MA25809A1 - Derives d'arylmethylamine pour usage comme inhibiteurs de tryptase - Google Patents
Derives d'arylmethylamine pour usage comme inhibiteurs de tryptaseInfo
- Publication number
- MA25809A1 MA25809A1 MA26919A MA26919A MA25809A1 MA 25809 A1 MA25809 A1 MA 25809A1 MA 26919 A MA26919 A MA 26919A MA 26919 A MA26919 A MA 26919A MA 25809 A1 MA25809 A1 MA 25809A1
- Authority
- MA
- Morocco
- Prior art keywords
- tryptase
- tryptase inhibitors
- arylmethylamine
- derivatives
- arylmethylamine derivatives
- Prior art date
Links
- 239000002750 tryptase inhibitor Substances 0.000 title 1
- 102000001400 Tryptase Human genes 0.000 abstract 2
- 108060005989 Tryptase Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001668 ameliorated effect Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0012362.0A GB0012362D0 (en) | 2000-05-22 | 2000-05-22 | Chemical compounds |
| US09/843,126 US6977263B2 (en) | 2000-05-22 | 2001-04-26 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA25809A1 true MA25809A1 (fr) | 2003-07-01 |
Family
ID=26244322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA26919A MA25809A1 (fr) | 2000-05-22 | 2002-11-21 | Derives d'arylmethylamine pour usage comme inhibiteurs de tryptase |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20050228018A1 (fr) |
| EP (1) | EP1296972B1 (fr) |
| KR (1) | KR100858642B1 (fr) |
| CN (1) | CN1230431C (fr) |
| AR (1) | AR033525A1 (fr) |
| AU (2) | AU5741301A (fr) |
| BR (1) | BR0111206A (fr) |
| CA (1) | CA2409827C (fr) |
| DZ (1) | DZ3347A1 (fr) |
| HR (1) | HRP20020926B1 (fr) |
| HU (1) | HU227630B1 (fr) |
| IL (1) | IL152830A0 (fr) |
| MA (1) | MA25809A1 (fr) |
| MX (1) | MXPA02011400A (fr) |
| NO (1) | NO327378B1 (fr) |
| OA (1) | OA12274A (fr) |
| PL (1) | PL360495A1 (fr) |
| WO (1) | WO2001090101A1 (fr) |
Families Citing this family (57)
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| US7662826B2 (en) | 2002-04-23 | 2010-02-16 | Shionogi & Co., Ltd. | Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same |
| EP1567493B1 (fr) | 2002-11-26 | 2009-03-18 | Pfizer Products Inc. | Composes de piperidine phenyle a substitution phenyle s'utilisant comme activateurs de ppar |
| GB0308613D0 (en) * | 2002-12-26 | 2003-05-21 | Aventis Pharma Inc | 4-(3-Aminomethylphenyl) piperidin-1-yl- 5-(2-fluorophenylethynyl) furan-2-yl- methanone as an inhibitor of mast cell tryptase |
| EP3345895B1 (fr) | 2003-04-11 | 2019-12-04 | PTC Therapeutics, Inc. | Composé d'acide benzoïque 1,2,4-oxadiazole et son utilisation pour la suppression non-sens et le traitement de maladies |
| EP1620405A2 (fr) * | 2003-05-01 | 2006-02-01 | Abbott Laboratories | Pyrazole-amides et sulfonamides modulateurs des canaux sodiques |
| SI1867644T1 (sl) | 2003-07-24 | 2009-10-31 | Euro Celtique Sa | Heteroaril-tetrahidropiperidilne spojine, koristne za zdravljenje ali preprečevanje bolečine |
| KR101182690B1 (ko) * | 2004-03-02 | 2012-09-14 | 아벤티스 파마슈티칼스 인크. | 트립타제 억제제의 제조방법 |
| EP1571150A1 (fr) * | 2004-03-02 | 2005-09-07 | Aventis Pharma Deutschland GmbH | Procédé pour la prparation des inhibiteurs de tryptase |
| DE602005017129D1 (de) | 2004-03-22 | 2009-11-26 | Lilly Co Eli | Pyridyl-derivate und ihre verwendung als mglu5-rezeptorantagonisten |
| DOP2005000039A (es) * | 2004-03-26 | 2005-10-31 | Aventis Pharma Inc | Hidrocloruro de [4-(5-aminometil-2-fluoro-fenil)- piperidin-1-il]-(4-bomo-3-metil-5-propoxi-tiofen-2-il)-metanona como un inhibidor de la triptasa de mastocitos |
| EP1775298B1 (fr) | 2004-07-01 | 2013-03-20 | Daiichi Sankyo Company, Limited | Dérivé de thiénopyrazole ayant une activité d'inhibition de la pde7 |
| CA2573223C (fr) * | 2004-08-06 | 2013-05-21 | Otsuka Pharmaceutical Co., Ltd. | Compose aromatique |
| WO2006044456A1 (fr) * | 2004-10-13 | 2006-04-27 | Ptc Therapeutics, Inc. | Composes de suppression de non-sens et procedes de leur utilisation |
| JP2008521821A (ja) | 2004-11-29 | 2008-06-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体のモジュレーター |
| CA2587664A1 (fr) * | 2004-12-21 | 2006-06-29 | Devgen N.V. | Composes inter-reagissant avec des canaux ioniques, en particulier avec des canaux ioniques de la famille kv |
| WO2007073432A2 (fr) | 2005-10-11 | 2007-06-28 | Chemocentryx, Inc. | Derives de la piperidine et procedes d’utilisation |
| CA2630468C (fr) | 2005-12-05 | 2015-01-20 | Otsuka Pharmaceutical Co., Ltd. | Medicament |
| RU2462246C2 (ru) | 2006-03-30 | 2012-09-27 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способы получения функционального белка из днк, имеющей нонсенс-мутацию, и лечения нарушений, ассоциированных с ней |
| WO2008019302A1 (fr) * | 2006-08-04 | 2008-02-14 | Decode Genetics Ehf | Inhibiteurs pyrazolylphényliques et pyrrolylphényliques de la lta4h pour le traitement de l'inflammation |
| UA95978C2 (ru) | 2006-10-02 | 2011-09-26 | Оцука Фармас'Ютікел Ко., Лтд. | Ингибитор активации stat3/5 |
| TW200833663A (en) * | 2006-12-21 | 2008-08-16 | Astrazeneca Ab | Therapeutic agents |
| WO2008075077A1 (fr) * | 2006-12-21 | 2008-06-26 | Astrazeneca Ab | Dérivés de pipéridine destinés au traitement de l'obésité |
| CA2687931C (fr) | 2007-05-31 | 2016-05-24 | Boehringer Ingelheim International Gmbh | Antagonistes des recepteurs ccr2 et utilisations de ceux-ci |
| US8703119B2 (en) * | 2007-10-05 | 2014-04-22 | Polygene Ltd. | Injectable biodegradable polymer compositions for soft tissue repair and augmentation |
| US8158792B2 (en) | 2007-11-21 | 2012-04-17 | Janssen Pharmaceutica N.V. | Spiropiperidines for use as tryptase inhibitors |
| PT2682120T (pt) * | 2007-12-20 | 2016-11-07 | Teva Pharma | Preparações de laquinimod estáveis |
| MX2011001135A (es) * | 2008-08-22 | 2011-03-21 | Sanofi Aventis | [4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-[7-fluoro-1-(2-m etoxi-etil)-4-trifluorometoxi-1h-indol-3-il]-metanona como un inhibidor de la triptasa de mastocitos. |
| CN102256963B (zh) | 2008-12-19 | 2014-06-11 | 贝林格尔.英格海姆国际有限公司 | 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺 |
| FR2955324A1 (fr) * | 2010-01-15 | 2011-07-22 | Sanofi Aventis | [4-(5-aminomethyl-phenyl)-piperidin-1-yl]-1h-indol-3-yl]-methanones disubstituees |
| MX346393B (es) | 2009-12-17 | 2017-03-17 | Centrexion Therapeutics Corp | Nuevos antagonistas del receptor ccr2 y usos de los mismo. |
