DK1198570T3 - Monomert protein af TGF-Beta-familien - Google Patents

Monomert protein af TGF-Beta-familien

Info

Publication number: DK1198570T3
Authority: DK; Denmark
Prior art keywords: proteins; tgf; nucleic acids; monomeric; monomeric protein
Prior art date: 1999-08-06

Application number

DK00958383T

Other languages

English (en)

Inventor

Gertrud Hoetten

Rolf Bechtold

Jens Pohl

Original Assignee

Hygene Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-06

Filing date

2000-08-04

Publication date

2005-10-31

2000-08-04 Application filed by Hygene Ag filed Critical Hygene Ag

2005-10-31 Application granted granted Critical

2005-10-31 Publication of DK1198570T3 publication Critical patent/DK1198570T3/da

Links

102000004169 proteins and genes Human genes 0.000 title abstract 6
108090000623 proteins and genes Proteins 0.000 title abstract 6
102000043168 TGF-beta family Human genes 0.000 title 1
108091085018 TGF-beta family Proteins 0.000 title 1
235000018102 proteins Nutrition 0.000 abstract 5
102000039446 nucleic acids Human genes 0.000 abstract 3
108020004707 nucleic acids Proteins 0.000 abstract 3
150000007523 nucleic acids Chemical class 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
235000018417 cysteine Nutrition 0.000 abstract 1
230000037430 deletion Effects 0.000 abstract 1
238000012217 deletion Methods 0.000 abstract 1
239000000539 dimer Substances 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1
239000013598 vector Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Oral & Maxillofacial Surgery (AREA)
Reproductive Health (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicinal Preparation (AREA)
Materials For Medical Uses (AREA)

DK00958383T 1999-08-06 2000-08-04 Monomert protein af TGF-Beta-familien DK1198570T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP99115613A EP1074620A1 (en)	1999-08-06	1999-08-06	Monomeric protein of the TGF-beta family
EP00958383A EP1198570B1 (en)	1999-08-06	2000-08-04	Monomeric protein of the tgf-beta family
PCT/EP2000/007600 WO2001011041A1 (en)	1999-08-06	2000-08-04	MONOMERIC PROTEIN OF THE TGF-β FAMILY

Publications (1)

Publication Number	Publication Date
DK1198570T3 true DK1198570T3 (da)	2005-10-31

Family

ID=8238746

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00958383T DK1198570T3 (da)	1999-08-06	2000-08-04	Monomert protein af TGF-Beta-familien

Country Status (12)

