DK1135162T3 - Ordnet molekylær præsentation af allergener, fremstillingsfremgangsmåde samt anvendelse - Google Patents

Ordnet molekylær præsentation af allergener, fremstillingsfremgangsmåde samt anvendelse

Info

Publication number
DK1135162T3
DK1135162T3 DK99972928T DK99972928T DK1135162T3 DK 1135162 T3 DK1135162 T3 DK 1135162T3 DK 99972928 T DK99972928 T DK 99972928T DK 99972928 T DK99972928 T DK 99972928T DK 1135162 T3 DK1135162 T3 DK 1135162T3
Authority
DK
Denmark
Prior art keywords
virus
production
antigen
particles
coated
Prior art date
Application number
DK99972928T
Other languages
English (en)
Inventor
Wolfgang A Renner
Lars Nieba
Frank Hennecke
Martin Bachmann
Original Assignee
Cytos Biotechnology Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytos Biotechnology Ag filed Critical Cytos Biotechnology Ag
Application granted granted Critical
Publication of DK1135162T3 publication Critical patent/DK1135162T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5256Virus expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK99972928T 1998-11-30 1999-11-30 Ordnet molekylær præsentation af allergener, fremstillingsfremgangsmåde samt anvendelse DK1135162T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11041498P 1998-11-30 1998-11-30
US14278899P 1999-07-08 1999-07-08
PCT/IB1999/001925 WO2000032227A2 (en) 1998-11-30 1999-11-30 Ordered molecular presentation of antigens, method of preparation and use

Publications (1)

Publication Number Publication Date
DK1135162T3 true DK1135162T3 (da) 2009-01-19

Family

ID=26808005

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99972928T DK1135162T3 (da) 1998-11-30 1999-11-30 Ordnet molekylær præsentation af allergener, fremstillingsfremgangsmåde samt anvendelse

Country Status (17)

