DK1124961T3 - Trombopoietiske forbindelser - Google Patents

Trombopoietiske forbindelser

Info

Publication number
DK1124961T3
DK1124961T3 DK99970998T DK99970998T DK1124961T3 DK 1124961 T3 DK1124961 T3 DK 1124961T3 DK 99970998 T DK99970998 T DK 99970998T DK 99970998 T DK99970998 T DK 99970998T DK 1124961 T3 DK1124961 T3 DK 1124961T3
Authority
DK
Denmark
Prior art keywords
thrombopoietic compounds
thrombopoietic
compounds
Prior art date
Application number
DK99970998T
Other languages
Danish (da)
English (en)
Inventor
Chuan-Fa Liu
Ulrich Feige
Janet Cheetham
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of DK1124961T3 publication Critical patent/DK1124961T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK99970998T 1998-10-23 1999-10-22 Trombopoietiske forbindelser DK1124961T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10534898P 1998-10-23 1998-10-23
PCT/US1999/024834 WO2000024770A2 (fr) 1998-10-23 1999-10-22 Composes thrombopoietiques

Publications (1)

Publication Number Publication Date
DK1124961T3 true DK1124961T3 (da) 2007-04-10

Family

ID=22305310

Family Applications (3)

Application Number Title Priority Date Filing Date
DK99970998T DK1124961T3 (da) 1998-10-23 1999-10-22 Trombopoietiske forbindelser
DK06022333T DK1783222T3 (da) 1998-10-23 1999-10-22 Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet
DK10011689T DK2319928T3 (da) 1998-10-23 1999-10-22 Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK06022333T DK1783222T3 (da) 1998-10-23 1999-10-22 Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet
DK10011689T DK2319928T3 (da) 1998-10-23 1999-10-22 Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet

Country Status (36)

Country Link
US (8) US6835809B1 (fr)
EP (3) EP2319928B9 (fr)
JP (2) JP3820105B2 (fr)
KR (1) KR100719202B1 (fr)
CN (2) CN1250721C (fr)
AR (1) AR020934A1 (fr)
AT (1) ATE348163T1 (fr)
AU (1) AU773891C (fr)
BG (3) BG65663B1 (fr)
BR (1) BRPI9914698B8 (fr)
CA (1) CA2346996C (fr)
CY (4) CY1107526T1 (fr)
CZ (1) CZ302155B6 (fr)
DE (2) DE122009000039I1 (fr)
DK (3) DK1124961T3 (fr)
EA (1) EA003998B1 (fr)
ES (3) ES2422231T3 (fr)
FR (1) FR09C0030I2 (fr)
HK (1) HK1042114B (fr)
HU (1) HU228582B1 (fr)
IL (1) IL142023A0 (fr)
LT (1) LTC1124961I2 (fr)
LU (1) LU91598I2 (fr)
ME (2) ME00238B (fr)
MY (1) MY126795A (fr)
NL (1) NL300398I2 (fr)
NO (2) NO331027B1 (fr)
NZ (1) NZ510529A (fr)
PL (1) PL219605B1 (fr)
PT (3) PT1783222E (fr)
RS (1) RS51237B (fr)
SI (3) SI2319928T1 (fr)
SK (1) SK287737B6 (fr)
TW (2) TWI257394B (fr)
WO (1) WO2000024770A2 (fr)
ZA (1) ZA200102102B (fr)

