DK1109892T3 - Fremgangsmåder til at frembringe höjtitrede, hjælpevirusfrie præparater af frie rekombinante AAV-vektorer - Google Patents
Fremgangsmåder til at frembringe höjtitrede, hjælpevirusfrie præparater af frie rekombinante AAV-vektorerInfo
- Publication number
- DK1109892T3 DK1109892T3 DK99968678T DK99968678T DK1109892T3 DK 1109892 T3 DK1109892 T3 DK 1109892T3 DK 99968678 T DK99968678 T DK 99968678T DK 99968678 T DK99968678 T DK 99968678T DK 1109892 T3 DK1109892 T3 DK 1109892T3
- Authority
- DK
- Denmark
- Prior art keywords
- free
- titled
- methods
- aav vectors
- recombinant aav
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000013607 AAV vector Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
- C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14247498A | 1998-09-04 | 1998-09-04 | |
| US12368599P | 1999-03-10 | 1999-03-10 | |
| PCT/US1999/020524 WO2000014205A2 (en) | 1998-09-04 | 1999-09-07 | Methods for generating high titer helper-free preparations of released recombinant aav vectors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1109892T3 true DK1109892T3 (da) | 2009-02-09 |
Family
ID=26821785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99968678T DK1109892T3 (da) | 1998-09-04 | 1999-09-07 | Fremgangsmåder til at frembringe höjtitrede, hjælpevirusfrie præparater af frie rekombinante AAV-vektorer |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1109892B1 (da) |
| JP (1) | JP4472182B2 (da) |
| AT (1) | ATE414146T1 (da) |
| CA (1) | CA2342849C (da) |
| CY (1) | CY1110695T1 (da) |
| DE (1) | DE69939903D1 (da) |
| DK (1) | DK1109892T3 (da) |
| ES (2) | ES2317709T3 (da) |
| PT (2) | PT1109892E (da) |
| WO (1) | WO2000014205A2 (da) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6924128B2 (en) | 1994-12-06 | 2005-08-02 | Targeted Genetics Corporation | Packaging cell lines for generation of high titers of recombinant AAV vectors |
| US6995006B2 (en) | 1997-09-05 | 2006-02-07 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| JP2001514845A (ja) * | 1997-09-05 | 2001-09-18 | ターゲティッド ジェネティクス コーポレイション | 組換えａａｖベクターの高力価ヘルパーなし調製物を生成するための方法 |
| US6566118B1 (en) | 1997-09-05 | 2003-05-20 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| US6346415B1 (en) | 1997-10-21 | 2002-02-12 | Targeted Genetics Corporation | Transcriptionally-activated AAV inverted terminal repeats (ITRS) for use with recombinant AAV vectors |
| US6893865B1 (en) | 1999-04-28 | 2005-05-17 | Targeted Genetics Corporation | Methods, compositions, and cells for encapsidating recombinant vectors in AAV particles |
| EP1939300A1 (en) | 1999-05-28 | 2008-07-02 | Targeted Genetics Corporation | Methods and compositions for lowering the level of tumor necrosis factor (TNF) in TNF-associated disorders |
| DE60040147D1 (de) | 1999-05-28 | 2008-10-16 | Targeted Genetics Corp | Methoden und zusammensetzungen zur reduktion des tumor-nekrosis-faktor-spiegels (tnf) bei tnf-assoziierten erkrankungen |
| PT1916258E (pt) | 1999-08-09 | 2014-07-29 | Genzyme Corp | Aumento da expressão de uma sequência nucleotídica heteróloga de cadeia simples a partir de vectores virais recombinantes por concepção da sequência de maneira que esta forme pares de bases intracadeia |
| US7115391B1 (en) | 1999-10-01 | 2006-10-03 | Genovo, Inc. | Production of recombinant AAV using adenovirus comprising AAV rep/cap genes |
| EP1833961B1 (en) * | 2004-10-15 | 2011-07-20 | Monell Chemical Senses Center | Methods for culturing mammalian taste cells |
| MX2007005379A (es) * | 2004-11-05 | 2007-07-04 | Wellstat Biologics Corp | Formulaciones de virus envueltos estables y filtrables. |
