DK1140061T3 - Mikrobiologisk sunde og stabile opløsninger af gamma-hydroxybutyratsalt til behandling af narcolepsi - Google Patents

Mikrobiologisk sunde og stabile opløsninger af gamma-hydroxybutyratsalt til behandling af narcolepsi

Info

Publication number
DK1140061T3
DK1140061T3 DK99964320T DK99964320T DK1140061T3 DK 1140061 T3 DK1140061 T3 DK 1140061T3 DK 99964320 T DK99964320 T DK 99964320T DK 99964320 T DK99964320 T DK 99964320T DK 1140061 T3 DK1140061 T3 DK 1140061T3
Authority
DK
Denmark
Prior art keywords
gamma
narcolepsy
treatment
disclosed
formulations
Prior art date
Application number
DK99964320T
Other languages
Danish (da)
English (en)
Inventor
Harry N Cook
Martha Hamilton
Doug Danielson
Colette Goderstad
Dayton Reardan
Original Assignee
Orphan Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22351244&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1140061(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Orphan Medical Inc filed Critical Orphan Medical Inc
Application granted granted Critical
Publication of DK1140061T3 publication Critical patent/DK1140061T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DK99964320T 1998-12-23 1999-12-22 Mikrobiologisk sunde og stabile opløsninger af gamma-hydroxybutyratsalt til behandling af narcolepsi DK1140061T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11374598P 1998-12-23 1998-12-23
PCT/US1999/030740 WO2000038672A2 (fr) 1998-12-23 1999-12-22 Solutions de sel d'hydroxybutyrate stables et saines au plan microbiologique, pour le traitement de la narcolepsie

Publications (1)

Publication Number Publication Date
DK1140061T3 true DK1140061T3 (da) 2003-08-25

Family

ID=22351244

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99964320T DK1140061T3 (da) 1998-12-23 1999-12-22 Mikrobiologisk sunde og stabile opløsninger af gamma-hydroxybutyratsalt til behandling af narcolepsi

Country Status (11)

