DK1179585T3 - Indretning og fremgangsmåde til lysis - Google Patents

Indretning og fremgangsmåde til lysis

Info

Publication number
DK1179585T3
DK1179585T3 DK01118242T DK01118242T DK1179585T3 DK 1179585 T3 DK1179585 T3 DK 1179585T3 DK 01118242 T DK01118242 T DK 01118242T DK 01118242 T DK01118242 T DK 01118242T DK 1179585 T3 DK1179585 T3 DK 1179585T3
Authority
DK
Denmark
Prior art keywords
sample
cartridge
fluid
component
flow path
Prior art date
Application number
DK01118242T
Other languages
English (en)
Inventor
Farzad Pourahmadi
Jesus Ching
Ronald Chang
Kurt E Petersen
William A Mcmillian
Lee A Christel
Gregory T Kovacs
M Allen Northrup
Original Assignee
Cepheid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cepheid filed Critical Cepheid
Application granted granted Critical
Publication of DK1179585T3 publication Critical patent/DK1179585T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/06—Hydrolysis; Cell lysis; Extraction of intracellular or cell wall material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6091—Cartridges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00427—Means for dispensing and evacuation of reagents using masks
    • B01J2219/00432—Photolithographic masks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00529—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/046—Chemical or electrochemical formation of bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/704—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow using marked regions or existing inhomogeneities within the fluid stream, e.g. statistically occurring variations in a fluid parameter
    • G01F1/708—Measuring the time taken to traverse a fixed distance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Nanotechnology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Paper (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK01118242T 1997-12-24 1998-12-24 Indretning og fremgangsmåde til lysis DK1179585T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99818897A 1997-12-24 1997-12-24
US11545498A 1998-07-14 1998-07-14
PCT/US1998/027632 WO1999033559A1 (en) 1997-12-24 1998-12-24 Integrated fluid manipulation cartridge

Publications (1)

Publication Number Publication Date
DK1179585T3 true DK1179585T3 (da) 2008-11-10

Family

ID=26813217

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01118242T DK1179585T3 (da) 1997-12-24 1998-12-24 Indretning og fremgangsmåde til lysis

Country Status (10)

Country Link
US (3) US6440725B1 (da)
EP (2) EP1179585B1 (da)
JP (3) JP4209589B2 (da)
AT (1) ATE400358T1 (da)
AU (1) AU758407B2 (da)
CA (1) CA2312102C (da)
DE (1) DE69839709D1 (da)
DK (1) DK1179585T3 (da)
ES (1) ES2309022T3 (da)
WO (1) WO1999033559A1 (da)