Country Link
US (1) US7229624B2 (da)
EP (1) EP1135162B1 (da)
JP (1) JP2010510960A (da)
CN (2) CN1193791C (da)
AT (1) ATE412434T1 (da)
AU (1) AU768807B2 (da)
BR (1) BR9915771A (da)
CA (1) CA2354183A1 (da)
DE (1) DE69939836D1 (da)
DK (1) DK1135162T3 (da)
ES (1) ES2317711T3 (da)
IL (2) IL143441A0 (da)
MX (1) MXPA01005389A (da)
NZ (1) NZ512456A (da)
PL (1) PL192016B1 (da)
RU (1) RU2245163C2 (da)
WO (1) WO2000032227A2 (da)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE314095T1 (de) 1998-10-21 2006-01-15 Us Health Virusähnliche partikel zur induktion von autoantikörpern
US6913749B2 (en) 1998-11-02 2005-07-05 Resistentia Pharmaceuticals Ab Immunogenic polypeptides for inducing anti-self IgE responses
US7476517B2 (en) 1999-06-30 2009-01-13 Evotec Ag Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics
US20040014033A1 (en) 1999-06-30 2004-01-22 Evotec Biosystems Ag, A Corporation Of Germany Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics
WO2001085208A2 (en) * 2000-05-05 2001-11-15 Cytos Biotechnology Ag Molecular antigen arrays and vaccines
DE60037263T2 (de) * 2000-12-29 2008-10-09 Evotec Ag Virus-ähnliche Partikel, ihre Herstellung und ihre Verwendung beim pharmazeutischen Screening und funktionelle Genomanwendungen
US7449188B2 (en) 2001-01-18 2008-11-11 Vlaams Interuniversitair Instituut Voor Biotechnologie Recombinant oligometric protein complexes with enhanced immunogenic potential
US7094409B2 (en) 2001-01-19 2006-08-22 Cytos Biotechnology Ag Antigen arrays for treatment of allergic eosinophilic diseases
AU2007202761B2 (en) * 2001-01-19 2010-01-21 Kuros Biosciences Ag Molecular antigen array
US7128911B2 (en) 2001-01-19 2006-10-31 Cytos Biotechnology Ag Antigen arrays for treatment of bone disease
US7320793B2 (en) * 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
EP1450856B1 (en) * 2001-09-14 2009-11-11 Cytos Biotechnology AG Packaging of immunostimulatory cpg into virus-like particles: method of preparation and use
CA2492823A1 (en) * 2001-09-14 2003-03-27 Cytos Biotechnology Ag In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
ES2321491T3 (es) * 2001-10-05 2009-06-08 Cytos Biotechnology Ag Conjugados que llevan peptido angiotensina y uso de los mismos.
US7115266B2 (en) 2001-10-05 2006-10-03 Cytos Biotechnology Ag Angiotensin peptide-carrier conjugates and uses thereof
MXPA04002644A (es) 2001-10-05 2004-07-08 Cytos Biotechnology Ag Conjugados que portan un peptido de angiotensina y usos de los mismos.
RU2350622C2 (ru) * 2001-10-05 2009-03-27 Цитос Байотекнолоджи Аг Конъюгат ангиотензиновой пептидной составляющей с носителем, композиция вакцины, способ иммунизации животного и способ лечения или профилактики физического нарушения, ассоциированного с активируемой ренином ангиотензиновой системой
ES2320638T3 (es) * 2001-11-07 2009-05-27 Cytos Biotechnology Ag Disposicion ordenada de antigenos il-5, il-13 o eotasina, para el tratamiento de enfermedades alergicas con un componente eosinofilico.
