ATE264328T1 - Substituierte 3-cyano-(1.7), (1.5) und (1.8)naphthyridininhibitoren von tyrosin kinasen - Google Patents
Substituierte 3-cyano-(1.7), (1.5) und (1.8)naphthyridininhibitoren von tyrosin kinasenInfo
- Publication number
- ATE264328T1 ATE264328T1 AT00926043T AT00926043T ATE264328T1 AT E264328 T1 ATE264328 T1 AT E264328T1 AT 00926043 T AT00926043 T AT 00926043T AT 00926043 T AT00926043 T AT 00926043T AT E264328 T1 ATE264328 T1 AT E264328T1
- Authority
- AT
- Austria
- Prior art keywords
- naphthhyridine
- cyano
- inhibitors
- substituted
- tyrosine kinases
- Prior art date
Links
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 title 1
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29550799A | 1999-04-21 | 1999-04-21 | |
| PCT/US2000/010250 WO2000066583A1 (en) | 1999-04-21 | 2000-04-18 | Substituted 3-cyano-[1.7], [1.5], and [1.8]-naphthyridine inhibitors of tyrosine kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE264328T1 true ATE264328T1 (de) | 2004-04-15 |
Family
ID=23138006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00926043T ATE264328T1 (de) | 1999-04-21 | 2000-04-18 | Substituierte 3-cyano-(1.7), (1.5) und (1.8)naphthyridininhibitoren von tyrosin kinasen |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1171440B1 (de) |
| JP (1) | JP2002543198A (de) |
| KR (1) | KR20020002433A (de) |
| CN (1) | CN100408576C (de) |
| AR (1) | AR029880A1 (de) |
| AT (1) | ATE264328T1 (de) |
| AU (1) | AU776962B2 (de) |
| BR (1) | BR0009870A (de) |
| CA (1) | CA2365212A1 (de) |
| CZ (1) | CZ20013660A3 (de) |
| DE (1) | DE60009888T2 (de) |
| DK (1) | DK1171440T3 (de) |
| ES (1) | ES2216884T3 (de) |
| HK (1) | HK1040077B (de) |
| HU (1) | HUP0200816A3 (de) |
| IL (1) | IL145870A0 (de) |
| NO (1) | NO20015062D0 (de) |
| NZ (1) | NZ514576A (de) |
| PL (1) | PL350920A1 (de) |
| PT (1) | PT1171440E (de) |
| RU (1) | RU2001131356A (de) |
| WO (1) | WO2000066583A1 (de) |
| ZA (1) | ZA200108015B (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2003002287A1 (es) * | 2002-11-25 | 2005-01-14 | Wyeth Corp | COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS |
| US7276519B2 (en) * | 2002-11-25 | 2007-10-02 | Wyeth | Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors |
| US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| EP2543376A1 (de) | 2004-04-08 | 2013-01-09 | Targegen, Inc. | Benzotriazin Kinasehemmer |
| MX2007014258A (es) * | 2005-05-18 | 2008-01-22 | Wyeth Corp | Inhibidores de 4,6-diamino-[1,7]naftiridin-3-carbonitrilo de la tpl2 cinasa y metodos de fabricacion y uso de los mismos. |
| JP5191391B2 (ja) | 2005-11-01 | 2013-05-08 | ターゲジェン インコーポレーティッド | キナーゼのビ−アリールメタ−ピリミジン阻害剤 |
| RS52298B (sr) | 2006-01-31 | 2012-12-31 | Array Biopharma Inc. | Inhibitori kinaze i postupak njihove upotrebe |
| ES2301380B1 (es) * | 2006-08-09 | 2009-06-08 | Laboratorios Almirall S.A. | Nuevos derivados de 1,7-naftiridina. |
| ES2320955B1 (es) | 2007-03-02 | 2010-03-16 | Laboratorios Almirall S.A. | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
| ES2329639B1 (es) | 2007-04-26 | 2010-09-23 | Laboratorios Almirall S.A. | Nuevos derivados de 4,8-difenilpoliazanaftaleno. |
| EP2108641A1 (de) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | Neue substituierte Spiro[Cycloalkyl-1,3'-indo]-2'(1'H)-on-Derivate und ihre Verwendung als p38 mitogen-activated Kinase Inhibitoren |
| EP2113503A1 (de) | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | Neue substituierte Indolin-2-on- Derivate und ihre Verwendung als p39 mitogen-activated Kinase Inhibitoren |
| CN102625799A (zh) * | 2009-06-25 | 2012-08-01 | 安姆根有限公司 | 杂环化合物及其用途 |
| EP2332939A1 (de) | 2009-11-26 | 2011-06-15 | Æterna Zentaris GmbH | Neuartige Naphthyridinderivate und ihre Verwendung als Kinasehemmer |
| AU2010363329A1 (en) | 2010-11-07 | 2013-05-09 | Targegen, Inc. | Compositions and methods for treating myelofibrosis |
