DK1129066T3 - Fremstilling af 2-amino-2-[2-(C2-20alkylphenyl)ethyl]propan-1,3-dioler - Google Patents
Fremstilling af 2-amino-2-[2-(C2-20alkylphenyl)ethyl]propan-1,3-diolerInfo
- Publication number
- DK1129066T3 DK1129066T3 DK99971797T DK99971797T DK1129066T3 DK 1129066 T3 DK1129066 T3 DK 1129066T3 DK 99971797 T DK99971797 T DK 99971797T DK 99971797 T DK99971797 T DK 99971797T DK 1129066 T3 DK1129066 T3 DK 1129066T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkylphenyl
- diols
- amino
- ethyl
- propane
- Prior art date
Links
- 125000005037 alkyl phenyl group Chemical group 0.000 title 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 title 1
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical class OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 title 1
- RDHPKYGYEGBMSE-UHFFFAOYSA-N bromoethane Chemical compound CCBr RDHPKYGYEGBMSE-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/20—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms
- C07C17/202—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction
- C07C17/208—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction the other compound being MX
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C22/00—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom
- C07C22/02—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings
- C07C22/04—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9824705.9A GB9824705D0 (en) | 1998-11-11 | 1998-11-11 | Organic compounds |
| GBGB9824706.7A GB9824706D0 (en) | 1998-11-11 | 1998-11-11 | Organic compounds |
| EP99971797A EP1129066B1 (de) | 1998-11-11 | 1999-11-09 | Herstellung von 2-amino-2(2-(4-alkylphenyl)äthyl)propan-1,3-diolen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1129066T3 true DK1129066T3 (da) | 2005-03-29 |
Family
ID=26314659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99971797T DK1129066T3 (da) | 1998-11-11 | 1999-11-09 | Fremstilling af 2-amino-2-[2-(C2-20alkylphenyl)ethyl]propan-1,3-dioler |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6605744B2 (de) |
| EP (2) | EP1457478B1 (de) |
| JP (1) | JP4503184B2 (de) |
| AT (1) | ATE288414T1 (de) |
| AU (1) | AU1161400A (de) |
| DE (1) | DE69923579T2 (de) |
| DK (1) | DK1129066T3 (de) |
| ES (2) | ES2237970T3 (de) |
| PT (2) | PT1129066E (de) |
| WO (1) | WO2000027798A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002018395A1 (en) | 2000-08-31 | 2002-03-07 | Merck & Co., Inc. | Phosphate derivatives as immunoregulatory agents |
| BR0306811A (pt) | 2002-01-11 | 2004-10-26 | Sankyo Co | Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero |
| JP2005272453A (ja) | 2004-02-24 | 2005-10-06 | Sankyo Co Ltd | アミノアルコール化合物 |
| MX2007001236A (es) | 2004-07-30 | 2007-03-23 | Novartis Ag | Formulaciones de compuestos de 2-amino-1, 3-propanodiol. |
| WO2007022718A1 (fr) * | 2005-08-25 | 2007-03-01 | Chunde Liu | Alcools alkylaryle, leurs derives et leur procede de preparation |
| US20090176744A1 (en) * | 2007-11-02 | 2009-07-09 | Concert Pharmaceuticals, Inc. | Deuterated fingolimod |
| PL2268603T3 (pl) | 2008-03-19 | 2015-07-31 | Novartis Ag | Proces wytwarzania 2-amino-2-[2-(4-C3-C21-alkilo-fenylo)etylo]propano-1,3-dioli |
| MX2011004924A (es) * | 2008-11-11 | 2011-05-30 | Novartis Ag | Sales de fingolimod. |
| CA2743232C (en) * | 2008-11-11 | 2015-12-29 | Novartis Ag | Crystalline forms of fingolimod hcl |
| JP5593164B2 (ja) * | 2010-06-29 | 2014-09-17 | 株式会社クラレ | 第１級アルキルハライドの製造方法 |
| EP2621889B1 (de) | 2010-10-01 | 2019-07-17 | Synthon BV | Verfahren zur herstellung von fingolimod-hydrochloridkristallen |
| PL2632889T3 (pl) | 2010-10-28 | 2019-04-30 | Mapi Pharma Ltd | Związki pośrednie i sposób wytwarzania fingolimodu |
| WO2012071524A1 (en) | 2010-11-24 | 2012-05-31 | Ratiopharm Gmbh | Arylsulfonate salts of fingolimod and processes for preparation thereof |
| EP2658840B1 (de) | 2010-12-28 | 2019-07-03 | Synthon BV | Verfahren zur herstellung von fingolimod-hydrochloridkristallen |
