SE9300977D0 - Foerfarande foer framstaellning av mellanprodukter avsedda foer framstaellning av antihyperkolesterolemiska medel - Google Patents

Foerfarande foer framstaellning av mellanprodukter avsedda foer framstaellning av antihyperkolesterolemiska medel

Info

Publication number: SE9300977D0
Authority: SE; Sweden
Prior art keywords: preparation; agents; esterolemic; antihypercol; procedures
Prior art date: 1987-02-25

Application number

SE19939300977A

Other languages

English (en)

Other versions

SE512485C2 (sv

SE9300977L (sv

Inventor

J *Wright John

*Sit Sing-Yuen

*Balasubramanian Neelakantan

J *Brown Peter

Original Assignee

Bristol-Myers Squibb Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-02-25

Filing date

1993-03-24

Publication date

1993-03-24

Publication of SE9300977L publication Critical patent/SE9300977L/xx

1993-03-24 Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company

1993-03-24 Publication of SE9300977D0 publication Critical patent/SE9300977D0/sv

2000-03-20 Publication of SE512485C2 publication Critical patent/SE512485C2/sv

Links

238000000034 method Methods 0.000 title abstract 2
239000013067 intermediate product Substances 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
125000001309 chloro group Chemical group Cl* 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
239000003529 anticholesteremic agent Substances 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000002346 iodo group Chemical group I* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003536 tetrazoles Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Obesity (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

SE9300977A 1987-02-25 1993-03-24 Förfarande för framställning av mellanprodukter avsedda för framställning av antihyperkolesterolemiska medel SE512485C2 (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1855887A	1987-02-25	1987-02-25
US07/151,512 US4898949A (en)	1987-02-25	1988-02-18	Intermediates for the preparation of antihypercholesterolemic tetrazole compounds

Publications (3)

Publication Number	Publication Date
SE9300977L SE9300977L (sv)
SE9300977D0 true SE9300977D0 (sv)	1993-03-24
SE512485C2 SE512485C2 (sv)	2000-03-20

Family

ID=26691250

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
SE8800637A SE504553C2 (sv)	1987-02-25	1988-02-24	Mellanprodukter och förfaranden för framställning av antihyperkolesterolemiska tetrazolföreningar
SE9300977A SE512485C2 (sv)	1987-02-25	1993-03-24	Förfarande för framställning av mellanprodukter avsedda för framställning av antihyperkolesterolemiska medel
SE9300976A SE503201C2 (sv)	1987-02-25	1993-03-24	Tetrazol mellanprodukter för användning för framställning av nya inhibitorer för enzymet HMG-CoA-reduktas

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
SE8800637A SE504553C2 (sv)	1987-02-25	1988-02-24	Mellanprodukter och förfaranden för framställning av antihyperkolesterolemiska tetrazolföreningar

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SE9300976A SE503201C2 (sv)	1987-02-25	1993-03-24	Tetrazol mellanprodukter för användning för framställning av nya inhibitorer för enzymet HMG-CoA-reduktas

Country Status (27)

Country	Link
US (1)	US4898949A (sv)
JP (1)	JP2603284B2 (sv)
KR (1)	KR960007167B1 (sv)
CN (1)	CN1030077C (sv)
AT (1)	AT395588B (sv)
AU (1)	AU610562B2 (sv)
BE (1)	BE1002115A3 (sv)
CA (1)	CA1328269C (sv)
CH (1)	CH678182A5 (sv)
DE (1)	DE3805789C2 (sv)
DK (2)	DK97388A (sv)
ES (1)	ES2009547A6 (sv)
FI (1)	FI96600C (sv)
FR (1)	FR2611201B1 (sv)
GB (1)	GB2202845B (sv)
GR (1)	GR1000473B (sv)
HU (3)	HU201533B (sv)
IE (1)	IE61608B1 (sv)
IT (1)	IT1216752B (sv)
LU (1)	LU87143A1 (sv)
MY (1)	MY102290A (sv)
NL (1)	NL8800468A (sv)
NO (1)	NO178432C (sv)
NZ (1)	NZ223621A (sv)
PT (1)	PT86821B (sv)
SE (3)	SE504553C2 (sv)
YU (1)	YU46781B (sv)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4870187A (en) *	1988-08-23	1989-09-26	Bristol-Myers Company	Antihypercholesterolemic tetrazol-1-yl compounds
FI94339C (sv)	1989-07-21	1995-08-25	Warner Lambert Co	Förfarande för framställning av farmaceutiskt användbar /R-(R,R)/-2-(4-fluorfenyl)- , -dihydroxi-5-(1-metyletyl)-3-fenyl-4-/(fenylamino)karbonyl/-1H-pyrrol-1-heptansyra och farmaceutiskt användbara salter därav
US5260325A (en) *	1991-08-19	1993-11-09	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking tertiary amides
CA2137049A1 (en) *	1993-12-15	1995-06-16	John K. Thottathil	Amino acid salts of and methods for preparing antihypercholesterolemic tetrazole compounds
EP1054860B1 (en) *	1997-12-19	2007-04-25	Pfizer Ireland Pharmaceuticals	Process for the synthesis of 1,3-diols