Country	Link
US (2)	US6972321B1 (da)
EP (3)	EP1074620A1 (da)
JP (1)	JP2003506086A (da)
AT (1)	ATE299937T1 (da)
AU (1)	AU782481B2 (da)
CA (1)	CA2381219C (da)
DE (1)	DE60021388T2 (da)
DK (1)	DK1198570T3 (da)
ES (1)	ES2242630T3 (da)
NZ (1)	NZ517125A (da)
WO (1)	WO2001011041A1 (da)
ZA (1)	ZA200201032B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6586388B2 (en)	1988-04-08	2003-07-01	Stryker Corporation	Method of using recombinant osteogenic protein to repair bone or cartilage defects
US7811793B2 (en) *	1996-12-25	2010-10-12	Biopharma Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh	Process for preparing purified active monomer of bone-derived factor
ATE470863T1 (de) *	2000-04-20	2010-06-15	St Vincents Hosp Sydney	Diagnostischer assay mit makrophagenhemmendem zytokin-1 (mic-1)
AU2002257703A1 (en)	2001-03-23	2002-10-08	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh	Use of cytokines of the tgf-beta superfamily for the treatment and diagnosis of skin related disorders
FI116827B (fi)	2001-08-24	2006-03-15	Univ Zuerich	Luun morfogeneettisen proteiinin deleetiomutantti, sitä sisältävä farmaseuttinen koostumus ja sen käyttö
EG23432A (da)	2001-12-17	2005-07-25	New Zealand Dairy Board
CA2491513A1 (en) *	2002-07-09	2004-01-15	Stryker Corporation	Compositions and methods for ligament growth and repair
EP1462126A1 (en)	2003-03-28	2004-09-29	BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH	Improved Osteoinductive Materials
GB0514262D0 (en) *	2005-07-12	2005-08-17	Renovo Ltd	Promotion of epithelial regeneration
WO2007057212A1 (en) *	2005-11-18	2007-05-24	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh	High activity growth factor mutants
GB0604966D0 (en) *	2006-03-11	2006-04-19	Renovo Ltd	Medicaments and proteins
GB0604938D0 (en) *	2006-03-11	2006-04-19	Renovo Ltd	Proteins, nucleic acids and medicaments
ES2557402T3 (es) *	2006-06-13	2016-01-25	Helix Biomedix Inc.	Fragmentos peptídicos para inducir la síntesis de proteínas de la matriz extracelular
EP1880731A1 (en)	2006-07-18	2008-01-23	BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH	Human growth and differentiation factor GDF-5
GB0617816D0 (en) *	2006-09-11	2006-10-18	Renovo Ltd	Nucleic acids and methods of protein expression
HRP20120698T1 (hr) *	2007-01-25	2013-09-30	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh	Uporaba dgf-5 za poboljšanje ili održavanje izgleda kože
US20100004175A1 (en) *	2008-06-09	2010-01-07	Tanya Shang	Novel bmp-12-related proteins and methods of their manufacture
US20130122066A1 (en)	2010-07-30	2013-05-16	Biopham Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh	Drug delivery devices and growth factor formulations for accelerated wound healing
US8455436B2 (en)	2010-12-28	2013-06-04	Depuy Mitek, Llc	Compositions and methods for treating joints
US8398611B2 (en)	2010-12-28	2013-03-19	Depuy Mitek, Inc.	Compositions and methods for treating joints
US8524662B2 (en)	2010-12-28	2013-09-03	Depuy Mitek, Llc	Compositions and methods for treating joints
EP2537538A1 (en)	2011-06-22	2012-12-26	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH	Bioresorbable Wound Dressing
US8623839B2 (en)	2011-06-30	2014-01-07	Depuy Mitek, Llc	Compositions and methods for stabilized polysaccharide formulations
EP2602264A1 (en)	2011-12-05	2013-06-12	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH	GDF-5 mutant for inducing cartilage formation
US9682099B2 (en)	2015-01-20	2017-06-20	DePuy Synthes Products, Inc.	Compositions and methods for treating joints
IL293988A (en)	2019-12-18	2022-08-01	Merck Patent Gmbh	Use of a gdf-5 mutant in the treatment of pain and cartilage destruction

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19525416A1 (de) *	1995-07-12	1997-01-16	Bioph Biotech Entw Pharm Gmbh	Verwendung von MP52 zur Behandlung und Prävention von Erkrankungen des Nervensystems
EP0690871A4 (en) *	1993-01-12	1999-10-20	Univ Johns Hopkins Med	GROWTH DIFFERENTIATION FACTOR-5
US5420243A (en) *	1993-01-26	1995-05-30	Celtrix Pharmaceuticals, Inc.	Biologically active TGF-β2 peptides
IL110589A0 (en) *	1993-08-10	1994-11-11	Bioph Biotech Entw Pharm Gmbh	Growth/differentiation factor of the TGF- beta family
AU689184B2 (en) *	1993-12-07	1998-03-26	Genetics Institute, Llc	BMP-12, BMP-13 and tendon-inducing compositions thereof
IL114397A0 (en) *	1994-07-01	1995-10-31	Bioph Biotech Entw Pharm Gmbh	Growth/differentiation factor of the TGF-beta-family
JPH09295945A (ja) *	1996-04-30	1997-11-18	Hoechst Yakuhin Kogyo Kk	成熟型骨誘導因子の製造方法
JPH11335398A (ja) *	1998-05-22	1999-12-07	Hoechst Marion Roussel Kk	新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬

