DK113897A - Fremgangsmåde til fremstilling af antihypercholesterolæmiske tetrazolforbindelser - Google Patents

Fremgangsmåde til fremstilling af antihypercholesterolæmiske tetrazolforbindelser Download PDF

Info

Publication number
DK113897A
DK113897A DK113897A DK113897A DK113897A DK 113897 A DK113897 A DK 113897A DK 113897 A DK113897 A DK 113897A DK 113897 A DK113897 A DK 113897A DK 113897 A DK113897 A DK 113897A
Authority
DK
Denmark
Prior art keywords
preparation
tetrazole compounds
antihypercholesterolemic
antihypercholesterolemic tetrazole
compounds
Prior art date
Application number
DK113897A
Other languages
English (en)
Inventor
John J Wright
Sing-Yuen Sit
Neelakantan Balasurbramanian
Peter J Brown
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of DK113897A publication Critical patent/DK113897A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK113897A 1987-02-25 1997-10-06 Fremgangsmåde til fremstilling af antihypercholesterolæmiske tetrazolforbindelser DK113897A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1855887A 1987-02-25 1987-02-25
US07/151,512 US4898949A (en) 1987-02-25 1988-02-18 Intermediates for the preparation of antihypercholesterolemic tetrazole compounds

Publications (1)

Publication Number Publication Date
DK113897A true DK113897A (da) 1997-10-06

Family

ID=26691250

Family Applications (2)

Application Number Title Priority Date Filing Date
DK097388A DK97388A (da) 1987-02-25 1988-02-24 Mellemprodukt og fremgangsmaade til fremstilling af antihypercholestrolemiske tetrazolforbindelser
DK113897A DK113897A (da) 1987-02-25 1997-10-06 Fremgangsmåde til fremstilling af antihypercholesterolæmiske tetrazolforbindelser

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK097388A DK97388A (da) 1987-02-25 1988-02-24 Mellemprodukt og fremgangsmaade til fremstilling af antihypercholestrolemiske tetrazolforbindelser

Country Status (27)

Country Link
US (1) US4898949A (da)
JP (1) JP2603284B2 (da)
KR (1) KR960007167B1 (da)
CN (1) CN1030077C (da)
AT (1) AT395588B (da)
AU (1) AU610562B2 (da)
BE (1) BE1002115A3 (da)
CA (1) CA1328269C (da)
CH (1) CH678182A5 (da)
DE (1) DE3805789C2 (da)
DK (2) DK97388A (da)
ES (1) ES2009547A6 (da)
FI (1) FI96600C (da)
FR (1) FR2611201B1 (da)
GB (1) GB2202845B (da)
GR (1) GR1000473B (da)
HU (3) HU201533B (da)
IE (1) IE61608B1 (da)
IT (1) IT1216752B (da)
LU (1) LU87143A1 (da)
MY (1) MY102290A (da)
NL (1) NL8800468A (da)
NO (1) NO178432C (da)
NZ (1) NZ223621A (da)
PT (1) PT86821B (da)
SE (3) SE504553C2 (da)
YU (1) YU46781B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4870187A (en) * 1988-08-23 1989-09-26 Bristol-Myers Company Antihypercholesterolemic tetrazol-1-yl compounds
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5260325A (en) * 1991-08-19 1993-11-09 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking tertiary amides
CA2137049A1 (en) * 1993-12-15 1995-06-16 John K. Thottathil Amino acid salts of and methods for preparing antihypercholesterolemic tetrazole compounds
ES2284219T3 (es) * 1997-12-19 2007-11-01 Pfizer Ireland Pharmaceuticals Procedimiento de sintesis de 1,3-dioles.