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4160100A (en) *	1973-03-23	1979-07-03	American Home Products Corporation	Oxamic acid derivatives
US4013647A (en) *	1976-03-23	1977-03-22	American Home Products Corporation	Morpholine containing tetrazole-5-carboxamide derivatives
JPS53147073A (en) *	1977-05-24	1978-12-21	Sankyo Co Ltd	Mevalonolactone derivatives
US4567289A (en) *	1979-08-17	1986-01-28	Merck & Co., Inc.	Substituted pyranone inhibitors of cholesterol synthesis
US4375475A (en) *	1979-08-17	1983-03-01	Merck & Co., Inc.	Substituted pyranone inhibitors of cholesterol synthesis
IL60751A (en) *	1979-08-17	1985-04-30	Merck & Co Inc	6-(2'-((substituted phenyl)ethyl and-ethenyl)-4-hydroxy-tetrahydro-2h-pyran-2-one derivatives,their preparation and pharmaceutical compositions containing them
EP0068038B1 (en) *	1981-06-29	1985-09-25	Merck & Co. Inc.	(+)-(4r,6s)-(e)-6-(2-(4'-fluoro-3,3',5-trimethyl-(1,1'-biphenyl)-2-yl)ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2h-pyran-2-one, a process for preparing and a pharmaceutical composition containing the same
US4739073A (en) *	1983-11-04	1988-04-19	Sandoz Pharmaceuticals Corp.	Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
HU204253B (en) *	1982-11-22	1991-12-30	Sandoz Ag	Process for producing mevalonolactone analogues and derivatives and pharmaceutical compositions containing them
PT77996B (en) *	1983-01-24	1986-05-30	Sandoz Sa	Process of the preparations of mevalonelactone analogs and derivatives thereof and of pharmaceutical compositions containing them
US5105017A (en) *	1983-07-18	1992-04-14	Eli Lilly And Company	Leukotriene antagonist intermediates
CA1327360C (en) *	1983-11-14	1994-03-01	William F. Hoffman	Oxo-analogs of mevinolin-like antihypercholesterolemic agents
ATE62906T1 (de) *	1984-06-22	1991-05-15	Sandoz Ag	Pyrazolanaloge von mevalonolakton und abkoemmlinge davon, verfahren zu deren herstellung und deren verwendung.
US4613610A (en) *	1984-06-22	1986-09-23	Sandoz Pharmaceuticals Corp.	Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
US4668794A (en) *	1985-05-22	1987-05-26	Sandoz Pharm. Corp.	Intermediate imidazole acrolein analogs
US4621099A (en) *	1985-09-23	1986-11-04	Usv Pharmaceutical Corporation	Polyene compounds useful in the treatment of allergic responses
US4681893A (en) *	1986-05-30	1987-07-21	Warner-Lambert Company	Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US4678806A (en) *	1986-09-02	1987-07-07	Merck & Co., Inc.	Prodrugs of antihypercholesterolemic compounds
AU601264B2 (en) *	1987-02-25	1990-09-06	Bristol-Myers Squibb Company	Antihypercholesterolemic tetrazole compounds