| RU2012131341A (ru) * | 2009-12-23 | 2014-01-27 | Санофи | Индол-пиперидинилбензиламины как ингибиторы бета-триптазы |
| WO2011079103A1 (fr) * | 2009-12-23 | 2011-06-30 | Sanofi | Spiropipéridine benzylaminesutiles comme inhibitrices de la bêta-tryptase |
| JP2013515723A (ja) * | 2009-12-23 | 2013-05-09 | サノフイ | 炎症性腸疾患の処置 |
| AU2010333772B2 (en) * | 2009-12-23 | 2016-07-14 | Sanofi | Prodrugs of [4[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(1H-pyrrolo-pyridin-yl)-methanones and synthesis thereof |
| AU2010333893A1 (en) * | 2009-12-23 | 2012-07-19 | Sanofi | [4[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(1H-pyrrolo-pyridin-yl)-methanones and synthesis thereof |
| EP3002008B8 (fr) * | 2010-03-11 | 2018-10-24 | New York University | Composés d'amido comme modulateurs roryt et leurs utilisations |
| JP2013526507A (ja) | 2010-05-12 | 2013-06-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ccr2受容体アンタゴニスト、その製造方法及び薬物としてのその使用 |
| WO2011141477A1 (fr) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | Nouveaux antagonistes du récepteur ccr2, leur procédé de production et leur utilisation en tant que médicaments |
| WO2011144501A1 (fr) | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Antagonistes du récepteur ccr2 et leurs utilisations |
| WO2011147772A1 (fr) | 2010-05-25 | 2011-12-01 | Boehringer Ingelheim International Gmbh | Antagonistes du récepteur ccr2 |
| US8962656B2 (en) | 2010-06-01 | 2015-02-24 | Boehringer Ingelheim International Gmbh | CCR2 antagonists |
| WO2013058824A1 (fr) | 2011-04-07 | 2013-04-25 | Cornell University | Monomères aptes à dimériser dans une solution aqueuse et leurs procédés d'utilisation |
| WO2013010839A1 (fr) | 2011-07-15 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Antagonistes de ccr2 nouveaux et sélectifs |
| US10092574B2 (en) | 2012-09-26 | 2018-10-09 | Valorisation-Recherche, Limited Partnership | Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof |
| AU2013353004A1 (en) | 2012-11-30 | 2015-07-09 | Kyowa Hakko Kirin Co., Ltd. | Nitrogen-containing heterocyclic compound |
| TW201441193A (zh) | 2012-12-06 | 2014-11-01 | Kyowa Hakko Kirin Co Ltd | 吡啶酮化合物 |
| JP6744218B2 (ja) | 2013-11-15 | 2020-08-19 | ザ ウィスター インスティテュート オブ アナトミー アンド バイオロジー | Ebna1阻害剤およびそれらの使用方法 |
| JP6946001B2 (ja) | 2014-03-06 | 2021-10-06 | ピーティーシー セラピューティクス, インコーポレイテッド | 薬学的組成物、および1,2,4−オキサジアゾール安息香酸の塩 |
| BR112017024481B1 (pt) | 2015-05-14 | 2020-11-17 | The Wistar Institute Of Anatomy And Biology | composto inibidor de ebna1, composição farmacêutica compreendendo dito composto e usos terapêuticos do mesmo |
| AU2016287584B2 (en) | 2015-07-02 | 2020-03-26 | Centrexion Therapeutics Corporation | (4-((3R,4R)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2R,6S)-6-(p-tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate |
| HK1251965A1 (zh) | 2015-10-30 | 2019-05-10 | Ptc医疗公司 | 用於治疗癫痫的方法 |
| CN112543634A (zh) | 2018-05-17 | 2021-03-23 | 威斯达研究所 | Ebna1抑制剂晶体形式及其制备和使用方法 |
| US12479816B2 (en) | 2019-02-08 | 2025-11-25 | University of Pittsburgh—of the Commonwealth System of Higher Education | 20-HETE formation inhibitors |
