DK1171440T3 - Substituerede 3-cyano-[1,7]-, [1,5]- og [1,8]-naphthyridininhibitorer af tyrosinkinaser - Google Patents

Substituerede 3-cyano-[1,7]-, [1,5]- og [1,8]-naphthyridininhibitorer af tyrosinkinaser

Info

Publication number
DK1171440T3
DK1171440T3 DK00926043T DK00926043T DK1171440T3 DK 1171440 T3 DK1171440 T3 DK 1171440T3 DK 00926043 T DK00926043 T DK 00926043T DK 00926043 T DK00926043 T DK 00926043T DK 1171440 T3 DK1171440 T3 DK 1171440T3
Authority
DK
Denmark
Prior art keywords
naphthyridine
cyano
inhibitors
substituted
tyrosine kinases
Prior art date
Application number
DK00926043T
Other languages
English (en)
Inventor
Allan Wissner
Philip Ross Hamann
Ayako Yamashita
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of DK1171440T3 publication Critical patent/DK1171440T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK00926043T 1999-04-21 2000-04-18 Substituerede 3-cyano-[1,7]-, [1,5]- og [1,8]-naphthyridininhibitorer af tyrosinkinaser DK1171440T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29550799A 1999-04-21 1999-04-21
PCT/US2000/010250 WO2000066583A1 (en) 1999-04-21 2000-04-18 Substituted 3-cyano-[1.7], [1.5], and [1.8]-naphthyridine inhibitors of tyrosine kinases

Publications (1)

Publication Number Publication Date
DK1171440T3 true DK1171440T3 (da) 2004-08-02

Family

ID=23138006

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00926043T DK1171440T3 (da) 1999-04-21 2000-04-18 Substituerede 3-cyano-[1,7]-, [1,5]- og [1,8]-naphthyridininhibitorer af tyrosinkinaser

Country Status (23)

Country Link
EP (1) EP1171440B1 (da)
JP (1) JP2002543198A (da)
KR (1) KR20020002433A (da)
CN (1) CN100408576C (da)
AR (1) AR029880A1 (da)
AT (1) ATE264328T1 (da)
AU (1) AU776962B2 (da)
BR (1) BR0009870A (da)
CA (1) CA2365212A1 (da)
CZ (1) CZ20013660A3 (da)
DE (1) DE60009888T2 (da)
DK (1) DK1171440T3 (da)
ES (1) ES2216884T3 (da)
HK (1) HK1040077B (da)
HU (1) HUP0200816A3 (da)
IL (1) IL145870A0 (da)
NO (1) NO20015062D0 (da)
NZ (1) NZ514576A (da)
PL (1) PL350920A1 (da)
PT (1) PT1171440E (da)
RU (1) RU2001131356A (da)
WO (1) WO2000066583A1 (da)
ZA (1) ZA200108015B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7276519B2 (en) * 2002-11-25 2007-10-02 Wyeth Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors
CL2003002287A1 (es) * 2002-11-25 2005-01-14 Wyeth Corp COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
US7456176B2 (en) 2004-04-08 2008-11-25 Targegen, Inc. Benzotriazine inhibitors of kinases
WO2006124944A1 (en) * 2005-05-18 2006-11-23 Wyeth 4, 6-diamino-[1,7] naphthyridine-3-carbonitrile inhibitors of tpl2 kinase and methods of making and using the same
US7528143B2 (en) 2005-11-01 2009-05-05 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
AU2007210073B2 (en) 2006-01-31 2011-10-06 Array Biopharma Inc. Kinase inhibitors and methods of use thereof
ES2301380B1 (es) * 2006-08-09 2009-06-08 Laboratorios Almirall S.A. Nuevos derivados de 1,7-naftiridina.
ES2320955B1 (es) 2007-03-02 2010-03-16 Laboratorios Almirall S.A. Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
ES2329639B1 (es) * 2007-04-26 2010-09-23 Laboratorios Almirall S.A. Nuevos derivados de 4,8-difenilpoliazanaftaleno.
EP2108641A1 (en) 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
EP2113503A1 (en) 2008-04-28 2009-11-04 Laboratorios Almirall, S.A. New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors
KR20140015121A (ko) * 2009-06-25 2014-02-06 암젠 인크 헤테로사이클릭 화합물 및 이의 용도
EP2332939A1 (en) 2009-11-26 2011-06-15 Æterna Zentaris GmbH Novel Naphthyridine derivatives and the use thereof as kinase inhibitors
WO2012060847A1 (en) 2010-11-07 2012-05-10 Targegen, Inc. Compositions and methods for treating myelofibrosis
CN102675311A (zh) * 2011-06-14 2012-09-19 苏春华 一种氟代丙烯酰胺的衍生物
MX353190B (es) 2012-01-30 2018-01-05 F Hoffmann La Roche Ag Star Derivados de isoquinolina y naftiridina.
UY35772A (es) 2013-10-14 2015-05-29 Bayer Cropscience Ag Nuevos compuestos plaguicidas
JP6983661B2 (ja) * 2015-12-24 2021-12-17 協和キリン株式会社 α、β不飽和アミド化合物
CN107556309B (zh) * 2017-09-11 2020-12-01 浙江永宁药业股份有限公司 多取代四氢萘啶类化合物的药物用途及其制备方法
CN108299429B (zh) * 2018-04-09 2021-10-08 中南大学 一类八氢苯并萘啶化合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9312891D0 (en) * 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
AU733551B2 (en) * 1996-09-25 2001-05-17 Astrazeneca Ab Qinoline derivatives inhibiting the effect of growth factors such as VEGF
UA73073C2 (uk) * 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
TW436485B (en) * 1997-08-01 2001-05-28 American Cyanamid Co Substituted quinazoline derivatives

Also Published As

Publication number Publication date
KR20020002433A (ko) 2002-01-09
IL145870A0 (en) 2002-07-25
PL350920A1 (en) 2003-02-10
AU776962B2 (en) 2004-09-30
HUP0200816A2 (en) 2002-08-28
DE60009888T2 (de) 2005-04-21
PT1171440E (pt) 2004-07-30
JP2002543198A (ja) 2002-12-17
HK1040077B (en) 2004-09-10
CA2365212A1 (en) 2000-11-09
ZA200108015B (en) 2003-03-26
NO20015062L (no) 2001-10-18
ES2216884T3 (es) 2004-11-01
CZ20013660A3 (cs) 2002-01-16
DE60009888D1 (de) 2004-05-19
ATE264328T1 (de) 2004-04-15
CN1347416A (zh) 2002-05-01
CN100408576C (zh) 2008-08-06
NZ514576A (en) 2004-02-27
HUP0200816A3 (en) 2003-06-30
BR0009870A (pt) 2002-01-08
EP1171440A1 (en) 2002-01-16
HK1040077A1 (en) 2002-05-24
AR029880A1 (es) 2003-07-23
EP1171440B1 (en) 2004-04-14
NO20015062D0 (no) 2001-10-18
RU2001131356A (ru) 2003-06-27
AU4463900A (en) 2000-11-17
WO2000066583A1 (en) 2000-11-09

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