1988
- 1988-02-18 US US07/151,512 patent/US4898949A/en not_active Expired - Lifetime
- 1988-02-24 FR FR888802212A patent/FR2611201B1/fr not_active Expired - Fee Related
- 1988-02-24 NO NO880802A patent/NO178432C/no not_active IP Right Cessation
- 1988-02-24 HU HU895124A patent/HU201533B/hu not_active IP Right Cessation
- 1988-02-24 GR GR880100100A patent/GR1000473B/el not_active IP Right Cessation
- 1988-02-24 JP JP63041828A patent/JP2603284B2/ja not_active Expired - Fee Related
- 1988-02-24 NZ NZ223621A patent/NZ223621A/en unknown
- 1988-02-24 MY MYPI88000180A patent/MY102290A/en unknown
- 1988-02-24 CH CH691/88A patent/CH678182A5/de not_active IP Right Cessation
- 1988-02-24 HU HU895133A patent/HU201534B/hu not_active IP Right Cessation
- 1988-02-24 SE SE8800637A patent/SE504553C2/sv not_active IP Right Cessation
- 1988-02-24 AT AT0046088A patent/AT395588B/de not_active IP Right Cessation
- 1988-02-24 NL NL8800468A patent/NL8800468A/nl not_active Application Discontinuation
- 1988-02-24 AU AU12132/88A patent/AU610562B2/en not_active Ceased
- 1988-02-24 FI FI880868A patent/FI96600C/sv not_active IP Right Cessation
- 1988-02-24 PT PT86821A patent/PT86821B/pt not_active IP Right Cessation
- 1988-02-24 HU HU88885A patent/HU201532B/hu not_active IP Right Cessation
- 1988-02-24 ES ES8800533A patent/ES2009547A6/es not_active Expired
- 1988-02-24 IT IT8819526A patent/IT1216752B/it active
- 1988-02-24 CA CA000559671A patent/CA1328269C/en not_active Expired - Fee Related
- 1988-02-24 DK DK097388A patent/DK97388A/da not_active Application Discontinuation
- 1988-02-24 IE IE50288A patent/IE61608B1/en not_active IP Right Cessation
- 1988-02-24 KR KR1019880001915A patent/KR960007167B1/ko not_active Expired - Fee Related
- 1988-02-24 DE DE3805789A patent/DE3805789C2/de not_active Expired - Fee Related
- 1988-02-24 GB GB8804281A patent/GB2202845B/en not_active Expired - Fee Related
- 1988-02-25 LU LU87143A patent/LU87143A1/fr unknown
- 1988-02-25 YU YU36488A patent/YU46781B/sh unknown
- 1988-02-25 BE BE8800219A patent/BE1002115A3/fr not_active IP Right Cessation
1992
- 1992-10-20 CN CN92111551A patent/CN1030077C/zh not_active Expired - Fee Related
1993
- 1993-03-24 SE SE9300977A patent/SE512485C2/sv not_active IP Right Cessation
- 1993-03-24 SE SE9300976A patent/SE503201C2/sv not_active IP Right Cessation
1997
- 1997-10-06 DK DK113897A patent/DK113897A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
PT86821A (pt)	1988-03-01
SE504553C2 (sv)	1997-03-03
US4898949A (en)	1990-02-06
AT395588B (de)	1993-01-25
NO178432C (no)	1996-03-27
GR880100100A (en)	1988-12-16
HU201532B (en)	1990-11-28
NO178432B (no)	1995-12-18
HU895124D0 (sv)	1990-01-28
NO880802L (no)	1988-08-26
BE1002115A3 (fr)	1990-07-10
GB2202845B (en)	1991-05-22
SE9300976L (sv)	1993-03-24
GB2202845A (en)	1988-10-05
CH678182A5 (sv)	1991-08-15
CN1030077C (zh)	1995-10-18
AU610562B2 (en)	1991-05-23
FI880868A0 (sv)	1988-02-24
PT86821B (pt)	1992-05-29
FR2611201A1 (fr)	1988-08-26
DE3805789A1 (de)	1988-09-15
NL8800468A (nl)	1988-09-16
NZ223621A (en)	1991-06-25
HU201534B (en)	1990-11-28
GB8804281D0 (en)	1988-03-23
YU46781B (sh)	1994-05-10
GR1000473B (el)	1992-07-30
ES2009547A6 (es)	1989-10-01
NO880802D0 (no)	1988-02-24
HU201533B (en)	1990-11-28
FI96600B (sv)	1996-04-15
HUT47258A (en)	1989-02-28
ATA46088A (de)	1992-06-15
CN1070642A (zh)	1993-04-07
DK113897A (da)	1997-10-06
JP2603284B2 (ja)	1997-04-23
IT8819526A0 (it)	1988-02-24
SE8800637D0 (sv)	1988-02-24
JPS63290872A (ja)	1988-11-28
FI880868A7 (sv)	1988-08-26
LU87143A1 (fr)	1988-09-20
KR880009946A (ko)	1988-10-06
CA1328269C (en)	1994-04-05
SE512485C2 (sv)	2000-03-20
SE8800637L (sv)	1988-08-26
SE9300976D0 (sv)	1993-03-24
DK97388D0 (da)	1988-02-24
MY102290A (en)	1992-05-15
YU36488A (en)	1990-02-28
DE3805789C2 (de)	2001-05-31
IT1216752B (it)	1990-03-08
KR960007167B1 (ko)	1996-05-29
DK97388A (da)	1988-08-26
IE880502L (en)	1988-08-18
AU1213288A (en)	1988-09-01
FR2611201B1 (fr)	1991-01-11
SE9300977L (sv)
IE61608B1 (en)	1994-11-16
SE503201C2 (sv)	1996-04-15
FI96600C (sv)	1996-07-25

Legal Events

Date	Code	Title	Description
2005-10-04	NUG	Patent has lapsed

Publication	Publication Date	Title
ATE195938T1 (de)	2000-09-15	2-(1',2',4'-triazol-3'yloxymethylen)-anilide und ihre verwendung als schädlingsbekämpfungsmittel
ATE178897T1 (de)	1999-04-15	Hypolipidämische benzothiazepin verbindungen
LTIP390A (lt)	1994-08-25	Triazolpiridazino junginiai,jų gavimo būdas ir panaudojimas
DE69131325D1 (de)	1999-07-15	Zwischenverbindungen zur herstellung von thioalkylthio cephalosporinderivaten
DE69231445D1 (de)	2000-10-19	Triazole enthaltende antifungizide mittel
DK0754682T3 (da)	2002-02-04	Aminostilbazolderivat og lægemiddel
ATE163921T1 (de)	1998-03-15	Azoxycyanbenzol-derivate
ATE14880T1 (de)	1985-08-15	Cephalosporinverbindungen und ihre herstellung.
DE69314911D1 (de)	1997-12-04	Cis-epoxide Derivate, verwendbar als irreversible HIV-Protease Inhibitoren und Verfahren und Zwischenprodukte zu ihrer Herstellung
SE9300977D0 (sv)	1993-03-24	Foerfarande foer framstaellning av mellanprodukter avsedda foer framstaellning av antihyperkolesterolemiska medel
NZ221699A (en)	1990-03-27	Pyridazinone derivatives; pharmaceutical compositions and intermediates
ATE46159T1 (de)	1989-09-15	Pyridazinone, inotrope mittel.
SE8001556L (sv)	1980-09-03	Tetrahydrobensotiazolylimidazolidinoner
EP0028936A3 (en)	1981-08-19	4-carbamoylimidazol-5-ol derivatives, their production and pharmaceutical compositions containing them
DK0449515T3 (da)	1995-10-16	Hidtil ukendte cephalosporin-mellemprodukter og fremgangsmåde til fremstilling af mellemprodukterne og slutprodukter deraf
ATE39682T1 (de)	1989-01-15	Derivate von 3-phenyl-2-propenamin, ihre herstellung und diese enthaltende arzneimittel.
MY130817A (en)	2007-07-31	Herbicides
ES8502699A1 (es)	1985-01-16	Procedimiento para la obtencion de tetrahidrotiopiran-3, 5-dion-4-carboxamidas
DK165592C (da)	1993-05-03	Benzoylurinstofforbindelser, fremgangsmaade til fremstilling deraf, pesticidt praeparat indeholdende saadan forbindelse samt fremgangsmaade til bekaempelse af skadelige organismer
ATE284379T1 (de)	2004-12-15	Aminderivate
FI955933A0 (sv)	1995-12-11	Abeo-ergolinderivat som 5HT1A-ligander
IL97289A0 (en)	1992-05-25	Tetraazaacenaphthylene-3-one derivatives,pharmaceutical compositions containing the same and processes for the preparation thereof
DE3873046D1 (de)	1992-08-27	N-phenyltetrahydrophthalimide.
DK0532725T3 (da)	1997-06-02	Isoxazolderivater som lysfilterpræparater
YU13197A (sh)	1999-09-27	Novi 2,3-benzodiazepinski derivati, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže