DK1150959T3 - Faststoftilstandsform af Celecoxib, der har foröget biotilgængelighed - Google Patents

Faststoftilstandsform af Celecoxib, der har foröget biotilgængelighed

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Publication number
DK1150959T3
DK1150959T3 DK00982255T DK00982255T DK1150959T3 DK 1150959 T3 DK1150959 T3 DK 1150959T3 DK 00982255 T DK00982255 T DK 00982255T DK 00982255 T DK00982255 T DK 00982255T DK 1150959 T3 DK1150959 T3 DK 1150959T3
Authority
DK
Denmark
Prior art keywords
celecoxib
amorphous
drug substance
solid state
state form
Prior art date
Application number
DK00982255T
Other languages
English (en)
Inventor
Michael J Hageman
Xiaorong He
Tugrul T Kararli
Lesley A Mackin
Patricia J Miyake
Brian R Rohrs
Kevin J Stefanski
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26865450&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1150959(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Application granted granted Critical
Publication of DK1150959T3 publication Critical patent/DK1150959T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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DK00982255T 1999-12-08 2000-12-06 Faststoftilstandsform af Celecoxib, der har foröget biotilgængelighed DK1150959T3 (da)

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Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA74539C2 (en) * 1999-12-08 2006-01-16 Pharmacia Corp Crystalline polymorphous forms of celecoxib (variants), a method for the preparation thereof (variants), a pharmaceutical composition (variants)
EA003612B1 (ru) * 1999-12-08 2003-06-26 Фармация Корпорейшн Твердая форма целекоксиба, имеющего повышенную биодоступность
DZ3227A1 (fr) 1999-12-23 2001-07-05 Pfizer Prod Inc Compositions pharmaceutiques fournissant des concentrations de medicaments ameliorees
US6800297B2 (en) * 2000-06-15 2004-10-05 Acusphere, Inc. Porous COX-2 inhibitor matrices and methods of manufacture thereof
US6589557B2 (en) 2000-06-15 2003-07-08 Acusphere, Inc. Porous celecoxib matrices and methods of manufacture thereof
TWI256305B (en) * 2000-08-18 2006-06-11 Pharmacia Corp Oral fast-melt pharmaceutical composition of a cyclooxygenase-2 inhibitor and process for preparing the same
MXPA03011784A (es) 2001-06-22 2004-04-02 Pfizer Prod Inc Composiciones farmaceuticas de dispersiones de farmacos y polimeros neutros.
WO2003063833A1 (en) 2002-02-01 2003-08-07 Pfizer Products Inc. Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials
US20090088443A1 (en) * 2002-02-15 2009-04-02 Julius Remenar Novel crystalline forms of conazoles and methods of making and using the same
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
WO2003074474A2 (en) * 2002-03-01 2003-09-12 University Of South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
WO2004026235A2 (en) * 2002-09-20 2004-04-01 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US20050025791A1 (en) 2002-06-21 2005-02-03 Julius Remenar Pharmaceutical compositions with improved dissolution
US20100311701A1 (en) * 2002-02-15 2010-12-09 Transform Pharmaceuticals, Inc Pharmaceutical Co-Crystal Compositions
MY139721A (en) * 2002-04-19 2009-10-30 Cpex Pharmaceuticals Inc Pharmaceutical composition
EP1505987A2 (en) * 2002-05-13 2005-02-16 Pharmacia Corporation Stable amorphous celecoxib composite and process therefor
AU2003295846A1 (en) * 2002-11-26 2004-06-18 Transform Pharmaceuticals, Inc. Pharmaceutical formulations of celcoxib
US8183290B2 (en) * 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
EP2339328A3 (en) 2002-12-30 2011-07-13 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of celecoxib
US20040156894A1 (en) * 2003-02-07 2004-08-12 Grother Leon Paul Use of edible acids in fast-dispersing pharmaceutical solid dosage forms
CA2514733A1 (en) * 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
US8512727B2 (en) 2003-03-03 2013-08-20 Alkermes Pharma Ireland Limited Nanoparticulate meloxicam formulations
MXPA06001417A (es) 2003-08-04 2006-05-15 Pfizer Prod Inc Composiciones farmaceuticas de adsorbatos de farmacos amorfos y materiales que forman microfases lipofilas.
EP1675585A2 (en) * 2003-10-17 2006-07-05 Tanabe Seiyaku Co., Ltd. Large conductance calcium-activated k channel opener
CA2549225A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride
US6984403B2 (en) 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
US8974823B2 (en) * 2003-12-31 2015-03-10 Bend Research, Inc. Solid compositions of low-solubility drugs and poloxamers
WO2005065656A2 (en) * 2003-12-31 2005-07-21 Pfizer Products Inc. Stabilized pharmaceutical solid compositions of low-solubility drugs, poloxamers, and stabilizing polymers
FR2879075B1 (fr) * 2004-12-15 2007-01-19 Adisseo France Sas Soc Par Act Procede de preparation de granules de principe actif hydrophile par extrusion
FR2881049B1 (fr) * 2005-01-24 2008-12-26 Vetoquinol Sa Sa Medicament destine a etre administre par voie orale comprenant un inhibiteur de la cyclo-oxygenase-2, et son procede de preparation
US20100009005A1 (en) * 2005-05-24 2010-01-14 Flamel Technologies ,S.A. Novel acetysalicylic acid formulations
US20080075768A1 (en) * 2006-07-21 2008-03-27 Vaughn Jason M Hydrophobic opioid abuse deterrent delivery system using opioid antagonists
PE20081506A1 (es) 2006-12-12 2008-12-09 Infinity Discovery Inc Formulaciones de ansamicina
WO2008085674A1 (en) * 2007-01-04 2008-07-17 Transform Pharmaceuticals, Inc. Pharmaceutical compositions comprising celecoxib co-crystals
US20100233272A1 (en) * 2007-11-15 2010-09-16 Leah Elizabeth Appel Dosage forms comprising celecoxib providing both rapid and sustained pain relief
EP2105130A1 (de) * 2008-03-25 2009-09-30 Ratiopharm GmbH Pharmazeutische Formulierung und Verfahren zu deren Herstellung
EP2133068A1 (de) * 2008-06-13 2009-12-16 Ratiopharm GmbH Verfahren zur Auswahl eines geeigneten Hilfsstoffs für die Herstellung von festen Dispersionen für pharmazeutische Formulierungen
CN102238941A (zh) * 2008-09-17 2011-11-09 迈兰实验室公司 颗粒、制备它们的方法和包含它们的药物产品
JP5778667B2 (ja) * 2009-06-19 2015-09-16 ナノフォーム ハンガリー リミテッド ナノ粒子のテルミサルタン組成物及びその調製方法
WO2010150144A2 (en) * 2009-06-25 2010-12-29 Wockhardt Research Centre Low dose pharmaceutical compositions of celecoxib
WO2011055233A2 (en) 2009-11-03 2011-05-12 Actavis Group Ptc Ehf Improved process for preparing celecoxib polymorph
US20110213159A1 (en) 2010-03-01 2011-09-01 Vamsee Krishna Muppidi Process for preparation of celecoxib crystalline form
CN102764264A (zh) * 2012-07-25 2012-11-07 杭州和泽医药科技有限公司 一种具高溶出度的塞来昔布固体组合物、制备方法及应用
CN103655478A (zh) * 2012-09-26 2014-03-26 北京星昊医药股份有限公司 一种塞来昔布固体分散体及其制备方法和应用
CA2898729C (en) * 2012-11-14 2018-05-08 Abon Pharmaceuticals, Llc Oral transmucosal drug delivery system
JP6304896B2 (ja) * 2013-07-30 2018-04-04 ライオン株式会社 錠剤
CA2943574A1 (en) * 2014-04-03 2015-10-08 Sandoz Ag Solid composition comprising amorphous sofosbuvir
AU2016267685A1 (en) * 2015-05-28 2017-12-07 Dr. Reddy's Laboratories Ltd. Oral composition of celecoxib for treatment of pain
US20180271890A1 (en) * 2015-10-07 2018-09-27 Sandoz Ag Solid Pharmaceutical Composition Comprising Amorphous Sofosbuvir
HUP1500618A2 (en) * 2015-12-16 2017-06-28 Druggability Tech Ip Holdco Ltd Complexes of celecoxib and its salts and derivatives, process for the preparation thereof and pharmaceutical composition containing them
WO2018031577A1 (en) * 2016-08-09 2018-02-15 Autotelic Llc Fixed dose combination for pain relief without edema
US10736905B1 (en) 2016-09-09 2020-08-11 Shahin Fatholahi Nefopam dosage forms and methods of treatment
KR102002906B1 (ko) * 2016-10-18 2019-07-23 경동제약 주식회사 셀레콕시브를 포함하는 정제
EP3554547A4 (en) 2016-12-14 2020-08-12 Druggability Technologies IP Holdco Limited PHARMACEUTICAL COMPOSITION CONTAINING CELECOXIB
US11446311B2 (en) 2017-09-08 2022-09-20 Shahin Fatholahi Methods for treating pain associated with sickle cell disease
US10736874B1 (en) 2017-09-08 2020-08-11 Shahin Fatholahi Methods for treating pain associated with sickle cell disease
WO2020214791A1 (en) * 2019-04-18 2020-10-22 Nangenex Nanotechnology Incorporated Celecoxib compositions and methods for their use
CN111505058A (zh) * 2020-03-05 2020-08-07 艾普康(香港)有限公司 乳房炎检测分析仪
CN112358492B (zh) * 2020-11-13 2022-04-15 兰州大学 碳硼烷基塞来昔布及其制备和在头颈癌硼中子俘获治疗药物中的应用
EP4267132A1 (en) 2020-12-28 2023-11-01 Dr. Reddy's Laboratories Ltd. Celecoxib for treating pain
AU2022305851A1 (en) * 2021-07-09 2024-02-15 US Nano Food & Drug INC Method of production of the composition of cyclooxygenase-2 (cox-2) inhibitors
KR102459968B1 (ko) * 2022-01-21 2022-10-27 주식회사 큐어팜텍 기능성 약물이 함유된 생분해성 수지 제조방법 및 이에 의해 제조된 생분해성 수지
CN116942630B (zh) * 2023-09-19 2023-12-26 北京福元医药股份有限公司 一种塞来昔布胶囊剂及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2525108B1 (fr) * 1982-04-19 1989-05-12 Elan Corp Ltd Medicaments a haut degre de solubilite et procede pour leur obtention
JPS60139688A (ja) * 1983-12-28 1985-07-24 Tokyo Tanabe Co Ltd 無定形ジヒドロピリジン粉末製剤
RO118291B1 (ro) * 1993-11-30 2003-04-30 Searle & Co Derivati de pirazol 1,3,4,5 - tetrasubstituiti si compozitie farmaceutica care ii contine
US5466823A (en) 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
CZ292320B6 (cs) * 1995-05-25 2003-09-17 G. D. Searle & Co. Způsob přípravy pyrazolů
CN1211928A (zh) 1996-11-04 1999-03-24 联合碳化化学品及塑料技术公司 提高基本不溶于水的化合物溶解度的方法
KR100187959B1 (ko) 1997-03-31 1999-06-01 윤재승 저융점 무정형 세푸록심 악세틸의 제조방법
SE9802333D0 (sv) * 1998-06-29 1998-06-29 Astra Pharma Prod Novel combination
ATE284691T1 (de) * 1998-11-02 2005-01-15 Merck & Co Inc Zusammensetzungen aus einem 5ht1b/1d agonisten und einem selektiven cox-2 hemmer zur behandlung von migräne
SA99191255B1 (ar) * 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
CA2360354A1 (en) 1999-01-14 2000-07-20 Sophie-Dorothee Clas Synthesis of 4-[(5-substituted or unsubstituted phenyl)-3-substituted-1h-pyrazol-1-yl] benzenesulfonamides
WO2000066562A1 (en) * 1999-05-03 2000-11-09 Dr. Reddy's Research Foundation Pyrazoles having antiinflammatory activity
US6395300B1 (en) * 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
GB9920558D0 (en) 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
EA003612B1 (ru) * 1999-12-08 2003-06-26 Фармация Корпорейшн Твердая форма целекоксиба, имеющего повышенную биодоступность
EP1505987A2 (en) * 2002-05-13 2005-02-16 Pharmacia Corporation Stable amorphous celecoxib composite and process therefor

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EP1150959A1 (en) 2001-11-07
EA003612B1 (ru) 2003-06-26
US20020006951A1 (en) 2002-01-17
US20050267190A1 (en) 2005-12-01
US6964978B2 (en) 2005-11-15
NO20013855D0 (no) 2001-08-08
CY1107389T1 (el) 2012-12-19
DE60038162D1 (de) 2008-04-10
DE60038162T2 (de) 2009-02-26
HUP0201450A3 (en) 2003-02-28
WO2001042221A1 (en) 2001-06-14
ES2299441T3 (es) 2008-06-01
NO320844B1 (no) 2006-02-06
US20070202160A1 (en) 2007-08-30
ATE387431T1 (de) 2008-03-15
PL203262B1 (pl) 2009-09-30
CA2362673A1 (en) 2001-06-14
BR0008058A (pt) 2002-03-26
NO20013855L (no) 2001-10-05
EA200100873A1 (ru) 2002-02-28
AU1931101A (en) 2001-06-18
NZ513964A (en) 2004-01-30
SK12682001A3 (sk) 2002-07-02
IL144761A (en) 2007-07-24
CN1376146A (zh) 2002-10-23
HUP0201450A2 (hu) 2002-12-28
PL349223A1 (en) 2002-07-01
JP2004500358A (ja) 2004-01-08
EP1150959B1 (en) 2008-02-27
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