) 2004-12-15
US6617121B1 (en) 2003-09-09
ES2161612B1 (es) 2002-06-01
US20070053891A1 (en) 2007-03-08
US7482159B2 (en) 2009-01-27
DE60016548T2 (de) 2005-12-08
DE60016548D1 (de) 2005-01-13
ES2161612A1 (es) 2001-12-01
AU5408300A (en) 2001-01-22
US20040037832A1 (en) 2004-02-26

Similar Documents

Publication Publication Date Title
PT1109021E (pt) Snail, novo marcador da progressao tumoral e proteina alvo de novos compostos antitumorais
AU2003253986A1 (en) Gene expression profiling in biopsied tumor tissues
DK3059322T3 (da) Genekspressionsmarkører for brystcancerprognose
NO20004631L (no) Forbindelser og fremgangsmÕter for terapi og diagnose av lungekreft
ATE396266T1 (de) Trp8 krebsmarker
ATE190313T1 (de) Dns-sequenz und kodiertes brustdrüsenspezifisisches brustkrebsprotein
CY1110029T1 (el) Γονιδιο που εκφραζεται στον καρκινο του προστατη
WO2003079020A3 (en) Methods and compositions for the identification, assessment, and therapy of small cell lung cancer
ATE332309T1 (de) Suppressor-gen
DE602004020266D1 (de) Therapeutische und diagnostische anti-hsp 70-antikörper
WO2005094348A3 (en) Anti-lfl2 antibodies for the diagnosis, prognosis and treatment of cancer
WO2002064023A3 (en) Fra-1 expression in brain cancer
IL207012A (en) 28sgp medicinal product and 28sgp accent cancer treatment vaccine
AU5302599A (en) Method for diagnosing bone metastasis of malignant tumor
WO2007020522A3 (en) Protein markers for diagnosing of colorectal cancer and use of said markers as drug targets for the treatment of said cancer type
WO2006113579A3 (en) Tumor inhibition by modulating sprouty expression or activity
DE60139150D1 (de) Zusammensetzungen und verfahren zur therapie und diagnose von lungenkrebs
WO2002002772A3 (en) Human extracellular matrix (ecm)-related tumor marker
ATE373711T1 (de) Gewebe-spezifische protein 103p2d6, hochexprimiert in verschiedene krebsarten
AU1128801A (en) Agents for treating human diseases, especially for treating tumors such as colonic cancers and melanomas or for regenerating tissue and promoting hair growth
ATE323103T1 (de) Proteinmarker für ösophaguskrebs
ATE328082T1 (de) Verkürztes bard1 protein und dessen diagnostische und therapeutische anwendungen
DE60134956D1 (de) Gene differentiell experimiert in brudtkrebs
WO2003020294A8 (de) Markierung der aromatase
ITBZ20020040A1 (it) Metodo per la identificazione attraverso la progettazione e l'uso di appositi microchip -dna microarray della trasformazione tumorale del tessuto prostatico, valutazione della sua malignita' e prognosi del cancro prostatico umano mediante un nuovo me