MA25809A1 - Derives d'arylmethylamine pour usage comme inhibiteurs de tryptase - Google Patents
Derives d'arylmethylamine pour usage comme inhibiteurs de tryptaseInfo
- Publication number
- MA25809A1 MA25809A1 MA26919A MA26919A MA25809A1 MA 25809 A1 MA25809 A1 MA 25809A1 MA 26919 A MA26919 A MA 26919A MA 26919 A MA26919 A MA 26919A MA 25809 A1 MA25809 A1 MA 25809A1
- Authority
- MA
- Morocco
- Prior art keywords
- tryptase
- tryptase inhibitors
- arylmethylamine
- derivatives
- arylmethylamine derivatives
- Prior art date
Links
- 239000002750 tryptase inhibitor Substances 0.000 title 1
- 102000001400 Tryptase Human genes 0.000 abstract 2
- 108060005989 Tryptase Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001668 ameliorated effect Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0012362.0A GB0012362D0 (en) | 2000-05-22 | 2000-05-22 | Chemical compounds |
| US09/843,126 US6977263B2 (en) | 2000-05-22 | 2001-04-26 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA25809A1 true MA25809A1 (fr) | 2003-07-01 |
Family
ID=26244322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA26919A MA25809A1 (fr) | 2000-05-22 | 2002-11-21 | Derives d'arylmethylamine pour usage comme inhibiteurs de tryptase |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20050228018A1 (fr) |
| EP (1) | EP1296972B1 (fr) |
| KR (1) | KR100858642B1 (fr) |
| CN (1) | CN1230431C (fr) |
| AR (1) | AR033525A1 (fr) |
| AU (2) | AU2001257413B2 (fr) |
| BR (1) | BR0111206A (fr) |
| CA (1) | CA2409827C (fr) |
| DZ (1) | DZ3347A1 (fr) |
| HR (1) | HRP20020926B1 (fr) |
| HU (1) | HU227630B1 (fr) |
| IL (1) | IL152830A0 (fr) |
| MA (1) | MA25809A1 (fr) |
| MX (1) | MXPA02011400A (fr) |
| NO (1) | NO327378B1 (fr) |
| OA (1) | OA12274A (fr) |
| PL (1) | PL360495A1 (fr) |
| WO (1) | WO2001090101A1 (fr) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040097375A (ko) * | 2002-04-23 | 2004-11-17 | 시오노기 앤드 컴파니, 리미티드 | 피라졸로[1, 5-에이]피리미딘 유도체 및 이를 함유한엔에이디(피)에이취 산화효소 저해제 |
| ATE425966T1 (de) | 2002-11-26 | 2009-04-15 | Pfizer Prod Inc | Durch phenyl subtituierten piperidinverbindungen zur verwendung als ppar-aktivatoren |
| GB0308613D0 (en) * | 2002-12-26 | 2003-05-21 | Aventis Pharma Inc | 4-(3-Aminomethylphenyl) piperidin-1-yl- 5-(2-fluorophenylethynyl) furan-2-yl- methanone as an inhibitor of mast cell tryptase |
| ES2887054T3 (es) | 2003-04-11 | 2021-12-21 | Ptc Therapeutics Inc | Compuesto de ácido 1,2,4-oxadiazol benzoico y su uso para la supresión sin sentido y el tratamiento de enfermedades |
| EP1620405A2 (fr) * | 2003-05-01 | 2006-02-01 | Abbott Laboratories | Pyrazole-amides et sulfonamides modulateurs des canaux sodiques |
| EP2080757A1 (fr) | 2003-07-24 | 2009-07-22 | Euro-Celtique S.A. | Composés de hétéroaryl-tétrahydropipéridyle utiles pour traiter ou prévenir la douleur |
| EP1571150A1 (fr) * | 2004-03-02 | 2005-09-07 | Aventis Pharma Deutschland GmbH | Procédé pour la prparation des inhibiteurs de tryptase |
| HRP20100040T1 (hr) * | 2004-03-02 | 2010-02-28 | Aventis Pharmaceuticals Inc. | Postupak dobivanja inhibitora triptaze |