Country Link
US (14) US6472431B2 (fr)
EP (1) EP1140061B1 (fr)
JP (2) JP4374441B2 (fr)
AT (1) ATE238783T1 (fr)
AU (1) AU779354B2 (fr)
CA (1) CA2355293C (fr)
DE (1) DE69907508T2 (fr)
DK (1) DK1140061T3 (fr)
ES (1) ES2193777T3 (fr)
IL (2) IL143733A0 (fr)
WO (1) WO2000038672A2 (fr)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000038672A2 (fr) 1998-12-23 2000-07-06 Orphan Medical, Inc. Solutions de sel d'hydroxybutyrate stables et saines au plan microbiologique, pour le traitement de la narcolepsie
DE10315640A1 (de) * 2003-04-04 2004-10-14 Ignatov, Konstantin Verfahren zur kontrollierten Freisetzung von Komponenten in eine Lösung
EP1629732A1 (fr) * 2004-08-27 2006-03-01 Purac Biochem BV Composition pour l'inactivation des levures ou des moisissures dans les boissons
BRPI0515645A (pt) * 2004-09-07 2008-03-04 Orphan Medical Inc métodos terapêuticos, composições, compostos e usos de compostos
KR20070085838A (ko) * 2004-11-10 2007-08-27 더 트러스티이스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 운동 장애의 치료 방법
US7838556B2 (en) * 2006-02-21 2010-11-23 University Of Maryland, Baltimore Ethers of 3-hydroxyphenylacetic acid as selective gamma-hydroxybutyric acid receptor ligands
EP2020869B1 (fr) * 2006-05-01 2013-10-16 Universiteit Gent Combinaison de poly-3-hydroxybutyrate et depolymerase en tant que composants d'aliments pour animaux ou d'additifs aux aliments pour animaux
BRPI0602825A2 (pt) * 2006-06-23 2012-04-24 Rhodia Br Ltda formulação de pó efervescente auto-refrigerante para bebidas e uso de formulação em pó efervescente
US8524944B2 (en) * 2008-04-15 2013-09-03 Norac Pharma Process for the preparation of sodium gamma-hydroxybutyrate
US8771735B2 (en) * 2008-11-04 2014-07-08 Jazz Pharmaceuticals, Inc. Immediate release dosage forms of sodium oxybate
US8778398B2 (en) 2008-11-04 2014-07-15 Jazz Pharmaceuticals, Inc. Immediate release formulations and dosage forms of gamma-hydroxybutyrate
FR2938431B1 (fr) * 2008-11-14 2013-12-20 Debregeas Et Associes Pharma Nouvelle composition a base d'acide gamma-hydroxybutyrique
US8410304B2 (en) * 2009-04-15 2013-04-02 Norac Pharma Process for preparing gamma-hydroxybutyrate
FR2949061B1 (fr) 2009-08-12 2013-04-19 Debregeas Et Associes Pharma Microgranules flottants
FR2949062B1 (fr) 2009-08-12 2011-09-02 Debregeas Et Associes Pharma Nouvelles formulations pharmaceutiques contre le mesusage des medicaments
MX391660B (es) 2010-03-24 2025-03-21 Jazz Pharmaceuticals Inc Formas de dosis de liberacion controlada para substancias de farmaco de alta dosis, solubles en agua e higroscopicas
EP2630957B1 (fr) * 2010-07-29 2020-01-08 Ecolab USA Inc. Méthode pour le traitement de l'eau potable pour les animaux comprenant un biocide administré en utilisant un intervalle posologique
ES2774932T3 (es) 2012-11-14 2020-07-23 Cj Cheiljedang Corp Producción de sales de 4-hidroxibutirato utilizando materias primas de base biológica
US8591922B1 (en) 2012-12-14 2013-11-26 Jazz Pharmacuticals, Inc. Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
WO2014096984A1 (fr) 2012-12-21 2014-06-26 Wockhardt Limited Composition pharmaceutique stable d'oxybate de sodium
US20150376152A1 (en) 2013-02-13 2015-12-31 Metabolix, Inc. Process for Ultra Pure Chemical Production from Biobased Raw Starting Materials
US9050302B2 (en) * 2013-03-01 2015-06-09 Jazz Pharmaceuticals Ireland Limited Method of administration of gamma hydroxybutyrate with monocarboxylate transporters