Families Citing this family (685)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
DK1179585T3 (da) * 1997-12-24 2008-11-10 Cepheid Indretning og fremgangsmåde til lysis
US6660228B1 (en) 1998-03-02 2003-12-09 Cepheid Apparatus for performing heat-exchanging, chemical reactions
US20060029926A1 (en) * 1998-05-06 2006-02-09 Metrika, Inc. Blocking compositions for immunoassays
AU4957699A (en) 1998-06-24 2000-01-10 Chen & Chen, Llc Fluid sample testing system
US7799521B2 (en) * 1998-06-24 2010-09-21 Chen & Chen, Llc Thermal cycling
US6780617B2 (en) * 2000-12-29 2004-08-24 Chen & Chen, Llc Sample processing device and method
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US7687039B2 (en) 1998-10-28 2010-03-30 Covaris, Inc. Methods and systems for modulating acoustic energy delivery
ATE381016T1 (de) * 1998-10-28 2007-12-15 Covaris Inc Vorrichtung und verfahren zur kontrolle einer akustischen behandlung
US6948843B2 (en) * 1998-10-28 2005-09-27 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
US7981368B2 (en) 1998-10-28 2011-07-19 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
US7914994B2 (en) 1998-12-24 2011-03-29 Cepheid Method for separating an analyte from a sample
US7214544B2 (en) * 1999-03-02 2007-05-08 Qualigen, Inc. Semi-continuous blood separation using magnetic beads
TW496775B (en) * 1999-03-15 2002-08-01 Aviva Bioscience Corp Individually addressable micro-electromagnetic unit array chips
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
WO2002043864A2 (en) * 2000-11-03 2002-06-06 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US9073053B2 (en) 1999-05-28 2015-07-07 Cepheid Apparatus and method for cell disruption
US8815521B2 (en) 2000-05-30 2014-08-26 Cepheid Apparatus and method for cell disruption
US20040200909A1 (en) * 1999-05-28 2004-10-14 Cepheid Apparatus and method for cell disruption
JP4078073B2 (ja) 1999-05-28 2008-04-23 シーフィード 流体試料分析装置および方法
US6818185B1 (en) 1999-05-28 2004-11-16 Cepheid Cartridge for conducting a chemical reaction
US6706519B1 (en) * 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
US6878540B2 (en) * 1999-06-25 2005-04-12 Cepheid Device for lysing cells, spores, or microorganisms
US8709153B2 (en) 1999-06-28 2014-04-29 California Institute Of Technology Microfludic protein crystallography techniques
US7052545B2 (en) * 2001-04-06 2006-05-30 California Institute Of Technology High throughput screening of crystallization of materials
US7195670B2 (en) 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
US6692697B1 (en) * 1999-07-30 2004-02-17 Texas Instruments Incorporated Versatile flow cell front-end for optically-based integrated sensors
US6406604B1 (en) * 1999-11-08 2002-06-18 Norberto A. Guzman Multi-dimensional electrophoresis apparatus
US7329388B2 (en) 1999-11-08 2008-02-12 Princeton Biochemicals, Inc. Electrophoresis apparatus having staggered passage configuration
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US6361958B1 (en) 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
GB2357288A (en) * 1999-12-13 2001-06-20 Ortho Clinical Diagnostics Solid phase carrier coated with a polymer for adsorbing macromolecules
US20030091477A1 (en) * 1999-12-22 2003-05-15 Paul Eric A. Flow-thru chip cartridge, chip holder, system & method thereof
JP2001188061A (ja) * 1999-12-28 2001-07-10 Shimadzu Corp 分析用マイクロチップ
US6403037B1 (en) 2000-02-04 2002-06-11 Cepheid Reaction vessel and temperature control system
EP1123739B1 (en) * 2000-02-11 2006-11-29 STMicroelectronics S.r.l. Integrated device for microfluid thermoregulation, and manufacturing process thereof
JP3442338B2 (ja) 2000-03-17 2003-09-02 株式会社日立製作所 Ｄｎａ分析装置、ｄｎａ塩基配列決定装置、ｄｎａ塩基配列決定方法、および反応モジュール
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
CA2406707A1 (en) * 2000-04-06 2001-10-18 Robert Nagle Microfluidic devices and systems incorporating cover layers
US6561208B1 (en) 2000-04-14 2003-05-13 Nanostream, Inc. Fluidic impedances in microfluidic system
US20020050456A1 (en) * 2000-05-15 2002-05-02 Sheppard Norman F. Use of vapor-deposited conformal coatings in microfluidic structures
US8329118B2 (en) * 2004-09-02 2012-12-11 Honeywell International Inc. Method and apparatus for determining one or more operating parameters for a microfluidic circuit
EP1161985B1 (en) * 2000-06-05 2005-10-26 STMicroelectronics S.r.l. Process for manufacturing integrated chemical microreactors of semiconductor material, and integrated microreactor
US8048386B2 (en) 2002-02-25 2011-11-01 Cepheid Fluid processing and control
US6374684B1 (en) 2000-08-25 2002-04-23 Cepheid Fluid control and processing system
JP3993372B2 (ja) 2000-09-13 2007-10-17 独立行政法人理化学研究所 リアクタの製造方法
US20020155033A1 (en) * 2000-10-06 2002-10-24 Protasis Corporation Fluid Separate conduit cartridge
US6613224B1 (en) * 2000-10-06 2003-09-02 Waters Investments Limited Liquid separation column smart cartridge
EP1328342A4 (en) * 2000-10-10 2006-03-15 Aviva Biosciences Corp INTEGRATED BIOCHIP SYSTEM FOR SAMPLE PREPARATION AND ANALYSIS
US20090118139A1 (en) * 2000-11-07 2009-05-07 Caliper Life Sciences, Inc. Microfluidic method and system for enzyme inhibition activity screening
US7105304B1 (en) * 2000-11-07 2006-09-12 Caliper Life Sciences, Inc. Pressure-based mobility shift assays
US20050221385A1 (en) * 2000-11-07 2005-10-06 Caliper Life Sciences, Inc. Pressure based mobility shift assays
US6623700B1 (en) * 2000-11-22 2003-09-23 Xerox Corporation Level sense and control system for biofluid drop ejection devices
WO2002052045A1 (en) * 2000-12-26 2002-07-04 Aviva Biosciences Active and biocompatible platforms prepared by polymerization of surface coating films
US20020098122A1 (en) * 2001-01-22 2002-07-25 Angad Singh Active disposable microfluidic system with externally actuated micropump
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
ITMI20010434A1 (it) * 2001-03-02 2002-09-02 Oglio Stefano Dall Unita' monouso sterilizzabile di campionamento per determinazioni in microbiologia e chimica-clinica
US7192557B2 (en) 2001-03-28 2007-03-20 Handylab, Inc. Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7323140B2 (en) * 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US6674525B2 (en) * 2001-04-03 2004-01-06 Micronics, Inc. Split focusing cytometer
DE10117772C2 (de) 2001-04-09 2003-04-03 Advalytix Ag Mischvorrichtung und Mischverfahren für die Durchmischung kleiner Flüssigkeitsmengen
GB2374560B (en) * 2001-04-17 2005-04-06 Rawson Francis F H Processing vessel
US6727479B2 (en) * 2001-04-23 2004-04-27 Stmicroelectronics S.R.L. Integrated device based upon semiconductor technology, in particular chemical microreactor
US6919046B2 (en) 2001-06-07 2005-07-19 Nanostream, Inc. Microfluidic analytical devices and methods
US6981522B2 (en) 2001-06-07 2006-01-03 Nanostream, Inc. Microfluidic devices with distributing inputs
US6729352B2 (en) 2001-06-07 2004-05-04 Nanostream, Inc. Microfluidic synthesis devices and methods
US6811695B2 (en) 2001-06-07 2004-11-02 Nanostream, Inc. Microfluidic filter
US7014747B2 (en) 2001-06-20 2006-03-21 Sandia Corporation Dielectrophoretic systems without embedded electrodes
WO2003004162A1 (en) * 2001-07-02 2003-01-16 Gene Logic, Inc. Flow-thru chip cartridge, chip holder, system & method thereof
WO2003005013A1 (en) * 2001-07-03 2003-01-16 Georgia Tech Research Corporation Filtration-based microarray chip
US7217513B2 (en) * 2001-07-10 2007-05-15 Massachusetts Institute Of Technology Apparatus and method for isolating a nucleic acid from a sample
EP1277438A1 (en) * 2001-07-10 2003-01-22 Agilent Technologies, Inc. (a Delaware corporation) System for point of care diagnosis and/or analysis
AU2002341644B2 (en) * 2001-09-11 2008-02-28 Iquum, Inc. Sample vessels
DE10146545A1 (de) * 2001-09-21 2003-04-10 Merck Patent Gmbh Mikrokomponente
US7344894B2 (en) * 2001-10-16 2008-03-18 Agilent Technologies, Inc. Thermal regulation of fluidic samples within a diagnostic cartridge
EP1447667B1 (en) 2001-10-29 2011-08-24 ARKRAY, Inc. Test apparatus
US7767437B2 (en) * 2001-11-02 2010-08-03 Genefluidics, Inc. System for detection of a component in a liquid
US20030087455A1 (en) * 2001-11-07 2003-05-08 Eggers Mitchell D Sample carrier system
FR2832507B1 (fr) * 2001-11-20 2004-02-20 Stago Diagnostica Methode de detection d'analyte(s) a l'aide de particules magnetiques colloidales
US7749442B2 (en) 2001-12-14 2010-07-06 Arkray, Inc. Sample measuring device
US20030116552A1 (en) * 2001-12-20 2003-06-26 Stmicroelectronics Inc. Heating element for microfluidic and micromechanical applications
US6739576B2 (en) 2001-12-20 2004-05-25 Nanostream, Inc. Microfluidic flow control device with floating element
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
JP3721334B2 (ja) * 2002-02-01 2005-11-30 富士写真フイルム株式会社 リセプター・リガンド会合反応方法およびそれに用いるリアクタ
CA2472945A1 (en) 2002-02-13 2003-08-21 Nanostream, Inc. Microfluidic separation column devices and fabrication methods
US7261812B1 (en) 2002-02-13 2007-08-28 Nanostream, Inc. Multi-column separation devices and methods
US6814859B2 (en) 2002-02-13 2004-11-09 Nanostream, Inc. Frit material and bonding method for microfluidic separation devices
DE10206464A1 (de) * 2002-02-16 2003-08-28 Micronas Gmbh Verfahren zur Herstellung einer Sensor- oder Aktuatoranordnung sowie Sensor- oder Aktuatoranordnung
US7419821B2 (en) 2002-03-05 2008-09-02 I-Stat Corporation Apparatus and methods for analyte measurement and immunoassay
WO2003082730A1 (en) * 2002-03-31 2003-10-09 Gyros Ab Efficient mmicrofluidic devices
US7022098B2 (en) 2002-04-10 2006-04-04 Baxter International Inc. Access disconnection systems and methods
US20040254513A1 (en) * 2002-04-10 2004-12-16 Sherwin Shang Conductive polymer materials and applications thereof including monitoring and providing effective therapy
US7052480B2 (en) 2002-04-10 2006-05-30 Baxter International Inc. Access disconnection systems and methods
US10155082B2 (en) 2002-04-10 2018-12-18 Baxter International Inc. Enhanced signal detection for access disconnection systems
US7364897B2 (en) * 2002-04-11 2008-04-29 Sequenom, Inc. Methods and devices for performing chemical reactions on a solid support
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
DE10216947B4 (de) * 2002-04-17 2007-10-04 Ehrfeld Mikrotechnik Bts Gmbh Verfahren zum Homogenisieren von Emulsionen
JP4095886B2 (ja) * 2002-05-08 2008-06-04 株式会社日立ハイテクノロジーズ 化学分析装置及び遺伝子診断装置
JP4106977B2 (ja) 2002-06-21 2008-06-25 株式会社日立製作所 分析チップ及び分析装置
US20040124085A1 (en) * 2002-06-26 2004-07-01 California Institute Of Technology Microfluidic devices and methods with electrochemically actuated sample processing
WO2004005553A1 (en) * 2002-07-10 2004-01-15 Massachusetts Institute Of Technology Apparatus and method for isolating a nucleic acid from a sample
US7452507B2 (en) * 2002-08-02 2008-11-18 Sandia Corporation Portable apparatus for separating sample and detecting target analytes
JP2004081019A (ja) * 2002-08-23 2004-03-18 Jsr Corp 細胞反応検査用装置および細胞反応検査方法
US20040038385A1 (en) * 2002-08-26 2004-02-26 Langlois Richard G. System for autonomous monitoring of bioagents
US7094345B2 (en) * 2002-09-09 2006-08-22 Cytonome, Inc. Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system
CN101199917A (zh) * 2002-09-09 2008-06-18 塞通诺米公司 微射流系统中的微射流部件的实现
US7455770B2 (en) * 2002-09-09 2008-11-25 Cytonome, Inc. Implementation of microfluidic components in a microfluidic system
US6878271B2 (en) * 2002-09-09 2005-04-12 Cytonome, Inc. Implementation of microfluidic components in a microfluidic system
ITTO20020808A1 (it) * 2002-09-17 2004-03-18 St Microelectronics Srl Dispositivo integrato di analisi del dna.
ITTO20020809A1 (it) * 2002-09-17 2004-03-18 St Microelectronics Srl Micropompa, in particolare per un dispositivo integrato di analisi del dna.
JP3725109B2 (ja) * 2002-09-19 2005-12-07 財団法人生産技術研究奨励会 マイクロ流体デバイス
US20040115830A1 (en) * 2002-09-25 2004-06-17 Igor Touzov Components for nano-scale Reactor
US7143900B2 (en) * 2002-10-28 2006-12-05 Hewlett-Packard Development Company, L.P. Separation device and method of making the same
US7932098B2 (en) * 2002-10-31 2011-04-26 Hewlett-Packard Development Company, L.P. Microfluidic system utilizing thin-film layers to route fluid
US7010964B2 (en) 2002-10-31 2006-03-14 Nanostream, Inc. Pressurized microfluidic devices with optical detection regions
US7105359B2 (en) * 2002-11-12 2006-09-12 Matsushita Electric Industrial Co., Ltd. Specific coupling reaction measuring method and reagent kit and specific coupling reaction measuring apparatus for use in the same
FR2846957B1 (fr) * 2002-11-13 2005-09-30 Commissariat Energie Atomique Micro-systeme a remplissage de micro-billes et procede d'obtention
GB2395196B (en) * 2002-11-14 2006-12-27 Univ Cardiff Microfluidic device and methods for construction and application
US7175810B2 (en) * 2002-11-15 2007-02-13 Eksigent Technologies Processing of particles
AU2003278682B2 (en) * 2002-11-18 2007-07-19 Agency For Science, Technology And Research Method and system for cell and/or nucleic acid molecules isolation
US7842234B2 (en) * 2002-12-02 2010-11-30 Epocal Inc. Diagnostic devices incorporating fluidics and methods of manufacture
EP1583950B1 (en) * 2002-12-26 2017-04-05 Meso Scale Technologies, LLC. Assay cartridges and methods of using the same
CA2513880A1 (en) * 2003-01-21 2004-08-05 Micronics Inc. Method and system for microfluidic manipulation, amplification and analysis of fluids, for example, bacteria assays and antiglobulin testing
WO2004083806A2 (en) 2003-01-22 2004-09-30 University Of South Florida Autonomous genosensor apparatus and methods for use
US7338637B2 (en) * 2003-01-31 2008-03-04 Hewlett-Packard Development Company, L.P. Microfluidic device with thin-film electronic devices
EP1603674B1 (en) * 2003-02-05 2016-01-06 Iquum, Inc. Sample processing
WO2004076056A2 (en) * 2003-02-26 2004-09-10 Lake Shore Cryotronics Inc. Microfluidic chemical reactor for the manufacture of chemically-produced nanoparticles
US8501402B2 (en) * 2003-03-24 2013-08-06 Boehringer Ingelheim Rcv Gmbh & Co Kg Methods and devices for producing biomolecules
GB0307999D0 (en) * 2003-04-07 2003-05-14 Glaxo Group Ltd A system
DE10319045A1 (de) * 2003-04-25 2004-12-09 november Aktiengesellschaft Gesellschaft für Molekulare Medizin Vorrichtung und Verfahren zur Aufbereitung Biopolymerhaltiger Flüssigkeiten
CA2526409A1 (en) * 2003-05-19 2004-12-02 Brandeis University Nucleic acid processing methods, kits and devices
US7170594B2 (en) * 2003-05-28 2007-01-30 Smiths Detection, Inc. Device for polymerase chain reactions
ES2220227B1 (es) * 2003-05-30 2006-02-16 INSTITUTO NACIONAL DE TECNICA AEROESPACIAL "ESTEBAN TERRADAS" Metodo y aparato para la deteccion de sustancias o analitos a partir del analisis de una o varias muestras.
US7648835B2 (en) * 2003-06-06 2010-01-19 Micronics, Inc. System and method for heating, cooling and heat cycling on microfluidic device
US7544506B2 (en) * 2003-06-06 2009-06-09 Micronics, Inc. System and method for heating, cooling and heat cycling on microfluidic device
US20050095722A1 (en) 2003-06-10 2005-05-05 Mcgill Robert A. Micro scale flow through sorbent plate collection device
US20040259076A1 (en) * 2003-06-23 2004-12-23 Accella Scientific, Inc. Nano and micro-technology virus detection method and device
US7416132B2 (en) * 2003-07-17 2008-08-26 Sandisk Corporation Memory card with and without enclosure
JP2007531083A (ja) 2003-07-17 2007-11-01 サンディスク　コーポレイション 隆起部を備えたメモリカード
US20050013106A1 (en) 2003-07-17 2005-01-20 Takiar Hem P. Peripheral card with hidden test pins
EP3718635A1 (en) 2003-07-31 2020-10-07 Handylab, Inc. Processing particle-containing samples
WO2005028635A2 (en) * 2003-09-19 2005-03-31 Microfluidic Systems Inc. Microfluidic differential extraction cartridge
US7541166B2 (en) * 2003-09-19 2009-06-02 Microfluidic Systems, Inc. Sonication to selectively lyse different cell types
US7524464B2 (en) 2003-09-26 2009-04-28 Ahn Chong H Smart disposable plastic lab-on-a-chip for point-of-care testing
SE0302649D0 (sv) * 2003-10-04 2003-10-04 Gyros Ab Compact dispenser system
US7032605B1 (en) 2003-10-15 2006-04-25 Douglas B. Dority Dual piston rotary valve
US8007725B2 (en) * 2003-11-07 2011-08-30 Princeton Biochemicals, Inc. Electrophoresis apparatus having valve system
CA2563310A1 (en) * 2003-11-07 2005-05-26 Princeton Biochemicals, Inc. Multi-dimensional electrophoresis apparatus
DE10353985A1 (de) * 2003-11-19 2005-06-23 Olympus Biosystems Gmbh Einrichtung und Verfahren zum Manipulieren und Analysieren von Mikroobjekten auf Grundlage eines zumindest bereichsweise als fluidisches Mikrosystem oder/und Chipsystem ausgeführten Mikrosystems
US7824857B2 (en) * 2003-12-02 2010-11-02 Musc Foundation For Research Development Methods and compositions for diagnosing epithelial cell cancer
WO2005056748A1 (en) 2003-12-08 2005-06-23 Covaris, Inc. Apparatus and methods for sample preparation
US7476360B2 (en) 2003-12-09 2009-01-13 Genefluidics, Inc. Cartridge for use with electrochemical sensor
US20050130177A1 (en) 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
US7322254B2 (en) * 2003-12-12 2008-01-29 3M Innovative Properties Company Variable valve apparatus and methods
FR2863626B1 (fr) 2003-12-15 2006-08-04 Commissariat Energie Atomique Procede et dispositif de division d'un echantillon biologique par effet magnetique
JP2007516446A (ja) * 2003-12-23 2007-06-21 ファストラック インコーポレイテッド ポイントオブケア診断プラットフォーム
US20050142570A1 (en) * 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and sedimenting reagent
US7939249B2 (en) 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
US20050142571A1 (en) * 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using solid phase material
US20050142565A1 (en) * 2003-12-30 2005-06-30 Agency For Science, Technology And Research Nucleic acid purification chip
US7384791B2 (en) * 2004-01-21 2008-06-10 Hewlett-Packard Development Company, L.P. Method of analyzing blood
SG10201405756WA (en) * 2004-01-25 2014-11-27 Fluidigm Corp Crystal forming devices and systems and methods for making and using the same
GB2416030B (en) * 2004-01-28 2008-07-23 Norchip As A diagnostic system for carrying out a nucleic acid sequence amplification and detection process
FR2865806B1 (fr) * 2004-01-30 2007-02-02 Commissariat Energie Atomique Laboratoire sur puce comprenant un reseau micro-fluidique et un nez d'electronebulisation coplanaires
EP1561418B1 (en) * 2004-02-03 2011-08-17 Sysmex Corporation Analyzer, cartridge, cartridge kit
WO2005084254A2 (en) * 2004-02-27 2005-09-15 Musc Foundation For Research Development Enhanced detection of rna using a panel of truncated gene-specific primers for reverse transcription
US8101431B2 (en) * 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US7160425B2 (en) * 2004-03-25 2007-01-09 Hewlett-Packard Development Company, L.P. Cell transporter for a biodevice
US7390388B2 (en) * 2004-03-25 2008-06-24 Hewlett-Packard Development Company, L.P. Method of sorting cells on a biodevice
US7390387B2 (en) * 2004-03-25 2008-06-24 Hewlett-Packard Development Company, L.P. Method of sorting cells in series
US20050244837A1 (en) * 2004-04-28 2005-11-03 Cepheid Method and device for sample preparation control
DE102004021822B3 (de) 2004-04-30 2005-11-17 Siemens Ag Verfahren und Anordnung zur DNA-Amplifikation mittels PCR unter Einsatz von Trockenreagenzien
DE102004021780B4 (de) * 2004-04-30 2008-10-02 Siemens Ag Verfahren und Anordnung zur DNA-Isolierung mit Trockenreagenzien
ES2553097T3 (es) * 2004-05-03 2015-12-04 Handylab, Inc. Procesamiento de muestras que contienen polinucleótidos
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US20050250138A1 (en) * 2004-05-04 2005-11-10 Millipore Corporation Process for the enumeration and identification of microorganisms
JP3952036B2 (ja) * 2004-05-13 2007-08-01 コニカミノルタセンシング株式会社 マイクロ流体デバイス並びに試液の試験方法および試験システム
EP1758937B1 (en) 2004-05-24 2009-09-02 Genvault Corporation Stable protein storage and stable nucleic acid storage in recoverable form
US7311386B2 (en) 2004-06-30 2007-12-25 Lexmark Interntional, Inc. Die attach methods and apparatus for micro-fluid ejection device
US7043838B2 (en) 2004-06-30 2006-05-16 Lexmark International, Inc. Process for manufacturing a micro-fluid ejection device
US20080125330A1 (en) * 2004-07-01 2008-05-29 Cornell Research Foundation, Inc. Real-Time Pcr Detection of Microorganisms Using an Integrated Microfluidics Platform
ITBO20040420A1 (it) 2004-07-07 2004-10-07 Type S R L Macchina per taglio e formatura di piattine metalliche
WO2006017150A2 (en) 2004-07-09 2006-02-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Educatiion Identification of markers in lung and breast cancer
US8329437B1 (en) 2004-07-29 2012-12-11 E.I. Spectra, Llc Disposable particle counter cartridge
JP4661125B2 (ja) * 2004-08-04 2011-03-30 日立電線株式会社 成分分離素子およびその製造方法
US20060051265A1 (en) * 2004-09-08 2006-03-09 Health Research, Inc. Apparatus and method for sorting microstructures in a fluid medium
US8053214B2 (en) 2004-09-09 2011-11-08 Microfluidic Systems, Inc. Apparatus and method of extracting and optically analyzing an analyte from a fluid-based sample
CA2583498A1 (en) 2004-09-09 2006-03-16 Microfluidic Systems Inc. A handheld and portable microfluidic device to automatically prepare nucleic acids for analysis
EP2261650A3 (en) * 2004-09-15 2011-07-06 IntegenX Inc. Microfluidic devices
KR20070085275A (ko) * 2004-09-20 2007-08-27 유니버시티 오브 피츠버그 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 멀티플 모드에 의한 멀티플렉스 반응 억제 방법
WO2006039293A2 (en) * 2004-09-29 2006-04-13 University Of Virginia Patent Foundation Localized control of thermal properties on microdevices and applications thereof
EP1795899B1 (en) * 2004-09-30 2012-06-06 ARKRAY, Inc. Analytical instrument with film heater
CN100565207C (zh) 2004-10-01 2009-12-02 株式会社日立高新技术 化学分析装置
EP1801196A4 (en) * 2004-10-06 2011-06-15 Universal Bio Research Co Ltd REACTION TANK AND REACTION CONTROL MODULE
US8056881B2 (en) 2004-10-13 2011-11-15 University Of Virginia Patent Foundation Electrostatic actuation for management of flow in micro-total analysis systems (μ-TAS) and related method thereof
DE102004050575B3 (de) * 2004-10-15 2006-01-05 Siemens Ag Verfahren zur kombinierten Isolierung von Magnet-Beads aus einer flüssigen Probe und anschließender Thermozyklisierung für die PCR und zugehörige Anordnung
US20060094028A1 (en) * 2004-11-04 2006-05-04 Welch Allyn, Inc. Rapid diagnostic assay
US7785868B2 (en) 2004-12-02 2010-08-31 Microfluidic Systems, Inc. Apparatus to automatically lyse a sample
AU2005311631B2 (en) * 2004-12-03 2012-06-07 Cytonome/St, Llc Unitary cartridge for particle processing
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US20070141576A1 (en) * 2004-12-13 2007-06-21 Bbk Bio Corporpation Biological chip and use thereof
CA2594277A1 (en) * 2004-12-22 2006-06-29 University Of Virginia Patent Foundation The use of microwaves for thermal and non-thermal applications in micro and nanoscale devices
US8883487B2 (en) 2004-12-23 2014-11-11 Abbott Point Of Care Inc. Molecular diagnostics system and methods
JP2008527312A (ja) * 2004-12-31 2008-07-24 メムズフロウ エイピーエス たとえば細胞溶解のための脈動圧力波の生成
CN101031802B (zh) * 2005-01-07 2012-11-07 积水化学工业株式会社 使用盒的检测装置
JP4361879B2 (ja) 2005-01-07 2009-11-11 株式会社日立ハイテクノロジーズ 化学分析装置及び化学分析カートリッジ
JP2008526255A (ja) * 2005-01-13 2008-07-24 マイクロニクス， インコーポレイテッド 微量流体希薄細胞検出デバイス
JP4422623B2 (ja) 2005-01-17 2010-02-24 株式会社日立ハイテクノロジーズ 化学分析装置および化学分析カートリッジ
JP2008526251A (ja) 2005-01-18 2008-07-24 バイオセプト インコーポレイティッド パターン化されたポストを有するマイクロチャネルを用いた細胞分離
US20060252087A1 (en) * 2005-01-18 2006-11-09 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
US20060166223A1 (en) * 2005-01-26 2006-07-27 Reed Michael W DNA purification and analysis on nanoengineered surfaces
US20070017812A1 (en) * 2005-03-30 2007-01-25 Luc Bousse Optimized Sample Injection Structures in Microfluidic Separations
US20100245803A1 (en) * 2005-04-12 2010-09-30 Chromedx Inc. Blood sample holder for spectroscopic analysis
CA2507323A1 (en) * 2005-05-13 2006-11-13 Chromedx Inc. Diagnostic whole blood and plasma apparatus
CA2517299A1 (en) * 2005-08-26 2007-02-26 Chromedx Inc. Hollow needle assembly
US8206650B2 (en) * 2005-04-12 2012-06-26 Chromedx Inc. Joint-diagnostic spectroscopic and biosensor meter
JP2006300548A (ja) * 2005-04-15 2006-11-02 Hitachi Software Eng Co Ltd 検査チップ及び検査チップシステム
EP1712284B1 (en) * 2005-04-15 2012-10-10 Samsung Electronics Co., Ltd. Cell separation method using hydrophobic solid supports
KR101931899B1 (ko) 2005-05-09 2018-12-21 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
EP1920070B1 (en) 2005-05-09 2019-08-07 BioFire Diagnostics, LLC Self-contained biological analysis
US8206974B2 (en) * 2005-05-19 2012-06-26 Netbio, Inc. Ruggedized apparatus for analysis of nucleic acid and proteins
DK1883474T3 (da) * 2005-05-25 2021-06-21 Boehringer Ingelheim Vetmedica Gmbh System til integreret og automatiseret dna- eller proteinanalyse og fremgangsmåde til at drive et sådan system
US10816563B2 (en) 2005-05-25 2020-10-27 Boehringer Ingelheim Vetmedica Gmbh System for operating a system for the integrated and automated analysis of DNA or protein
WO2007053186A2 (en) 2005-05-31 2007-05-10 Labnow, Inc. Methods and compositions related to determination and use of white blood cell counts
EP1888235A1 (en) * 2005-06-06 2008-02-20 Decision Biomarkers Incorporated Assays based on liquid flow over arrays
US20060280029A1 (en) * 2005-06-13 2006-12-14 President And Fellows Of Harvard College Microfluidic mixer
JP4870946B2 (ja) * 2005-06-17 2012-02-08 凸版印刷株式会社 反応容器および反応方法
ES2373686T3 (es) * 2005-06-23 2012-02-07 Biocartis Sa Cartucho, sistema y procedimiento para diagnósticos médicos automatizados.
EP2508867A1 (en) * 2005-06-24 2012-10-10 Board Of Regents, The University Of Texas System Systems and methods including self-contained cartridges with detection systems and fluid delivery systems
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
ITBO20050481A1 (it) 2005-07-19 2007-01-20 Silicon Biosystems S R L Metodo ed apparato per la manipolazione e/o l'individuazione di particelle
US7757561B2 (en) * 2005-08-01 2010-07-20 Covaris, Inc. Methods and systems for processing samples using acoustic energy
US8343755B2 (en) * 2005-08-01 2013-01-01 University Of Virginia Patent Foundation Microdevices for chemical sensing and chemical actuation
TW200712489A (en) * 2005-08-02 2007-04-01 3M Innovative Properties Co Apparatus assembly and method for detecting an analyte
TW200712495A (en) * 2005-08-02 2007-04-01 3M Innovative Properties Co Apparatus and method for detecting an analyte
TW200712487A (en) * 2005-08-02 2007-04-01 3M Innovative Properties Co Apparatus and method for detecting an analyte
TW200714898A (en) * 2005-08-02 2007-04-16 3M Innovative Properties Co Apparatus and method for detecting an analyte
KR100714988B1 (ko) * 2005-08-09 2007-05-09 삼성전자주식회사 산화막이 표면에 형성된 실리콘 구조물 표면을 이용한ｄｎａ 정제 방법 및 정제장치
US7618588B2 (en) 2005-08-10 2009-11-17 Microfluidic Systems, Inc. Disposable integrated heater and tube assembly for thermally-driven chemical reactions
AU2006283177B2 (en) 2005-08-23 2011-11-17 University Of Virginia Patent Foundation Passive components for micro-fluidic flow profile shaping and related method thereof
WO2007041692A2 (en) 2005-10-04 2007-04-12 Magic Technologies, Inc. Microfluidic detection of analytes
CA2624914A1 (en) * 2005-10-04 2007-04-12 University Of Virginia Patent Foundation Microchip-based acoustic trapping or capture of cells for forensic analysis and related method thereof
US20070090026A1 (en) * 2005-10-06 2007-04-26 Jongyoon Han Continuous biomolecule separation in a nanofilter
JP2009511059A (ja) * 2005-10-11 2009-03-19 ハンディーラブ インコーポレイテッド ポリヌクレオチドサンプル調製装置
WO2007047336A2 (en) * 2005-10-12 2007-04-26 University Of Virginia Patent Foundation Integrated microfluidic analysis systems
US9233846B2 (en) * 2005-10-14 2016-01-12 The Regents Of The University Of California Formation and encapsulation of molecular bilayer and monolayer membranes
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
ITBO20050646A1 (it) 2005-10-26 2007-04-27 Silicon Biosystem S R L Metodo ed apparato per la caratterizzazione ed il conteggio di particelle
EP1951860A4 (en) * 2005-11-21 2012-06-06 Life Technologies Corp PORTABLE PREPARATION, ANALYSIS AND DETECTION APPARATUS FOR THE TREATMENT OF NUCLEIC ACIDS
DE102005059536B4 (de) * 2005-12-13 2008-08-28 Siemens Ag Verfahren und Biochip zur Untersuchung einer biologischen Probe
CA2634735A1 (en) 2005-12-29 2007-07-12 I-Stat Corporation Molecular diagnostics amplification system and methods