Families Citing this family (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091311B2 (en) * 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
HK1042114B (zh) 1998-10-23 2006-09-29 Amgen K-A, Inc. 与mp1受体结合并具有血小板生成活性的模拟二聚体血小板生成素肽
US6808902B1 (en) * 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
JP2003530871A (ja) * 2000-04-21 2003-10-21 アムジエン・インコーポレーテツド インテグリン／接着因子アンタゴニスト
US20020090646A1 (en) * 2000-05-03 2002-07-11 Amgen Inc. Calcitonin-related molecules
EP1351709B8 (fr) * 2000-06-09 2004-12-22 The Government of The United States of America, as represented by The Department of Health and Human Services Pegylation de lieurs ameliorant l'activite antitumorale et reduisant la toxicite d'immunoconjugues
US7396917B2 (en) * 2000-12-05 2008-07-08 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
AU2002234001B2 (en) * 2000-12-05 2008-05-01 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
US20040018203A1 (en) * 2001-06-08 2004-01-29 Ira Pastan Pegylation of linkers improves antitumor activity and reduces toxicity of immunoconjugates
EP1434798B1 (fr) 2001-08-17 2012-04-04 Enkam Pharmaceuticals A/S Composes permettant d'effectuer la differentiation, la proliferation, la regeneration, la plasticite et la survie des cellules
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
CA2499625A1 (fr) * 2002-09-18 2004-04-01 Ortho-Mcneil Pharmaceutical, Inc. Procedes pour augmenter la production de cellules souches plaquettaires et hematopoietiques
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
ES2395413T3 (es) 2003-05-12 2013-02-12 Affymax, Inc. Péptidos que se unen al receptor de eritropoyetina
EP1626983B8 (fr) * 2003-05-12 2010-12-22 Affymax, Inc. Nouveaux composes modifies par du poly(ethylene glycol) et leurs utilisations
JP2007500218A (ja) 2003-05-12 2007-01-11 アフィーマックス・インコーポレイテッド ポリ（エチレングリコール）修飾ペプチド系化合物の新規スペーサー部分
DE602004020610D1 (de) 2003-05-12 2009-05-28 Affymax Inc Neue, an den erythropoietinrezeptor bindende peptide
CA2571292C (fr) 2004-06-30 2013-05-21 Nektar Therapeutics Al, Corporation Conjugues polymere-fraction facteur ix
CA2572765C (fr) * 2004-07-08 2013-05-21 Amgen Inc. Peptides therapeutiques
US7442778B2 (en) 2004-09-24 2008-10-28 Amgen Inc. Modified Fc molecules
US7550433B2 (en) 2005-06-03 2009-06-23 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
EA200800109A1 (ru) * 2005-06-23 2008-06-30 Аплаген Гмбх Суправалентные соединения
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
WO2007075899A2 (fr) * 2005-12-21 2007-07-05 Maxygen, Inc. Composes agonistes doubles et leur utilisation
US9012605B2 (en) 2006-01-23 2015-04-21 Amgen Inc. Crystalline polypeptides
EP1986677A2 (fr) * 2006-01-25 2008-11-05 Amgen Inc. Composes thrombopoietiques
US9283260B2 (en) 2006-04-21 2016-03-15 Amgen Inc. Lyophilized therapeutic peptibody formulations
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
AU2007278748B2 (en) 2006-07-24 2013-08-15 The University Of Queensland Method of producing a population of cells
CA2676820A1 (fr) 2007-01-31 2008-08-07 Affymax, Inc. Groupements de liaison a base d'azote destines a attacher des groupements modificateurs a des polypeptides et autres macromolecules
EP2738257A1 (fr) 2007-05-22 2014-06-04 Amgen Inc. Compositions et procédés pour produire des protéines de fusion bioactives
WO2008157824A2 (fr) * 2007-06-21 2008-12-24 Conjuchem Biotechnologies Inc. Conjugués de peptides thrombopoïétiques
MX2010002249A (es) * 2007-08-31 2010-03-17 Amgen Inc Formulacion de proteina de estado solido.
AU2008304111B2 (en) 2007-09-27 2014-04-24 Amgen Inc. Pharmaceutical formulations
EP3381445B1 (fr) 2007-11-15 2023-10-25 Amgen Inc. Formulation aqueuse d'anticorps stabilisée par des antioxydants pour administration parentérale
ES2559634T3 (es) 2007-11-28 2016-02-15 Enkam Pharmaceuticals A/S Péptidos derivados de NCAM (FGLs)
EP3385279B1 (fr) 2009-03-20 2020-02-26 Amgen Inc. Immunoglobulines porteuses et utilisations de celles-ci
BRPI1014089A2 (pt) 2009-04-02 2016-04-19 Roche Glycart Ag anticorpos multiespecíficos que compreendem anticorpos de comprimento completo e fragmentos fab de cadeia simples
MX2012003396A (es) 2009-09-16 2012-04-10 Genentech Inc Complejos de proteina conteniendo helice super-enrollada y/o enlazador tether y usos de los mismos.
WO2011047188A1 (fr) * 2009-10-16 2011-04-21 Amgen Inc. Composés thrombopoïétiques
MX344382B (es) 2009-10-23 2016-12-14 Amgen Inc * Adaptador de vial y sistema.
WO2011098095A1 (fr) 2010-02-09 2011-08-18 Aplagen Gmbh Peptides se liant au récepteur de tpo
TW201138821A (en) 2010-03-26 2011-11-16 Roche Glycart Ag Bispecific antibodies
CA2796633C (fr) 2010-04-23 2020-10-27 Genentech, Inc. Production de proteines heteromultimeres
ES2545411T5 (es) 2010-06-07 2024-04-05 Amgen Inc Dispositivo de administración de fármaco
CN104474546A (zh) 2010-08-13 2015-04-01 弗·哈夫曼-拉罗切有限公司 用于疾病治疗的针对IL-1β和IL-18的抗体
RU2013110875A (ru) 2010-08-24 2014-09-27 Ф.Хоффманн-Ля Рош Аг БИСПЕЦИФИЧЕСКИЕ АНТИТЕЛА, СОДЕРЖАЩИЕ СТАБИЛИЗИРОВАННЫЙ ДИСУЛЬФИДОМ ФРАГМЕНТ Fv
EP2619226B1 (fr) 2010-09-22 2018-09-12 Amgen Inc. Immunoglobulines porteuses et leur utilisation
JP5766296B2 (ja) 2010-12-23 2015-08-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
US10689447B2 (en) 2011-02-04 2020-06-23 Genentech, Inc. Fc variants and methods for their production
WO2012106587A1 (fr) 2011-02-04 2012-08-09 Genentech, Inc. Variantes génétiques de fc et leurs procédés de production
CA2831100C (fr) 2011-03-31 2020-02-18 Mark Dominis Holt Adaptateur de flacon et systeme
CA3021845C (fr) 2011-04-20 2022-03-29 Amgen Inc. Appareil auto-injecteur
HRP20240230T1 (hr) 2011-10-11 2024-04-26 F. Hoffmann - La Roche Ag Poboljšani sklop bispecifičnih protutijela
LT3045187T (lt) 2011-10-14 2019-07-10 Amgen Inc. Injekcijų įrenginys ir surinkimo būdas
CN104105711B (zh) 2012-02-10 2018-11-30 弗·哈夫曼-拉罗切有限公司 单链抗体及其他异多聚体
CN102552184A (zh) * 2012-02-16 2012-07-11 山东泉港药业有限公司 一种血小板生成素拟肽冻干制剂
