DK1142885T3 - 2-(N-cyanoimino)thiazolidin-4-on-derivater - Google Patents
2-(N-cyanoimino)thiazolidin-4-on-derivaterInfo
- Publication number
- DK1142885T3 DK1142885T3 DK99974189T DK99974189T DK1142885T3 DK 1142885 T3 DK1142885 T3 DK 1142885T3 DK 99974189 T DK99974189 T DK 99974189T DK 99974189 T DK99974189 T DK 99974189T DK 1142885 T3 DK1142885 T3 DK 1142885T3
- Authority
- DK
- Denmark
- Prior art keywords
- group
- alkyl group
- atom
- hydrogen atom
- branched
- Prior art date
Links
- PFSHNSJERVOFEU-UHFFFAOYSA-N (4-oxo-1,3-thiazol-2-yl)cyanamide Chemical class O=C1CSC(=NC#N)N1 PFSHNSJERVOFEU-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000004450 alkenylene group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
- C07D277/74—Sulfur atoms substituted by carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP1999/006352 WO2001036402A1 (en) | 1998-07-14 | 1999-11-12 | Novel 2-(n-cyanoimino)thiazolidin-4-one derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1142885T3 true DK1142885T3 (da) | 2007-02-26 |
Family
ID=14237278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99974189T DK1142885T3 (da) | 1999-11-12 | 1999-11-12 | 2-(N-cyanoimino)thiazolidin-4-on-derivater |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6380229B1 (da) |
| EP (1) | EP1142885B1 (da) |
| JP (1) | JP4285723B2 (da) |
| KR (1) | KR100608416B1 (da) |
| CN (1) | CN1159305C (da) |
| AT (1) | ATE345332T1 (da) |
| AU (1) | AU767923C (da) |
| CA (1) | CA2355243C (da) |
| DE (1) | DE69934027T2 (da) |
| DK (1) | DK1142885T3 (da) |
| ES (1) | ES2276547T3 (da) |
| HK (1) | HK1041691B (da) |
| IL (1) | IL144229A (da) |
| PT (1) | PT1142885E (da) |
| WO (1) | WO2001036402A1 (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0013671A (pt) | 1999-08-31 | 2003-06-10 | Maxia Pharmaceuticals Inc | Derivados heterocìclicos para o tratamento do diabetes e outras doenças |
| JP2001199888A (ja) | 2000-01-24 | 2001-07-24 | Fujimoto Brothers:Kk | 糖尿病治療剤 |
| WO2002072009A2 (en) | 2001-03-07 | 2002-09-19 | Maxia Pharmaceuticals, Inc. | Heterocyclic derivatives for the treatment of cancer and other proliferative diseases |
| JP2004523571A (ja) | 2001-03-08 | 2004-08-05 | マキシア・ファーマシューティカルズ・インコーポレイテッド | Ｒｘｒ活性化分子 |
| WO2002092576A1 (en) | 2001-05-16 | 2002-11-21 | Boehringer Ingelheim Pharmaceuticals, Inc. | Diarylurea derivatives useful as anti-inflammatory agents |
| EP1456187A4 (en) | 2001-11-15 | 2005-02-09 | Incyte San Diego Inc | N-SUBSTITUTED HETEROCYCLES FOR THE TREATMENT OF HYPERCHOLESTERINEMIA, DYSLIPIDEMIA AND OTHER METABOLIC DISORDER, CANCER AND OTHER DISEASES |
| AR037714A1 (es) * | 2001-12-06 | 2004-12-01 | Maxia Pharmaceuticals Inc | Derivados de tiazolidinona y oxazolidinona 2-sustituidos para la inhibicion de fosfatasas y el tratamiento de cancer |
| US7102000B2 (en) | 2002-03-08 | 2006-09-05 | Incyte San Diego Inc. | Heterocyclic amide derivatives for the treatment of diabetes and other diseases |
| US7196108B2 (en) | 2002-03-08 | 2007-03-27 | Incyte San Diego Inc. | Bicyclic heterocycles for the treatment of diabetes and other diseases |
| US7435828B2 (en) | 2003-11-21 | 2008-10-14 | Actelion Pharmaceuticals Ltd. | Thiazolidin-4-one derivatives |
| USRE43833E1 (en) | 2003-11-21 | 2012-11-27 | Actelion Pharmaceuticals Ltd. | Thiazolidin-4-one derivatives |
