DK117193A - Fremgangsmaade til fremstilling af mellemprodukter, der kan omdannes til epipodophyllotoxin og dermed beslaegtede forbindelser, og deres anvendelse - Google Patents

Fremgangsmaade til fremstilling af mellemprodukter, der kan omdannes til epipodophyllotoxin og dermed beslaegtede forbindelser, og deres anvendelse

Info

Publication number: DK117193A
Authority: DK; Denmark
Prior art keywords: epipodophyllotoxin; intermediates; converted; procedure; preparation
Prior art date: 1985-04-12

Application number

DK117193A

Other languages

English (en)

Other versions

DK117193D0 (da

Inventor

Dolatrai M Vyas

Paul M Skonezny

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-12

Filing date

1993-10-18

Publication date

1993-10-18

1993-10-18 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1993-10-18 Publication of DK117193D0 publication Critical patent/DK117193D0/da

1993-10-18 Publication of DK117193A publication Critical patent/DK117193A/da

Links

YJGVMLPVUAXIQN-LGWHJFRWSA-N (5s,5ar,8ar,9r)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5h-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-LGWHJFRWSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 title 1
239000000543 intermediate Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Oil, Petroleum & Natural Gas (AREA)
Biotechnology (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

DK117193A 1985-04-12 1993-10-18 Fremgangsmaade til fremstilling af mellemprodukter, der kan omdannes til epipodophyllotoxin og dermed beslaegtede forbindelser, og deres anvendelse DK117193A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/722,932 US4644072A (en)	1985-04-12	1985-04-12	Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof

Publications (2)

Publication Number	Publication Date
DK117193D0 DK117193D0 (da)	1993-10-18
DK117193A true DK117193A (da)	1993-10-18

Family

ID=24904037

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK167986A DK167986A (da)	1985-04-12	1986-04-11	Mellemprodukter til fremstilling af epipodophyllotoxin og dermed beslaegtede forbindelser, deres fremstilling og anvendelse
DK117193A DK117193A (da)	1985-04-12	1993-10-18	Fremgangsmaade til fremstilling af mellemprodukter, der kan omdannes til epipodophyllotoxin og dermed beslaegtede forbindelser, og deres anvendelse

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK167986A DK167986A (da)	1985-04-12	1986-04-11	Mellemprodukter til fremstilling af epipodophyllotoxin og dermed beslaegtede forbindelser, deres fremstilling og anvendelse

Country Status (33)

Country	Link
US (1)	US4644072A (da)
JP (1)	JPS61238758A (da)
KR (1)	KR900005624B1 (da)
CN (2)	CN1021822C (da)
AT (1)	ATA96986A (da)
AU (6)	AU587021B2 (da)
BE (1)	BE904587A (da)
CA (1)	CA1275651C (da)
CH (2)	CH669190A5 (da)
CY (1)	CY1599A (da)
DE (1)	DE3612278A1 (da)
DK (2)	DK167986A (da)
EG (1)	EG18077A (da)
ES (2)	ES8802044A1 (da)
FI (1)	FI861508A7 (da)
FR (1)	FR2587335B1 (da)
GB (1)	GB2176181B (da)
GR (1)	GR860982B (da)
HK (1)	HK53391A (da)
HU (4)	HU204044B (da)
IE (1)	IE59039B1 (da)
IL (1)	IL78451A0 (da)
IT (1)	IT1208593B (da)
LU (1)	LU86392A1 (da)
MY (1)	MY101618A (da)
NL (1)	NL8600938A (da)
PT (1)	PT82383B (da)
RU (1)	RU1819265C (da)
SE (2)	SE468768B (da)
SG (1)	SG44791G (da)
SU (1)	SU1547707A3 (da)
YU (2)	YU44785B (da)
ZA (1)	ZA862747B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4644072A (en) *	1985-04-12	1987-02-17	Bristol-Myers Company	Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US5011948A (en) *	1985-04-12	1991-04-30	Bristol-Myers Company	Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US5106996A (en) *	1985-12-05	1992-04-21	Bristol-Myers Company	Process for the preparation of podophyllotoxin
US5013851A (en) *	1985-12-05	1991-05-07	Bristol-Myers Company	Intermediates for the production of podophyllotoxin and related compounds
US4734512A (en) *	1985-12-05	1988-03-29	Bristol-Myers Company	Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof
US5880131A (en) *	1993-10-20	1999-03-09	Enzon, Inc.	High molecular weight polymer-based prodrugs
US5840900A (en) *	1993-10-20	1998-11-24	Enzon, Inc.	High molecular weight polymer-based prodrugs
US5605976A (en) *	1995-05-15	1997-02-25	Enzon, Inc.	Method of preparing polyalkylene oxide carboxylic acids
GB9422947D0 (en) *	1994-11-14	1995-01-04	Univ Salamanca	Immunosuppressive cyclolignan derivatives
ATE186054T1 (de) *	1995-06-30	1999-11-15	Cerbios Pharma Sa	Glykoside, deren zuckerfreie abbauprodukte und derivate derselben
US6051721A (en) *	1997-10-02	2000-04-18	The Board Of Regents Of The University Of Nebraska	Ring E-modified analogues of(-)-podophyllotoxin and etoposide and a method for their synthesis
CA2385528C (en)	1999-10-01	2013-12-10	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US11332480B2 (en)	2017-04-27	2022-05-17	Pharma Mar, S.A.	Antitumoral compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL6613143A (da) *	1965-09-21	1967-03-22
US3716574A (en) *	1967-12-01	1973-02-13	Rayonier Inc	Pure crystalline plicatic acid tetrahydrate and the methyl ester thereof
US4122092A (en) *	1977-08-25	1978-10-24	University Of Rochester	Total synthesis of (±)-picropodophyllone and (±)-4'-demethylpicropodophyllone
US4391982A (en) *	1980-03-05	1983-07-05	The University Of Rochester	Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
US4294763A (en) *	1980-03-05	1981-10-13	University Of Rochester	Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
EP0207124B1 (en) *	1984-12-28	1991-10-09	Conpharm Ab	Use of podophyllotoxin and derivatives thereof
ES8705837A1 (es) *	1985-01-10	1987-05-16	Tanabe Seiyaku Co	Un procedimiento para la preparacion de derivados de naftaleno.
US4644072A (en) *	1985-04-12	1987-02-17	Bristol-Myers Company	Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4734512A (en) *	1985-12-05	1988-03-29	Bristol-Myers Company	Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof

1985
- 1985-04-12 US US06/722,932 patent/US4644072A/en not_active Expired - Fee Related
1986
- 1986-04-04 FR FR868604873A patent/FR2587335B1/fr not_active Expired - Fee Related
- 1986-04-08 IL IL78451A patent/IL78451A0/xx unknown
- 1986-04-09 FI FI861508A patent/FI861508A7/fi not_active Application Discontinuation
- 1986-04-10 ES ES553868A patent/ES8802044A1/es not_active Expired
- 1986-04-10 EG EG197/86A patent/EG18077A/xx active
- 1986-04-11 AU AU55993/86A patent/AU587021B2/en not_active Ceased
- 1986-04-11 CH CH1455/86A patent/CH669190A5/de not_active IP Right Cessation
- 1986-04-11 HU HU873238A patent/HU204044B/hu not_active IP Right Cessation
- 1986-04-11 DE DE19863612278 patent/DE3612278A1/de not_active Ceased
- 1986-04-11 HU HU863527A patent/HU198063B/hu not_active IP Right Cessation
- 1986-04-11 ZA ZA862747A patent/ZA862747B/xx unknown
- 1986-04-11 LU LU86392A patent/LU86392A1/fr unknown
- 1986-04-11 KR KR1019860002773A patent/KR900005624B1/ko not_active Expired
- 1986-04-11 IE IE95586A patent/IE59039B1/en not_active IP Right Cessation
- 1986-04-11 HU HU883526A patent/HU201541B/hu not_active IP Right Cessation
- 1986-04-11 CN CN86102404A patent/CN1021822C/zh not_active Expired - Fee Related
- 1986-04-11 RU SU864027396A patent/RU1819265C/ru active
- 1986-04-11 CH CH490/89A patent/CH672635A5/de not_active IP Right Cessation
- 1986-04-11 IT IT8620048A patent/IT1208593B/it active
- 1986-04-11 GB GB8608808A patent/GB2176181B/en not_active Expired
- 1986-04-11 BE BE0/216525A patent/BE904587A/fr not_active IP Right Cessation
- 1986-04-11 HU HU861538A patent/HU199846B/hu not_active IP Right Cessation
- 1986-04-11 CA CA000506409A patent/CA1275651C/en not_active Expired - Fee Related
- 1986-04-11 JP JP61084008A patent/JPS61238758A/ja active Pending
- 1986-04-11 DK DK167986A patent/DK167986A/da not_active IP Right Cessation
- 1986-04-11 SE SE8601646A patent/SE468768B/sv not_active IP Right Cessation
- 1986-04-14 GR GR860982A patent/GR860982B/el unknown
- 1986-04-14 AT AT0096986A patent/ATA96986A/de not_active Application Discontinuation
- 1986-04-14 PT PT82383A patent/PT82383B/pt not_active IP Right Cessation
- 1986-04-14 YU YU594/86A patent/YU44785B/xx unknown
- 1986-04-14 NL NL8600938A patent/NL8600938A/nl not_active Application Discontinuation
1987
- 1987-02-10 SU SU874028952A patent/SU1547707A3/ru active
- 1987-06-16 YU YU112487A patent/YU46212B/sh unknown
- 1987-10-01 MY MYPI87002724A patent/MY101618A/en unknown
- 1987-10-16 ES ES557772A patent/ES8900046A1/es not_active Expired
1989
- 1989-06-09 AU AU36285/89A patent/AU617183B2/en not_active Ceased
- 1989-06-09 AU AU36284/89A patent/AU617182B2/en not_active Ceased
- 1989-06-09 AU AU36286/89A patent/AU617184B2/en not_active Ceased
- 1989-06-09 AU AU36288/89A patent/AU617185B2/en not_active Ceased
- 1989-06-09 AU AU36287/89A patent/AU607337B2/en not_active Ceased
1991
- 1991-06-15 SG SG44791A patent/SG44791G/en unknown
- 1991-07-11 HK HK533/91A patent/HK53391A/xx unknown
- 1991-10-10 CN CN91109623A patent/CN1059520A/zh active Pending
1992
- 1992-04-03 CY CY1599A patent/CY1599A/en unknown
- 1992-08-28 SE SE9202476A patent/SE9202476D0/xx unknown
1993
- 1993-10-18 DK DK117193A patent/DK117193A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
GB2176181B (en)	1989-06-28
CA1275651C (en)	1990-10-30
SE468768B (sv)	1993-03-15
HU201541B (en)	1990-11-28
AU3628889A (en)	1989-10-05
PT82383A (en)	1986-05-01
FI861508A0 (fi)	1986-04-09
FR2587335B1 (fr)	1990-09-14
DK117193D0 (da)	1993-10-18
ZA862747B (en)	1986-11-26
CH669190A5 (de)	1989-02-28
AU5599386A (en)	1986-10-16
JPS61238758A (ja)	1986-10-24
RU1819265C (ru)	1993-05-30
YU46212B (sh)	1993-05-28
KR900005624B1 (ko)	1990-08-01
AU617183B2 (en)	1991-11-21
DE3612278A1 (de)	1986-10-16
EG18077A (en)	1991-08-30
GR860982B (en)	1986-09-01
ES8802044A1 (es)	1988-03-16
PT82383B (pt)	1988-10-14
HUT44773A (en)	1988-04-28
FR2587335A1 (fr)	1987-03-20
AU607337B2 (en)	1991-02-28
KR860008198A (ko)	1986-11-12
AU617185B2 (en)	1991-11-21
IT1208593B (it)	1989-07-10
AU3628489A (en)	1989-10-05
SU1547707A3 (ru)	1990-02-28
YU59486A (en)	1988-02-29
DK167986D0 (da)	1986-04-11
MY101618A (en)	1991-12-17
SE9202476A0 (sv)	1992-08-28
ATA96986A (de)	1994-05-15
BE904587A (fr)	1986-10-13
IL78451A0 (en)	1986-08-31
ES557772A0 (es)	1988-11-16
CN1059520A (zh)	1992-03-18
CN86102404A (zh)	1986-12-03
AU587021B2 (en)	1989-08-03
HU204044B (en)	1991-11-28
GB8608808D0 (en)	1986-05-14
CN1021822C (zh)	1993-08-18
AU3628589A (en)	1989-10-05
AU617184B2 (en)	1991-11-21
HK53391A (en)	1991-07-19
HUT47071A (en)	1989-01-30
HU199846B (en)	1990-03-28
AU3628689A (en)	1989-10-05
AU3628789A (en)	1989-10-05
SG44791G (en)	1991-07-26
IE860955L (en)	1986-10-12
HU198063B (en)	1989-07-28
NL8600938A (nl)	1986-11-03
GB2176181A (en)	1986-12-17
ES8900046A1 (es)	1988-11-16
LU86392A1 (fr)	1986-11-05
CY1599A (en)	1992-04-03
YU112487A (en)	1988-02-29
HUT47088A (en)	1989-01-30
US4644072A (en)	1987-02-17
SE8601646D0 (sv)	1986-04-11
CH672635A5 (da)	1989-12-15
YU44785B (en)	1991-02-28
IT8620048A0 (it)	1986-04-11
DK167986A (da)	1986-10-13
SE8601646L (sv)	1986-11-28
AU617182B2 (en)	1991-11-21
IE59039B1 (en)	1993-12-15
SE9202476D0 (sv)	1992-08-28
FI861508A7 (fi)	1986-10-13
ES553868A0 (es)	1988-03-16