MX2014014804A (es) 2012-06-27 2015-02-12 Hoffmann La Roche Metodo para la elaboracion de conjugados de la region fc de anticuerpos que comprenden por lo menos una entidad de union que se une especificamente a un objetivo y usos del mismo.
EP2867253B1 (fr) 2012-06-27 2016-09-14 F. Hoffmann-La Roche AG Méthode de sélection et de production d'entités de ciblage personnalisées fortement sélectives et multi-spécifiques renfermant au moins deux entités de liaison différentes et leurs utilisations
SI3081249T1 (sl) 2012-11-21 2021-03-31 Amgen Inc. Naprava za dajanje zdravila
EP2968775B1 (fr) 2013-03-15 2019-12-18 Amgen Inc. Boîte à médicament, autoinjecteur et système d'autoinjecteur
CN104046642B (zh) * 2013-03-15 2018-07-06 兰州大学 发酵生产二聚体化融合蛋白的方法
CN105142695B (zh) 2013-03-15 2020-06-02 安进公司 身体轮廓可调适的自动注射器装置
CN104045715B (zh) * 2013-03-15 2018-05-01 兰州大学 二聚体化融合蛋白的制备及应用
TWI580451B (zh) 2013-03-15 2017-05-01 安美基公司 用於注射器之匣盒及使用具有自動注射器及匣盒之自動注射器設備之方法
SG11201507878SA (en) 2013-03-22 2015-10-29 Amgen Inc Injector and method of assembly
BR112015027291A8 (pt) 2013-05-03 2019-12-24 Selecta Biosciences Inc uso de um imunossupressor que têm uma vida eficaz farmacodinâmica especificada e composição compreendendo o referido imunossupressor
EP3060281B1 (fr) 2013-10-24 2019-01-30 Amgen Inc. Système de distribution de médicaments équipé d'un dispositif de commande sensible à la température
EP3421066B1 (fr) 2013-10-24 2021-03-03 Amgen Inc. Injecteur et procédé d'assemblage
WO2015119906A1 (fr) 2014-02-05 2015-08-13 Amgen Inc. Système d'administration de médicament doté d'un générateur de champ électromagnétique
CN105017408B (zh) * 2014-04-30 2019-11-05 重庆派金生物科技有限公司 聚乙二醇化血小板生成素模拟肽同源四聚体及其用途
HRP20231139T1 (hr) 2014-05-06 2024-01-05 F. Hoffmann - La Roche Ag Proizvodnja heteromultimernih proteina upotrebom stanica sisavaca
JP6640113B2 (ja) 2014-05-07 2020-02-05 アムジエン・インコーポレーテツド 衝撃低減要素を有する自動注入器
CN112237662B (zh) 2014-06-03 2022-10-21 安姆根有限公司 药物递送系统和使用方法
US10112977B2 (en) 2014-06-23 2018-10-30 Toagosei Co., Ltd. Peptide for inducing multinucleation in cells, and use therefor
AP2017009826A0 (en) * 2014-09-26 2017-03-31 Bayer Pharma AG Stabilized adrenomedullin derivatives and use thereof
WO2016061220A2 (fr) 2014-10-14 2016-04-21 Amgen Inc. Dispositif d'injection de médicament comportant des témoins visuels et sonores
CN107001482B (zh) 2014-12-03 2021-06-15 豪夫迈·罗氏有限公司 多特异性抗体
US11357916B2 (en) 2014-12-19 2022-06-14 Amgen Inc. Drug delivery device with live button or user interface field
EP3848072A1 (fr) 2014-12-19 2021-07-14 Amgen Inc. Dispositif d'administration de médicament comportant un capteur de proximité
JP6730705B2 (ja) * 2015-02-12 2020-07-29 国立大学法人岩手大学 哺乳動物細胞に対する外来遺伝子の導入効率の向上剤
CA2976935C (fr) 2015-02-17 2020-03-10 Amgen Inc. Dispositif d'administration de medicament a securisation assistee par depression et/ou retour d'informations
WO2016138434A1 (fr) 2015-02-27 2016-09-01 Amgen Inc. Dispositif d'administration de médicament ayant un mécanisme de protection d'aiguille présentant un seuil réglable de résistance au mouvement de l'élément de protection d'aiguille
WO2017039786A1 (fr) 2015-09-02 2017-03-09 Amgen Inc. Adaptateur d'ensemble de seringue pour une seringue
ES2755717T3 (es) 2015-12-09 2020-04-23 Amgen Inc Autoinyector con tapa de señalización
US11154661B2 (en) 2016-01-06 2021-10-26 Amgen Inc. Auto-injector with signaling electronics
US11200298B2 (en) 2016-03-15 2021-12-14 Amgen Inc. Reducing probability of glass breakage in drug delivery devices
US11541168B2 (en) 2016-04-29 2023-01-03 Amgen Inc. Drug delivery device with messaging label
WO2017192287A1 (fr) 2016-05-02 2017-11-09 Amgen Inc. Adaptateur de seringue et guide pour remplir un injecteur sur le corps
EP3455142B1 (fr) 2016-05-13 2023-08-09 Amgen Inc. Ensemble manchon de flacon
US11238150B2 (en) 2016-05-16 2022-02-01 Amgen Inc. Data encryption in medical devices with limited computational capability
US11541176B2 (en) 2016-06-03 2023-01-03 Amgen Inc. Impact testing apparatuses and methods for drug delivery devices
WO2018004842A1 (fr) 2016-07-01 2018-01-04 Amgen Inc. Dispositif d'administration de médicament présentant un risque réduit au minimum de fracture de composant lors d'événements d'impact
WO2018034784A1 (fr) 2016-08-17 2018-02-22 Amgen Inc. Dispositif d'administration de médicament avec détection de positionnement.
US20200261643A1 (en) 2016-10-25 2020-08-20 Amgen Inc. On-body injector
CN108264547B (zh) * 2016-12-30 2021-09-21 四川科伦博泰生物医药股份有限公司 一种纯化蛋白的方法以及试剂盒
WO2018136398A1 (fr) 2017-01-17 2018-07-26 Amgen Inc. Dispositifs d'injection et procédés d'utilisation et d'assemblage associés
US11369736B2 (en) 2017-02-17 2022-06-28 Amgen Inc. Cannula insertion and retraction mechanisms
US11752258B2 (en) 2017-02-17 2023-09-12 Amgen Inc. Drug delivery device with sterile fluid flowpath and related method of assembly
CA3050927A1 (fr) 2017-03-06 2018-09-13 Brian Stonecipher Dispositif d'administration de medicaments dote d'une fonction de prevention d'activation
KR102627069B1 (ko) 2017-03-07 2024-01-18 암겐 인코포레이티드 과압에 의한 바늘 삽입
EP3592404A1 (fr) 2017-03-09 2020-01-15 Amgen Inc. Mécanisme d'insertion pour dispositif d'administration de médicament
KR102753928B1 (ko) 2017-03-11 2025-01-14 셀렉타 바이오사이언시즈, 인크. 항염증제, 및 면역억제제를 포함하는 합성 나노담체를 사용한 조합 치료와 관련된 방법 및 조성물
KR102651078B1 (ko) 2017-03-28 2024-03-22 암겐 인코포레이티드 플런저 로드 및 주사기 조립 시스템 및 방법
US11590294B2 (en) 2017-06-08 2023-02-28 Amgen Inc. Syringe assembly for a drug delivery device and method of assembly
JP7200134B2 (ja) 2017-06-08 2023-01-06 アムジエン・インコーポレーテツド トルク駆動式薬物送達デバイス
JP7195276B2 (ja) 2017-06-22 2022-12-23 アムジエン・インコーポレーテツド デバイス起動による衝突／衝撃の低減
MA49461A (fr) 2017-06-23 2020-04-29 Amgen Inc Dispositif électronique d'administration de médicament comprenant un bouchon activé par un ensemble commutateur
MA49562A (fr) 2017-07-14 2020-05-20 Amgen Inc Système d'insertion-rétractation d'aiguille présentant un système à ressort en double torsion