| ES2332184T3 (es) * | 2004-03-22 | 2010-01-28 | ELI LILLY & COMPANY | Derivados de piridilo y su uso como antagonistas del receptor mglu5. |
| DOP2005000039A (es) * | 2004-03-26 | 2005-10-31 | Aventis Pharma Inc | Hidrocloruro de [4-(5-aminometil-2-fluoro-fenil)- piperidin-1-il]-(4-bomo-3-metil-5-propoxi-tiofen-2-il)-metanona como un inhibidor de la triptasa de mastocitos |
| EP2433943B1 (fr) | 2004-07-01 | 2013-09-11 | Daiichi Sankyo Company, Limited | Intermédiaires pour dérivés de thiénopyrazole ayant une activité inhibitrice de la PDE7 |
| RU2416608C2 (ru) * | 2004-08-06 | 2011-04-20 | Оцука Фармасьютикал Ко., Лтд. | Ароматическое соединение |
| EP1815206B1 (fr) * | 2004-10-13 | 2016-04-06 | PTC Therapeutics, Inc. | Composes de suppression de non-sens et procedes de leur utilisation |
| JP2008521821A (ja) | 2004-11-29 | 2008-06-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体のモジュレーター |
| KR20070092297A (ko) * | 2004-12-21 | 2007-09-12 | 데브젠 엔브이 | Kv4 이온 채널 활성을 갖는 화합물 |
| WO2007044885A2 (fr) * | 2005-10-11 | 2007-04-19 | Chemocentryx, Inc. | Derives de piperidine et leurs procedes d'utilisation |
| AU2006323700B2 (en) | 2005-12-05 | 2011-02-17 | Otsuka Pharmaceutical Co., Ltd. | Diarylether derivatives as antitumor agents |
| IN2014CN04406A (fr) | 2006-03-30 | 2015-09-04 | Ptc Therapeutics Inc | |
| US8115005B2 (en) | 2006-08-04 | 2012-02-14 | Decode Genetics Ehf. | Pyrazolylphenyl and pyrrolylphenyl inhibitors of LTA4H for treating inflammation |
| UA95978C2 (ru) | 2006-10-02 | 2011-09-26 | Оцука Фармас'Ютікел Ко., Лтд. | Ингибитор активации stat3/5 |
| WO2008075077A1 (fr) * | 2006-12-21 | 2008-06-26 | Astrazeneca Ab | Dérivés de pipéridine destinés au traitement de l'obésité |
| TW200833663A (en) * | 2006-12-21 | 2008-08-16 | Astrazeneca Ab | Therapeutic agents |
| WO2008145681A2 (fr) | 2007-05-31 | 2008-12-04 | Boehringer Ingelheim International Gmbh | Antagonistes des récepteurs ccr2 et utilisations de ceux-ci |
| US8703119B2 (en) * | 2007-10-05 | 2014-04-22 | Polygene Ltd. | Injectable biodegradable polymer compositions for soft tissue repair and augmentation |
| ES2469824T3 (es) | 2007-11-21 | 2014-06-20 | Janssen Pharmaceutica N.V. | Espiropiperidinas para su uso como inhibidores de la triptasa |
| WO2009082471A1 (fr) * | 2007-12-20 | 2009-07-02 | Teva Pharmaceutical Industries, Ltd. | Préparations de laquinimod stables |
| BRPI0916920A2 (pt) * | 2008-08-22 | 2015-11-24 | Sanofi Aventis | 4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-[7-fluoro-1-(2-metóxi-etil)-4-trifluorometóxi-1h-indol-3-il]-metanona como inibidor de triptase de mastócito, seu uso e método de preparação, bem como forma cristalina |
| DK2379525T3 (en) | 2008-12-19 | 2015-10-19 | Boehringer Ingelheim Int | Cyclic pyrimidin-4-carboxamides, as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD |
| FR2955324A1 (fr) * | 2010-01-15 | 2011-07-22 | Sanofi Aventis | [4-(5-aminomethyl-phenyl)-piperidin-1-yl]-1h-indol-3-yl]-methanones disubstituees |
| WO2011073154A1 (fr) | 2009-12-17 | 2011-06-23 | Boehringer Ingelheim International Gmbh | Nouveaux antagonistes du récepteur ccr2 et leurs utilisations |