BR0213941A (pt) * 2001-11-07 2004-08-31 Cytos Biotechnology Ag Arranjos de antìgeno para o tratamento de doença óssea
WO2003059386A2 (en) * 2002-01-18 2003-07-24 Cytos Biotechnology Ag Prion protein carrier-conjugates
CA2486118A1 (en) 2002-06-07 2003-12-18 Large Scale Biology Corporation Flexible vaccine assembly and vaccine delivery platform
BR0311995A (pt) * 2002-06-20 2005-04-05 Cytos Biotechnology Ag Partìculas semelhantes a vìrus empacotadas para o uso como adjuvantes: método de preparação e uso
JP4726483B2 (ja) 2002-07-17 2011-07-20 サイトス バイオテクノロジー アーゲー 分子抗原アレイ
KR101228376B1 (ko) 2002-07-18 2013-01-31 사이토스 바이오테크놀로지 아게 합텐-캐리어 컨쥬게이트 및 그의 용도
MXPA04011247A (es) * 2002-07-19 2005-02-17 Cytos Biotechnology Ag Conjugados portadores de grelina.
DE60336902D1 (de) * 2002-07-19 2011-06-09 Cytos Biotechnology Ag Impfstoffzusammensetzungen enthaltende amyloid beta 1-6 antigenarrays
JP2006505252A (ja) * 2002-08-14 2006-02-16 アヴィディス エスアー 抗原およびアジュバントの多量体複合体
US7537767B2 (en) 2003-03-26 2009-05-26 Cytis Biotechnology Ag Melan-A- carrier conjugates
RU2351362C2 (ru) 2003-03-26 2009-04-10 Цитос Байотекнолоджи Аг КОНЪЮГАТЫ ПЕПТИДА Melan-A, АНАЛОГА ВИРУСОПОДОБНОЙ ЧАСТИЦЫ
EP1623229A2 (en) * 2003-05-15 2006-02-08 Cytos Biotechnology AG Selection of b cells with specificity of interest: method of preparation and use
US7923109B2 (en) 2004-01-05 2011-04-12 Board Of Regents, The University Of Texas System Inorganic nanowires
CN1905903A (zh) * 2004-01-20 2007-01-31 赛托斯生物技术公司 生长素释放肽-载体偶联物
AR044603A1 (es) 2004-06-03 2005-09-21 Consejo Nac Invest Cient Tec Proteinas quimericas aisladas de lumazina sintetasa modificada para la presentacion multiple de moleculas y sus aplicaciones
US7862829B2 (en) 2004-07-09 2011-01-04 University Of North Carolina At Chapel Hill Viral adjuvants
CN101052411B (zh) 2004-10-05 2011-04-06 赛托斯生物技术公司 Vlp-抗原偶联物及其作为疫苗的用途
AU2005298689A1 (en) 2004-10-25 2006-05-04 Cytos Biotechnology Ag Gastric inhibitory polypeptide (GIP) antigen arrays and uses thereof
GB0424563D0 (en) 2004-11-05 2004-12-08 Novartis Ag Organic compounds
PL1868642T3 (pl) * 2005-03-18 2013-10-31 Cytos Biotechnology Ag Białka fuzyjne alergenów kocich i ich zastosowania
FR2885901B1 (fr) * 2005-05-17 2008-02-29 Chelator Sa Para-tertio-butylcalix(6)arenes portant des fonctions triacides en positions 2,4 et 6, membranes liquides supportees et materiaux supports les comportant et leurs utilisations
US20110027220A1 (en) 2005-09-28 2011-02-03 Cytos Biotechnology Ag Interleukin-1 Conjugates and Uses Thereof
WO2007068747A1 (en) 2005-12-14 2007-06-21 Cytos Biotechnology Ag Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity
WO2007092315A2 (en) * 2006-02-03 2007-08-16 The Regents Of The University Of California Immunostimulation by cpg oligonucleotide-virus complexes
CA2932591C (en) 2006-02-07 2023-07-25 Ticketmaster Methods and systems for reducing burst usage of a networked computer system
JP5437797B2 (ja) 2006-06-12 2014-03-12 サイトス バイオテクノロジー アーゲー Rnaバクテリオファージのウイルス様粒子にオリゴヌクレオチドをパッケージ化するための方法
EP2125854B1 (en) 2006-12-12 2016-10-26 Kuros Biosciences AG Oligonucleotides containing high concentrations of guanine monomers