US9549909B2 (en) 2013-05-03 2017-01-24 The Katholieke Universiteit Leuven Method for the treatment of dravet syndrome
US9801852B2 (en) * 2013-08-30 2017-10-31 Jazz Pharmaceuticals, Inc. Devices and methods for facilitating and controlling use of a medication
BR112017006219A8 (pt) 2014-09-29 2023-02-14 Zogenix International Ltd Sistema de controle para controle de distribuição de medicamentos
US10398662B1 (en) 2015-02-18 2019-09-03 Jazz Pharma Ireland Limited GHB formulation and method for its manufacture
US9750811B2 (en) 2015-09-15 2017-09-05 Boveda, Inc. Devices and methods for controlling headspace humidity and oxygen levels
CN108283000B (zh) 2015-09-23 2021-04-13 凯瑞康宁生物工程（武汉）有限公司 γ-羟基丁酸的前药及其组合物和用途
DK3800177T3 (da) 2015-12-22 2025-03-31 Zogenix International Ltd Fenfluramin-sammensætninger og fremgangsmåder til fremstilling af samme
US10689324B2 (en) 2015-12-22 2020-06-23 Zogenix International Limited Metabolism resistant fenfluramine analogs and methods of using the same
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12478604B1 (en) 2016-07-22 2025-11-25 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11000498B2 (en) 2016-07-22 2021-05-11 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12186296B1 (en) 2016-07-22 2025-01-07 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
RU2021106383A (ru) 2016-08-24 2021-04-05 Зодженикс Интернэшнл Лимитед Состав для ингибирования образования агонистов 5-ht2b и способы его применения
US10195151B2 (en) 2016-09-06 2019-02-05 Jazz Pharmaceuticals International Iii Limited Formulations of (R)-2-amino-3-phenylpropyl carbamate
CN121202730A (zh) 2016-09-06 2025-12-26 爱尔兰贾兹制药有限公司 (r)-2-氨基-3-苯丙基氨基甲酸酯盐酸盐的制备方法、其组合物及用途
JP7074750B2 (ja) 2016-10-06 2022-05-24 ジャズ ファーマスティカルズ アイルランド リミテッド カルバモイルフェニルアラニノール化合物およびその使用
WO2018071706A1 (fr) 2016-10-12 2018-04-19 Lissa Biesecker Longacre Récipient et ensemble de fermeture à humidité prédéterminée et procédé associé
US12098015B2 (en) 2016-10-12 2024-09-24 Boveda Inc. Device for controlling headspace humidity and methods for making the same
US20180263936A1 (en) 2017-03-17 2018-09-20 Jazz Pharmaceuticals Ireland Limited Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
US20180303821A1 (en) * 2017-04-24 2018-10-25 BraneQuest, Inc. Membrane active molecules
KR20200016889A (ko) 2017-06-02 2020-02-17 재즈 파마슈티칼즈 아일랜드 리미티드 과다 졸림증을 치료하기 위한 방법 및 조성물
SG11202000817SA (en) 2017-07-31 2020-02-27 Jazz Pharmaceuticals Ireland Ltd Carbamoyl phenylalaninol analogs and uses thereof
US10682317B2 (en) 2017-09-26 2020-06-16 Zogenix International Limited Ketogenic diet compatible fenfluramine formulation
US11666546B2 (en) 2017-12-18 2023-06-06 Tris Pharma, Inc GHB pharmaceutical compositions comprising a floating interpenetrating polymer network forming system
US12514818B2 (en) 2017-12-18 2026-01-06 Tris Pharma, Inc. Pharmaceutical compositions comprising a floating interpenetrating polymer network forming system
US11337920B2 (en) 2017-12-18 2022-05-24 Tris Pharma, Inc. Pharmaceutical composition comprising GHB gastro-retentive raft forming systems having trigger pulse drug release
AU2018388577B2 (en) 2017-12-18 2024-06-06 Tris Pharma, Inc. Modified release drug powder composition comprising gastro-retentive raft forming systems having trigger pulse drug release
CA3097335A1 (fr) 2018-05-11 2019-11-14 Zogenix International Limited Compositions et methodes pour traiter la mort subite provoquee par la crise epileptique