JP5000666B2 (ja) * 2006-01-25 2012-08-15 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 流体を分析する装置
JP4906362B2 (ja) 2006-01-30 2012-03-28 株式会社日立ハイテクノロジーズ 化学分析前処理装置
US8263360B2 (en) * 2006-01-30 2012-09-11 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Hydrophilic IR transparent membrane, spectroscopic sample holder comprising same and method of using same
US20110189714A1 (en) * 2010-02-03 2011-08-04 Ayliffe Harold E Microfluidic cell sorter and method
WO2009126257A1 (en) 2008-04-07 2009-10-15 E.I. Spectra, Llc Method for manufactiring a microfluidic sensor
US8616048B2 (en) * 2006-02-02 2013-12-31 E I Spectra, LLC Reusable thin film particle sensor
US9452429B2 (en) 2006-02-02 2016-09-27 E. I. Spectra, Llc Method for mutiplexed microfluidic bead-based immunoassay
US9293311B1 (en) 2006-02-02 2016-03-22 E. I. Spectra, Llc Microfluidic interrogation device
US8171778B2 (en) * 2006-05-05 2012-05-08 E I Spectra, LLC Thin film particle sensor
JP5063616B2 (ja) 2006-02-03 2012-10-31 インテジェニックス インコーポレイテッド マイクロ流体デバイス
US7815868B1 (en) * 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
EP2319558B1 (en) 2006-03-14 2014-05-21 University Of Southern California Mems device for delivery of therapeutic agents
ES2692380T3 (es) 2006-03-24 2018-12-03 Handylab, Inc. Método para realizar PCR con un cartucho con varias pistas
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US8741230B2 (en) * 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
ITTO20060226A1 (it) 2006-03-27 2007-09-28 Silicon Biosystem S P A Metodo ed apparato per il processamento e o l'analisi e o la selezione di particelle, in particolare particelle biologiche
US20100120132A1 (en) * 2006-03-31 2010-05-13 Intel Corporation Bioassays by direct optical detection of nanoparticles
JP4685691B2 (ja) * 2006-04-13 2011-05-18 株式会社日立ソリューションズ 検査チップ及び検査チップシステム
EP2016415B1 (en) 2006-04-21 2013-08-14 Nanobiosym, Inc. Single-molecule platform for drug discovery: methods for drug discovery, including discovery of anticancer and antiviral agents
EP2016611A2 (en) * 2006-04-25 2009-01-21 University Of South Florida Portable reactor for real-time nucleic acid amplification and detection
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US20100216657A1 (en) * 2006-05-16 2010-08-26 Arcxis Biotechnologies, Inc. Pcr-free sample preparation and detection systems for high speed biologic analysis and identification
JP5627886B2 (ja) * 2006-05-16 2014-11-19 フルイディウム コーポレーション 生物学的な高速解析および高速識別のための、ｐｃｒを使用しない試料調製および検出システム
KR100785016B1 (ko) * 2006-05-22 2007-12-12 삼성전자주식회사 단일 마이크로 챔버에서 핵산의 농축 및 증폭을 수행하는방법 및 장치
JP4759451B2 (ja) 2006-06-16 2011-08-31 株式会社日立ソリューションズ 生体物質の前処理チップ及び前処理チップシステム
DE102006028101B4 (de) * 2006-06-19 2014-02-13 Siemens Aktiengesellschaft Verfahren zur Analyse von amplifizierten Nukleinsäuren
US8119352B2 (en) * 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
US7549349B2 (en) * 2006-06-22 2009-06-23 Evogen, Inc. Sample cartridge for air-sampling device
US20100240022A1 (en) * 2006-06-23 2010-09-23 Mcneely Michael R Reagent preparation and valving design for liquid testing
KR101269741B1 (ko) * 2006-07-04 2013-05-30 쓰리엠 이노베이티브 프로퍼티즈 캄파니 탄성 및 접착성을 갖는 전자기파 차단용 가스켓
US8187557B2 (en) * 2006-07-13 2012-05-29 Cepheid Reagent reservoir system for analytical instruments
EP1878496A1 (en) * 2006-07-14 2008-01-16 Roche Diagnostics GmbH Apparatus for performing nucleic acid analysis
EP1878802A1 (en) * 2006-07-14 2008-01-16 Roche Diagnostics GmbH Disposable device for analysing a liquid sample containing a nucleic acid with a nucleic acid amplification apparatus
US7858363B2 (en) * 2006-07-22 2010-12-28 Zymo Research Corporation Plasmid DNA isolation
US8252160B2 (en) * 2006-07-28 2012-08-28 Hewlett-Packard Development Company, L.P. Prevention of fluid delivered to reservoir from wicking into channels within microfluidic device
JP2008051803A (ja) * 2006-07-28 2008-03-06 Sharp Corp 分析用マイクロ流路デバイス
WO2008016691A2 (en) * 2006-08-01 2008-02-07 Covaris, Inc. Methods and apparatus for treating samples with acoustic energy
US8158411B2 (en) * 2006-08-21 2012-04-17 Samsung Electronics Co., Ltd. Method of separating microorganism using nonplanar solid substrate and device for separating microorganism using the same
US7919278B2 (en) * 2006-08-21 2011-04-05 Samsung Electronics Co., Ltd. Method of amplifying nucleic acid from a cell using a nonplanar solid substrate
US20080069732A1 (en) * 2006-09-20 2008-03-20 Robert Yi Diagnostic test system
GB0618966D0 (en) * 2006-09-26 2006-11-08 Iti Scotland Ltd Cartridge system
EP2089410A4 (en) * 2006-10-11 2011-08-03 Arcxis Biotechnologies Inc DISPOSABLE MICRO-PURIFICATION CARDS, METHODS AND SYSTEMS THEREOF
US8012744B2 (en) 2006-10-13 2011-09-06 Theranos, Inc. Reducing optical interference in a fluidic device
CN101578520B (zh) 2006-10-18 2015-09-16 哈佛学院院长等 基于形成图案的多孔介质的横向流动和穿过生物测定装置、及其制备方法和使用方法
US20080153096A1 (en) * 2006-11-02 2008-06-26 Vectrant Technologies Inc. Cartridge for conducting diagnostic assays
US8765076B2 (en) 2006-11-14 2014-07-01 Handylab, Inc. Microfluidic valve and method of making same
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US20080113391A1 (en) * 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
US9102911B2 (en) 2009-05-15 2015-08-11 Biofire Diagnostics, Llc High density self-contained biological analysis
EP1925359A1 (en) 2006-11-22 2008-05-28 Covaris, Inc. Methods and apparatus for treating samples with acoustic energy to form particles and particulates
ITMI20062272A1 (it) * 2006-11-27 2008-05-28 Genedia S R L Reattore per lo svolgimento di processi biochimici particolarmente di estrazione purificazione arricchimento sedimentazione
US20080121591A1 (en) * 2006-11-29 2008-05-29 Canon U.S. Life Sciences, Inc. Device for nucleic acid preparation
US7993525B2 (en) * 2006-12-29 2011-08-09 Intel Corporation Device and method for particle complex handling
US8338166B2 (en) * 2007-01-04 2012-12-25 Lawrence Livermore National Security, Llc Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture
US10001496B2 (en) * 2007-01-29 2018-06-19 Gearbox, Llc Systems for allergen detection
NL1033317C2 (nl) * 2007-02-01 2008-08-04 C2V B V Inrichting voor capillaire chromatografie en werkwijze voor het vervaardigen van zo een inrichting.
WO2008101196A1 (en) * 2007-02-15 2008-08-21 Osmetech Molecular Diagnostics Fluidics devices
US8367397B2 (en) * 2007-02-15 2013-02-05 Honeywell International Inc. Active biochip for nucleic acid analysis
WO2008109878A2 (en) * 2007-03-07 2008-09-12 California Institute Of Technology Testing device
CA2984820C (en) 2007-04-04 2021-12-07 Ande Corporation Plastic microfluidic separation and detection platforms
DE102007020444A1 (de) * 2007-04-27 2008-11-06 Bayer Materialscience Ag Verfahren zur Oxidation eines Chlorwasserstoffenthaltenden Gasgemisches
FR2917095B1 (fr) * 2007-06-07 2009-07-17 Biomerieux Sa Dispositif de lyse de microorganismes presents dans un echantillon environnemental ou clinique et d'extraction des acides nucleiques desdits microorganismes aux fins d'analyse.
CA2754884C (en) 2007-06-21 2013-04-30 Gen-Probe Incorporated Methods of concentrating an analyte
JP5433139B2 (ja) * 2007-06-29 2014-03-05 株式会社東芝 マイクロ化学分析装置、その測定方法、及びマイクロカセット
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
AU2008276211B2 (en) 2007-07-13 2015-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
NZ582786A (en) * 2007-07-23 2012-09-28 Clondiag Gmbh Assays for nucleic acids
US8088341B2 (en) * 2007-07-25 2012-01-03 University Of Louisville Research Foundation, Inc. Analyte collection devices and methods
US20090030342A1 (en) * 2007-07-27 2009-01-29 3M Innovative Properties Company Apparatus and method for releasing a sample of material
EP2171420A1 (en) * 2007-07-31 2010-04-07 Micronics, Inc. Sanitary swab collection system, microfluidic assay device, and methods for diagnostic assays
WO2009019452A1 (en) * 2007-08-03 2009-02-12 Enigma Diagnostics Limited Reaction vessel
GB0715171D0 (en) 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Sample processor
GB0715170D0 (en) 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Reaction vessel
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
ITBO20070588A1 (it) 2007-08-13 2009-02-14 Silicon Biosystems Spa Metodo per legare uno strato di silicone ad un substrato di polimero metacrilico
US20110126929A1 (en) * 2007-08-15 2011-06-02 Massachusetts Institute Of Technology Microstructures For Fluidic Ballasting and Flow Control
US8308926B2 (en) 2007-08-20 2012-11-13 Purdue Research Foundation Microfluidic pumping based on dielectrophoresis
CN102316988B (zh) * 2007-09-29 2014-02-19 Ei频谱有限责任公司 仪表化移液器吸头
ES2447875T3 (es) 2007-10-02 2014-03-13 Theranos, Inc. Dispositivos modulares para punto de cuidados y usos de los mismos
EP2056114A1 (en) * 2007-10-29 2009-05-06 Koninklijke Philips Electronics N.V. Automatic detection of infectious diseases
ITTO20070771A1 (it) 2007-10-29 2009-04-30 Silicon Biosystems Spa Metodo e apparato per la identificazione e manipolazione di particelle
WO2009070246A1 (en) * 2007-11-27 2009-06-04 E.I Spectra, Llc Fluorescence-based pipette instrument
US8178045B2 (en) * 2007-12-17 2012-05-15 University Of Louisville Research Foundation, Inc. Interchangeable preconcentrator connector assembly
ES2425769T5 (es) 2007-12-20 2017-07-28 University Of Southern California Aparato para la administración de agentes terapéuticos
JP5663311B2 (ja) 2008-01-09 2015-02-04 ケック グラデュエイト インスティテュート 物質の調整及び／又は取扱システム、装置及び方法
US20090203022A1 (en) * 2008-02-07 2009-08-13 Arizona Board Of Regents For And On Behalf Of Arizona State University Analysis
EP2250286A1 (en) 2008-02-15 2010-11-17 Life Technologies Corporation Methods and compositions for shearing of polymers by sonication
WO2009115950A1 (en) * 2008-03-17 2009-09-24 Koninklijke Philips Electronics N.V. Biosensor device having reduced electrical power consumption
CA2719800A1 (en) * 2008-03-27 2009-10-01 President And Fellows Of Harvard College Paper-based microfluidic systems
EP2265959B1 (en) * 2008-03-27 2014-03-05 President and Fellows of Harvard College Paper-based cellular arrays
AU2009228014B2 (en) * 2008-03-27 2014-10-02 President And Fellows Of Harvard College Cotton thread as a low-cost multi-assay diagnostic platform
CN102016595B (zh) 2008-03-27 2014-08-06 哈佛学院院长等 三维微流体装置
US8961902B2 (en) 2008-04-23 2015-02-24 Bioscale, Inc. Method and apparatus for analyte processing
ES2534865T3 (es) 2008-05-08 2015-04-29 Minipumps, Llc Bombas de administración de fármacos
EP2163239A1 (de) 2008-05-27 2010-03-17 Qiagen GmbH Produkte, die Biopartikel enthalten, Verfahren zu ihrer Herstellung
KR101102532B1 (ko) * 2008-07-10 2012-01-03 삼성전자주식회사 시약 카트리지, 시약 카트리지를 구비하는 미세유동장치, 그 제조방법, 및 이를 이용한 시료분석방법
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US8114043B2 (en) * 2008-07-25 2012-02-14 Baxter International Inc. Electromagnetic induction access disconnect sensor
US8771613B2 (en) * 2008-07-31 2014-07-08 University Of Louisville Research Foundation, Inc. Large volume analyte preconcentrator
CN102203605B (zh) * 2008-08-27 2014-07-23 生命技术公司 处理生物样品的设备和方法
US11235323B2 (en) * 2008-08-27 2022-02-01 Life Technologies Corporation Apparatus for and method of processing biological samples
US8133451B2 (en) 2008-08-28 2012-03-13 Microfluidic Systems, Inc. Sample preparation apparatus
EP2334792B1 (en) 2008-09-12 2020-09-09 GenTegra LLC Matrices and media for storage and stabilization of biomolecules
US20100104485A1 (en) * 2008-10-28 2010-04-29 Microfluidic Systems, Inc. Flow-through thermal cycling device
IT1391619B1 (it) 2008-11-04 2012-01-11 Silicon Biosystems Spa Metodo per l'individuazione, selezione e analisi di cellule tumorali
US10895575B2 (en) 2008-11-04 2021-01-19 Menarini Silicon Biosystems S.P.A. Method for identification, selection and analysis of tumour cells
FR2938062B1 (fr) * 2008-11-05 2014-02-28 Biomerieux Sa Dispositif de preparation et/ou de traitement d'un echantillon biologique
FR2938063B1 (fr) 2008-11-05 2014-09-19 Commissariat Energie Atomique Dispositif de preparation et/ou de traitement d'un echantillon biologique
GB0901593D0 (en) 2009-01-30 2009-03-11 Touchlight Genetics Ltd Production of closed linear DNA
EP2394152B1 (en) 2009-02-03 2019-05-01 ANDE Corporation Nucleic acid purification
EP2393941A2 (en) * 2009-02-09 2011-12-14 Frederic Zenhausern Improvements in and relating to microfluidic devices for processing a sample
US9739771B2 (en) * 2009-02-27 2017-08-22 Yale University Physiologic sample preparation for nanosensors
ES2612507T3 (es) 2009-03-06 2017-05-17 President And Fellows Of Harvard College Dispositivos microfluídicos y electroquímicos
KR20100102926A (ko) * 2009-03-12 2010-09-27 삼성전자주식회사 표적물질 정제를 위한 필터유닛 및 이를 채용한 미세유동장치
CA2782123C (en) 2009-03-17 2017-05-02 Silicon Biosystems S.P.A. Microfluidic device for isolation of cells
ITBO20090154A1 (it) * 2009-03-17 2010-09-18 Silicon Biosystems Spa Sistema microfluidico
ITBO20090155A1 (it) * 2009-03-17 2010-09-18 Silicon Biosystems Spa Metodo per l'isolamento di particelle
ITBO20090152A1 (it) * 2009-03-17 2010-09-18 Silicon Biosystems Spa Dispositivo microfluidico
US8448532B2 (en) * 2009-03-18 2013-05-28 The United States Of America As Represented By The Secretary Of The Navy Actively cooled vapor preconcentrator
JP2012521558A (ja) * 2009-03-23 2012-09-13 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 生物学的サンプル中の磁性粒子の操作
WO2010110741A1 (en) * 2009-03-25 2010-09-30 Haiqing Gong Apparatus and method for detection of organisms
EP2478369A4 (en) * 2009-03-25 2012-11-14 Lyzer Diagnostics Inc APPARATUS AND METHODS FOR ANALYZING VARIABLES RELATED TO FLUIDS
CN102326074B (zh) * 2009-03-31 2016-01-20 株式会社日立高新技术 液体色谱仪、液体色谱仪用反应柱以及液体色谱仪用反应柱过滤器的应用
US8709356B2 (en) * 2009-04-10 2014-04-29 Canon U.S. Life Sciences, Inc. Systems and methods for minimization or elimination of diffusion effects in a microfluidic system
CA2752715C (en) 2009-04-14 2018-05-01 Arie R. Van Doorn Hifu induced cavitation with reduced power threshold
EP3357579A1 (en) 2009-04-15 2018-08-08 Biocartis NV Cartridge for optical analysis by a bioanalytical reaction device
KR20120012468A (ko) 2009-04-15 2012-02-10 비오까르띠 에스아 ｒｔＰＣＲ 반응을 모니터링하기 위한 광학 검출 시스템
EP2427270B1 (en) 2009-05-06 2015-04-01 Biocartis NV Device for cutting a sample carrier