1999
- 1999-08-06 EP EP99115613A patent/EP1074620A1/en not_active Withdrawn
2000
- 2000-08-04 EP EP05013166A patent/EP1574578A1/en not_active Withdrawn
- 2000-08-04 AT AT00958383T patent/ATE299937T1/de active
- 2000-08-04 US US10/048,458 patent/US6972321B1/en not_active Expired - Lifetime
- 2000-08-04 NZ NZ517125A patent/NZ517125A/en not_active IP Right Cessation
- 2000-08-04 DE DE60021388T patent/DE60021388T2/de not_active Expired - Lifetime
- 2000-08-04 JP JP2001515827A patent/JP2003506086A/ja active Pending
- 2000-08-04 DK DK00958383T patent/DK1198570T3/da active
- 2000-08-04 AU AU69927/00A patent/AU782481B2/en not_active Ceased
- 2000-08-04 ES ES00958383T patent/ES2242630T3/es not_active Expired - Lifetime
- 2000-08-04 WO PCT/EP2000/007600 patent/WO2001011041A1/en not_active Ceased
- 2000-08-04 CA CA002381219A patent/CA2381219C/en not_active Expired - Fee Related
- 2000-08-04 EP EP00958383A patent/EP1198570B1/en not_active Expired - Lifetime
2002
- 2002-02-06 ZA ZA200201032A patent/ZA200201032B/xx unknown
2005
- 2005-07-28 US US11/191,072 patent/US7569227B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2381219A1 (en)	2001-02-15
AU6992700A (en)	2001-03-05
ES2242630T3 (es)	2005-11-16
US6972321B1 (en)	2005-12-06
CA2381219C (en)	2008-11-18
ZA200201032B (en)	2002-12-24
EP1198570B1 (en)	2005-07-20
AU782481B2 (en)	2005-08-04
ATE299937T1 (de)	2005-08-15
EP1574578A1 (en)	2005-09-14
DE60021388D1 (de)	2005-08-25
EP1074620A1 (en)	2001-02-07
JP2003506086A (ja)	2003-02-18
US7569227B2 (en)	2009-08-04
NZ517125A (en)	2003-08-29
EP1198570A1 (en)	2002-04-24
WO2001011041A1 (en)	2001-02-15
DE60021388T2 (de)	2006-01-05
US20050282255A1 (en)	2005-12-22

Publication	Publication Date	Title
DK1198570T3 (da)	2005-10-31	Monomert protein af TGF-Beta-familien
BRPI0512286A (pt)	2008-03-18	proteìnas quiméricas inibidoras da angiogênese e o uso
CY1113684T1 (el)	2016-06-22	Anti-mikρobiaka πεπτιδια που περιλαμβανουν μια αργινινη (arginine)- kai/ή λυσινη (lysine)- που περιεχουν υποκινητη
EA200400815A1 (ru)	2004-12-30	Контролируемый синтез зипразидона и его композиции
DK0625989T3 (da)	2000-06-26	DNA-sekvenser kodende for hidtil ukendte vækst-/differentieringsfaktorer
EA200901129A1 (ru)	2010-04-30	Нуклеиновые кислоты и полипептиды нового рецептора
ATE258598T1 (de)	2004-02-15	Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht
DE69433690D1 (de)	2004-05-13	Chimere proteine, welche borrelia polypeptide beinhalten, verwendungen dafür
BRPI0411363A (pt)	2006-07-25	seqüências de ácidos nucléicos codificando e composições compreendendo peptìdeo sinal ige e/ou il-15 e processos para uso das mesmas
ATE463580T1 (de)	2010-04-15	Verfahren zur herstellung von rekombinantem protein und fusionsprotein
WO2001021807A8 (en)	2001-10-11	Hepatitis c virus envelope two protein (e2) which lacks all or part of the hypervariable region one (hvr1), corresponding nucleic acids, chimeric viruses and uses thereof
DE69504808D1 (de)	1998-10-22	Corticotropin freisetzende rezeptoren des faktor 2
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BR0312889A (pt)	2005-06-14	Polipeptìdeo t20 peguilado
DK1279677T3 (da)	2007-05-07	GD3-mimetiske peptider
EA200600042A1 (ru)	2006-08-25	Способы образования дисульфидных связей и гликозилирования белков и реагенты, применяемые в этих способах
BR0008589A (pt)	2002-01-29	Composto de tipirano, processo para sua preparação e seu uso
WO2005042717A3 (en)	2007-08-16	Primate prokineticin and prokineticin receptor polypeptides, related compositions and methods
ATE442444T1 (de)	2009-09-15	Glykosylphosphatidylinositolhaltige polypeptide
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ATE235509T1 (de)	2003-04-15	Peptide zur inhibition von hpv e7 proteinen
ES2059801T3 (es)	1994-11-16	Nuevas linfoquinas, secuencias de adn que codifican para estas linfoquinas, y composiciones farmaceuticas conteniendo estas linfoquinas.
EA200501508A1 (ru)	2006-02-24	Семейство секретируемых белков