BR112021006027A2 (pt) 2018-11-19 2021-06-29 Jazz Pharmaceuticals Ireland Limited formulações de fármaco resistente a álcool
WO2020105005A1 (fr) 2018-11-19 2020-05-28 Zogenix International Limited Méthodes de traitement du syndrome de rett à l'aide de fenfluramine
GB201821066D0 (en) * 2018-12-21 2019-02-06 Univ Oxford Innovation Ltd Sleep modulation
BR112021013766A2 (pt) 2019-03-01 2021-09-21 Flamel Ireland Limited Composições de gama-hidroxibutirato com farmacocinética melhorada no estado alimentado
KR20220119429A (ko) * 2019-12-24 2022-08-29 재즈 파마슈티칼즈 아일랜드 리미티드 감마-히드록시부티레이트(ghb) 투약
KR102944046B1 (ko) 2020-02-13 2026-03-25 지티이 코포레이션 랜덤 액세스 절차에서의 프리앰블 및 페이로드 메시지의 전송
TW202139986A (zh) 2020-02-21 2021-11-01 愛爾蘭商爵士製藥愛爾蘭有限責任公司 治療原發性嗜睡症之方法
US10940133B1 (en) 2020-03-19 2021-03-09 Jazz Pharmaceuticals Ireland Limited Methods of providing solriamfetol therapy to subjects with impaired renal function
AU2021292406B2 (en) 2020-06-18 2024-03-14 XWPharma Ltd. Controlled release granulations of water-soluble active pharmaceutical ingredients
US11612574B2 (en) 2020-07-17 2023-03-28 Zogenix International Limited Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
WO2022020621A1 (fr) 2020-07-24 2022-01-27 XWPharma Ltd. Compositions pharmaceutiques et pharmacocinétiques d'un dérivé de l'acide gamma-hydroxybutyrique
AU2021357705B2 (en) 2020-10-05 2024-09-26 XWPharma Ltd. Modified release compositions of a gamma-hydroxybutyric acid derivative
US12582622B2 (en) 2020-10-08 2026-03-24 Jazz Pharmaceuticals Ireland Limited Sodium oxybate to treat idiopathic hypersomnia
AU2021362222A1 (en) 2020-10-16 2023-06-01 Jazz Pharmaceuticals Ireland Limited Treatment methods using ghb
DK4308086T3 (da) 2021-03-19 2025-11-17 Xwpharma Ltd Farmakokinetik af formuleringer med kombineret frigivelse af et gamma-hydroxysmørsyrederivat
EP4415701A1 (fr) 2021-10-11 2024-08-21 Jazz Pharmaceuticals Ireland Limited Procédé d'administration d'oxybate
US20230118007A1 (en) * 2021-10-18 2023-04-20 Synovent Laboratories, LLC Medical devices and systems for use
US12293330B2 (en) 2021-10-27 2025-05-06 Express Scripts Strategic Development, Inc. Product packing system and method
US12293315B2 (en) 2021-10-27 2025-05-06 Express Scripts Strategic Development, Inc. System and method for load balancing carrier devices among stations in a packing system
US12651663B2 (en) 2021-10-28 2026-06-09 Express Scripts Strategic Development, Inc. Pharmaceutical order processing systems and methods
WO2023135150A1 (fr) 2022-01-11 2023-07-20 Jazz Pharmaceuticals Ireland Limited Procédé d'administration d'oxybate
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
WO2023178288A1 (fr) 2022-03-17 2023-09-21 Azora Therapeutics, Inc. Diagnostic compagnon et stratégies de traitement avec un composé agoniste du récepteur d'hydrocarbone d'aryle
CN121038779A (zh) 2023-02-03 2025-11-28 特瑞斯制药公司 每晚一次的低钠羟丁酸盐组合物
EP4719375A1 (fr) 2023-05-30 2026-04-08 Axsome Therapeutics, Inc. Solriamfétol pour le traitement d'une déficience cognitive chez un sujet ayant une cognition altérée associée à une apnée obstructive du sommeil et une somnolence diurne excessive
CN121620365A (zh) 2023-06-29 2026-03-06 艾克萨姆治疗股份有限公司 向哺乳期妇女施用索安非托的方法
WO2025178942A1 (fr) 2024-02-20 2025-08-28 Auros Pharma LLC Compositions, formulations et procédés de stimulation de la respiration