| CN110357833B (zh) * | 2019-06-03 | 2022-05-24 | 杭州维坦医药科技有限公司 | 芳杂乙酰胺类衍生物及其制备和应用 |
| TW202115086A (zh) | 2019-06-28 | 2021-04-16 | 美商輝瑞大藥廠 | Bckdk抑制劑 |
| JP7789016B2 (ja) * | 2020-06-04 | 2025-12-19 | ピライ ユニバーサル エルエルシー | 癌治療における標的化不能kraの標的分解のための新規の小分子 |
| WO2025195508A1 (fr) * | 2024-03-22 | 2025-09-25 | 润尔眼科药物(广州)有限公司 | Composé de phényle hétérocyclique et son utilisation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4407139A1 (de) * | 1994-03-04 | 1995-09-07 | Thomae Gmbh Dr K | Aryl-1-azacycloalkane und deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| US6673908B1 (en) * | 1999-02-22 | 2004-01-06 | Nuvelo, Inc. | Tumor necrosis factor receptor 2 |
-
2001
- 2001-04-27 AU AU5741301A patent/AU5741301A/xx active Pending
- 2001-04-27 CN CNB018119522A patent/CN1230431C/zh not_active Expired - Lifetime
- 2001-04-27 KR KR1020027015683A patent/KR100858642B1/ko not_active Expired - Fee Related
- 2001-04-27 DZ DZ013347A patent/DZ3347A1/fr active
- 2001-04-27 HU HU0302485A patent/HU227630B1/hu not_active IP Right Cessation
- 2001-04-27 PL PL36049501A patent/PL360495A1/xx not_active Application Discontinuation
- 2001-04-27 AU AU2001257413A patent/AU2001257413B2/en not_active Ceased
- 2001-04-27 OA OA1200200357A patent/OA12274A/en unknown
- 2001-04-27 CA CA2409827A patent/CA2409827C/fr not_active Expired - Lifetime
- 2001-04-27 WO PCT/US2001/013811 patent/WO2001090101A1/fr not_active Ceased
- 2001-04-27 IL IL15283001A patent/IL152830A0/xx unknown
- 2001-04-27 HR HR20020926A patent/HRP20020926B1/xx not_active IP Right Cessation
- 2001-04-27 MX MXPA02011400A patent/MXPA02011400A/es active IP Right Grant
- 2001-04-27 AR ARP010102009A patent/AR033525A1/es active IP Right Grant
- 2001-04-27 EP EP01930925A patent/EP1296972B1/fr not_active Expired - Lifetime
- 2001-04-27 BR BR0111206-6A patent/BR0111206A/pt not_active IP Right Cessation
-
2002
- 2002-11-21 MA MA26919A patent/MA25809A1/fr unknown
- 2002-11-21 NO NO20025601A patent/NO327378B1/no not_active IP Right Cessation
-
2005
- 2005-02-14 US US11/057,809 patent/US20050228018A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1296972B1 (fr) | 2009-12-23 |
| BR0111206A (pt) | 2003-04-15 |
| KR100858642B1 (ko) | 2008-09-17 |
| CA2409827C (fr) | 2010-06-01 |
| CN1439003A (zh) | 2003-08-27 |
| CA2409827A1 (fr) | 2001-11-29 |
| PL360495A1 (en) | 2004-09-06 |
| HU227630B1 (hu) | 2011-10-28 |
| IL152830A0 (en) | 2003-06-24 |
| NO20025601D0 (no) | 2002-11-21 |
| AR033525A1 (es) | 2003-12-26 |
| HUP0302485A2 (hu) | 2003-12-29 |
| CN1230431C (zh) | 2005-12-07 |
| AU5741301A (en) | 2001-12-03 |
| KR20030003294A (ko) | 2003-01-09 |
| EP1296972A1 (fr) | 2003-04-02 |
| OA12274A (en) | 2006-05-09 |
| DZ3347A1 (fr) | 2001-11-29 |
| HRP20020926A2 (en) | 2005-02-28 |
| HUP0302485A3 (en) | 2007-09-28 |
| AU2001257413B2 (en) | 2007-01-18 |
| HK1057899A1 (en) | 2004-04-23 |
| MXPA02011400A (es) | 2003-05-23 |
| NO327378B1 (no) | 2009-06-22 |
| HRP20020926B1 (en) | 2011-01-31 |
| NO20025601L (no) | 2003-01-06 |
| US20050228018A1 (en) | 2005-10-13 |
| WO2001090101A1 (fr) | 2001-11-29 |
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