WO2009109428A2 (en) * 2008-02-01 2009-09-11 Alpha-O Peptides Ag Self-assembling peptide nanoparticles useful as vaccines
MX337723B (es) 2008-12-09 2016-03-15 Pfizer Vaccines Llc Vacuna de peptido ch3 de ige.
PL222497B1 (pl) 2009-06-26 2016-08-31 Inst Biochemii I Biofizyki Pan Wektorowa cząsteczka wirusopodobna, sposób jej wytwarzania, kompozycja farmaceutyczna oraz zastosowanie wektorowej cząsteczki wirusopodobnej
CA2768346A1 (en) 2009-07-30 2011-02-03 Pfizer Vaccines Llc Antigenic tau peptides and uses thereof
DK2473605T3 (da) 2009-09-03 2018-05-28 Pfizer Vaccines Llc Pcsk9-vaccine
EP2942061A3 (en) 2010-06-07 2016-01-13 Pfizer Vaccines LLC Ige ch3 peptide vaccine
JP6023061B2 (ja) 2010-10-06 2016-11-09 ザ ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャライゼーションThe University Of Washington Through Its Center For Commercialization ポリペプチド、ならびに呼吸器多核体ウイルス感染症の治療および制限における該ポリペプチドの使用
CN102146411B (zh) * 2011-01-06 2013-01-02 中国人民解放军第三军医大学第三附属医院 新型双功能抗瘢痕和组织纤维化寡聚核苷酸药物
WO2012131504A1 (en) 2011-03-02 2012-10-04 Pfizer Inc. Pcsk9 vaccine
WO2013003752A2 (en) 2011-06-30 2013-01-03 University Of Washington Through Its Center For Commercialization Methods for design of epitope scaffolds
US20130028857A1 (en) 2011-07-29 2013-01-31 Selecta Biosciences, Inc. Synthetic nanocarriers comprising polymers comprising multiple immunomodulatory agents
US9701720B2 (en) 2012-04-05 2017-07-11 University Of Washington Through Its Center For Commercialization Epitope-scaffold immunogens against respiratory syncytial virus (RSV)
EP3060056A4 (en) 2013-10-21 2017-10-18 Drexel University Use of sting agonists to treat chronic hepatitis b virus infection
WO2015123291A1 (en) 2014-02-11 2015-08-20 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Pcsk9 vaccine and methods of using the same
JP6409528B2 (ja) * 2014-11-27 2018-10-24 Jnc株式会社 アミノ基を含むイオン交換基とブチル基を含む疎水性基とを有する多孔性セルロース粒子及びそれを含むクロマトグラフィー担体ならびにb型肝炎ウィルスのウィルス様粒子の精製方法
WO2017179025A1 (en) 2016-04-15 2017-10-19 Alk-Abelló A/S Epitope polypeptides of ragweed pollen allergens
GB201616365D0 (en) * 2016-09-27 2016-11-09 Helsingin Yliopisto Non-genetic modification of enveloped viruses
US11633471B2 (en) 2018-03-06 2023-04-25 Unm Rainforest Innovations Compositions and methods for reducing serum triglycerides
JP7366057B2 (ja) 2018-04-19 2023-10-20 チェックメイト ファーマシューティカルズ, インコーポレイテッド 合成rig-i様受容体アゴニスト
US12161710B2 (en) 2019-07-24 2024-12-10 Unm Rainforest Innovations Malaria immunogen and methods for using same
JP7707161B2 (ja) 2019-10-23 2025-07-14 チェックメイト ファーマシューティカルズ, インコーポレイテッド 合成rig-i様受容体アゴニスト
US12121574B2 (en) 2021-09-28 2024-10-22 Unm Rainforest Innovations Malaria immunogen and methods for using same
WO2024049946A1 (en) 2022-08-31 2024-03-07 Unm Rainforest Innovations Compositions targeting apoptosis-associated speck-like protein with caspase activation and recruitment domain (asc) and methods of use
WO2025242657A1 (en) 2024-05-21 2025-11-27 Shape Biopharmaceuticals Ag Lipopeptide building blocks and aggregates

