DK1136474T3 - 1-Acetyl-5-brom-4,6-dimethylindolin - Google Patents

1-Acetyl-5-brom-4,6-dimethylindolin

Info

Publication number: DK1136474T3
Authority: DK; Denmark
Prior art keywords: inhibitors; pharmaceutically acceptable; acat; hyperlipemia; useful
Prior art date: 1994-09-20

Application number

DK01114083T

Other languages

Danish (da)

English (en)

Inventor

Hiroshi Matsui

Hiroaki Shirahase

Shohei Nakamura

Katsuo Wada

Shoji Kamiya

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-20

Filing date

1995-09-20

Publication date

2004-02-23

1995-09-20 Application filed by Sankyo Co filed Critical Sankyo Co

2004-02-23 Application granted granted Critical

2004-02-23 Publication of DK1136474T3 publication Critical patent/DK1136474T3/da

Links

JKOLKMZCWFCDDR-UHFFFAOYSA-N 1-(5-bromo-4,6-dimethyl-2,3-dihydroindol-1-yl)ethanone Chemical compound C1=C(C)C(Br)=C(C)C2=C1N(C(=O)C)CC2 JKOLKMZCWFCDDR-UHFFFAOYSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 abstract 4
125000000623 heterocyclic group Chemical group 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
201000005577 familial hyperlipidemia Diseases 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
230000002248 lipoperoxidative effect Effects 0.000 abstract 2
206010003210 Arteriosclerosis Diseases 0.000 abstract 1
208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
210000004556 brain Anatomy 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
208000023589 ischemic disease Diseases 0.000 abstract 1
230000003902 lesion Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK01114083T 1994-09-20 1995-09-20 1-Acetyl-5-brom-4,6-dimethylindolin DK1136474T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP22516694A JP3720395B2 (ja)	1994-09-20	1994-09-20	新規ヘテロ環誘導体、その製造方法およびその医薬用途

Publications (1)

Publication Number	Publication Date
DK1136474T3 true DK1136474T3 (da)	2004-02-23

Family

ID=16824983

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK95932172T DK0782986T3 (da)	1994-09-20	1995-09-20	Nye heterocycliske derivater, fremgangsmåde til fremstilling af samme og medicinsk anvendelse deraf
DK01114083T DK1136474T3 (da)	1994-09-20	1995-09-20	1-Acetyl-5-brom-4,6-dimethylindolin

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK95932172T DK0782986T3 (da)	1994-09-20	1995-09-20	Nye heterocycliske derivater, fremgangsmåde til fremstilling af samme og medicinsk anvendelse deraf

Country Status (13)

Country	Link
US (4)	US5990150A (de)
EP (2)	EP0782986B1 (de)
JP (1)	JP3720395B2 (de)
KR (1)	KR100365503B1 (de)
AT (2)	ATE255091T1 (de)
AU (1)	AU693261B2 (de)
CA (1)	CA2200472A1 (de)
DE (2)	DE69532216T2 (de)
DK (2)	DK0782986T3 (de)
ES (2)	ES2200003T3 (de)
HK (1)	HK1040513B (de)
PT (2)	PT782986E (de)
WO (1)	WO1996009287A1 (de)

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ATE210116T1 (de)	1995-10-05	2001-12-15	Kyoto Pharma Ind	Neue heterozyklische derivate und ihre medizinische anwendung
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US5929250A (en) *	1997-01-23	1999-07-27	Smithkline Beecham Corporation	IL-8 receptor antagonists
AR015425A1 (es) *	1997-09-05	2001-05-02	Smithkline Beecham Corp	Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion
US6861448B2 (en) *	1998-01-14	2005-03-01	Virtual Drug Development, Inc.	NAD synthetase inhibitors and uses thereof
WO1999036422A1 (en)	1998-01-14	1999-07-22	The Uab Research Foundation	Methods of synthesizing and screening inhibitors of bacterial nad synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial nad synthetase enzyme
US6673827B1 (en)	1999-06-29	2004-01-06	The Uab Research Foundation	Methods of treating fungal infections with inhibitors of NAD synthetase enzyme
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FR2783519B1 (fr)	1998-09-23	2003-01-24	Sod Conseils Rech Applic	Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
MXPA03001857A (es) *	2000-09-01	2003-06-04	Sankyo Co	Composicones medicinales.
TW200600497A (en) *	2001-02-02	2006-01-01	Sankyo Co	Preparation of indoline derivative
WO2002072147A1 (fr) *	2001-03-14	2002-09-19	Sankyo Company, Limited	Compositions medicinales contenant un inhibiteur de transporteur d'acide biliaire
CA2459017A1 (en) *	2001-08-28	2003-03-13	Sankyo Company, Limited	Medicinal compositions containing angiotensin ii receptor antagonist
US20050119314A1 (en) *	2002-04-05	2005-06-02	Sankyo Company, Limited	Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent
RU2318808C2 (ru)	2002-07-17	2008-03-10	Киото Фармасьютикал Индастриз, Лтд.	Новое соединение индолина и его применение в медицине
US7205329B2 (en) *	2003-05-30	2007-04-17	Microbia, Inc.	Modulators of CRTH2 activity
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JP2007527397A (ja) *	2003-07-01	2007-09-27	マイクロバイアインコーポレイテッド	Ｃｏｘ−２及びｆａａｈ阻害剤
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CN1882327A (zh)	2003-11-19	2006-12-20	症变治疗公司	含磷的新的拟甲状腺素药
US20050234244A1 (en) *	2004-04-20	2005-10-20	Wilmin Bartolini	Synthesis of COX-2 and FAAH inhibitors
US20050234030A1 (en) *	2004-04-20	2005-10-20	Wilmin Bartolini	Modulators of CRTH2, COX-2 and FAAH
US9164104B2 (en)	2004-10-06	2015-10-20	The Brigham And Women's Hospital, Inc.	Relevance of achieved levels of markers of systemic inflammation following treatment
TW200619191A (en) *	2004-10-27	2006-06-16	Sankyo Co	Phenyl compounds with more than 2 substitutes
US8022188B2 (en) *	2006-04-24	2011-09-20	Abbott Laboratories	Immunosuppressant binding antibodies and methods of obtaining and using same
US7883855B2 (en) *	2006-07-21	2011-02-08	Abbott Laboratories	Immunosuppressant drug extraction reagent for immunoassays
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US20120046364A1 (en)	2009-02-10	2012-02-23	Metabasis Therapeutics, Inc.	Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use

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IL101785A0 (en)	1991-05-10	1992-12-30	Fujisawa Pharmaceutical Co	Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
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JP3720395B2 (ja)	1994-09-20	2005-11-24	京都薬品工業株式会社	新規ヘテロ環誘導体、その製造方法およびその医薬用途
ATE210116T1 (de) *	1995-10-05	2001-12-15	Kyoto Pharma Ind	Neue heterozyklische derivate und ihre medizinische anwendung

1994
- 1994-09-20 JP JP22516694A patent/JP3720395B2/ja not_active Expired - Fee Related
1995
- 1995-09-20 PT PT95932172T patent/PT782986E/pt unknown
- 1995-09-20 AU AU35324/95A patent/AU693261B2/en not_active Ceased
- 1995-09-20 DK DK95932172T patent/DK0782986T3/da active
- 1995-09-20 EP EP95932172A patent/EP0782986B1/de not_active Expired - Lifetime
- 1995-09-20 WO PCT/JP1995/001873 patent/WO1996009287A1/ja not_active Ceased
- 1995-09-20 US US08/809,242 patent/US5990150A/en not_active Expired - Fee Related
- 1995-09-20 EP EP01114083A patent/EP1136474B1/de not_active Expired - Lifetime
- 1995-09-20 DE DE69532216T patent/DE69532216T2/de not_active Expired - Fee Related
- 1995-09-20 ES ES95932172T patent/ES2200003T3/es not_active Expired - Lifetime
- 1995-09-20 ES ES01114083T patent/ES2206367T3/es not_active Expired - Lifetime
- 1995-09-20 AT AT01114083T patent/ATE255091T1/de not_active IP Right Cessation
- 1995-09-20 DE DE69531213T patent/DE69531213T2/de not_active Expired - Fee Related
- 1995-09-20 CA CA002200472A patent/CA2200472A1/en not_active Abandoned
- 1995-09-20 PT PT01114083T patent/PT1136474E/pt unknown
- 1995-09-20 AT AT95932172T patent/ATE244220T1/de not_active IP Right Cessation
- 1995-09-20 KR KR1019970701786A patent/KR100365503B1/ko not_active Expired - Fee Related
- 1995-09-20 DK DK01114083T patent/DK1136474T3/da active
1999
- 1999-08-12 US US09/373,509 patent/US6127403A/en not_active Expired - Fee Related
- 1999-08-12 US US09/373,163 patent/US6414012B1/en not_active Expired - Fee Related
2001
- 2001-02-15 US US09/784,434 patent/US6489475B2/en not_active Expired - Fee Related
2002
- 2002-03-13 HK HK02101935.4A patent/HK1040513B/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0782986A1 (de)	1997-07-09
ES2200003T3 (es)	2004-03-01
ATE244220T1 (de)	2003-07-15
JP3720395B2 (ja)	2005-11-24
PT1136474E (pt)	2004-04-30
EP1136474B1 (de)	2003-11-26
EP0782986A4 (de)	2000-04-05
US6489475B2 (en)	2002-12-03
DE69532216T2 (de)	2004-09-16
AU693261B2 (en)	1998-06-25
DE69532216D1 (de)	2004-01-08
EP1136474A1 (de)	2001-09-26
DE69531213T2 (de)	2004-04-15
JPH0892210A (ja)	1996-04-09
DE69531213D1 (de)	2003-08-07
ATE255091T1 (de)	2003-12-15
KR970706252A (ko)	1997-11-03
KR100365503B1 (ko)	2003-06-12
AU3532495A (en)	1996-04-09
US6127403A (en)	2000-10-03
HK1040513B (en)	2004-06-18
US6414012B1 (en)	2002-07-02
PT782986E (pt)	2003-11-28
HK1040513A1 (en)	2002-06-14
DK0782986T3 (da)	2003-10-06
EP0782986B1 (de)	2003-07-02
US20010014740A1 (en)	2001-08-16
WO1996009287A1 (en)	1996-03-28
CA2200472A1 (en)	1996-03-28
US5990150A (en)	1999-11-23
ES2206367T3 (es)	2004-05-16

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DK1136474T3 (da)	2004-02-23	1-Acetyl-5-brom-4,6-dimethylindolin
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EP0866059A4 (de)	1998-12-02	Neue heterozyklische derivate und ihre medizinische anwendung
AU692090B2 (en)	1998-05-28	Novel 4,6-diarylpyrimidine derivatives and salts thereof
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ATE114154T1 (de)	1994-12-15	Thienotriazolodiazepine und ihre pharmazeutische verwendung.
DE69713648D1 (de)	2002-08-08	Benzopyranderivate und ihre Verwendung zur Behandlung von Herzkrankheiten
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ATE212842T1 (de)	2002-02-15	Quinoxalin-derivate zur behandlung von tinnitus
HUP9900916A2 (hu)	1999-09-28	Benzotiofénszármazékok felhasználása az érszövetek kalciumvezetékeit antagonizáló hatású gyógyszerkészítmények előállítására
AU2013888A (en)	1989-02-02	Uricosuric composition