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB922029A (en) 1960-05-19 1963-03-27 Equilibre Biolog L Therapeutic composition
US3051619A (en) 1960-05-19 1962-08-28 Equilibre Biolog L 4-hydroxy butyric acid therapeutic compositions and process of use for clinical sedation, hypnosis, or anaesthesia
US4183916A (en) 1978-03-31 1980-01-15 Beecham Inc. Oral compositions
US4374441A (en) * 1980-05-23 1983-02-22 Book Covers, Inc. Method of making a book cover and pocket element therefor
EP0044801B1 (fr) * 1980-07-17 1984-02-15 Josef Dr. Klosa Sels non hygroscopiques de l'acide 4-hydroxybutyrique, procédé pour leur préparation et leur utilisation pour la fabrication des agents pharmaceutiques
ZA814854B (en) 1980-07-17 1982-07-28 J Klosa Nonhygroscopic salts of 4-hydroxybutryric acid, methods of their production and pharmaceutical preparations containing these salts
EP0235408B1 (fr) 1984-08-06 1991-01-09 The University Of Toronto Innovations Foundation Composition pharmaceutique et traitement
US4738985A (en) * 1986-03-19 1988-04-19 The University Of Toronto Innovations Foundations Pharmaceutical composition and treatment
US5210083A (en) 1986-07-17 1993-05-11 Ed. Geistlich Sohne A.G. Fur Chemische Industrie Pharmaceutical compositions
IT1217783B (it) 1988-06-03 1990-03-30 Farmaceutico Ct S R L Lab Impiego di salo dell,acido gamma idrossi butirrico per la preparazione di composizioni farmaceutiche adatta ad essereimpiegate nella terapia dell,alcolismo e composizioni relative
CA2011365A1 (fr) 1989-03-06 1990-09-06 Eugene L. Inman Formule de diluant de la daptomycine
JP2564690B2 (ja) 1990-06-14 1996-12-18 三省製薬 株式会社 メラニン生成抑制外用剤
DE4113984C2 (de) * 1991-04-29 2002-05-08 Koehler Chemie Dr Franz Salze der 4-Hydroxy-Buttersäure
US5286497A (en) 1991-05-20 1994-02-15 Carderm Capital L.P. Diltiazem formulation
IT1248588B (it) 1991-06-28 1995-01-19 Gaetano Crepaldi Composizioni farmaceutiche per la terapia dell'astinenza, del " craving", della dipendenza da sostanze stupefacenti, da sostanze psicoattive, da nicotina e dei disturbi alimentari.
US5371424A (en) 1992-11-25 1994-12-06 Motorola, Inc. Transmitter/receiver circuit and method therefor
IT1271403B (it) 1993-03-26 1997-05-28 Ct Lab Farm Srl Sali dell'acido gamma-idrossibutirrico ad attivita' ansiolitica e per il trattamento degli stati depressivi
IT1266565B1 (it) 1993-07-22 1997-01-09 Ct Lab Farm Srl Composizioni farmaceutiche a rilascio controllato a base di uno o piu' sali farmaceuticamente accettabili dell'acido gamma-idrossi-butirrico.
US5840331A (en) 1995-06-07 1998-11-24 Arch Development Corporation Use of γ-hydroxybutyrate for the stimulation of sleep-related secretion growth hormone and prolactin
US6077545A (en) 1995-10-30 2000-06-20 Matrix Pharmaceuticals, Inc. Process and composition for therapeutic cisplatin (CDDP)
DE19602664A1 (de) 1996-01-25 1997-08-07 Waltenberger Karl Hans Mittel zum Inhibieren des Algenwachstums
NZ330774A (en) 1996-04-05 1999-06-29 Takeda Chemical Industries Ltd Pharmaceutical composition having angiotensin ii antagonistic activity or salt thereof with an insulin-sensitivity increasing compound and postprandial hyperglycemia in diabetes mellitus and antagonistic activity and increased insulin-sensitivity
IT1283782B1 (it) 1996-08-09 1998-04-30 Ct Lab Farm Srl Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo
HUP9904363A3 (en) 1996-08-15 2000-12-28 Schering Corp Piperidine ether muscarinic antagonists and pharmaceutical compositions containing them
US20080292700A1 (en) 1997-04-21 2008-11-27 Biovail Laboratories Controlled release formulations using intelligent polymers
US5990162A (en) * 1997-08-29 1999-11-23 Orphan Medical, Inc. Method for treatment of fibromyalgia and chronic fatigue syndrome
WO2000038672A2 (fr) * 1998-12-23 2000-07-06 Orphan Medical, Inc. Solutions de sel d'hydroxybutyrate stables et saines au plan microbiologique, pour le traitement de la narcolepsie