EP3655063A1 (fr) 2017-07-21 2020-05-27 Amgen Inc. Élément d'étanchéité perméable aux gaz pour récipient à médicament et procédés d'assemblage
US11484648B2 (en) 2017-07-25 2022-11-01 Amgen Inc. Drug delivery device with container access system and related method of assembly
MA49677A (fr) 2017-07-25 2021-04-21 Amgen Inc Dispositif d'administration de médicament avec module d'engrenage et procédé d'assemblage associé
MA49838A (fr) 2017-08-09 2020-06-17 Amgen Inc Systèm de administration de médicaments avec pression hydraulique-pneumatique de chambre
WO2019036181A1 (fr) 2017-08-18 2019-02-21 Amgen Inc. Injecteur sur-corps avec patch adhésif stérile
US11103636B2 (en) 2017-08-22 2021-08-31 Amgen Inc. Needle insertion mechanism for drug delivery device
WO2019070472A1 (fr) 2017-10-04 2019-04-11 Amgen Inc. Adaptateur d'écoulement destiné à un dispositif d'administration de médicament
CN111132711B (zh) 2017-10-06 2022-07-01 安进公司 带有联锁组件的药物递送装置及相关组装方法
MA50348A (fr) 2017-10-09 2020-08-19 Amgen Inc Dispositif d'administration de médicament comprenant un ensemble d'entraînement et procédé d'assemblage associé
WO2019090086A1 (fr) 2017-11-03 2019-05-09 Amgen Inc. Systèmes et approches pour stériliser un dispositif d'administration de médicament
IL273664B1 (en) 2017-11-06 2026-02-01 Amgen Inc Full-fledged assemblies and related methods
US20200261648A1 (en) 2017-11-06 2020-08-20 Amgen Inc. Drug delivery device with placement and flow sensing
IL319987A (en) 2017-11-10 2025-06-01 Amgen Inc Plungers for drug delivery devices
SG11202003004RA (en) 2017-11-16 2020-04-29 Amgen Inc Door latch mechanism for drug delivery device
AU2018368338B2 (en) 2017-11-16 2024-07-25 Amgen Inc. Autoinjector with stall and end point detection
US10835685B2 (en) 2018-05-30 2020-11-17 Amgen Inc. Thermal spring release mechanism for a drug delivery device
US11083840B2 (en) 2018-06-01 2021-08-10 Amgen Inc. Modular fluid path assemblies for drug delivery devices
EP3586860A1 (fr) * 2018-06-22 2020-01-01 Universität Ulm Inhibiteurs de complément et leurs utilisations
CA3103681A1 (fr) 2018-07-24 2020-01-30 Amgen Inc. Dispositifs d'administration pour l'administration de medicaments
WO2020023336A1 (fr) 2018-07-24 2020-01-30 Amgen Inc. Dispositifs hybrides d'administration de médicament dotés d'une partie de préhension
WO2020023220A1 (fr) 2018-07-24 2020-01-30 Amgen Inc. Dispositifs d'administration de médicament hybrides dotés d'une partie de fixation collante à placer sur la peau et procédé de préparation associé
WO2020023451A1 (fr) 2018-07-24 2020-01-30 Amgen Inc. Dispositifs d'administration pour l'administration de médicaments
EP3829692A1 (fr) 2018-07-31 2021-06-09 Amgen Inc. Ensemble de trajet de fluide pour dispositif d'administration de médicament
EP3856284A1 (fr) 2018-09-24 2021-08-04 Amgen Inc. Systèmes et procédés de dosage interventionnel
MA53718A (fr) 2018-09-28 2022-01-05 Amgen Inc Ensemble d'activation d'échappement de fil de muscle pour un dispositif d'administration de médicament
MX2021003492A (es) 2018-10-02 2021-06-18 Amgen Inc Sistemas de inyeccion para la administracion de farmacos con transmision de fuerza interna.
JP7547325B2 (ja) 2018-10-05 2024-09-09 アムジエン・インコーポレーテツド 投薬量インジケータを有する薬物送達デバイス
SG11202103800RA (en) 2018-10-15 2021-05-28 Amgen Inc Drug delivery device having damping mechanism
AU2019359801B2 (en) 2018-10-15 2025-01-02 Amgen Inc. Platform assembly process for drug delivery device
BR112021007710A2 (pt) * 2018-10-26 2021-08-10 Kyowa Kirin Co., Ltd. composição farmacêutica para tratar anemia aplástica
ES3010833T3 (en) 2018-11-01 2025-04-04 Amgen Inc Drug delivery devices with partial drug delivery member retraction
MA54057A (fr) 2018-11-01 2022-02-09 Amgen Inc Dispositifs d'administration de médicament à rétraction partielle d'élément d'administration de médicament
TWI831847B (zh) 2018-11-01 2024-02-11 美商安進公司 部分針頭縮回之藥物遞送裝置及其操作方法
AU2020263289B2 (en) 2019-04-24 2025-05-22 Amgen Inc. Syringe sterilization verification assemblies and methods
WO2020223303A1 (fr) 2019-04-29 2020-11-05 The Children's Hospital Of Philadelphia Compositions et procédés pour augmenter la production de mégacaryocytes
EP3980784A1 (fr) 2019-06-04 2022-04-13 Selecta Biosciences, Inc. Formulations et doses d'uricase pégylée
MX2022002149A (es) 2019-08-23 2022-03-17 Amgen Inc Dispositivo de suministro de farmacos con componentes de acoplamiento de capuchon de aguja configurable y metodos relacionados.
ES3040791T3 (en) 2020-12-18 2025-11-05 Richter Gedeon Nyrt Methods for the purification of refolded fc-peptide fusion protein
EP4340890A4 (fr) * 2021-02-24 2025-11-19 Purdue Research Foundation Compositions ostéootropiques et leurs utilisations
CN113402614A (zh) * 2021-04-22 2021-09-17 山东泉港药业有限公司 血小板生成素拟肽融合蛋白(fc-tmp)编码基因与应用
MX2023013640A (es) 2021-05-21 2023-11-30 Amgen Inc Metodo de optimizacion de una receta de llenado para un contenedor de medicamento.
WO2023044774A1 (fr) * 2021-09-24 2023-03-30 Sichuan Clover Biopharmaceuticals, Inc. Protéines de fusion mimétiques de tpo et procédés d'utilisation de la soumission de listage de séquences dans un fichier de texte ascii
WO2023149443A1 (fr) 2022-02-02 2023-08-10 国立大学法人 筑波大学 Composition pharmaceutique pour la récupération des cellules sanguines après une greffe de sang de cordon
EP4476356A1 (fr) 2022-03-24 2024-12-18 Richter Gedeon Nyrt. Procédé de fabrication de produits biopharmaceutiques
CA3264659A1 (fr) 2022-08-11 2024-02-15 Cartesian Therapeutics, Inc. Compositions et procédés associés à des protéases d'immunoglobuline et à des fusions de celles-ci
WO2025037108A2 (fr) 2023-08-15 2025-02-20 Board Of Trustees Of The Leland Stanford Junior University Thrombopoïétine modifiée
CN117986346B (zh) * 2024-04-07 2024-07-26 中国人民解放军军事科学院军事医学研究院 一种tpo模拟肽及其应用
WO2026030152A1 (fr) 2024-07-29 2026-02-05 Amgen Inc. Système et procédé d'évaluation de la transférabilité d'une recette de remplissage
CN119780301B (zh) * 2025-01-10 2025-08-01 山东泉港药业有限公司 一种血小板生成素拟肽的肽图检测分析方法

Family Cites Families (178)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA705953B (en) * 1969-09-01 1971-09-29 Geetainers Ltd Cover-lock for containers
US3691016A (en) 1970-04-17 1972-09-12 Monsanto Co Process for the preparation of insoluble enzymes
CA1023287A (fr) 1972-12-08 1977-12-27 Boehringer Mannheim G.M.B.H. Procede de fixation d'une proteine sur un substrat
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US3941763A (en) 1975-03-28 1976-03-02 American Home Products Corporation PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates
US4002531A (en) * 1976-01-22 1977-01-11 Pierce Chemical Company Modifying enzymes with polyethylene glycol and product produced thereby
US4195128A (en) 1976-05-03 1980-03-25 Bayer Aktiengesellschaft Polymeric carrier bound ligands
US4330440A (en) 1977-02-08 1982-05-18 Development Finance Corporation Of New Zealand Activated matrix and method of activation
CA1093991A (fr) 1977-02-17 1981-01-20 Hideo Hirohara Traduction non-disponible
US4229537A (en) 1978-02-09 1980-10-21 New York University Preparation of trichloro-s-triazine activated supports for coupling ligands
US4289872A (en) 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4503235A (en) 1983-03-11 1985-03-05 Warner-Lambert Company Process for producing 4-carbamoyl-1H-imidazolium-5-olate
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
EP0154316B1 (fr) 1984-03-06 1989-09-13 Takeda Chemical Industries, Ltd. Lymphokine chimiquement modifiée et son procédé de préparation
EP0173494A3 (fr) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Récepteurs chimériques par liaison et expression de l'ADN
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
US5017691A (en) * 1986-07-03 1991-05-21 Schering Corporation Mammalian interleukin-4
US5985599A (en) * 1986-05-29 1999-11-16 The Austin Research Institute FC receptor for immunoglobulin
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
WO1988001213A1 (fr) 1986-08-18 1988-02-25 Clinical Technologies Associates, Inc. Systemes de distribution pour agents pharmacologiques
US5229490A (en) 1987-05-06 1993-07-20 The Rockefeller University Multiple antigen peptide system
US5336603A (en) 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
DE3889853D1 (de) 1987-11-05 1994-07-07 Hybritech Inc Polysaccharidmodifizierte Immunglobuline mit reduziertem immunogenem Potential oder verbesserter Pharmakokinetik.
US4904584A (en) * 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
EP0721983A1 (fr) 1988-01-22 1996-07-17 ZymoGenetics, Inc. Procédé de préparation de peptides dimères biologiquement actifs
CA1340810C (fr) 1988-03-31 1999-11-02 Motoo Yamasaki Derives de polypeptides actifs comme facteurs stimulant les colonies de granulocytes chez l'homme
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8824591D0 (en) 1988-10-20 1988-11-23 Royal Free Hosp School Med Fractionation process
EP1201757A3 (fr) * 1988-12-22 2002-09-11 Genentech, Inc. Procédé de préparation de polypeptides solubles dans l'eau
WO1990006952A1 (fr) 1988-12-22 1990-06-28 Kirin-Amgen, Inc. Facteur de stimulation de colonies de granulocytes modifies chimiquement
US5089261A (en) * 1989-01-23 1992-02-18 Cetus Corporation Preparation of a polymer/interleukin-2 conjugate
US4902502A (en) 1989-01-23 1990-02-20 Cetus Corporation Preparation of a polymer/interleukin-2 conjugate
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5216131A (en) * 1989-02-23 1993-06-01 Genentech, Inc. Lymphocyte homing receptors
US5098833A (en) * 1989-02-23 1992-03-24 Genentech, Inc. DNA sequence encoding a functional domain of a lymphocyte homing receptor
US5627262A (en) * 1989-07-05 1997-05-06 The Board Of Regents Of The University Of Oklahoma Method and composition for the treatment of septic shock
DE59010908D1 (de) * 1989-09-12 2000-08-10 Hoffmann La Roche TNF-bindende Proteine
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
JPH04218000A (ja) 1990-02-13 1992-08-07 Kirin Amgen Inc 修飾ポリペプチド
US5723286A (en) * 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
CA2109602C (fr) 1990-07-10 2002-10-01 Gregory P. Winter Methodes de production de membres de paires de liaison specifiques
ATE224911T1 (de) 1990-07-17 2002-10-15 Univ Oklahoma Gmp-140 ligand
IE912365A1 (en) 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
US5252714A (en) * 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
NZ241954A (en) 1991-03-15 1994-01-26 Amgen Inc Compositions of g-csf for pulmonary administration.
GEP20033082B (en) 1991-03-15 2003-10-27 Amgen Inc Pegylation of Polypeptides
US5595732A (en) * 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
US6139843A (en) 1991-04-02 2000-10-31 Albert Einstein College Of Medicine Of Yeshiva University Peptide compositions for the treatment of HIV
US5281698A (en) * 1991-07-23 1994-01-25 Cetus Oncology Corporation Preparation of an activated polymer ester for protein conjugation
US5362852A (en) * 1991-09-27 1994-11-08 Pfizer Inc. Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties
US5733731A (en) * 1991-10-16 1998-03-31 Affymax Technologies N.V. Peptide library and screening method
US5270170A (en) * 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
NZ244778A (en) 1991-10-21 1994-03-25 Ortho Pharma Corp Peg imidates and protein derivatives thereof
KR100283541B1 (ko) * 1991-10-25 2001-03-02 크리스토퍼 엘. 와이트, 스코트 지. 홀퀴스트, 스티븐 엘. 말라스카 신규 사이토킨
US5376367A (en) * 1991-11-22 1994-12-27 Immunex Corporation Fusion proteins comprising MGF and IL-3
ATE156158T1 (de) 1992-04-14 1997-08-15 Cornell Res Foundation Inc Makromoleküle auf basis von dendritischen polymeren und verfahren zur herstellung
DK0615451T3 (da) 1992-05-26 2006-04-24 Immunex Corp Hidtil ukendt cytokin der binder til CD30
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
CA2142007C (fr) * 1992-08-11 2007-10-30 Robert Glen Urban Peptides immunomodulateurs
EP0672068A4 (fr) * 1992-09-25 1997-02-26 Commw Scient Ind Res Org Polypeptide se fixant a une cible.
GB9225448D0 (en) 1992-12-04 1993-01-27 Erba Carlo Spa Improved synthesis of polymer bioactive conjugates
NZ247231A (en) * 1993-03-23 1994-10-26 Holyoake Ind Ltd Diffuser for air conditioning system; outlet air direction thermostatically controlled
WO1995009917A1 (fr) 1993-10-07 1995-04-13 The Regents Of The University Of California Anticorps bispecifiques et tetravalents, obtenus par genie genetique
US5922545A (en) * 1993-10-29 1999-07-13 Affymax Technologies N.V. In vitro peptide and antibody display libraries
US5773569A (en) * 1993-11-19 1998-06-30 Affymax Technologies N.V. Compounds and peptides that bind to the erythropoietin receptor
US5981478A (en) 1993-11-24 1999-11-09 La Jolla Cancer Research Foundation Integrin-binding peptides
SG47030A1 (en) 1994-01-03 1998-03-20 Genentech Inc Thrombopoietin
US5608035A (en) * 1994-02-02 1997-03-04 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
US5786331A (en) * 1994-02-02 1998-07-28 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
US5880096A (en) * 1994-02-02 1999-03-09 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
KR100260272B1 (ko) * 1994-02-14 2000-07-01 마나배 게이사꾸 Tpo활성을 갖는 단백질의 아미노산을 코딩하는 염기 서열을 포함하는 dna
WO1995021919A2 (fr) 1994-02-14 1995-08-17 Kirin Brewery Company, Limited Proteine a activite de thrombopoietine (tpo)
NZ271230A (en) 1994-02-14 1998-03-25 Zymogenetics Inc Hematopoietic proteins, production and use
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
DE69503849T2 (de) 1994-03-31 1999-04-01 Amgen Inc., Thousand Oaks, Calif. Zusammensetzungen und Verfahren zur Anregung des Wachstums und der Differenzierung von Megakaryozyten
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
IL111196A0 (en) 1994-10-07 1994-12-29 Yeda Res & Dev Peptides and pharmaceutical compositions comprising them
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
AU693478B2 (en) * 1994-11-10 1998-07-02 Metabolic Pharmaceuticals Limited Treatment of obesity
IL116026A (en) * 1994-11-22 2005-08-31 Rhone Poulenc Rorer Sa Peptides capable of linking to the sh3 domain of gap, nucleotide sequences encoding the same, their preparation and uses
JP3511321B2 (ja) * 1994-11-29 2004-03-29 出光興産株式会社 スチレン系重合体の分子量制御方法
US5641655A (en) * 1994-11-30 1997-06-24 Zymogenetics, Inc. Methods for producing thrombopoietin polypeptides using a mammalian tissue plasminogen activator secretory peptide
CA2206848A1 (fr) 1994-12-07 1996-06-13 Bionebraska, Inc. Production de peptides au moyen de proteines de fusion de recombinaison
EP1621206A1 (fr) 1994-12-12 2006-02-01 Beth Israel Deaconess Medical Center, Inc. Cytokines chimeres et leur utilisation
US5888763A (en) * 1994-12-30 1999-03-30 The Rockefeller University Peptides specific for the first Crk-SH3 domain
WO1996023899A1 (fr) 1995-02-01 1996-08-08 University Of Massachusetts Medical Center Procedes de selection d'un peptide aleatoire se liant a une proteine cible
IL113159A0 (en) 1995-03-28 1995-06-29 Yeda Res & Dev Synthetic peptides and pharmaceutical compositions comprising them
US5739277A (en) 1995-04-14 1998-04-14 Genentech Inc. Altered polypeptides with increased half-life
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
EA001220B1 (ru) * 1995-06-07 2000-12-25 Глаксо Груп Лимитед Пептид или пептидомиметик, который связывается с рецептором тромбоэтина, фармацевтическая композиция и способ лечения
US5767078A (en) 1995-06-07 1998-06-16 Johnson; Dana L. Agonist peptide dimers
YU34196A (sh) * 1995-06-07 1999-03-04 Glaxo Group Limited Peptidi i jedinjenja koja se vezuju za receptor
US6251864B1 (en) * 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
IL118524A (en) 1995-06-19 2004-02-19 Akzo Nobel Nv Peptides and pharmaceutical preparations containing them useful in the treatment of peptide tolerance
CA2226575C (fr) 1995-07-27 2011-10-18 Genentech, Inc. Formulation de proteine lyophilisee isotonique et stable
US5746516A (en) * 1995-08-11 1998-05-05 Hitachi Powdered Metals Co., Ltd. Porous bearing system having internal grooves and electric motor provided with the same
WO1997008553A1 (fr) 1995-08-22 1997-03-06 The Regents Of The University Of California Ciblage de proteine sur la paroi cellulaire de bacteries gram-positives
US5817750A (en) 1995-08-28 1998-10-06 La Jolla Cancer Research Foundation Structural mimics of RGD-binding sites
JPH09151200A (ja) 1995-09-29 1997-06-10 Ajinomoto Co Inc ヒト胃癌に対する免疫応答を誘導できるペプチド及び該ペプチドを含むヒト胃癌治療、予防剤
US5670110A (en) 1995-12-21 1997-09-23 The Procter & Gamble Company Method for making three-dimensional macroscopically-expanded webs having improved functional surfaces
US6369027B1 (en) 1995-12-22 2002-04-09 Amgen Inc. Osteoprotegerin
CN1154971A (zh) * 1996-01-19 1997-07-23 北京医科大学 血小板生长因子(tpo)及其制备方法和用途
US5714577A (en) * 1996-01-26 1998-02-03 University Of Pittsburgh Antimicrobial peptides
CA2244664C (fr) 1996-02-09 2008-06-03 Amgen Inc. Composition comprenant un inhibiteur de l'interleukine 1 et un polymere a liberation controlee
IL117223A0 (en) 1996-02-22 1996-06-18 Yeda Res & Dev Antipathogenic polypeptides and compositions comprising them
ATE279947T1 (de) 1996-03-18 2004-11-15 Univ Texas Immunglobulinähnliche domäne mit erhöhten halbwertszeiten
JP4088344B2 (ja) 1996-03-28 2008-05-21 カイロン コーポレイション ウロキナーゼレセプターのペプチドリガンド
IL118003A0 (en) 1996-04-23 1996-08-04 Yeda Res & Dev Novel vip fragments and pharmaceutical compositions comprising them
FR2748028B1 (fr) 1996-04-30 1998-08-14 Lab Francais Du Fractionnement Peptides derives du facteur von willebrand et leur utilisation comme anticoagulant
US6100071A (en) 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
WO1997046668A1 (fr) 1996-06-07 1997-12-11 Takeda Chemical Industries, Ltd. Peptide, procede de production et mode d'utilisation correspondants
US6126939A (en) 1996-09-03 2000-10-03 Yeda Research And Development Co. Ltd. Anti-inflammatory dipeptide and pharmaceutical composition thereof
JP2001501600A (ja) 1996-09-10 2001-02-06 ザ バーナム インスティテュート 腫瘍ホーミング分子、それに由来する結合体、およびその使用方法
US5932546A (en) 1996-10-04 1999-08-03 Glaxo Wellcome Inc. Peptides and compounds that bind to the thrombopoietin receptor
CA2273852C (fr) 1996-12-06 2009-09-29 Amgen Inc. Therapie combinee utilisant un inhibiteur de l'il-1 pour traiter les maladies induites par l'il-1
CA2275183A1 (fr) 1996-12-20 1998-07-02 Amgen Inc. Procedes et compositions de proteines de fusion ob
KR19980066046A (ko) 1997-01-18 1998-10-15 정용훈 고역가의 CTLA4-Ig 융합단백질