| EP2702034A4 (de) | 2011-04-29 | 2015-03-25 | Reddys Lab Ltd Dr | Herstellung von fingolimod und dessen salzen |
| CN103539683A (zh) * | 2012-07-17 | 2014-01-29 | 广东东阳光药业有限公司 | 治疗硬化病的药物的新晶型及其制备方法 |
| CN102796022B (zh) * | 2012-08-27 | 2015-03-25 | 南京华威医药科技开发有限公司 | 制备2-氨基-2-[2-(4-烷基苯基)乙基]-1,3-丙二醇盐酸盐的方法 |
| EP2945927A4 (de) | 2013-01-17 | 2017-01-18 | Shilpa Medicare Limited | Herstellung von fingolimod und seinen salzen |
| US9815772B2 (en) * | 2013-03-05 | 2017-11-14 | Biocon Limited | Process for the preparation of 2-amino-1,3-propane diol compounds and salts thereof |
| WO2015092809A2 (en) | 2013-11-25 | 2015-06-25 | Emcure Pharmaceuticals Limited | Fingolimod hydrochloride process |
| CN115916201B (zh) | 2020-06-26 | 2024-09-17 | 国立大学法人大阪大学 | 药剂诱发性心动过缓及心动过缓性心律失常治疗药 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE269856C (de) | ||||
| JPS5912643B2 (ja) | 1975-04-03 | 1984-03-24 | 和光純薬工業 （株） | フエネチルブロマイド類の製法 |
| JPS52108943A (en) | 1976-03-10 | 1977-09-12 | Teikoku Hormone Mfg Co Ltd | Alkyl phenyl ketone derivative |
| JPS5951932B2 (ja) | 1980-04-14 | 1984-12-17 | 東ソー株式会社 | ハロベンゼン類とオレフィン類との付加化合物の製造方法 |
| DD269856A1 (de) * | 1988-03-03 | 1989-07-12 | Univ Halle Wittenberg | Fluessig-kristalline amphiphile |
| US5604229A (en) * | 1992-10-21 | 1997-02-18 | Yoshitomi Pharmaceutical Industries, Ltd. | 2-amino-1,3-propanediol compound and immunosuppressant |
| US5508272A (en) | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
| IT1265101B1 (it) * | 1993-07-23 | 1996-10-30 | Erba Carlo Spa | Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico |
| DE69524962D1 (de) | 1994-08-22 | 2002-02-14 | Welfide Corp | Benzolderivate und deren medizinische verwendung |
| GB9624038D0 (en) | 1996-11-19 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| WO1999001420A1 (en) | 1997-07-03 | 1999-01-14 | Taito Co., Ltd. | Process for the preparation of 2-aminomalonic acid derivatives and intermediates used in the process |
| JP4079505B2 (ja) | 1998-04-28 | 2008-04-23 | 田辺三菱製薬株式会社 | ２−アミノ−２−［２−（４−オクチルフェニル）エチル］プロパン−１，３−ジオールの新規な製造法 |
-
1999
- 1999-11-09 EP EP04005240.9A patent/EP1457478B1/de not_active Expired - Lifetime
- 1999-11-09 ES ES99971797T patent/ES2237970T3/es not_active Expired - Lifetime
- 1999-11-09 ES ES04005240.9T patent/ES2644413T3/es not_active Expired - Lifetime
- 1999-11-09 AT AT99971797T patent/ATE288414T1/de active
- 1999-11-09 PT PT99971797T patent/PT1129066E/pt unknown
- 1999-11-09 PT PT4005240T patent/PT1457478T/pt unknown
- 1999-11-09 EP EP99971797A patent/EP1129066B1/de not_active Expired - Lifetime
- 1999-11-09 AU AU11614/00A patent/AU1161400A/en not_active Abandoned
- 1999-11-09 WO PCT/EP1999/008577 patent/WO2000027798A1/en not_active Ceased
- 1999-11-09 JP JP2000580978A patent/JP4503184B2/ja not_active Expired - Lifetime
- 1999-11-09 DE DE69923579T patent/DE69923579T2/de not_active Expired - Lifetime
- 1999-11-09 DK DK99971797T patent/DK1129066T3/da active
-
2001
- 2001-05-08 US US09/850,851 patent/US6605744B2/en not_active Expired - Lifetime
-
2003
- 2003-06-18 US US10/464,294 patent/US7026522B2/en not_active Expired - Lifetime
-
2005
- 2005-11-29 US US11/288,549 patent/US20060079715A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69923579T2 (de) | 2006-01-12 |
| US20020072635A1 (en) | 2002-06-13 |
| US6605744B2 (en) | 2003-08-12 |
| EP1457478B1 (de) | 2017-07-19 |
| ATE288414T1 (de) | 2005-02-15 |
| US7026522B2 (en) | 2006-04-11 |
| EP1457478A2 (de) | 2004-09-15 |
| JP2002529441A (ja) | 2002-09-10 |
| DE69923579D1 (de) | 2005-03-10 |
| US20060079715A1 (en) | 2006-04-13 |
| AU1161400A (en) | 2000-05-29 |
| ES2237970T3 (es) | 2005-08-01 |
| JP4503184B2 (ja) | 2010-07-14 |
| EP1129066B1 (de) | 2005-02-02 |
| EP1457478A3 (de) | 2004-12-22 |
| ES2644413T3 (es) | 2017-11-28 |
| PT1129066E (pt) | 2005-05-31 |
| EP1129066A1 (de) | 2001-09-05 |
| PT1457478T (pt) | 2017-10-26 |
| US20030229251A1 (en) | 2003-12-11 |
| WO2000027798A1 (en) | 2000-05-18 |
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