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4160100A (en) * 1973-03-23 1979-07-03 American Home Products Corporation Oxamic acid derivatives
US4013647A (en) * 1976-03-23 1977-03-22 American Home Products Corporation Morpholine containing tetrazole-5-carboxamide derivatives
JPS53147073A (en) * 1977-05-24 1978-12-21 Sankyo Co Ltd Mevalonolactone derivatives
US4567289A (en) * 1979-08-17 1986-01-28 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
US4375475A (en) * 1979-08-17 1983-03-01 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
NZ194557A (en) * 1979-08-17 1984-09-28 Merck & Co Inc Substituted pyranone derivatives;dihydroxy acids therefrom;pharmaceutical compositions
EP0068038B1 (en) * 1981-06-29 1985-09-25 Merck & Co. Inc. (+)-(4r,6s)-(e)-6-(2-(4'-fluoro-3,3',5-trimethyl-(1,1'-biphenyl)-2-yl)ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2h-pyran-2-one, a process for preparing and a pharmaceutical composition containing the same
HU204253B (en) * 1982-11-22 1991-12-30 Sandoz Ag Process for producing mevalonolactone analogues and derivatives and pharmaceutical compositions containing them
US4739073A (en) * 1983-11-04 1988-04-19 Sandoz Pharmaceuticals Corp. Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
DE3461180D1 (en) * 1983-01-24 1986-12-11 Sandoz Ag Analogs of mevalonolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
US5105017A (en) * 1983-07-18 1992-04-14 Eli Lilly And Company Leukotriene antagonist intermediates
CA1327360C (en) * 1983-11-14 1994-03-01 William F. Hoffman Oxo-analogs of mevinolin-like antihypercholesterolemic agents
US4613610A (en) * 1984-06-22 1986-09-23 Sandoz Pharmaceuticals Corp. Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
FI860755A0 (fi) * 1984-06-22 1986-02-20 Sandoz Ag Pyrazolanaloger av mevolonolakton och deras derivat, foerfaranden foer deras framstaellning samt deras andvaendning.
US4668794A (en) * 1985-05-22 1987-05-26 Sandoz Pharm. Corp. Intermediate imidazole acrolein analogs
US4621099A (en) * 1985-09-23 1986-11-04 Usv Pharmaceutical Corporation Polyene compounds useful in the treatment of allergic responses
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US4678806A (en) * 1986-09-02 1987-07-07 Merck & Co., Inc. Prodrugs of antihypercholesterolemic compounds
AU601264B2 (en) * 1987-02-25 1990-09-06 Bristol-Myers Squibb Company Antihypercholesterolemic tetrazole compounds

Also Published As

Publication number Publication date
HU895124D0 (da) 1990-01-28
AT395588B (de) 1993-01-25
GR880100100A (en) 1988-12-16
FR2611201B1 (fr) 1991-01-11
FI96600C (fi) 1996-07-25
AU610562B2 (en) 1991-05-23
PT86821A (pt) 1988-03-01
FI880868A0 (fi) 1988-02-24
SE9300976D0 (sv) 1993-03-24
GB8804281D0 (en) 1988-03-23
LU87143A1 (fr) 1988-09-20
NO880802D0 (no) 1988-02-24
DK97388A (da) 1988-08-26
HU201534B (en) 1990-11-28
CN1030077C (zh) 1995-10-18
FI96600B (fi) 1996-04-15
JPS63290872A (ja) 1988-11-28
BE1002115A3 (fr) 1990-07-10
NO880802L (no) 1988-08-26
US4898949A (en) 1990-02-06
YU36488A (en) 1990-02-28
SE8800637L (sv) 1988-08-26
NO178432B (no) 1995-12-18
SE504553C2 (sv) 1997-03-03
IT1216752B (it) 1990-03-08
ATA46088A (de) 1992-06-15
SE9300976L (da) 1993-03-24
IE880502L (en) 1988-08-18
NL8800468A (nl) 1988-09-16
CN1070642A (zh) 1993-04-07
SE9300977L (da)
GR1000473B (el) 1992-07-30
SE9300977D0 (sv) 1993-03-24
NO178432C (no) 1996-03-27
CA1328269C (en) 1994-04-05
SE512485C2 (sv) 2000-03-20
KR880009946A (ko) 1988-10-06
ES2009547A6 (es) 1989-10-01
MY102290A (en) 1992-05-15
JP2603284B2 (ja) 1997-04-23
GB2202845B (en) 1991-05-22
PT86821B (pt) 1992-05-29
FI880868A7 (fi) 1988-08-26
GB2202845A (en) 1988-10-05
YU46781B (sh) 1994-05-10
IT8819526A0 (it) 1988-02-24
DE3805789C2 (de) 2001-05-31
IE61608B1 (en) 1994-11-16
SE8800637D0 (sv) 1988-02-24
FR2611201A1 (fr) 1988-08-26
HU201533B (en) 1990-11-28
SE503201C2 (sv) 1996-04-15
KR960007167B1 (ko) 1996-05-29
NZ223621A (en) 1991-06-25
AU1213288A (en) 1988-09-01
HUT47258A (en) 1989-02-28
CH678182A5 (da) 1991-08-15
HU201532B (en) 1990-11-28
DE3805789A1 (de) 1988-09-15
DK97388D0 (da) 1988-02-24