| RU2012131146A (ru) | 2009-12-23 | 2014-02-10 | Санофи | Пролекарства [4[4-(5-аминометил-2-фторфенил)пиперидин-1-ил]-(1н-пирролпиридинил)метанонов и их синтез |
| WO2011079103A1 (fr) * | 2009-12-23 | 2011-06-30 | Sanofi | Spiropipéridine benzylaminesutiles comme inhibitrices de la bêta-tryptase |
| CN102770431A (zh) * | 2009-12-23 | 2012-11-07 | 赛诺菲 | [4[4-(5-氨基甲基-2-氟-苯基)-哌啶-1-基]-(1h-吡咯并吡啶-基)-甲酮及其合成 |
| AU2010333779A1 (en) * | 2009-12-23 | 2012-07-12 | Sanofi | Indolyl-piperidinyl benzylamines as beta-tryptase inhibitors |
| KR20120107999A (ko) * | 2009-12-23 | 2012-10-04 | 사노피 | 염증성 장 질환의 치료 |
| ES2703176T3 (es) * | 2010-03-11 | 2019-03-07 | Univ New York | Compuestos amido como moduladores de RORgammat y usos de los mismos |
| EP2569295B1 (fr) | 2010-05-12 | 2014-11-19 | Boehringer Ingelheim International GmbH | Nouveaux antagonistes du récepteur ccr2, son procédé de production et utilisation associée en tant que médicaments |
| US8877745B2 (en) | 2010-05-12 | 2014-11-04 | Boehringer Ingelheim International Gmbh | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| US8841313B2 (en) | 2010-05-17 | 2014-09-23 | Boehringer Ingelheim International Gmbh | CCR2 antagonists and uses thereof |
| US9018212B2 (en) | 2010-05-25 | 2015-04-28 | Boehringer Ingelheim International Gmbh | Pyridazine carboxamides as CCR2 receptor antagonists |
| EP2576538B1 (fr) | 2010-06-01 | 2015-10-28 | Boehringer Ingelheim International GmbH | Nouveaux antagonistes de CCR2 |
| US20140194383A1 (en) | 2011-04-07 | 2014-07-10 | Cornell University | Monomers capable of dimerizing in an aqueous solution, and methods of using same |
| JP5786258B2 (ja) | 2011-07-15 | 2015-09-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規かつ選択的なccr2拮抗薬 |
| US10092574B2 (en) | 2012-09-26 | 2018-10-09 | Valorisation-Recherche, Limited Partnership | Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof |
| EP2927214B1 (fr) * | 2012-11-30 | 2018-03-21 | Kyowa Hakko Kirin Co., Ltd. | Composé hétérocyclique contenant de l'azote |
| TW201441193A (zh) | 2012-12-06 | 2014-11-01 | Kyowa Hakko Kirin Co Ltd | 吡啶酮化合物 |
| MX2016006325A (es) | 2013-11-15 | 2016-12-02 | Wistar Inst | Inhibidores del antígeno nuclear 1 de epstein-barr, y su método de uso. |
| TWI695717B (zh) | 2014-03-06 | 2020-06-11 | 美商 Ptc 治療公司 | 1,2,4-二唑苯甲酸之鹽及醫藥組合物 |
| EP3294705B1 (fr) | 2015-05-14 | 2021-07-21 | The Wistar Institute Of Anatomy And Biology | Inhibiteurs d'ebna1 et méthodes les utilisant |
| WO2017004537A1 (fr) | 2015-07-02 | 2017-01-05 | Centrexion Therapeutics Corporation | Citrate de (4-((3r,4r)-3-méthoxytétrahydro-pyran-4-ylamino)pipéridin-1-yl)(5-méthyl-6-(((2r,6s)-(p-tolyl)tétrahydro-2h-pyran-2-yl)méthylamino)pyrimidin-4-yl)méthanone |
| HK1251965A1 (zh) | 2015-10-30 | 2019-05-10 | Ptc医疗公司 | 用於治疗癫痫的方法 |
| WO2019222470A1 (fr) | 2018-05-17 | 2019-11-21 | The Wistar Institute | Formes cristallines d'inhibiteur d'ebna1 et procédés de préparation et méthodes d'utilisation de celles-ci |
| WO2020163689A1 (fr) | 2019-02-08 | 2020-08-13 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Inhibiteurs de formation de 20-hete |
| CN110357833B (zh) * | 2019-06-03 | 2022-05-24 | 杭州维坦医药科技有限公司 | 芳杂乙酰胺类衍生物及其制备和应用 |