WO1998033812A1 (fr) 1997-02-05 1998-08-06 Brigham And Women's Hospital, Inc. Inhibiteurs peptidiques des proteases de mastocytes
US5863735A (en) 1997-02-24 1999-01-26 Incyte Pharmaceuticals, Inc. Human transmembrane 4 superfamily protein
SI0975754T2 (sl) 1997-04-16 2016-04-29 Amgen Inc., Vezivni proteini in receptorji osteoprotegerina
CN1202862C (zh) 1997-04-17 2005-05-25 安姆根有限公司 包含具有抗体Fc链的稳定、有活性人OB蛋白的结合物的组合物及方法
US6265535B1 (en) 1997-05-30 2001-07-24 The Trustees Of The University Of Pennsylvania Peptides and peptide analogues designed from binding sites of tumor necrosis factor receptor superfamily and their uses
IL133315A0 (en) 1997-06-06 2001-04-30 Regeneron Pharma Ntn-2 member of tnf ligand family
CA2298067A1 (fr) 1997-07-24 1999-02-04 Ulo Langel Conjugues de peptides transporteurs et analogues d'acides nucleiques ainsi que leur utilisation
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
US6238667B1 (en) 1997-09-19 2001-05-29 Heinz Kohler Method of affinity cross-linking biologically active immunogenic peptides to antibodies
AU9790798A (en) 1997-10-06 1999-04-27 Millennium Pharmaceuticals, Inc. Signal peptide containing proteins and uses therefor
JP4439111B2 (ja) 1997-10-10 2010-03-24 サイトビア インコーポレイテッド ジペプチドのアポトーシスインヒビターおよびそれらの使用
JP2001522863A (ja) 1997-11-07 2001-11-20 コンジュケム，インコーポレーテッド Ｒｇｄ含有ペプチドおよび内因性担体の新規コンジュゲート
AU2481399A (en) 1998-01-29 1999-08-16 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Variant peptide ligands that selectively induce apoptosis
US6162613A (en) 1998-02-18 2000-12-19 Vertex Pharmaceuticals, Inc. Methods for designing inhibitors of serine/threonine-kinases and tyrosine kinases
DE69921102T2 (de) * 1998-03-05 2006-02-02 Chiron Corp., Emeryville Verfahren zur verbesserung der serum-halbwertszeit von biologisch aktiven molekülen
US6235872B1 (en) 1998-03-12 2001-05-22 The Burnham Institute Proapoptotic peptides dependence polypeptides and methods of use
JP4361684B2 (ja) 1998-03-20 2009-11-11 中外製薬株式会社 エリトロポエチン受容体のためのペプチドリガンド
EP0947524A1 (fr) 1998-03-30 1999-10-06 Upither B.V. Nouveaux peptides destinés au traitement de maladies auto-immunes
JP2002510641A (ja) 1998-04-06 2002-04-09 アドヴァンスト・イミューニット・インク 神経退化疾患治療用短ペプチド
ATE399567T1 (de) * 1998-04-28 2008-07-15 Serono Lab Peg konjugate von lhrh analogen
EP0972780A1 (fr) 1998-05-18 2000-01-19 Applied Research Systems ARS Holding N.V. Peptides antagonistes de l'Il-6
ES2218796T3 (es) 1998-05-21 2004-11-16 Tecnogen Scpa Uso de un compuesto peptidico para el tratamiento del lupus erimatoso sistemico.
JP3753612B2 (ja) 1998-05-22 2006-03-08 アボット・ラボラトリーズ 抗血管新生作用を有するペプチド医薬
US5932548A (en) 1998-06-03 1999-08-03 Deghenghi; Romano Lysine containing peptides for treatment of heart disease
WO2000001402A1 (fr) 1998-07-02 2000-01-13 Envision Biomedical Consulting Proteines et peptides antiproliferants et antiviraux
US6168785B1 (en) 1998-07-16 2001-01-02 Institut Pasteur Biological applications of new peptides of IL-2 and derivatives and use as therapeutic agents
EP1105427A2 (fr) 1998-08-17 2001-06-13 Abgenix, Inc. Production de molecules modifiees avec demi-vie serique prolongee
AU5300299A (en) 1998-08-21 2000-03-14 Yeda Research And Development Co. Ltd. Anti-inflammatory peptides derived from il-2 and analogues thereof
US6660843B1 (en) * 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US7488590B2 (en) * 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
HK1042114B (zh) * 1998-10-23 2006-09-29 Amgen K-A, Inc. 与mp1受体结合并具有血小板生成活性的模拟二聚体血小板生成素肽
AU2880400A (en) 1999-02-12 2000-08-29 Amgen, Inc. Tnf-related proteins
US6635646B1 (en) * 1999-05-04 2003-10-21 Schering Corporation Pegylated interferon alfa-CCR5 antagonist combination HIV therapy
IL147270A0 (en) 1999-07-02 2002-08-14 Genentech Inc Fusion peptides comprising a peptide ligand domain and a multimerization domain
US6586398B1 (en) * 2000-04-07 2003-07-01 Amgen, Inc. Chemically modified novel erythropoietin stimulating protein compositions and methods
AU5943201A (en) 2000-05-03 2001-11-12 Amgen Inc Modified peptides as therapeutic agents
AU2002234001B2 (en) 2000-12-05 2008-05-01 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
US7396917B2 (en) 2000-12-05 2008-07-08 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
WO2002078612A2 (fr) 2001-04-02 2002-10-10 Euro-Celtique S.A. Anticorps synthetique contenant de la thrombopoietine (tpo) pour la stimulation de la production de plaquettes
US7205275B2 (en) 2001-10-11 2007-04-17 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2
US7332474B2 (en) * 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
US7138370B2 (en) 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
BR0312276A (pt) 2002-06-28 2005-04-26 Centocor Inc Mimeticorpos ch1-removidos miméticos de epo de mamìfero, composições, métodos e usos
CA2490409A1 (fr) 2002-06-28 2004-01-08 Centocor, Inc. Corps mimetiques mammaliens a deletion ch1, compositions, procedes et utilisations
US6919426B2 (en) * 2002-09-19 2005-07-19 Amgen Inc. Peptides and related molecules that modulate nerve growth factor activity
WO2004039337A2 (fr) 2002-10-31 2004-05-13 Protein Design Labs, Inc. Formulations pharmaceutiques liquides stables d'anticorps ayant tendance a l'isomerisation
KR20110086881A (ko) 2002-12-20 2011-08-01 암겐 인코포레이티드 미오스타틴을 저해하는 결합제
UA82710C2 (uk) 2003-08-28 2008-05-12 Орто-Макнейл Фармацевтикал, Инк. Пептид, що зв'язується з тромбопоетиновим рецептором (варіанти), та спосіб лікування тромбоциторенії (варіанти)
CA2572765C (fr) * 2004-07-08 2013-05-21 Amgen Inc. Peptides therapeutiques
US7442778B2 (en) * 2004-09-24 2008-10-28 Amgen Inc. Modified Fc molecules
CA2600749C (fr) 2005-03-10 2014-04-15 Nascacell Ip Gmbh Microproteines dimeriques ou multimeriques
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
EP1986677A2 (fr) * 2006-01-25 2008-11-05 Amgen Inc. Composes thrombopoietiques
US9283260B2 (en) 2006-04-21 2016-03-15 Amgen Inc. Lyophilized therapeutic peptibody formulations
US7981425B2 (en) * 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
US8197642B2 (en) * 2007-07-26 2012-06-12 Nichiha Corporation Inorganic board and method for manufacturing the same
US10534898B2 (en) 2017-01-18 2020-01-14 International Business Machines Corporation Code identification