US20100300882A1 (en) * 2009-05-26 2010-12-02 General Electric Company Devices and methods for in-line sample preparation of materials
DE102009040151B4 (de) * 2009-05-26 2013-09-12 Analytik Jena Ag Anordnung zur Detektion von Chemolumineszenz an Gasen
JP2012529268A (ja) 2009-06-05 2012-11-22 インテジェンクス，インコーポレイテッド ユニバーサルサンプル調製システムおよび統合解析システムの使用方法
EP2443254A2 (en) 2009-06-15 2012-04-25 NetBio, Inc. Improved methods for forensic dna quantitation
JP5711227B2 (ja) 2009-06-26 2015-04-30 クレアモント バイオソリューソンズ エルエルシー 試料破壊用ビーズを利用した生物検体の捕捉および溶出
JP2011010616A (ja) * 2009-07-03 2011-01-20 Olympus Corp 脂肪組織処理容器
EP2459994A4 (en) * 2009-07-27 2017-11-22 Meso Scale Technologies, LLC Assay information management methods and devices
EP2459999A1 (en) * 2009-07-28 2012-06-06 Yeda Research and Development Co. Ltd. Ultrasound assisted immunoassay
US9063136B2 (en) 2009-08-02 2015-06-23 Qvella Corporation Cell concentration, capture and lysis devices and methods of use thereof
EP2311563A1 (en) * 2009-08-07 2011-04-20 F. Hoffmann-La Roche AG Processing units and methods for the processing of liquid samples
US20110039267A1 (en) * 2009-08-13 2011-02-17 Cha-Mei Tang Sample Preparation And Detection Of Analytes Using Silica Beads
DE102009029305A1 (de) * 2009-09-09 2011-03-10 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Analysegerät zur automatisierten Bestimmung einer Messgröße einer Flüssigkeitsprobe
FR2950358B1 (fr) 2009-09-18 2015-09-11 Biomerieux Sa Dispositif d'amplification d'acides nucleiques simplifie et son procede de mise en oeuvre
US8664377B2 (en) * 2009-09-30 2014-03-04 Samsung Electronics Co., Ltd. Method and apparatus for isolating nucleic acids
CA3081708C (en) 2009-10-19 2023-10-03 Theranos Ip Company, Llc Integrated health data capture and analysis system
GB0919159D0 (en) 2009-11-02 2009-12-16 Sec Dep For Environment Food A Device and apparatus
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
USD638951S1 (en) 2009-11-13 2011-05-31 3M Innovative Properties Company Sample processing disk cover
USD638550S1 (en) 2009-11-13 2011-05-24 3M Innovative Properties Company Sample processing disk cover
USD667561S1 (en) 2009-11-13 2012-09-18 3M Innovative Properties Company Sample processing disk cover
US8569691B2 (en) 2009-11-24 2013-10-29 University Of Louisville Research Foundation Preconcentrator for analysis instruments
EP4459241A3 (en) 2009-12-07 2025-01-01 Meso Scale Technologies, LLC. Assay cartridge reader
KR101155085B1 (ko) * 2009-12-18 2012-06-11 광주과학기술원 세포 용해 장치 및 그 제조 방법
FR2955508B1 (fr) * 2010-01-25 2012-03-30 Corning Inc Microreacteurs avec dispositif microfluidique plan et systeme d'application d'ultrasons ; mise en oeuvre de reactions chimiques en leur sein
US8438903B2 (en) * 2010-01-27 2013-05-14 International Business Machines Corporation Molecule detection device formed in a semiconductor structure
EP2531300A1 (en) 2010-02-03 2012-12-12 President and Fellows of Harvard College Devices and methods for multiplexed assays
JP5691187B2 (ja) * 2010-02-10 2015-04-01 ソニー株式会社 核酸増幅反応用マイクロチップ及びその製造方法
US20110212453A1 (en) * 2010-02-12 2011-09-01 Agarwal Abhishek K Assay card for sample acquisition, treatment and reaction
KR20160088958A (ko) 2010-02-23 2016-07-26 루미넥스 코포레이션 일체화된 샘플 제조, 반응 및 검출을 위한 장치 및 방법
AU2015221472B2 (en) * 2010-02-23 2017-01-19 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
JP5308390B2 (ja) * 2010-03-31 2013-10-09 富士フイルム株式会社 被検物質検出方法および被検物質検出装置
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
FR2959312B1 (fr) 2010-04-23 2023-01-20 Biomerieux Sa Dispositif de preparation et/ou de traitement d'un echantillon biologique
KR20130028929A (ko) * 2010-04-28 2013-03-20 파나소닉 주식회사 화학 센서
JP5775929B2 (ja) * 2010-05-27 2015-09-09 コーニンクレッカ フィリップス エヌ ヴェ 超音波及び熱を選択的に生成する超音波トランスデューサ
US9132422B2 (en) 2010-06-03 2015-09-15 Spinomix, S.A. Fluidic interfacing system and assembly
US20110312554A1 (en) * 2010-06-17 2011-12-22 Geneasys Pty Ltd Microfluidic device with dialysis device, loc and interconnecting cap
WO2012044387A2 (en) * 2010-07-06 2012-04-05 T2 Biosystems, Inc. Methods and compositions for detection of analytes
ITBO20100503A1 (it) * 2010-08-04 2012-02-05 Silicon Biosystems Spa Sistema microfluidico
GB201013153D0 (en) 2010-08-04 2010-09-22 Touchlight Genetics Ltd Primer for production of closed linear DNA
ITBO20100504A1 (it) * 2010-08-04 2012-02-05 Silicon Biosystems Spa Sistema microfluidico
US9803236B2 (en) 2010-08-06 2017-10-31 Tsinghua University Microarray-based assay integrated with particles for analyzing molecular interactions
US9121058B2 (en) 2010-08-20 2015-09-01 Integenx Inc. Linear valve arrays
CN102375069A (zh) * 2010-08-26 2012-03-14 南京神州英诺华医疗科技有限公司 一种新型的呼吸道样本自动处理仪
US8459121B2 (en) 2010-10-28 2013-06-11 Covaris, Inc. Method and system for acoustically treating material
CN102465110B (zh) * 2010-10-29 2015-08-19 三星电子株式会社 细胞裂解装置和使细胞或病毒裂解的方法
KR101776215B1 (ko) * 2010-10-29 2017-09-08 삼성전자 주식회사 세포 파쇄용 마이크로 디바이스 및 이를 이용한 세포 파쇄 방법
WO2012069463A2 (de) * 2010-11-24 2012-05-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Mikrofluidisches system mit temperierung und verfahren zur temperierung in einem mikrofluidischen system
IT1403518B1 (it) 2010-12-22 2013-10-31 Silicon Biosystems Spa Dispositivo microfluidico per la manipolazione di particelle
US8709359B2 (en) 2011-01-05 2014-04-29 Covaris, Inc. Sample holder and method for treating sample material
EP4024029A3 (en) 2011-01-21 2022-09-14 Labrador Diagnostics LLC Systems and methods for sample use maximization
EP2678664B1 (en) 2011-02-24 2019-08-07 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
ES2653916T3 (es) 2011-03-08 2018-02-09 Universite Laval Dispositivo centrípeto fluídico
JP5637300B2 (ja) * 2011-03-28 2014-12-10 学校法人加計学園 試料溶液濃度測定方法及び試料溶液濃度測定装置
JP5931347B2 (ja) * 2011-04-12 2016-06-08 株式会社東芝 自動分析装置
JP6088487B2 (ja) 2011-04-15 2017-03-01 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 走査リアルタイムマイクロ流体熱サイクラーと同期熱サイクリング及び走査光学検出の方法
CN104023834B (zh) 2011-05-04 2016-09-28 卢米耐克斯公司 用于集成的样品制备、反应和检测的设备与方法
USD672467S1 (en) 2011-05-18 2012-12-11 3M Innovative Properties Company Rotatable sample processing disk
MX336625B (es) 2011-05-18 2016-01-26 3M Innovative Properties Co Sistemas y metodos para medicion volumetrica en dispositivo de procesamiento de muestra.
CN103648649A (zh) 2011-05-18 2014-03-19 3M创新有限公司 检测选定体积的材料在样本处理装置中存在的系统和方法
US9067205B2 (en) 2011-05-18 2015-06-30 3M Innovative Properties Company Systems and methods for valving on a sample processing device
EP2726838A4 (en) * 2011-07-01 2015-05-06 Univ Singapore SYSTEM AND METHOD FOR DETECTING ONE OR MORE ANALYTES IN A LIQUID
ES2759824T3 (es) 2011-07-25 2020-05-12 Qvella Corp Métodos y dispositivos para preparación de muestra eléctrica
WO2013022778A1 (en) * 2011-08-05 2013-02-14 Ibis Biosciences, Inc. Nucleic acid sequencing by electrochemical detection
US8599009B2 (en) 2011-08-16 2013-12-03 Elwha Llc Systematic distillation of status data relating to regimen compliance
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US9632102B2 (en) * 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
RU2622432C2 (ru) 2011-09-30 2017-06-15 Бектон, Дикинсон Энд Компани Унифицированная полоска для реактивов
EP2578207A3 (en) 2011-10-05 2015-10-07 Jacob J. Schmidt Masking apertures enabling automation and solution exchange in sessile droplet lipid bilayers
US8535241B2 (en) 2011-10-13 2013-09-17 Magnolia Medical Technologies, Inc. Fluid diversion mechanism for bodily-fluid sampling
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
ITTO20110990A1 (it) 2011-10-28 2013-04-29 Silicon Biosystems Spa Metodo ed apparato per l'analisi ottica di particelle a basse temperature
WO2013067202A1 (en) 2011-11-04 2013-05-10 Handylab, Inc. Polynucleotide sample preparation device
US9050593B2 (en) * 2011-11-23 2015-06-09 Wisconsin Alumni Research Foundation Self-loading microfluidic device and methods of use
ITBO20110766A1 (it) 2011-12-28 2013-06-29 Silicon Biosystems Spa Dispositivi, apparato, kit e metodo per il trattamento di un campione biologico
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
WO2013123035A1 (en) 2012-02-13 2013-08-22 Molecular Systems Corporation System and method for processing and detecting nucleic acids
US11485968B2 (en) 2012-02-13 2022-11-01 Neumodx Molecular, Inc. Microfluidic cartridge for processing and detecting nucleic acids
US9604213B2 (en) 2012-02-13 2017-03-28 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US9637775B2 (en) 2012-02-13 2017-05-02 Neumodx Molecular, Inc. System and method for processing biological samples
US11648561B2 (en) 2012-02-13 2023-05-16 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US8804105B2 (en) 2012-03-27 2014-08-12 E. I. Spectra, Llc Combined optical imaging and electrical detection to characterize particles carried in a fluid
WO2013158972A1 (en) 2012-04-20 2013-10-24 Cepheid Methods of detecting bladder cancer
US10132728B2 (en) 2012-04-27 2018-11-20 Cepheid Apparatus with heterogeneous processing modules
US9063121B2 (en) 2012-05-09 2015-06-23 Stat-Diagnostica & Innovation, S.L. Plurality of reaction chambers in a test cartridge
US9081001B2 (en) 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9022951B2 (en) 2012-05-30 2015-05-05 Magnolia Medical Technologies, Inc. Fluid diversion mechanism for bodily-fluid sampling
US9060724B2 (en) 2012-05-30 2015-06-23 Magnolia Medical Technologies, Inc. Fluid diversion mechanism for bodily-fluid sampling
TWI512261B (zh) 2012-06-22 2015-12-11 Panasonic Corp 微流體元件
WO2014022275A1 (en) 2012-08-01 2014-02-06 Magnolia Medical Technologies, Inc. Fluid diversion mechanism for bodily-fluid sampling
DE102012107651A1 (de) 2012-08-21 2014-02-27 Astrium Gmbh Verfahren zur Durchführung einer biochemischen Analyse, insbesondere im Weltraum
EP2705899A1 (en) 2012-09-07 2014-03-12 Fluigent A microfluidic system comprising a homogenizing component
DE102012109026A1 (de) * 2012-09-25 2014-03-27 Eads Deutschland Gmbh Detektionsvorrichtung und Detektionsverfahren zur automatischen Bestimmung von Biomasse
CA2886605A1 (en) 2012-09-28 2014-04-03 Cepheid Two-primer pcr for microrna multiplex assay
EP3906952A1 (en) 2012-10-11 2021-11-10 Magnolia Medical Technologies, Inc. Systems and methods for delivering a fluid to a patient with reduced contamination
US20150285794A1 (en) * 2012-10-19 2015-10-08 Ecole Polytechnique Federale De Lausanne (Epfl) High-throughput nanoimmunoassay chip
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
JP1628115S (da) 2012-10-24 2019-04-01
JP2013019911A (ja) * 2012-10-25 2013-01-31 Seiko Instruments Inc マイクロ流体装置
US20140120544A1 (en) 2012-10-25 2014-05-01 Neumodx Molecular, Inc. Method and materials for isolation of nucleic acid materials
EP3498168B1 (en) 2012-11-30 2021-01-20 Magnolia Medical Technologies, Inc. Syringe based fluid diversion mechanism for bodily-fluid sampling
US10772548B2 (en) 2012-12-04 2020-09-15 Magnolia Medical Technologies, Inc. Sterile bodily-fluid collection device and methods
CA2932536C (en) 2012-12-04 2023-02-28 Magnolia Medical Technologies, Inc. Sterile bodily-fluid collection device and methods
US9987576B2 (en) 2012-12-10 2018-06-05 University Of Virginia Patent Foundation Frequency-based filtering of mechanical actuation using fluidic device
US10000557B2 (en) 2012-12-19 2018-06-19 Dnae Group Holdings Limited Methods for raising antibodies
US9434940B2 (en) 2012-12-19 2016-09-06 Dna Electronics, Inc. Methods for universal target capture
US20140206007A1 (en) * 2013-01-18 2014-07-24 The Johns Hopkins University Electromagnetically actuated droplet microfluidic chip and system
EP2964786B1 (en) 2013-03-06 2018-12-19 Cepheid Methods of detecting bladder cancer
US9623409B2 (en) 2013-03-11 2017-04-18 Cue Inc. Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
AU2014248813B2 (en) 2013-03-11 2016-05-19 Cue Health Inc. Systems and methods for detection and quantification of analytes
US10545161B2 (en) 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
US20160016171A1 (en) 2013-03-15 2016-01-21 Nanobiosym, Inc. Systems and Methods for Mobile Device Analysis of Nucleic Acids and Proteins
CN107866286A (zh) 2013-03-15 2018-04-03 金马克诊断股份有限公司 用于操纵可变形流体容器的系统、方法和设备
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
US9359632B2 (en) 2013-03-15 2016-06-07 Theranos, Inc. Devices, systems and methods for sample preparation
US9458488B2 (en) * 2013-03-15 2016-10-04 Nanomix, Inc. Point of care sensor systems
CN105229465A (zh) * 2013-03-15 2016-01-06 赛拉诺斯股份有限公司 用于样品制备的装置、系统和方法
US20150028876A1 (en) * 2013-07-24 2015-01-29 Nathan McLaughlin Method and apparatus for testing a lighting device under temperature
KR20150016036A (ko) * 2013-08-02 2015-02-11 삼성전자주식회사 핵산 증폭 방법
JP6295578B2 (ja) * 2013-09-30 2018-03-20 凸版印刷株式会社 反応容器、核酸解析装置、および核酸解析方法
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
CN105873681B (zh) 2013-11-18 2019-10-11 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
US9283560B2 (en) * 2013-11-22 2016-03-15 Sharp Kabushiki Kaisha Passive microfluidic metering device
WO2015083166A1 (en) 2013-12-04 2015-06-11 Pocared Diagnostics Ltd. Method and apparatus for processing and analyzing particles extracted from tangential filtering
DE102014200501A1 (de) 2014-01-14 2015-07-16 Robert Bosch Gmbh Aufschlussvorrichtung und Verfahren zum Aufschließen einer Zellen enthaltenden, biologischen Probe sowie Verfahren zum Herstellen einer Aufschlussvorrichtung
DE102014200505A1 (de) 2014-01-14 2015-07-16 Robert Bosch Gmbh Behälter und Vorrichtung für einen Aufschluss und/oder eine Homogenisierung eines Fluids sowie Verfahren zum Aufschließen und/oder Homogenisieren eines Fluids
US10195610B2 (en) 2014-03-10 2019-02-05 Click Diagnostics, Inc. Cartridge-based thermocycler
CN106459869B (zh) * 2014-03-11 2020-01-21 伊鲁米那股份有限公司 一次性的集成微流体盒及其制备和使用的方法
EP3594360B1 (en) 2014-04-24 2021-06-23 Lucira Health, Inc. Colorimetric detection of nucleic acid amplification
EP3134731A4 (en) * 2014-04-25 2018-03-07 Hewlett-Packard Development Company, L.P. Diagnostic cassette
DE102014207775A1 (de) 2014-04-25 2015-10-29 Robert Bosch Gmbh Verfahren und mikrofluidisches System zum Aufbereiten von organischen Zellen und Herstellungsverfahren zum Herstellen eines mikrofluidischen Systems zum Aufbereiten von organischen Zellen