| US8912340B2 (en) | 2006-11-23 | 2014-12-16 | Actelion Pharmaceuticals Ltd. | Process for the preparation of 2-imino-thiazolidin-4-one derivatives |
| MX2009005048A (es) * | 2006-11-23 | 2009-05-25 | Actelion Pharmaceuticals Ltd | Nuevo proceso para la preparacion de derivados de 2-imino-tiazolidin-4-ona. |
| CA2963784A1 (en) | 2007-06-08 | 2008-12-18 | Mannkind Corporation | Ire-1.alpha. inhibitors |
| SMT202000298T1 (it) | 2012-08-17 | 2020-07-08 | Actelion Pharmaceuticals Ltd | Processo per la produzione di (2z,5z)-5-(3-cloro-4((r)-2,3-diidrossipropossi) benziliden)-2-(propilimmino)-3-(o-tolil)tiazolidin-4-one e intermedio usato in detto processo |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07165371A (ja) | 1993-10-06 | 1995-06-27 | Japan Tobacco Inc | テープ巻き付け方法および装置 |
| JPH0892249A (ja) * | 1994-07-20 | 1996-04-09 | Sankyo Co Ltd | スルホンアミド誘導体 |
| JP3871354B2 (ja) * | 1994-07-29 | 2007-01-24 | 株式会社フジモト・コーポレーション | 新規な２−（ｎ−シアノイミノ）チアゾリジン−４−オン誘導体 |
| JPH08157461A (ja) * | 1994-12-07 | 1996-06-18 | Sankyo Co Ltd | スルホン誘導体 |
| JPH09165371A (ja) | 1995-10-09 | 1997-06-24 | Sankyo Co Ltd | 複素環化合物を含有する医薬 |
| EP0801063B1 (en) * | 1996-04-09 | 2003-01-15 | Dr. Reddy's Laboratories Ltd. | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| JP2000026438A (ja) * | 1998-07-14 | 2000-01-25 | Fujimoto Brothers:Kk | 新規な２−（ｎ−シアノイミノ）チアゾリジン−４− オン誘導体 |
-
1999
- 1999-11-12 KR KR1020017008765A patent/KR100608416B1/ko not_active Expired - Fee Related
- 1999-11-12 CA CA002355243A patent/CA2355243C/en not_active Expired - Fee Related
- 1999-11-12 DE DE69934027T patent/DE69934027T2/de not_active Expired - Lifetime
- 1999-11-12 DK DK99974189T patent/DK1142885T3/da active
- 1999-11-12 AU AU11801/00A patent/AU767923C/en not_active Ceased
- 1999-11-12 EP EP99974189A patent/EP1142885B1/en not_active Expired - Lifetime
- 1999-11-12 IL IL144229A patent/IL144229A/en not_active IP Right Cessation
- 1999-11-12 HK HK02102951.1A patent/HK1041691B/zh not_active IP Right Cessation
- 1999-11-12 US US09/889,103 patent/US6380229B1/en not_active Expired - Lifetime
- 1999-11-12 WO PCT/JP1999/006352 patent/WO2001036402A1/ja not_active Ceased
- 1999-11-12 ES ES99974189T patent/ES2276547T3/es not_active Expired - Lifetime
- 1999-11-12 AT AT99974189T patent/ATE345332T1/de active
- 1999-11-12 PT PT99974189T patent/PT1142885E/pt unknown
- 1999-11-12 CN CNB998154482A patent/CN1159305C/zh not_active Expired - Fee Related
- 1999-11-12 JP JP2001538891A patent/JP4285723B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE345332T1 (de) | 2006-12-15 |
| CN1333762A (zh) | 2002-01-30 |
| US6380229B1 (en) | 2002-04-30 |
| CA2355243A1 (en) | 2001-05-25 |
| AU1180100A (en) | 2001-05-30 |
| KR100608416B1 (ko) | 2006-08-02 |
| AU767923B2 (en) | 2003-11-27 |
| CA2355243C (en) | 2009-01-27 |
| EP1142885A1 (en) | 2001-10-10 |
| AU767923C (en) | 2005-03-24 |
| JP4285723B2 (ja) | 2009-06-24 |
| IL144229A0 (en) | 2002-05-23 |
| HK1041691A1 (en) | 2002-07-19 |
| ES2276547T3 (es) | 2007-06-16 |
| EP1142885A4 (en) | 2003-01-29 |
| WO2001036402A1 (en) | 2001-05-25 |
| DE69934027T2 (de) | 2007-06-21 |
| KR20010108089A (ko) | 2001-12-07 |
| CN1159305C (zh) | 2004-07-28 |
| HK1041691B (zh) | 2004-12-24 |
| EP1142885B1 (en) | 2006-11-15 |
| PT1142885E (pt) | 2007-02-28 |
| IL144229A (en) | 2006-10-05 |
| DE69934027D1 (de) | 2006-12-28 |
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