Also Published As

Publication number Publication date
CY2009012I2 (el) 2010-07-28
AU773891C (en) 2005-02-17
EP1783222A1 (fr) 2007-05-09
KR20010099695A (ko) 2001-11-09
PL348041A1 (en) 2002-05-06
BG66190B1 (bg) 2011-12-30
CY1113107T1 (el) 2016-04-13
AR020934A1 (es) 2002-06-05
NO20011962L (no) 2001-06-21
HUP0104327A2 (hu) 2002-02-28
LTC1124961I2 (lt) 2022-03-25
NO2012005I2 (no) 2015-02-02
PT2319928E (pt) 2013-06-28
HK1042114B (zh) 2006-09-29
EA200100465A1 (ru) 2001-10-22
NL300398I2 (nl) 2009-12-01
LTPA2009006I1 (lt) 2022-03-10
CN1250721C (zh) 2006-04-12
NZ510529A (en) 2003-10-31
US20090186822A1 (en) 2009-07-23
HU228582B1 (en) 2013-04-29
DK2319928T3 (da) 2013-06-24
PL219605B1 (pl) 2015-06-30
DE69934425T2 (de) 2007-09-27
LU91598I9 (fr) 2019-01-03
CN1325447A (zh) 2001-12-05
BR9914698A (pt) 2003-01-07
CY1114940T1 (el) 2016-12-14
US9534032B2 (en) 2017-01-03
SK287737B6 (sk) 2011-08-04
IL142023A0 (en) 2002-03-10
US20070142295A1 (en) 2007-06-21
US20060189531A1 (en) 2006-08-24
DE122009000039I1 (de) 2009-11-05
CY1107526T1 (el) 2010-07-28
ES2422231T3 (es) 2013-09-09
EP1783222B1 (fr) 2012-06-06
BG110221A (en) 2009-06-30
US8618044B2 (en) 2013-12-31
US7994117B2 (en) 2011-08-09
US20120034657A1 (en) 2012-02-09
WO2000024770A9 (fr) 2000-10-26
KR100719202B1 (ko) 2007-05-16
CA2346996C (fr) 2013-11-19
US8748571B2 (en) 2014-06-10
CN1810832A (zh) 2006-08-02
BG105401A (en) 2003-02-28
HK1042114A1 (en) 2002-08-02
SI2319928T1 (sl) 2013-08-30
US8044174B2 (en) 2011-10-25
SI1124961T1 (sl) 2007-06-30
AU773891B2 (en) 2004-06-10
LU91598I2 (fr) 2009-09-30
NL300398I1 (nl) 2009-10-01
SK4962001A3 (en) 2001-12-03
US20150024431A1 (en) 2015-01-22
PT1783222E (pt) 2012-07-26
AU1223900A (en) 2000-05-15
EA003998B1 (ru) 2003-12-25
DK1783222T3 (da) 2012-07-09
PT1124961E (pt) 2007-02-28
JP2006230413A (ja) 2006-09-07
HK1093075A1 (en) 2007-02-23
BRPI9914698B8 (pt) 2021-05-25
ES2279649T3 (es) 2007-08-16
NO2012005I1 (no) 2012-04-02
ZA200102102B (en) 2001-11-15
EP1124961B9 (fr) 2010-07-21
FR09C0030I2 (fr) 2010-12-31
DE69934425D1 (en) 2007-01-25
TWI250988B (en) 2006-03-11
EP2319928A1 (fr) 2011-05-11
JP2002536960A (ja) 2002-11-05
ATE348163T1 (de) 2007-01-15
MEP42108A (en) 2011-02-10
CZ20011287A3 (cs) 2001-10-17
NO331027B1 (no) 2011-09-12
MY126795A (en) 2006-10-31
ES2388341T3 (es) 2012-10-11
FR09C0030I1 (fr) 2009-09-25
JP4332163B2 (ja) 2009-09-16
TW200606175A (en) 2006-02-16
US6835809B1 (en) 2004-12-28
EP1124961B1 (fr) 2006-12-13
WO2000024770A2 (fr) 2000-05-04
CY2009012I1 (el) 2010-07-28
JP3820105B2 (ja) 2006-09-13
SI1783222T1 (en) 2012-09-28
YU24301A (sh) 2005-07-19
WO2000024770A3 (fr) 2000-09-14
US20120208760A1 (en) 2012-08-16
US9145450B2 (en) 2015-09-29
ME00238B (me) 2011-02-10
BR9914698B1 (pt) 2014-04-29
TWI257394B (en) 2006-07-01
RS51237B (sr) 2010-12-31
EP2319928B1 (fr) 2013-03-27
HUP0104327A3 (en) 2003-09-29
BG65663B1 (bg) 2009-05-29
CA2346996A1 (fr) 2000-05-04
CZ302155B6 (cs) 2010-11-18
CN1810832B (zh) 2012-12-12
NO20011962D0 (no) 2001-04-20
US20050080014A1 (en) 2005-04-14
EP1124961A2 (fr) 2001-08-22
EP2319928B9 (fr) 2014-04-16

Similar Documents

Publication Publication Date Title
NL300398I2 (nl) Thrombopoïete verbindingen
ATE229954T1 (de) Betacarbolinverbindungen
ID28266A (id) Senyawa-senyawa amidin
NO20011745L (no) Forbindelser
DE69905038D1 (de) Cyclische boroprolinverbindungen
ID22850A (id) Senyawa-senyawa pirazina
FI4209U1 (fi) Uusia yhdisteitä
ID20323A (id) Senyawa-senyawa triazinilaminostilbena
EE9900448A (et) Ühendid
NO20005006L (no) Kalsilytiske forbindelser
DE69939378D1 (de) Antithrombotische verbindungen
NO20006662L (no) Fluorfenylresin-forbindelser
EE9900475A (et) Ühendid
EE9900602A (et) Ühendid
ID22983A (id) Senyawa-senyawa fluorometoksimino
EE9900466A (et) Ühendid
DE69737634D1 (de) Insektizide oxadiazinverbindungen
SE9800626D0 (sv) Compounds
IDP000021799A (id) Senyawa-senyawa pirolum tersubstitusi
IDP000021790A (id) Senyawa-senyawa pirolum tersubstitusi
SE9800509D0 (sv) New Compounds
SE9800977D0 (sv) New compounds
SE9800508D0 (sv) New Compounds
SE9800512D0 (sv) New compounds
SE9803746D0 (sv) New compounds