DE102014207774B4 (de) * 2014-04-25 2015-12-31 Robert Bosch Gmbh Verfahren und Vorrichtung zur Aufreinigung von biologischen Molekülen
USD745423S1 (en) 2014-05-12 2015-12-15 Cue Inc. Automated analyzer test cartridge and sample collection device for analyte detection
WO2015179098A1 (en) 2014-05-21 2015-11-26 Integenx Inc. Fluidic cartridge with valve mechanism
US10093918B2 (en) 2014-06-04 2018-10-09 Lucigen Corporation Sample collection and analysis devices
MX372869B (es) * 2014-06-18 2020-07-07 Zoetis Denmark Aps Un sistema de detección microfluídico y un cartucho microfluídico.
KR102238956B1 (ko) * 2014-06-24 2021-04-13 삼성전자주식회사 유체 분석 시트, 이를 포함하는 유체 분석 카트리지 및 유체 분석 카트리지의 제조방법
US20190210042A1 (en) * 2014-07-09 2019-07-11 Sudhin Biopharma Particle setting devices
US10596492B2 (en) * 2014-07-09 2020-03-24 Sudhin Biopharma Particle settling devices
US20160041156A1 (en) * 2014-08-11 2016-02-11 OncoGenesis Inc. Integrated Device for Measuring Multiple Analytes
US10480036B2 (en) 2014-08-22 2019-11-19 Cepheid Methods of detecting influenza
GB201415789D0 (en) 2014-09-05 2014-10-22 Touchlight Genetics Ltd Synthesis of DNA
US10196678B2 (en) 2014-10-06 2019-02-05 ALVEO Technologies Inc. System and method for detection of nucleic acids
WO2016089477A1 (en) 2014-10-16 2016-06-09 Cepheid Biosecurity screening system and method
US10690627B2 (en) 2014-10-22 2020-06-23 IntegenX, Inc. Systems and methods for sample preparation, processing and analysis
WO2016069853A2 (en) 2014-10-30 2016-05-06 Cepheid Methods of detecting ebola
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
EP3223945B1 (en) * 2014-11-26 2019-04-03 IMEC vzw Compact glass-based fluid analysis device and method to fabricate
WO2016087957A1 (en) * 2014-12-05 2016-06-09 Diasys Diagnostics India Private Limited Multiplexed microfluidic device
CN114369596B (zh) 2014-12-15 2025-07-08 塞弗德公司 底数大于2的指数核酸扩增
CN105806685B (zh) * 2014-12-29 2020-05-05 徕卡显微系统(上海)有限公司 具有移动式分配器的包埋机
CN204330461U (zh) * 2014-12-29 2015-05-13 徕卡显微系统(上海)有限公司 包埋机
EP4029606A1 (en) 2014-12-31 2022-07-20 Visby Medical, Inc. Molecular diagnostic testing
US20180245144A1 (en) * 2015-02-13 2018-08-30 Ecole Supérieure De Physique Et De Chimie Industrielles De La Ville De Paris Paper device for genetic diagnosis
US9861982B2 (en) * 2015-03-09 2018-01-09 Emd Millipore Corporation Connectors for pneumatic devices in microfluidic systems
JP6834947B2 (ja) * 2015-04-28 2021-02-24 パナソニック株式会社 化学物質濃縮器
CN107667168A (zh) 2015-05-27 2018-02-06 凯杰有限公司 用于破碎组织材料的组合物和方法
CN113791203B (zh) 2015-06-12 2024-05-17 芯易诊有限公司 用于分析生物样品的方法
US10634602B2 (en) 2015-06-12 2020-04-28 Cytochip Inc. Fluidic cartridge for cytometry and additional analysis
WO2016205233A2 (en) * 2015-06-15 2016-12-22 Cepheid Integrated purification and measurement of dna methylation and co-measurement of mutations and/or mrna expression levels in an automated reaction cartridge
US11248255B2 (en) * 2015-06-19 2022-02-15 The Governing Council Of The University Of Toronto Amplification of nanoparticle based assay
US20160367918A1 (en) * 2015-06-22 2016-12-22 Fuji Electric Co., Ltd. Filter system
EP3112869A1 (en) * 2015-06-30 2017-01-04 IMEC vzw Sensor device
EP3322968B1 (en) 2015-07-14 2024-02-21 Cytochip Inc. Volume sensing in a fluidic cartridge
US10775370B2 (en) 2015-07-17 2020-09-15 Stat-Diagnostica & Innovation, S.L. Fluidic system for performing assays
KR102604091B1 (ko) 2015-07-17 2023-11-22 큐 헬스 인코퍼레이티드 분석물질의 증진된 검출 및 정량을 위한 시스템 및 방법
AU2016298048B2 (en) 2015-07-24 2022-08-04 Cepheid Compositions and methods for DNA and RNA extraction from tissue samples
US11071982B2 (en) * 2015-08-27 2021-07-27 Ativa Medical Corporation Fluid holding and dispensing micro-feature
EP3733067B1 (en) 2015-09-03 2023-06-14 Magnolia Medical Technologies, Inc. System for maintaining sterility of a specimen container
USD799715S1 (en) 2015-10-23 2017-10-10 Gene POC, Inc. Fluidic centripetal device
WO2017087707A1 (en) * 2015-11-18 2017-05-26 Beckman Coulter, Inc. Filtering device for analyzing instrument
EP3429543B1 (en) * 2016-03-14 2024-11-20 Pfizer Inc. Selectively vented biological assay devices and associated methods
JP6949864B2 (ja) 2016-03-14 2021-10-13 ルシラ ヘルス インコーポレイテッド 生物学的アッセイ試料調製および送り出しのための装置および方法
ES2927062T3 (es) 2016-03-14 2022-11-02 Lucira Health Inc Dispositivos y procedimientos para modificar propiedades ópticas
AU2017232340B2 (en) 2016-03-14 2022-04-28 Pfizer Inc. Systems and methods for performing biological assays
US10987674B2 (en) 2016-04-22 2021-04-27 Visby Medical, Inc. Printed circuit board heater for an amplification module
WO2017197040A1 (en) 2016-05-11 2017-11-16 Click Diagnostics, Inc. Devices and methods for nucleic acid extraction
US10774393B2 (en) 2016-05-20 2020-09-15 Roche Molecular Systems, Inc. Cell surface marker depletion in a sample processing device
EP3464596B1 (en) 2016-06-07 2025-07-30 Cepheid Thermostable polymerase inhibitor compositions and methods
USD800331S1 (en) 2016-06-29 2017-10-17 Click Diagnostics, Inc. Molecular diagnostic device
MX2018015889A (es) 2016-06-29 2019-05-27 Click Diagnostics Inc Dispositivos y metodos para la deteccion de moleculas usando una celda de flujo.
USD800913S1 (en) 2016-06-30 2017-10-24 Click Diagnostics, Inc. Detection window for molecular diagnostic device
USD800914S1 (en) 2016-06-30 2017-10-24 Click Diagnostics, Inc. Status indicator for molecular diagnostic device
CN109689887A (zh) * 2016-07-08 2019-04-26 加州理工学院 用于进行低浓度分析物的流动通过捕获的方法和装置
US11440009B2 (en) 2016-07-15 2022-09-13 Hewlett-Packard Development Company, L.P. Plurality of filters
CN109923417B (zh) 2016-09-08 2021-06-08 希米斯保健股份有限公司 诊断系统和方法
US10349589B2 (en) 2016-09-08 2019-07-16 Hemex Health, Inc. Diagnostics systems and methods
KR20220151011A (ko) * 2016-09-23 2022-11-11 알베오 테크놀로지스 인크. 분석물을 검출하기 위한 방법 및 조성물
EP3523032A2 (en) * 2016-10-07 2019-08-14 Boehringer Ingelheim Vetmedica GmbH Cartridge for testing a sample
CN109789409A (zh) 2016-10-07 2019-05-21 勃林格殷格翰维特梅迪卡有限公司 用于测试样品的方法和分析系统
TW201818076A (zh) 2016-10-07 2018-05-16 德商百靈佳殷格翰維美迪加股份有限公司 用於檢測樣本之分析裝置及方法
US10422012B2 (en) 2016-10-10 2019-09-24 Roche Molecular Systems, Inc. Devices comprising bacteriophage PHI6 internal control compositions
CN106568982B (zh) * 2016-10-31 2018-05-29 浙江大学 一种用于二维液滴阵列形成和筛选的装置及其使用方法
KR102103582B1 (ko) * 2016-11-29 2020-04-23 삼육대학교산학협력단 실리카 나노입자를 포함하는 미세유체칩 및 그의 제조방법
MX2019006628A (es) 2016-12-12 2019-11-12 Cepheid Purificacion y medicion integradas de metilacion de adn y co-medicion de mutaciones y/o niveles de expresion de arnm en un cartucho de reaccion automatizado.
TWI611171B (zh) 2016-12-14 2018-01-11 財團法人工業技術研究院 生物樣品處理裝置
US11237161B2 (en) 2017-01-25 2022-02-01 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes
CN108654138B (zh) * 2017-04-01 2023-06-16 四川大学 一种离心力微流体萃取装置及其萃取方法
US11080848B2 (en) 2017-04-06 2021-08-03 Lucira Health, Inc. Image-based disease diagnostics using a mobile device
US20190093155A1 (en) 2017-05-25 2019-03-28 Roche Molecular Systems, Inc. Multiplex Nucleic Acid Amplification Assay
US11602750B2 (en) 2017-05-30 2023-03-14 Roche Molecular Systems, Inc. Customizable sample processing device
EP4249118B1 (en) 2017-06-09 2024-12-11 Magnolia Medical Technologies, Inc. Fluid control devices
CN111065904A (zh) 2017-08-02 2020-04-24 普凯尔德诊断技术有限公司 包括通过过滤器去除废液的方法和装置的处理器过滤器布置
JP7204742B2 (ja) 2017-09-12 2023-01-16 マグノリア メディカル テクノロジーズ，インコーポレイテッド 流体制御デバイス及び流体制御デバイスを使用する方法
CN113777011B (zh) 2017-09-14 2024-11-19 辉瑞公司 具有电子读出的复用生物测定装置
US10549275B2 (en) 2017-09-14 2020-02-04 Lucira Health, Inc. Multiplexed biological assay device with electronic readout
DE102017008908A1 (de) 2017-09-22 2019-03-28 Friz Biochem Gesellschaft Für Bioanalytik Mbh Tragbarer Behälter für die Tuberkulose-Präanalytik
WO2019083844A1 (en) 2017-10-23 2019-05-02 Cytochip Inc. DEVICES AND METHOD FOR MEASURING TARGET ANALYTES AND PARTICLES
CA3080871C (en) 2017-10-31 2024-05-28 F. Hoffmann-La Roche Ag Improved magnetic beads comprising a liquid-glass coating and uses thereof in nucleic acid capture or purification
SG11202002931VA (en) 2017-11-09 2020-04-29 Visby Medical Inc Portable molecular diagnostic device and methods for the detection of target viruses
CN109868205A (zh) * 2017-12-05 2019-06-11 台达电子国际（新加坡）私人有限公司 生物样本处理装置及其生物样本处理方法
EP3727805B1 (en) 2017-12-19 2023-09-13 F. Hoffmann-La Roche AG Sealing press and method of making a frangible seal in a sample processing device
US11759784B2 (en) * 2018-03-21 2023-09-19 Precision Planting Llc Reagent cartridge
AU2019257236B2 (en) * 2018-04-18 2022-09-01 Sudhin Biopharma Particle settling devices
AU2019310601A1 (en) 2018-07-27 2021-02-04 Zepto Life Technology, Inc. System and method for sensing analytes in GMR-based detection of biomarkers
JP2020024202A (ja) * 2018-08-06 2020-02-13 積水化学工業株式会社 分析用具及び洗浄方法
KR20210081335A (ko) 2018-09-03 2021-07-01 비스비 메디컬, 인코포레이티드 항생제 감수성 시험을 위한 장치 및 방법
CA3118000A1 (en) 2018-10-29 2020-05-07 Cepheid Exponential base-3 nucleic acid amplification with reduced amplification time using nested overlapping primers
FR3088340B1 (fr) * 2018-11-12 2021-01-22 Commissariat Energie Atomique Systeme automatise de preparation, de detection et d'analyse d'un echantillon fluidique
CA3121127C (en) 2018-11-30 2023-06-13 Illumina, Inc. Systems and methods for active warming of a cartridge
CN109406238B (zh) * 2018-12-07 2023-10-17 郑州机械研究所有限公司 一种用于金相试样制备的多功能卡具及金相试样制备方法
JP2022516443A (ja) * 2018-12-20 2022-02-28 アルヴェオ テクノロジーズ インコーポレイテッド インピーダンスに基づく分析物検出用の携帯型診断検査システム
USD907232S1 (en) 2018-12-21 2021-01-05 Lucira Health, Inc. Medical testing device
WO2020139210A1 (en) * 2018-12-28 2020-07-02 Mikro Biyosistemler Elektronik Sanayi Ve Ticaret A.S. A method of microfluidic particle separation enhancement and the device thereof
CN113412157B (zh) * 2019-01-10 2024-01-09 仪器实验室公司 全血的超声溶解
US11786155B2 (en) 2019-02-08 2023-10-17 Magnolia Medical Technologies, Inc. Devices and methods for bodily fluid collection and distribution
GB201902810D0 (en) * 2019-03-01 2019-04-17 Vidya Holdings Ltd Disposition of reagents in assay device
EP3938108B1 (en) 2019-03-11 2023-08-02 Magnolia Medical Technologies, Inc. Fluid control devices
JP2022530323A (ja) 2019-04-28 2022-06-29 ビスビュー メディカル，インコーポレイテッド デジタル検出能力および無線接続性を有する分子診断デバイス
WO2020264182A1 (en) 2019-06-25 2020-12-30 Hemex Health, Inc. Diagnostics systems and methods
CN114829925B (zh) * 2019-12-12 2024-05-28 株式会社岛津制作所 色谱系统
US11254979B2 (en) 2020-06-01 2022-02-22 Shaheen Innovations Holding Limited Systems and devices for infectious disease screening
US11730193B2 (en) 2019-12-15 2023-08-22 Shaheen Innovations Holding Limited Hookah device
US11352675B2 (en) 2020-01-03 2022-06-07 Visby Medical, Inc. Devices and methods for antibiotic susceptability testing
EP4087625A4 (en) 2020-01-08 2024-03-13 Zepto Life Technology, LLC POLYMER COMPOSITIONS AND BIOSURFACES INCLUDING THEM ON SENSORS
EP4121214A4 (en) 2020-03-19 2024-07-10 Sudhin Biopharma Particle settling devices
GEP20247656B (en) * 2020-04-06 2024-08-26 Shaheen Innovations Holding Ltd Cell lysis systems and methods
AU2021252180B2 (en) * 2020-04-06 2024-09-12 Shaheen Innovations Holding Limited Cell lysis systems and methods
US20230140317A1 (en) * 2020-04-23 2023-05-04 Hewlett-Packard Development Company, L.P. Measuring deformability of a cell
USD953561S1 (en) 2020-05-05 2022-05-31 Lucira Health, Inc. Diagnostic device with LED display
CA3180786A1 (en) * 2020-06-01 2021-05-28 Imad Lahoud An infectious disease screening system
EP3919176A1 (en) * 2020-06-01 2021-12-08 Shaheen Innovations Holding Limited Assay devices for infectious disease screening
KR20230034987A (ko) 2020-06-01 2023-03-10 샤힌 이노베이션즈 홀딩 리미티드 감염증 스크리닝 장치
EP3919175A1 (en) * 2020-06-01 2021-12-08 Shaheen Innovations Holding Limited Systems and devices for infectious disease screening
USD962470S1 (en) 2020-06-03 2022-08-30 Lucira Health, Inc. Assay device with LCD display
KR20230030639A (ko) 2020-06-26 2023-03-06 세페이드 Sars-cov-2, 인플루엔자 및 rsv를 검출하는 방법
US11904314B2 (en) * 2020-07-30 2024-02-20 Wainamics, Inc. System and self-metering cartridges for point of care bioassays
US12472492B2 (en) 2020-08-14 2025-11-18 Alveo Technologies, Inc. Systems and methods of sample depositing and testing
EP4226158A1 (en) 2020-10-06 2023-08-16 Cepheid Methods of diagnosing tuberculosis and differentiating between active and latent tuberculosis
EP4026615A1 (en) * 2021-01-11 2022-07-13 Curiosity Diagnostics sp. z o.o Microfluidic circuit, microfluidic chip, kit and method for isolating and purifying an analyte from a biologic sample
EP4308729B1 (en) 2021-03-16 2025-10-29 Cepheid Methods for discriminating bacterial and viral infections in a human subject
WO2022251508A1 (en) * 2021-05-28 2022-12-01 Proof Diagnostics Reaction cartridge
CN113686843A (zh) * 2021-07-19 2021-11-23 清华大学深圳国际研究生院 一种基于超声波裂解的比色反应微流控快速检测设备
USD1064314S1 (en) 2021-08-13 2025-02-25 Visby Medical, Inc. Molecular diagnostic device
WO2023055917A1 (en) * 2021-09-29 2023-04-06 Fremonta Corporation Methods and systems for sample processing utilizing filter aid materials and aggregating samplers for equipment
EP4419715A1 (en) 2021-10-22 2024-08-28 Cepheid Compositions and methods of diagnosing and treating tuberculosis
USD1106481S1 (en) * 2022-01-24 2025-12-16 Sony Group Corporation Sample sorting device
WO2023177748A1 (en) * 2022-03-15 2023-09-21 Cepheid Unitary cartridge body and associated components and methods of manufacture
CN115141739A (zh) * 2022-09-06 2022-10-04 至美时代生物智能科技(北京)有限公司 一种空气微生物采样检测一体化装置及采样检测方法
CN120641576A (zh) 2022-12-16 2025-09-12 塞弗德公司 Mpox演化支ii生物标志物组
KR20250138809A (ko) 2023-01-30 2025-09-22 세페이드 호흡기 바이오마커 패널
CN116296667B (zh) * 2023-02-28 2025-08-22 浙江大学 一种自支撑离子型COFs膜截面制样方法
CN116272025B (zh) * 2023-03-16 2026-03-20 广东高瓷科技股份有限公司 一种高效全自动配浆压滤洗涤系统
TWI889052B (zh) * 2023-08-16 2025-07-01 新加坡商克雷多生醫股份有限公司 卡匣及其定量方法
WO2025064410A1 (en) 2023-09-18 2025-03-27 Cepheid Three-phase nested amplification and multi-phasic detection
WO2025175133A1 (en) 2024-02-14 2025-08-21 Cepheid Melt shape genotyping
WO2025179142A1 (en) 2024-02-22 2025-08-28 Cepheid Maximizing optical channel capabilities for target detection
WO2026020144A1 (en) 2024-07-19 2026-01-22 Cepheid Liposomal controlled release of pcr reaction reagents
WO2026055639A1 (en) 2024-09-06 2026-03-12 Cepheid Sample in sequencing-ready library out automated library preparation solution