Also Published As

Publication number Publication date
US20120202879A1 (en) 2012-08-09
US9539330B2 (en) 2017-01-10
US20170224825A1 (en) 2017-08-10
US20190328882A1 (en) 2019-10-31
DE69907508T2 (de) 2003-11-20
US20120020833A1 (en) 2012-01-26
US20020077334A1 (en) 2002-06-20
CA2355293A1 (fr) 2000-07-06
US8952062B2 (en) 2015-02-10
ATE238783T1 (de) 2003-05-15
US20160058862A1 (en) 2016-03-03
JP2009167189A (ja) 2009-07-30
WO2000038672A3 (fr) 2000-11-09
AU779354B2 (en) 2005-01-20
WO2000038672A2 (fr) 2000-07-06
JP2002533388A (ja) 2002-10-08
US20040209955A1 (en) 2004-10-21
US8263650B2 (en) 2012-09-11
US20130267595A1 (en) 2013-10-10
US20110039929A1 (en) 2011-02-17
US7851506B2 (en) 2010-12-14
IL143733A0 (en) 2002-04-21
JP5204685B2 (ja) 2013-06-05
US7262219B2 (en) 2007-08-28
CA2355293C (fr) 2005-08-16
EP1140061B1 (fr) 2003-05-02
JP4374441B2 (ja) 2009-12-02
US20130143965A1 (en) 2013-06-06
US8324275B2 (en) 2012-12-04
AU2059000A (en) 2000-07-31
US20150073052A1 (en) 2015-03-12
US20120202880A1 (en) 2012-08-09
US6780889B2 (en) 2004-08-24
US20030125385A1 (en) 2003-07-03
EP1140061A2 (fr) 2001-10-10
US8461203B2 (en) 2013-06-11
US6472431B2 (en) 2002-10-29
US8859619B2 (en) 2014-10-14
DE69907508D1 (de) 2003-06-05
IL143733A (en) 2006-10-31
US20070270491A1 (en) 2007-11-22
ES2193777T3 (es) 2003-11-01

Similar Documents

Publication Publication Date Title
IL143733A0 (en) Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy
PT1333887E (pt) Metodo de tratamento de desordens musculares
NZ515567A (en) Method for treating chronic pain using MEK inhibitors
MXPA02007639A (es) Inhibidores de la oxidacion parcial de los acidos grasos en el tratamiento de la falla cardiaca congestiva.
DK0867184T3 (da) Anvendelse af tiagabin til behandling af søvnforstyrrelser
IS6560A (is) Lyfjasamsetning fyrir meðhöndlun á bráðum, þrálátum sársauka og/eða taugakerfissársauka og mígreni
DE50014190D1 (de) Verwendung von phthalazin-derivaten zur behandlung neurodegenerativer krankheiten
WO2003030819A3 (fr) Derives de tetracycline et methodes d'utilisation
EP1889614A3 (fr) Procédés d'utilisation d'inhibiteurs de récapture de la sérotonine sélective à départ rapide pour le traitement de dysfonctionnements sexuels
MXPA03000188A (es) Metodo de tratamiento de enfermedades relacionadas con neutroficos con anestesicos locales.
DK1261333T3 (da) Anvendelse af topiramate for behandling og diagnosticering af sövnbesværet vejrtrækning og midler for udförsel af behandlingen og diagnosticeringen
SE0102147D0 (sv) New methods
PT1572178E (pt) Tratamento de mastalgia com 4-hidroxi-tamoxifeno
DE50111407D1 (de) Mittel enthaltend n-chlortaurin sowie dessen verwendung zur behandlung von schleimhautpolypen
GEP20063822B (en) Diclofenac-based composition for the topical treatment of oropharyngeal cavity disorders
WO2003092669A3 (fr) Procede de traitement des troubles vasculaires medies par le facteur de croissance endothelial
SE0101256D0 (sv) Treatment of low back pain
AU2976095A (en) Use of selegilin in the treatment of epileptic conditions
NO20024545D0 (no) Fremgangsmåte for behandling av kongestiv hjertefeil
MXPA04000418A (es) Tratamiento de dolor cronico con 3-heterocicloxi- y -cicloalquiloxi-3-fenilpropanaminas.
WO2005021095A3 (fr) Traitement de begaiement et d'autres troubles de la communication au moyen d'inhibiteurs du recaptage de la noradrenaline
TR200100670T2 (tr) R(+)-alfa-(2,3-Dimetoksifenil)-1- [2-(4-florofenil)etil]-4-piperidinmetanol' ün uyku düzensizlikleri tedavisinde kullanımı.
UA38347A (uk) Горілка особлива "банкетна учта"
AU2002237762A1 (en) Delivery catheter with mocroporous membrane to treat brain and other tumors
UA72956C2 (uk) Спосіб масажу рубцевозміненої крайньої плоті після циркумцизії