| JP5879256B2 (ja) | 2009-05-02 | 2016-03-08 | ジェンザイム・コーポレーション | 神経変性障害のための遺伝子治療 |
| CA2829774C (en) * | 2011-03-14 | 2019-09-24 | National Research Council Of Canada | Method of viral production in cells |
| EP3020808B1 (en) | 2013-07-11 | 2019-09-11 | Takara Bio Inc. | Method for manufacturing adeno-associated virus |
| EP3168298B1 (en) | 2014-07-10 | 2019-04-17 | Takara Bio Inc. | Production method for non-enveloped virus particles |
| WO2016111343A1 (ja) | 2015-01-09 | 2016-07-14 | タカラバイオ株式会社 | 非エンベロープウイルス粒子の製造方法 |
| AU2017269371B2 (en) | 2016-05-25 | 2021-08-05 | Lonza Houston Inc. | Methods for isolating adeno-associated virus using a polydiallyldialkylammonium salt |
| ES3012649T3 (en) | 2016-10-14 | 2025-04-09 | Ultragenyx Pharmaceutical Inc | Use of tonicifying agents to enhance recombinant adeno-associated virus yield |
| WO2023114901A2 (en) * | 2021-12-15 | 2023-06-22 | Oxford Biomedica Solutions Llc | Methods and compositions for the production of adeno-associated virus |
| CN120835797A (zh) | 2023-03-21 | 2025-10-24 | 豪夫迈·罗氏有限公司 | 用于产生重组aav颗粒制备物的方法 |
| WO2025168663A1 (en) | 2024-02-09 | 2025-08-14 | F. Hoffmann-La Roche Ag | Method for producing recombinant adeno-associated viral particles |
| US20260022401A1 (en) | 2024-07-22 | 2026-01-22 | Hoffmann-La Roche Inc. | Novel AAV rep ORFs and Rep polypeptides |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6686200B1 (en) * | 1993-08-31 | 2004-02-03 | Uab Research Foundation | Methods and compositions for the large scale production of recombinant adeno-associated virus |
| AU722196B2 (en) * | 1995-08-30 | 2000-07-27 | Genzyme Corporation | Chromatographic purification of adenovirus and AAV |
| US5910434A (en) * | 1995-12-15 | 1999-06-08 | Systemix, Inc. | Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant |
| FR2750433B1 (fr) * | 1996-07-01 | 1998-08-14 | Rhone Poulenc Rorer Sa | Procede de production d'adenovirus recombinants |
| JP2001514845A (ja) * | 1997-09-05 | 2001-09-18 | ターゲティッド ジェネティクス コーポレイション | 組換えａａｖベクターの高力価ヘルパーなし調製物を生成するための方法 |
-
1999
- 1999-09-07 ES ES99968678T patent/ES2317709T3/es not_active Expired - Lifetime
- 1999-09-07 DK DK99968678T patent/DK1109892T3/da active
- 1999-09-07 EP EP99968678A patent/EP1109892B1/en not_active Expired - Lifetime
- 1999-09-07 ES ES07024137.7T patent/ES2541540T3/es not_active Expired - Lifetime
- 1999-09-07 PT PT99968678T patent/PT1109892E/pt unknown
- 1999-09-07 JP JP2000568952A patent/JP4472182B2/ja not_active Expired - Lifetime
- 1999-09-07 DE DE69939903T patent/DE69939903D1/de not_active Expired - Lifetime
- 1999-09-07 WO PCT/US1999/020524 patent/WO2000014205A2/en not_active Ceased
- 1999-09-07 CA CA2342849A patent/CA2342849C/en not_active Expired - Lifetime
- 1999-09-07 PT PT70241377T patent/PT1930418E/pt unknown
- 1999-09-07 AT AT99968678T patent/ATE414146T1/de active
-
2009
- 2009-02-04 CY CY20091100126T patent/CY1110695T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4472182B2 (ja) | 2010-06-02 |
| DE69939903D1 (de) | 2008-12-24 |
| ES2541540T3 (es) | 2015-07-21 |
| EP1109892B1 (en) | 2008-11-12 |
| PT1930418E (pt) | 2015-08-26 |
| PT1109892E (pt) | 2009-02-17 |
| CA2342849A1 (en) | 2000-03-16 |
| JP2002524070A (ja) | 2002-08-06 |
| CY1110695T1 (el) | 2015-06-10 |
| ATE414146T1 (de) | 2008-11-15 |
| WO2000014205A9 (en) | 2000-09-08 |
| WO2000014205A3 (en) | 2000-05-25 |
| WO2000014205A2 (en) | 2000-03-16 |
| CA2342849C (en) | 2013-01-29 |
| ES2317709T3 (es) | 2009-04-16 |
| EP1109892A2 (en) | 2001-06-27 |
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