Family Cites Families (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB938163A (en) 1960-09-20 1963-10-02 Boots Pure Drug Co Ltd Improvements in or relating to particle size reduction or cellular disruption
US3799742A (en) 1971-12-20 1974-03-26 C Coleman Miniaturized integrated analytical test container
EP0001137A1 (fr) 1977-08-31 1979-03-21 S.A. Anarec Appareil pour le traitement de fluides
US4426451A (en) 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
SE8102316L (sv) 1981-04-10 1982-10-11 Pharmacia Diagnostics Ab Anordning for genomforande av analyser
AU570439B2 (en) 1983-03-28 1988-03-17 Compression Labs, Inc. A combined intraframe and interframe transform coding system
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
US4822731A (en) * 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
AU604684B2 (en) * 1986-03-20 1991-01-03 Gen-Probe Incorporated Method for releasing RNA and DNA from cells
GB2191110B (en) 1986-06-06 1989-12-06 Plessey Co Plc Chromatographic separation device
US4789628A (en) 1986-06-16 1988-12-06 Vxr, Inc. Devices for carrying out ligand/anti-ligand assays, methods of using such devices and diagnostic reagents and kits incorporating such devices
US4915812A (en) 1986-06-20 1990-04-10 Molecular Devices Corporation Zero volume cell
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
CH667599A5 (fr) 1986-12-11 1988-10-31 Battelle Memorial Institute Enceinte destinee a contenir un milieu liquide.
US4918025A (en) 1987-03-03 1990-04-17 Pb Diagnostic Systems, Inc. Self contained immunoassay element
US4855240A (en) 1987-05-13 1989-08-08 Becton Dickinson And Company Solid phase assay employing capillary flow
AU1983588A (en) * 1987-06-23 1989-01-19 Norman G. Anderson Centrifugal fast chromatograph
US4908318A (en) 1987-09-04 1990-03-13 Integrated Genetics, Inc. Nucleic acid extraction methods
US4923978A (en) 1987-12-28 1990-05-08 E. I. Du Pont De Nemours & Company Process for purifying nucleic acids
AU2613988A (en) * 1988-01-04 1989-08-01 E.I. Du Pont De Nemours And Company Multiple stage affinity process for isolation of specific cells from a cell mixture
US4921952A (en) 1988-01-21 1990-05-01 The United States Of America As Represented By The United States Department Of Energy Nucleic acid isolation process
JPH0721485B2 (ja) * 1988-03-11 1995-03-08 ダイソー株式会社 苛性アルカリ中塩化物イオンの流れ分析法
US4983523A (en) 1988-04-08 1991-01-08 Gene-Trak Systems Methods for preparing sample nucleic acids for hybridization
SE8801299L (sv) 1988-04-08 1989-10-09 Bertil Hoeoek Mikromekanisk envaegsventil
US5374533A (en) 1988-05-10 1994-12-20 Tetjin Limited Method for determining chondrocalcin
US4908112A (en) 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
FR2634892B1 (fr) 1988-07-28 1990-09-14 Guigan Jean Dispositif pour la realisation d'analyses biologiques par detection immuno-enzymatique d'anticorps ou d'antigenes dans un serum
US5188963A (en) 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
US5229297A (en) 1989-02-03 1993-07-20 Eastman Kodak Company Containment cuvette for PCR and method of use
US5234809A (en) 1989-03-23 1993-08-10 Akzo N.V. Process for isolating nucleic acid
US5207988A (en) 1989-07-06 1993-05-04 The Cleveland Clinic Foundation Apparatus for detecting and quantifying clot lysis and establishing optimum medication and dosages
US5124444A (en) 1989-07-24 1992-06-23 Microprobe Corporation Lactam-containing compositions and methods useful for the extraction of nucleic acids
US5231015A (en) 1989-10-18 1993-07-27 Eastman Kodak Company Methods of extracting nucleic acids and pcr amplification without using a proteolytic enzyme
AU642444B2 (en) 1989-11-30 1993-10-21 Mochida Pharmaceutical Co., Ltd. Reaction vessel
US5858188A (en) 1990-02-28 1999-01-12 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
US5770029A (en) * 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5143084A (en) 1990-05-24 1992-09-01 Spacelabs, Inc. Disposable cartridge for sampling and analyzing body fluids
KR0182619B1 (ko) 1990-06-15 1999-05-01 로버트 피. 블랙버언 내장된 분석 조립체 및 장치
US5114858A (en) 1990-06-26 1992-05-19 E. I. Du Pont De Nemours And Company Cellular component extraction process in a disposable filtration vessel
DE4126436A1 (de) 1990-09-17 1992-03-19 Abion Ohg Einwegreaktionsgefaess fuer die festphasenimmunanalytik und verfahren zur messung von ueber immunreaktionen bestimmbaren komponenten
DE4034036C2 (de) * 1990-10-26 1994-03-03 Diagen Inst Molekularbio Vorrichtung und Verfahren zur Isolierung von Nukleinsäuren aus Zellsuspensionen
US5652141A (en) 1990-10-26 1997-07-29 Oiagen Gmbh Device and process for isolating nucleic acids from cell suspension
US5654179A (en) * 1990-11-14 1997-08-05 Hri Research, Inc. Nucleic acid preparation methods
US5352777A (en) 1990-12-26 1994-10-04 Pioneer Hi-Bred International, Inc. DNA isolation from animal cells
SE9100392D0 (sv) 1991-02-08 1991-02-08 Pharmacia Biosensor Ab A method of producing a sealing means in a microfluidic structure and a microfluidic structure comprising such sealing means
US5264184A (en) 1991-03-19 1993-11-23 Minnesota Mining And Manufacturing Company Device and a method for separating liquid samples
US5422241A (en) 1991-07-03 1995-06-06 Ambion, Inc. Methods for the recovery of nucleic acids from reaction mixtures
US5155018A (en) 1991-07-10 1992-10-13 Hahnemann University Process and kit for isolating and purifying RNA from biological sources
US5329000A (en) 1991-10-31 1994-07-12 Becton, Dickinson And Company Purification of DNA with silicon tetrahydrazide
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
DE69324716T2 (de) 1992-02-13 1999-09-09 Becton Dickinson And Co. Celithydrat und Reinigung von DNS
US5223219A (en) 1992-04-10 1993-06-29 Biotrack, Inc. Analytical cartridge and system for detecting analytes in liquid samples
US5296375A (en) 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5744366A (en) * 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5409586A (en) 1992-08-26 1995-04-25 Hitachi, Ltd. Method for analyzing nucleic acid or protein and apparatus therefor
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US5422271A (en) 1992-11-20 1995-06-06 Eastman Kodak Company Nucleic acid material amplification and detection without washing
US5795714A (en) * 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US5399486A (en) 1993-02-18 1995-03-21 Biocircuits Corporation Disposable unit in diagnostic assays
US5798215A (en) 1993-02-18 1998-08-25 Biocircuits Corporation Device for use in analyte detection assays
US5503985A (en) 1993-02-18 1996-04-02 Cathey; Cheryl A. Disposable device for diagnostic assays
US5427663A (en) 1993-06-08 1995-06-27 British Technology Group Usa Inc. Microlithographic array for macromolecule and cell fractionation
GB9314249D0 (en) * 1993-07-09 1993-08-18 Proofname Ltd Purification method and apparatus
EP0722563A4 (en) 1993-08-24 1998-03-04 Metrika Lab Inc NEW ELECTRONIC DISPOSABLE ANALYSIS DEVICE
US5438127A (en) 1993-09-27 1995-08-01 Becton Dickinson And Company DNA purification by solid phase extraction using a PCl3 modified glass fiber membrane
US5438129A (en) 1993-09-27 1995-08-01 Becton Dickinson And Company DNA purification by solid phase extraction using partially fluorinated aluminum hydroxide adsorbant
ATE424927T1 (de) 1993-10-28 2009-03-15 Houston Advanced Res Ct Mikrofabriziertes poröses durchflussgerät zur diskreten bestimmung von bindungsreaktionen
US6129828A (en) 1996-09-06 2000-10-10 Nanogen, Inc. Apparatus and methods for active biological sample preparation
US5976824A (en) 1993-11-24 1999-11-02 Abbott Laboratories Method and apparatus for collecting a cell sample from a liquid specimen
DE69422604T2 (de) 1994-03-08 2000-06-08 Zeptosens Ag, Witterwil Vorrichtung und Verfahren, die Bioaffinitätsassay und elektrophoretische Auftrennung kombinieren
EP0695941B1 (en) * 1994-06-08 2002-07-31 Affymetrix, Inc. Method and apparatus for packaging a chip
US5580435A (en) 1994-06-10 1996-12-03 The Board Of Trustees Of The Leland Stanford Junior University System for detecting components of a sample in electrophoretic separation
DE4420732A1 (de) 1994-06-15 1995-12-21 Boehringer Mannheim Gmbh Vorrichtung zur Behandlung von Nukleinsäuren aus einer Probe
US5639428A (en) 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
WO1996007954A1 (en) 1994-09-09 1996-03-14 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Microstructures and methods for manufacturing microstructures
US5707799A (en) * 1994-09-30 1998-01-13 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture
US5641400A (en) 1994-10-19 1997-06-24 Hewlett-Packard Company Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems
US5500071A (en) 1994-10-19 1996-03-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5571410A (en) * 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
ATE235292T1 (de) 1994-10-22 2003-04-15 Central Research Lab Ltd Verfahren und vorichtung fur diffusionsaustausch zwischen nicht mischbare flüssigkeiten
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
EP0821726B1 (en) 1995-03-10 2014-05-07 Meso Scale Technologies, LLC. Multi-array, multi-specific electrochemiluminescence testing
DE19519015C1 (de) 1995-05-24 1996-09-05 Inst Physikalische Hochtech Ev Miniaturisierter Mehrkammer-Thermocycler
JP3477918B2 (ja) * 1995-05-29 2003-12-10 株式会社島津製作所 キャピラリ電気泳動チップ
US5716852A (en) 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5589136A (en) * 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
EP0838025B1 (en) 1995-07-13 2007-04-25 Applera Corporation Self-contained device integrating nucleic acid extraction, amplification and detection
DE59610489D1 (de) * 1995-08-17 2003-07-10 Hoffmann La Roche Chromatographie-Verfahren
EP1291441A3 (en) 1995-09-12 2003-03-19 Becton, Dickinson and Company Device and method for DNA amplification and assay
US5705018A (en) 1995-12-13 1998-01-06 Hartley; Frank T. Micromachined peristaltic pump
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
AU1989197A (en) * 1996-03-06 1997-09-22 Akzo Nobel N.V. Automated nucleic acid extraction from samples
US5707860A (en) 1996-03-12 1998-01-13 Becton Dickinson And Company Vehicle for delivery of particles to a sample
US5846727A (en) 1996-06-06 1998-12-08 Board Of Supervisors Of Louisiana State University And Agricultural & Mechanical College Microsystem for rapid DNA sequencing
US5863801A (en) 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
CN1329729C (zh) 1996-06-28 2007-08-01 卡钳生命科学股份有限公司 微流体系统
US5779868A (en) 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
EP0826412A3 (en) 1996-08-26 1999-06-02 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin Method for producing filter elements and the filter elements thus produced
AU730718B2 (en) * 1996-09-18 2001-03-15 Promega Corporation Improved filtration system and method
US5874046A (en) 1996-10-30 1999-02-23 Raytheon Company Biological warfare agent sensor system employing ruthenium-terminated oligonucleotides complementary to target live agent DNA sequences
US5882903A (en) 1996-11-01 1999-03-16 Sarnoff Corporation Assay system and method for conducting assays
AU6152498A (en) 1997-02-05 1998-08-25 California Institute Of Technology Microfluidic sub-millisecond mixers
ID22965A (id) 1997-02-28 1999-12-23 Burstein Lab Inc Laboratorium dalam suatu disk
US5939259A (en) 1997-04-09 1999-08-17 Schleicher & Schuell, Inc. Methods and devices for collecting and storing clinical samples for genetic analysis
CN1105914C (zh) 1997-04-25 2003-04-16 卡钳技术有限公司 改进了通道几何结构的微型流体装置
US5786182A (en) 1997-05-02 1998-07-28 Biomerieux Vitek, Inc. Dual chamber disposable reaction vessel for amplification reactions, reaction processing station therefor, and methods of use
US6156273A (en) 1997-05-27 2000-12-05 Purdue Research Corporation Separation columns and methods for manufacturing the improved separation columns
US5922288A (en) 1997-05-29 1999-07-13 Herst; C. V. Taylor Device for isolating a component of a physiological sample
US5869004A (en) 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
AU745989B2 (en) * 1997-08-13 2002-04-11 Cepheid Microstructures for the manipulation of fluid samples
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
DK1179585T3 (da) * 1997-12-24 2008-11-10 Cepheid Indretning og fremgangsmåde til lysis
US6261848B1 (en) * 1998-05-08 2001-07-17 The Johns Hopkins University Miniature immuno-optical rapid analyte sensor platform
US6100084A (en) 1998-11-05 2000-08-08 The Regents Of The University Of California Micro-sonicator for spore lysis
US6261431B1 (en) 1998-12-28 2001-07-17 Affymetrix, Inc. Process for microfabrication of an integrated PCR-CE device and products produced by the same
US6878540B2 (en) * 1999-06-25 2005-04-12 Cepheid Device for lysing cells, spores, or microorganisms