| TW202115086A (zh) | 2019-06-28 | 2021-04-16 | 美商輝瑞大藥廠 | Bckdk抑制劑 |
| EP4161511B1 (fr) * | 2020-06-04 | 2026-04-29 | Pillai Universal LLC | Nouvelles petites molécules pour la dégradation ciblée de kras ne pouvant être ciblé dans une thérapie anticancéreuse |
| WO2025195508A1 (fr) * | 2024-03-22 | 2025-09-25 | 润尔眼科药物(广州)有限公司 | Composé de phényle hétérocyclique et son utilisation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4407139A1 (de) * | 1994-03-04 | 1995-09-07 | Thomae Gmbh Dr K | Aryl-1-azacycloalkane und deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| US6673908B1 (en) * | 1999-02-22 | 2004-01-06 | Nuvelo, Inc. | Tumor necrosis factor receptor 2 |
-
2001
- 2001-04-27 OA OA1200200357A patent/OA12274A/en unknown
- 2001-04-27 HR HR20020926A patent/HRP20020926B1/xx not_active IP Right Cessation
- 2001-04-27 HU HU0302485A patent/HU227630B1/hu not_active IP Right Cessation
- 2001-04-27 IL IL15283001A patent/IL152830A0/xx unknown
- 2001-04-27 PL PL36049501A patent/PL360495A1/xx not_active Application Discontinuation
- 2001-04-27 WO PCT/US2001/013811 patent/WO2001090101A1/fr not_active Ceased
- 2001-04-27 AU AU2001257413A patent/AU2001257413B2/en not_active Ceased
- 2001-04-27 CA CA2409827A patent/CA2409827C/fr not_active Expired - Lifetime
- 2001-04-27 AR ARP010102009A patent/AR033525A1/es active IP Right Grant
- 2001-04-27 MX MXPA02011400A patent/MXPA02011400A/es active IP Right Grant
- 2001-04-27 DZ DZ013347A patent/DZ3347A1/fr active
- 2001-04-27 EP EP01930925A patent/EP1296972B1/fr not_active Expired - Lifetime
- 2001-04-27 BR BR0111206-6A patent/BR0111206A/pt not_active IP Right Cessation
- 2001-04-27 AU AU5741301A patent/AU5741301A/xx active Pending
- 2001-04-27 KR KR1020027015683A patent/KR100858642B1/ko not_active Expired - Fee Related
- 2001-04-27 CN CNB018119522A patent/CN1230431C/zh not_active Expired - Lifetime
-
2002
- 2002-11-21 MA MA26919A patent/MA25809A1/fr unknown
- 2002-11-21 NO NO20025601A patent/NO327378B1/no not_active IP Right Cessation
-
2005
- 2005-02-14 US US11/057,809 patent/US20050228018A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR0111206A (pt) | 2003-04-15 |
| EP1296972A1 (fr) | 2003-04-02 |
| EP1296972B1 (fr) | 2009-12-23 |
| HRP20020926A2 (en) | 2005-02-28 |
| NO20025601D0 (no) | 2002-11-21 |
| NO327378B1 (no) | 2009-06-22 |
| CN1439003A (zh) | 2003-08-27 |
| DZ3347A1 (fr) | 2001-11-29 |
| HUP0302485A2 (hu) | 2003-12-29 |
| WO2001090101A1 (fr) | 2001-11-29 |
| NO20025601L (no) | 2003-01-06 |
| US20050228018A1 (en) | 2005-10-13 |
| AR033525A1 (es) | 2003-12-26 |
| OA12274A (en) | 2006-05-09 |
| HU227630B1 (hu) | 2011-10-28 |
| CA2409827C (fr) | 2010-06-01 |
| AU5741301A (en) | 2001-12-03 |
| HRP20020926B1 (en) | 2011-01-31 |
| KR100858642B1 (ko) | 2008-09-17 |
| HK1057899A1 (en) | 2004-04-23 |
| MXPA02011400A (es) | 2003-05-23 |
| KR20030003294A (ko) | 2003-01-09 |
| AU2001257413B2 (en) | 2007-01-18 |
| HUP0302485A3 (en) | 2007-09-28 |
| CN1230431C (zh) | 2005-12-07 |
| IL152830A0 (en) | 2003-06-24 |
| CA2409827A1 (fr) | 2001-11-29 |
| PL360495A1 (en) | 2004-09-06 |
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