Legal Events

Date	Code	Title	Description
1993-10-18	A0	Application filed
1994-08-22	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
DK306885D0 (da)	1985-07-04	Substituerede benzoatestere af 3-hydroxymorphinaner, deres fremstilling og anvendelse
DK165922C (da)	1993-06-28	1,2,3,6-tetrahydro-5-nitro-pyrimidinderivater, fremgangsmaade til deres fremstilling og deres anvendelse til bekaempelse af skadelige organismer
DK117193D0 (da)	1993-10-18	Fremgangsmaade til fremstilling af mellemprodukter, der kan omdannes til epipodophyllotoxin og dermed beslaegtede forbindelser, og deres anvendelse
NO871555D0 (no)	1987-04-13	Fremgangsmaate for aa skjoete endene av to med spor forsynte kjerner.
DK382486D0 (da)	1986-08-11	Fremgangsmaade til fremstilling af sphingosinderivater
DK214585D0 (da)	1985-05-14	Fremgangsmaade til fremstilling af imidazorifamyciner
DK516286D0 (da)	1986-10-28	Fremgangsmaade til fremstilling af oxazolderivater
DK328280A (da)	1981-02-01	Fremgangsmaade til fremstilling af 7-alkoxycarbonyl-6,8-dimethyl-4-hydroxymethyl-1-phthalazon og mellemprodukter herved
DK169386D0 (da)	1986-04-14	Fremgangsmaade til fremstilling af azetidinderivater og mellemprodukter dertil
DK437287A (da)	1988-02-23	2,3-dihydrofuranderivater, deres fremstilling og deres anvendelse som mellemprodukter til fremstilling af tetrahydrofuranderivater
DK28788D0 (da)	1988-01-22	Fremgangsmaade til fremstilling af alkansulfonamider
DK184687A (da)	1987-10-18	Fremgangsmaade til fremstilling af diacetonesorbose
DK533287A (da)	1988-04-16	Fremgangsmaade til fremstilling af azetidinoner
DK558487D0 (da)	1987-10-23	Fremgangsmaade til fremstilling af moertel
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DK509986D0 (da)	1986-10-24	Fremgangsmaade til fremstilling af aryl-cyanamider
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