Also Published As

Publication number Publication date
JP4399507B2 (ja) 2010-01-20
DE69839709D1 (de) 2008-08-21
CA2312102C (en) 2007-09-04
JP4209589B2 (ja) 2009-01-14
US6440725B1 (en) 2002-08-27
JP2001527220A (ja) 2001-12-25
JP2009014736A (ja) 2009-01-22
US6893879B2 (en) 2005-05-17
US7569346B2 (en) 2009-08-04
EP1179585A3 (en) 2002-03-13
EP1179585B1 (en) 2008-07-09
JP4522480B2 (ja) 2010-08-11
EP1042061A1 (en) 2000-10-11
ATE400358T1 (de) 2008-07-15
JP2009236933A (ja) 2009-10-15
US20050194316A1 (en) 2005-09-08
AU1947299A (en) 1999-07-19
WO1999033559A1 (en) 1999-07-08
EP1179585A2 (en) 2002-02-13
CA2312102A1 (en) 1999-07-08
AU758407B2 (en) 2003-03-20
ES2309022T3 (es) 2008-12-16
US20020042125A1 (en) 2002-04-11

Similar Documents

Publication Publication Date Title
DK1179585T3 (da) Indretning og fremgangsmåde til lysis
EP0345782A3 (en) Fluid analysis with particulate reagent suspension
EP1419387A4 (en) METHOD AND DEVICE FOR DIAGNOSTIC TESTING
US7188731B2 (en) Variable flexure-based fluid filter
EP1322934B1 (en) Sampler for collecting particles from air
ATE44620T1 (de) Schnellanalyseprozessor.
DE69630295D1 (de) Diagnostische vorrichtung und verfahren
WO2000028297A3 (en) A method for the assessment of particles and a system and a device for use in the method
EP2214823A1 (en) Integrated separation and detection cartridge with means and method for increasing signal to noise ratio
ATE106569T1 (de) Diagnostische vorrichtung und verfahren, gekennzeichnet durch einen gezielten durchfluss.
EP1012560A1 (en) Method for collecting samples of liquid specimens for analytical testing
WO2006026253A3 (en) Automated low-volume tangential flow filtration process development device
WO1993022055A3 (en) Fluid handling in microfabricated analytical devices
WO2004061418A3 (en) Assay cartridges and methods of using the same
SE0103340D0 (sv) Metod och anordning för analys av biologiskt material
DK0925494T3 (da) Mikrostrømningssystem til partikelseparation og analyse
WO2005117556A3 (en) Quantitative lateral flow system and assay
WO2008066607A3 (en) Device for detection of molecules in biological fluids
JPH1026625A5 (da)
ATE283913T1 (de) Vorrichtung zum trennen und nachweis von bewegungsfähigen spermatozoen
SE9500020L (sv) Kemiska sensorer baserade på utbytbara igekänningskomponenter
WO2003014726A8 (en) A lateral flow plasma separation device
GB2378753A (en) Collection and analysis of entrained components
WO2002063290A3 (de) Verfahren zur gaschromatographischen analyse einer probe
WO2003011768A3 (en) Microfluidic device for molecular analysis