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3160926D1 (en) * 1980-04-15 1983-10-27 Beecham Group Plc Allergens modified with polysarcosines
US4722840A (en) 1984-09-12 1988-02-02 Chiron Corporation Hybrid particle immunogens
US5374426A (en) 1986-09-03 1994-12-20 University Of Saskatchewan Rotavirus nucleocapsid protein VP6 in vaccine compositions
CA1319101C (en) 1986-09-03 1993-06-15 Marta Iris Sabara Rotavirus nucleocapsid protein with or without binding peptides as immunologic carriers for macromolecules
US5143726A (en) * 1986-12-09 1992-09-01 The Scripps Research Institute T cell epitopes of the hepatitis B virus nucleocapsid protein
RU2092180C1 (ru) * 1988-06-22 1997-10-10 Эпплаид Микробиолоджи Инк. Антимикробная композиция
GB8903313D0 (en) * 1989-02-14 1989-04-05 Wellcome Found Conjugates
ATE121754T1 (de) 1989-09-04 1995-05-15 Wellcome Found Vakzine gegen bordetella.
US5334394A (en) 1990-06-22 1994-08-02 The Regents Of The University Of California Human immunodeficiency virus decoy
US5178882A (en) 1990-06-22 1993-01-12 The Regents Of The University Of California Viral decoy vaccine
SE9003978D0 (sv) 1990-12-13 1990-12-13 Henrik Garoff Dna expressionssystem baserade paa ett virus replikon
WO1992011291A1 (en) 1990-12-20 1992-07-09 Smithkline Beecham Biologicals (S.A.) Vaccines based on hepatitis b surface antigen
ES2109362T3 (es) * 1991-06-21 1998-01-16 Univ Cincinnati Unas proteinas administrables oralmente y metodo para hacerlas.
GB9114003D0 (en) * 1991-06-28 1991-08-14 Mastico Robert A Chimaeric protein
FR2695563B1 (fr) 1992-09-11 1994-12-02 Pasteur Institut Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires.
US6004763A (en) 1992-09-11 1999-12-21 Institut Pasteur Antigen-carrying microparticles and their use in the induction of humoral or cellular responses
AU6172194A (en) * 1993-02-08 1994-08-29 Paravax, Inc. Defective sindbis virus vectors that express (toxoplasma gondii) p30 antigens
US6015686A (en) 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
US6180771B1 (en) * 1993-12-08 2001-01-30 Immulogic Pharmaceutical Corp. Nucleic acids encoding a house dust mite allergen, Der p III, and uses therefor
AT402898B (de) 1994-08-08 1997-09-25 Int Centre Genetic Eng & Bio Molekulares präsentiersystem
WO1996030523A2 (en) 1995-03-31 1996-10-03 Hans Wolf Antigen presentation system based on retrovirus-like particles
US5792462A (en) * 1995-05-23 1998-08-11 University Of North Carolina At Chapel Hill Alphavirus RNA replicon systems
JPH09202735A (ja) * 1996-01-25 1997-08-05 Nof Corp リポソーム型アレルギー治療薬
CA2245497C (en) 1996-03-01 2009-02-24 Novartis Ag Peptide immunogens for vaccination against and treatment of allergy
US5786161A (en) * 1996-06-06 1998-07-28 Miltenyi Biotec. Gmbh Isolation and characterization of allergen-binding cells for diagnosis of hypersensitivity
US5770380A (en) 1996-09-13 1998-06-23 University Of Pittsburgh Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold
GB9621091D0 (en) 1996-10-09 1996-11-27 Fondation Pour Le Perfectionem Attenuated microorganisms strains and their uses
SE9604815D0 (sv) * 1996-12-20 1996-12-20 Pharmacia & Upjohn Ab A metod of diagnosis
WO1999007839A2 (en) 1997-08-05 1999-02-18 Vlaams Interuniversitair Instituut Voor Biotechnologie Immunoprotective influenza antigen and its use in vaccination
ATE249240T1 (de) * 1998-02-12 2003-09-15 Immune Complex Corp Strategisch modifizierte hepatitis b kernproteine und ihre derivate
TWI227241B (en) 1998-06-20 2005-02-01 United Biomedical Inc IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate
ATE314095T1 (de) * 1998-10-21 2006-01-15 Us Health Virusähnliche partikel zur induktion von autoantikörpern
KR100715954B1 (ko) * 1998-12-04 2007-05-09 바이오겐 아이덱 엠에이 인코포레이티드 펩티드 리간드에 의하여 부착된 다중 면역원성 성분을보유한 hbv 코어 항원 입자
WO2001085208A2 (en) * 2000-05-05 2001-11-15 Cytos Biotechnology Ag Molecular antigen arrays and vaccines

Also Published As

Publication number Publication date
CA2354183A1 (en) 2000-06-08
ES2317711T3 (es) 2009-04-16
IL143441A0 (en) 2002-04-21
MXPA01005389A (es) 2003-03-27
US7229624B2 (en) 2007-06-12
DE69939836D1 (de) 2008-12-11
PL192016B1 (pl) 2006-08-31
PL348452A1 (en) 2002-05-20
CN1679932A (zh) 2005-10-12
CN100534529C (zh) 2009-09-02
CN1333693A (zh) 2002-01-30
US20040136962A1 (en) 2004-07-15
IL143441A (en) 2006-10-31
AU1402000A (en) 2000-06-19
ATE412434T1 (de) 2008-11-15
BR9915771A (pt) 2001-12-26
CN1193791C (zh) 2005-03-23
EP1135162A2 (en) 2001-09-26
AU768807B2 (en) 2004-01-08
NZ512456A (en) 2003-10-31
WO2000032227A3 (en) 2000-10-12
WO2000032227A2 (en) 2000-06-08
EP1135162B1 (en) 2008-10-29
RU2245163C2 (ru) 2005-01-27
JP2010510960A (ja) 2010-04-08

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