Similar Documents

Publication Publication Date Title
IS3369A7 (is) Aðferð til framleiðslu efnasambanda sem afleidd eru af benzopyran
DK0518874T3 (da) Fremgangsmåde til fremstilling af tagatose
DK0672670T3 (da) Fremgangsmåde til fremstilling af clavulansyre
DK89091A (da) Fremgangsmaade til fremstilling af vitamin-d-forbindelser
GR880100101A (en) Process for the preparation of antihypercholesterolemic tetrazol compounds
DK0670835T3 (da) Fremgangsmåde til fremstilling af benzopyranforbindelser
FI881064A7 (fi) Menetelmä tulehduksenvastaisten tai analgeettisten -aminoetyylisubstituoitujen fenyyliyhdisteiden valmistamiseksi
FI902316A0 (fi) Menetelmä valmistaa terapeuttisesti vaikuttavia substituoituja dihydropyrrolitsiiniyhdisteitä
FI103804B1 (fi) Menetelmä tetrahydrofotolaattiyhdisteiden optisesti puhtaiden diastereoisomeerien valmistamiseksi
NO932860L (no) Fremgangsmaate for fremstilling av kalsium-L-askorbat-2-fosfat
PT87643A (pt) Process for the preparation of pyran compounds
DK0483927T3 (da) Fremgangsmåde til fremstilling af krystallinsk aluminiumphosphat
DK113897A (da) Fremgangsmåde til fremstilling af antihypercholesterolæmiske tetrazolforbindelser
DK28788D0 (da) Fremgangsmaade til fremstilling af alkansulfonamider
FI892144A7 (fi) Menetelmä 5-C-hydroksimetyylialdoheksoosipohjaisten yhdisteiden valmistamiseksi
FI910662A7 (fi) Menetelmä 7-amino-3-metoksimetyyli-kef-3-emi-4-karboksyylihapon valmistamiseksi
FI943660A7 (fi) Menetelmä 3-karbonyyliandrostadieeni-17-karboksamidien valmistamiseksi
DK505888A (da) Fremgangsmaade til fremstilling af makrolidforbindelser
DK504988A (da) Fremgangsmaade til fremstilling af makrolidforbindelser
DK0398404T3 (da) Fremgangsmåde til fremstilling af acylureaforbindelser
DK73596A (da) Fremgangsmåde til fremstilling af penemforbindelser
DK0380180T3 (da) Fremgangsmåde til fremstilling af sammensatte krystallinske silikater
DK0599044T3 (da) Fremgangsmåde til fremstilling af chlorphenylphosphaner
DK426887D0 (da) Fremgangsmaade til fremstilling af kemiske forbindelser
DK0381622T3 (da) Fremgangsmåde til fremstilling af dihalogenbutyraldehyder

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment