DK1156798T3 - Felbamat-afledte forbindelser - Google Patents
Felbamat-afledte forbindelserInfo
- Publication number
- DK1156798T3 DK1156798T3 DK00907199T DK00907199T DK1156798T3 DK 1156798 T3 DK1156798 T3 DK 1156798T3 DK 00907199 T DK00907199 T DK 00907199T DK 00907199 T DK00907199 T DK 00907199T DK 1156798 T3 DK1156798 T3 DK 1156798T3
- Authority
- DK
- Denmark
- Prior art keywords
- felbamate
- derived compounds
- derivatives
- treat
- epilepsy
- Prior art date
Links
- WKGXYQFOCVYPAC-UHFFFAOYSA-N felbamate Chemical compound NC(=O)OCC(COC(N)=O)C1=CC=CC=C1 WKGXYQFOCVYPAC-UHFFFAOYSA-N 0.000 title abstract 4
- 229960003472 felbamate Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000000451 tissue damage Effects 0.000 abstract 1
- 231100000827 tissue damage Toxicity 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
- C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D265/10—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compounds Of Iron (AREA)
- Hard Magnetic Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Paper (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11925499P | 1999-02-09 | 1999-02-09 | |
| US13688199P | 1999-06-01 | 1999-06-01 | |
| US13720499P | 1999-06-02 | 1999-06-02 | |
| PCT/US2000/003147 WO2000047202A1 (en) | 1999-02-09 | 2000-02-08 | Felbamate derived compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1156798T3 true DK1156798T3 (da) | 2003-11-03 |
Family
ID=27382271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00907199T DK1156798T3 (da) | 1999-02-09 | 2000-02-08 | Felbamat-afledte forbindelser |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US6538024B1 (de) |
| EP (1) | EP1156798B1 (de) |
| JP (1) | JP2002536409A (de) |
| AT (1) | ATE244564T1 (de) |
| AU (1) | AU771936B2 (de) |
| CA (1) | CA2360258A1 (de) |
| DE (1) | DE60003791T2 (de) |
| DK (1) | DK1156798T3 (de) |
| ES (1) | ES2197078T3 (de) |
| MX (1) | MXPA01007968A (de) |
| NZ (1) | NZ513319A (de) |
| PT (1) | PT1156798E (de) |
| WO (1) | WO2000047202A1 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2407697A1 (en) * | 2000-05-05 | 2001-11-15 | University Of Virginia Patent Foundation | Felbamate derived compounds |
| WO2002056827A2 (en) * | 2000-10-25 | 2002-07-25 | University Of Virginia Patent Foundation | Substituted felbamate derived compounds |
| US20030166648A1 (en) * | 2002-11-01 | 2003-09-04 | Macdonald Timothy L | Felbamate derived compounds |
| PL1756225T3 (pl) | 2004-06-08 | 2009-04-30 | Lanxess Deutschland Gmbh | Masy do formowania z poliamidów o polepszonej zdolności płynięcia |
| JP4732457B2 (ja) | 2004-06-08 | 2011-07-27 | ランクセス・ドイチュランド・ゲーエムベーハー | 熱可塑性ポリエステルをベースとする改良された流動性を有する成形用組成物 |
| DK1809273T3 (da) * | 2004-09-16 | 2010-08-02 | Janssen Pharmaceutica Nv | Anvendelse af 2-phenyl-1,2-ethandiol-(di)carbamater til behandling af epileptogenese |
| EP1888570A4 (de) * | 2005-04-21 | 2010-05-19 | Medpointe Healthcare Inc | Verfahren zur synthese von dicarbamat-verbindungen und zwischenprodukte bei deren formierung |
| US20070021501A1 (en) * | 2005-07-12 | 2007-01-25 | Twyman Roy E | Methods of treating epileptogenesis |
| DE102006020984A1 (de) * | 2006-05-04 | 2007-11-08 | Lanxess Deutschland Gmbh | Leichtbauteil in Hybridbauweise |
| DE102007006493A1 (de) | 2007-02-09 | 2008-08-14 | Lanxess Deutschland Gmbh | Leichtbauteil in Hybridbauweise |
| WO2009129181A1 (en) * | 2008-04-14 | 2009-10-22 | Concert Pharmaceuticals Inc. | Propanediol-dicarbamate derivatives |
| DE102008032205A1 (de) | 2008-07-09 | 2010-01-14 | Lanxess Deutschland Gmbh | Fließverbesserte Thermoplasten |
| DE202008015396U1 (de) | 2008-11-19 | 2010-04-08 | Lanxess Deutschland Gmbh | Fahrwerkstruktur |
| DE202008015392U1 (de) | 2008-11-19 | 2010-04-08 | Lanxess Deutschland Gmbh | Pedalstruktur |
| DE202008015398U1 (de) | 2008-11-19 | 2010-04-08 | Lanxess Deutschland Gmbh | Ölwanne |
| DE102008058224A1 (de) * | 2008-11-19 | 2010-05-20 | Lanxess Deutschland Gmbh | Leichtbauteil in Hybridbauweise |
| DE202008015401U1 (de) | 2008-11-19 | 2010-04-08 | Lanxess Deutschland Gmbh | Sitzstrukturen |
| DE202008015400U1 (de) | 2008-11-19 | 2010-04-08 | Lanxess Deutschland Gmbh | Instrumententafel |
| DE202008015391U1 (de) | 2008-11-19 | 2010-04-22 | Lanxess Deutschland Gmbh | Türen- und Klappenstrukturen |
| DE102008058225A1 (de) * | 2008-11-19 | 2010-07-08 | Lanxess Deutschland Gmbh | Leichtbauteil in Hybridbauweise |
| DE202008015395U1 (de) | 2008-11-19 | 2010-04-22 | Lanxess Deutschland Gmbh | Vorderwagenstruktur |
| DE202008015399U1 (de) | 2008-11-19 | 2010-04-08 | Lanxess Deutschland Gmbh | Dachstruktur |
| DE202008015394U1 (de) | 2008-11-19 | 2010-04-08 | Lanxess Deutschland Gmbh | Längsträgerstruktur |
| DE202008015397U1 (de) | 2008-11-19 | 2010-04-22 | Lanxess Deutschland Gmbh | Säulenstruktur |
| DE102009005763A1 (de) | 2009-01-23 | 2010-07-29 | Lanxess Deutschland Gmbh | Rahmenseitenteil einer Kraftfahrzeug Karosserie |
| PL2233519T3 (pl) | 2009-03-27 | 2012-01-31 | Lanxess Deutschland Gmbh | Poliester odporny na żarzący się drut |
| DE102009020090A1 (de) | 2009-05-06 | 2010-11-11 | Lanxess Deutschland Gmbh | Reduktion des Einflusses der Wasseraufnahme auf die elektrische Leitfähigkeit von elektrisch leitfähigen Polyamid-Formmassen |
| DE102009034767A1 (de) | 2009-07-25 | 2011-01-27 | Lanxess Deutschland Gmbh & Co. Kg | Organoblechstrukturbauteil |
| US7964594B1 (en) * | 2009-12-10 | 2011-06-21 | Hoffmann-La Roche Inc. | Amino oxazine derivatives |
| UA103272C2 (uk) * | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
| CN102190866A (zh) | 2010-03-10 | 2011-09-21 | 朗盛德国有限责任公司 | 用于在熔融物中防止热降解的包括-n=c=n-的化合物 |
| DE102010053483A1 (de) | 2010-12-04 | 2012-06-06 | Lanxess Deutschland Gmbh | =N=C=N- enthaltende Verbindung zur Verhinderung des thermischen Abbaus in Schmelzen |
| EP2365028B1 (de) | 2010-03-10 | 2012-10-03 | LANXESS Deutschland GmbH | -N=C=N- enthaltende Verbindungen zur Verhinderung des thermischen Abbaus von Metall-dialkylphosphinat enthaltenden Polyalkylenterephthalaten in der Schmelze |
| EP2463338B1 (de) | 2010-12-13 | 2013-08-28 | LANXESS Deutschland GmbH | Verfahren zur Optimierung des Kristallisationsverhaltens von Polyester Formmassen |
| EP2465896A1 (de) | 2010-12-14 | 2012-06-20 | LANXESS Deutschland GmbH | Polyester Zusammensetzungen |
| US20140178479A1 (en) * | 2011-08-12 | 2014-06-26 | Perosphere, Inc. | Concentrated Felbamate Formulations for Parenteral Administration |
| EP2818297B1 (de) | 2013-06-25 | 2016-08-10 | LANXESS Deutschland GmbH | Spritzgießverfahren |
| ES2616282T3 (es) | 2013-11-27 | 2017-06-12 | Lanxess Deutschland Gmbh | Composiciones de poliéster |
| EP2878625A1 (de) | 2013-11-27 | 2015-06-03 | LANXESS Deutschland GmbH | Polyester Zusammensetzungen |
| DE102014000612A1 (de) | 2014-01-18 | 2015-07-23 | Lanxess Deutschland Gmbh | Polyester Zusammensetzungen |
| IN2014DE03298A (de) | 2013-11-27 | 2015-09-25 | Lanxess Deutschland Gmbh | |
| DE102014000613A1 (de) | 2014-01-18 | 2015-07-23 | Lanxess Deutschland Gmbh | Polyester Zusammensetzungen |
| EP2878626B1 (de) | 2013-11-27 | 2021-10-27 | LANXESS Deutschland GmbH | Verwendung von polyester-zusammensetzungen |
| EP2878630B1 (de) | 2013-11-28 | 2019-11-20 | LANXESS Deutschland GmbH | Polyamidzusammensetzungen |
| EP2915841A1 (de) | 2014-03-04 | 2015-09-09 | LANXESS Deutschland GmbH | Polyester Zusammensetzung |
| HUE039596T2 (hu) | 2014-05-05 | 2019-01-28 | Lanxess Deutschland Gmbh | Poliészter vegyületek |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2884444A (en) * | 1956-01-13 | 1959-04-28 | Carter Prod Inc | 2-phenyl-1,3 propane diol dicarbamate |
| US4161582A (en) * | 1976-11-22 | 1979-07-17 | Hoffman-La Roche Inc. | Process to produce oxazinomycin |
| US4384115A (en) * | 1981-12-14 | 1983-05-17 | The Dow Chemical Company | Process for preparing tetrahydro-1,3-oxazin-2-ones |
| US4868327A (en) | 1987-06-03 | 1989-09-19 | Carter-Wallace, Inc. | Synthesis of 2-phenyl-1,3-propanediol |
| US5292772A (en) | 1989-09-26 | 1994-03-08 | Carter-Wallace, Inc. | Method for the prevention and control of epileptic seizure associated with Lennox-Gastaut syndrome |
| US4978680A (en) | 1989-09-26 | 1990-12-18 | Carter-Wallace, Inc. | Method for the prevention and control of epileptic seizure |
| US5082861A (en) | 1989-09-26 | 1992-01-21 | Carter-Wallace, Inc. | Method for the prevention and control of epileptic seizure associated with complex partial seizures |
| US5055489A (en) | 1990-05-04 | 1991-10-08 | Carter-Wallace, Inc. | Method for the prevention and control of hypoxic damage resulting from cerebral ischemic events |
| AU5159393A (en) * | 1992-09-18 | 1994-04-12 | Schering Corporation | Process for preparing felbamate, 2-phenyl-1,3-propanediol and intermediates |
| US5462966A (en) | 1993-10-15 | 1995-10-31 | Carter-Wallace Inc. | Methods for the prevention and control of cellular damage resulting from coronary artery occlusion-reperfusion |
| US5492930A (en) * | 1994-04-25 | 1996-02-20 | Schering Corporation | Method and formulation for treating CNS disorders |
| US5728728A (en) | 1996-04-10 | 1998-03-17 | Kozachuk; Walter E. | Methods of providing neuroprotection |
-
2000
- 2000-02-08 DK DK00907199T patent/DK1156798T3/da active
- 2000-02-08 ES ES00907199T patent/ES2197078T3/es not_active Expired - Lifetime
- 2000-02-08 NZ NZ513319A patent/NZ513319A/en unknown
- 2000-02-08 EP EP00907199A patent/EP1156798B1/de not_active Expired - Lifetime
- 2000-02-08 WO PCT/US2000/003147 patent/WO2000047202A1/en not_active Ceased
- 2000-02-08 MX MXPA01007968A patent/MXPA01007968A/es not_active IP Right Cessation
- 2000-02-08 AT AT00907199T patent/ATE244564T1/de not_active IP Right Cessation
- 2000-02-08 DE DE60003791T patent/DE60003791T2/de not_active Expired - Fee Related
- 2000-02-08 JP JP2000598154A patent/JP2002536409A/ja active Pending
- 2000-02-08 PT PT00907199T patent/PT1156798E/pt unknown
- 2000-02-08 CA CA002360258A patent/CA2360258A1/en not_active Abandoned
- 2000-02-08 AU AU28734/00A patent/AU771936B2/en not_active Ceased
-
2001
- 2001-08-09 US US09/925,224 patent/US6538024B1/en not_active Expired - Fee Related
- 2001-12-17 US US10/023,059 patent/US6599935B2/en not_active Expired - Fee Related
-
2003
- 2003-06-06 US US10/456,117 patent/US6759402B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6538024B1 (en) | 2003-03-25 |
| CA2360258A1 (en) | 2000-08-17 |
| AU771936B2 (en) | 2004-04-08 |
| EP1156798B1 (de) | 2003-07-09 |
| AU2873400A (en) | 2000-08-29 |
| EP1156798A1 (de) | 2001-11-28 |
| DE60003791D1 (de) | 2003-08-14 |
| JP2002536409A (ja) | 2002-10-29 |
| DE60003791T2 (de) | 2004-02-05 |
| EP1156798A4 (de) | 2002-07-17 |
| ES2197078T3 (es) | 2004-01-01 |
| PT1156798E (pt) | 2003-11-28 |
| US6599935B2 (en) | 2003-07-29 |
| US6759402B2 (en) | 2004-07-06 |
| US20020156070A1 (en) | 2002-10-24 |
| ATE244564T1 (de) | 2003-07-15 |
| WO2000047202A1 (en) | 2000-08-17 |
| US20030229086A1 (en) | 2003-12-11 |
| MXPA01007968A (es) | 2003-07-14 |
| NZ513319A (en) | 2003-08-29 |
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