| CN102675311A (zh) * | 2011-06-14 | 2012-09-19 | 苏春华 | 一种氟代丙烯酰胺的衍生物 |
| EP2809652B1 (de) | 2012-01-30 | 2019-05-15 | F.Hoffmann-La Roche Ag | Isochinolin- und naphthyridinderivate |
| UY35772A (es) | 2013-10-14 | 2015-05-29 | Bayer Cropscience Ag | Nuevos compuestos plaguicidas |
| SG11201805286RA (en) * | 2015-12-24 | 2018-07-30 | Kyowa Hakko Kirin Co Ltd | α,β-UNSATURATED AMIDE COMPOUND |
| CN107556309B (zh) * | 2017-09-11 | 2020-12-01 | 浙江永宁药业股份有限公司 | 多取代四氢萘啶类化合物的药物用途及其制备方法 |
| CN108299429B (zh) * | 2018-04-09 | 2021-10-08 | 中南大学 | 一类八氢苯并萘啶化合物及其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9312891D0 (en) * | 1993-06-22 | 1993-08-04 | Boots Co Plc | Therapeutic agents |
| WO1998013350A1 (en) * | 1996-09-25 | 1998-04-02 | Zeneca Limited | Qinoline derivatives inhibiting the effect of growth factors such as vegf |
| UA73073C2 (uk) * | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| TW436485B (en) * | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
-
2000
- 2000-04-18 ES ES00926043T patent/ES2216884T3/es not_active Expired - Lifetime
- 2000-04-18 HK HK02101412.6A patent/HK1040077B/en not_active IP Right Cessation
- 2000-04-18 IL IL14587000A patent/IL145870A0/xx unknown
- 2000-04-18 AT AT00926043T patent/ATE264328T1/de not_active IP Right Cessation
- 2000-04-18 NZ NZ514576A patent/NZ514576A/xx unknown
- 2000-04-18 HU HU0200816A patent/HUP0200816A3/hu unknown
- 2000-04-18 RU RU2001131356/04A patent/RU2001131356A/ru not_active Application Discontinuation
- 2000-04-18 JP JP2000615613A patent/JP2002543198A/ja active Pending
- 2000-04-18 DE DE60009888T patent/DE60009888T2/de not_active Expired - Lifetime
- 2000-04-18 AU AU44639/00A patent/AU776962B2/en not_active Ceased
- 2000-04-18 DK DK00926043T patent/DK1171440T3/da active
- 2000-04-18 CZ CZ20013660A patent/CZ20013660A3/cs unknown
- 2000-04-18 BR BR0009870-1A patent/BR0009870A/pt not_active Application Discontinuation
- 2000-04-18 CN CNB008064261A patent/CN100408576C/zh not_active Expired - Fee Related
- 2000-04-18 PT PT00926043T patent/PT1171440E/pt unknown
- 2000-04-18 KR KR1020017013299A patent/KR20020002433A/ko not_active Withdrawn
- 2000-04-18 CA CA002365212A patent/CA2365212A1/en not_active Abandoned
- 2000-04-18 EP EP00926043A patent/EP1171440B1/de not_active Expired - Lifetime
- 2000-04-18 PL PL00350920A patent/PL350920A1/xx not_active Application Discontinuation
- 2000-04-18 WO PCT/US2000/010250 patent/WO2000066583A1/en not_active Ceased
- 2000-04-19 AR ARP000101876A patent/AR029880A1/es not_active Application Discontinuation
-
2001
- 2001-09-28 ZA ZA200108015A patent/ZA200108015B/xx unknown
- 2001-10-18 NO NO20015062A patent/NO20015062D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ514576A (en) | 2004-02-27 |
| BR0009870A (pt) | 2002-01-08 |
| DE60009888T2 (de) | 2005-04-21 |
| AU4463900A (en) | 2000-11-17 |
| DE60009888D1 (de) | 2004-05-19 |
| CZ20013660A3 (cs) | 2002-01-16 |
| AR029880A1 (es) | 2003-07-23 |
| HUP0200816A3 (en) | 2003-06-30 |
| PT1171440E (pt) | 2004-07-30 |
| EP1171440B1 (de) | 2004-04-14 |
| HUP0200816A2 (en) | 2002-08-28 |
| AU776962B2 (en) | 2004-09-30 |
| RU2001131356A (ru) | 2003-06-27 |
| PL350920A1 (en) | 2003-02-10 |
| HK1040077A1 (en) | 2002-05-24 |
| DK1171440T3 (da) | 2004-08-02 |
| WO2000066583A1 (en) | 2000-11-09 |
| HK1040077B (en) | 2004-09-10 |
| CA2365212A1 (en) | 2000-11-09 |
| NO20015062L (no) | 2001-10-18 |
| EP1171440A1 (de) | 2002-01-16 |
| JP2002543198A (ja) | 2002-12-17 |
| ZA200108015B (en) | 2003-03-26 |
| CN1347416A (zh) | 2002-05-01 |
| IL145870A0 (en) | 2002-07-25 |
| KR20020002433A (ko) | 2002-01-09 |
| CN100408576C (zh) | 2008-08-06 |
| NO20015062D0 (no) | 2001-10-18 |
| ES2216884T3 (es) | 2004-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1171440 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |