DK1200384T3 - 2-Alkyl-5-halogen-pent-4-encarboxylsyrer og deres fremstilling - Google Patents

2-Alkyl-5-halogen-pent-4-encarboxylsyrer og deres fremstilling

Info

Publication number: DK1200384T3
Authority: DK; Denmark
Prior art keywords: sub; alkyl; alkoxy; formula; pent
Prior art date: 1999-07-29

Application number

DK00940109T

Other languages

English (en)

Inventor

Peter Herold

Stefan Stutz

Original Assignee

Speedel Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-29

Filing date

2000-07-13

Publication date

2004-08-02

2000-07-13 Application filed by Speedel Pharma Ag filed Critical Speedel Pharma Ag

2004-08-02 Application granted granted Critical

2004-08-02 Publication of DK1200384T3 publication Critical patent/DK1200384T3/da

Links

239000002253 acid Substances 0.000 title 1
150000007513 acids Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 23
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000004103 aminoalkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
150000001412 amines Chemical class 0.000 abstract 1
IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
238000007245 halolactonization reaction Methods 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
238000007142 ring opening reaction Methods 0.000 abstract 1
-1 tetramethylene, pentamethylene, 3-oxa-1,5-pentylene Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/20—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/12—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/06—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/64—Acyl halides
- C07C57/76—Acyl halides containing halogen outside the carbonyl halide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/65—Halogen-containing esters of unsaturated acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK00940109T 1999-07-29 2000-07-13 2-Alkyl-5-halogen-pent-4-encarboxylsyrer og deres fremstilling DK1200384T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
CH140199		1999-07-29
CH442000		2000-01-11
PCT/CH2000/000385 WO2001009079A1 (de)	1999-07-29	2000-07-13	2-alkyl-5-halogen-pent-4-encarbonsäuren und deren herstellung

Publications (1)

Publication Number	Publication Date
DK1200384T3 true DK1200384T3 (da)	2004-08-02

Family

ID=25687539

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK00940108T DK1200390T3 (da)	1999-07-29	2000-07-13	Fremstilling af N-substituerede 2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoylamider
DK00940109T DK1200384T3 (da)	1999-07-29	2000-07-13	2-Alkyl-5-halogen-pent-4-encarboxylsyrer og deres fremstilling

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK00940108T DK1200390T3 (da)	1999-07-29	2000-07-13	Fremstilling af N-substituerede 2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoylamider

Country Status (10)

Country	Link
US (3)	US6777574B1 (da)
EP (2)	EP1200390B1 (da)
JP (2)	JP4580606B2 (da)
AT (2)	ATE406346T1 (da)
AU (2)	AU5518400A (da)
DE (2)	DE50006271D1 (da)
DK (2)	DK1200390T3 (da)
ES (2)	ES2312346T3 (da)
PT (2)	PT1200390E (da)
WO (2)	WO2001009079A1 (da)

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AU7376301A (en)	2000-07-05	2002-01-14	Speedel Pharma Ag	Process for the preparation of substituted octanoyl amides
IL158586A0 (en)	2001-05-15	2004-05-12	Speedel Pharma Ag	Process for the preparation of substituted carboxylic acid esters by enzymatic hydrolysis
US20060154926A1 (en) *	2002-06-11	2006-07-13	Elan Pharmaceuticals, Inc.	Methods of treating alzheimer's disease using aryl alkanoic acid amides
DE60312214T3 (de)	2002-12-09	2015-02-26	Asahi Glass Co., Ltd.	Verfahren zur herstellung von(4e)-5-chloro-2-isopropyl-4-pentensäureester und optischaktivem isomer davon
EP1626093A1 (en) *	2004-08-11	2006-02-15	Dow Global Technologies Inc.	Process for the production of (S)-5-chloro-2-isopropylpent-4-enoic acid esters
WO2006099926A1 (en) *	2005-03-09	2006-09-28	Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg	Process for preparing enantiopure e-(2s)-alkyl-5-halopent-4-enoic acids and esters
JP4763771B2 (ja) *	2005-03-17	2011-08-31	ビーエーエスエフソシエタス・ヨーロピア	光学活性３−フェニルプロピオン酸誘導体を生成する方法、およびその誘導体の後続生成物
WO2006117057A1 (en) *	2005-05-02	2006-11-09	Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg	Process for preparing enantiomerically enriched e-(2s)- and (2r)-alkyl-5-halopent-4-enecarboxylic acids or their esters
AT502257B1 (de) *	2005-07-25	2007-04-15	Dsm Fine Chem Austria Gmbh	Verfahren zur herstellung von racemischen alkyl-5-halogen-pent-4-en-carbonsäuren bzw. -carbonsäureestern
DE102005042458A1 (de) *	2005-09-06	2007-03-22	Basf Ag	Verfahren zur Herstellung von 2-substituierten Carbonsäuren
WO2007036491A1 (de) *	2005-09-30	2007-04-05	Basf Aktiengesellschaft	Verfahren zur herstellung von alpha-substituierten carbonsäuren
GB0521083D0 (en)	2005-10-17	2005-11-23	Novartis Ag	Organic compounds
GB2431640A (en) *	2005-10-25	2007-05-02	Novartis Ag	Alternative synthesis of aryl-octanoyl amide compounds
GB2431654A (en) *	2005-10-25	2007-05-02	Novartis Ag	Alternative synthesis of aryl-octanoyl amide compounds
DE102005052195A1 (de)	2005-10-28	2007-05-03	Reuter Chemischer Apparatebau Kg	Verfahren zur Herstellung von chiralen Octensäurederivaten
WO2007069745A1 (ja) *	2005-12-16	2007-06-21	Asahi Glass Company, Limited	光学活性な（４ｅ）－５－クロロ－２－イソプロピル－４－ペンテン酸またはその塩基性アミノ酸塩の製造方法
TW200837046A (en) *	2006-11-08	2008-09-16	Speedel Experimenta Ag	Process for preparing organic compounds
EP1958666A1 (en)	2007-02-13	2008-08-20	Speedel Experimenta AG	Heterocyclic-substituted alkanamides as therapeutic compounds
DE102007049039A1 (de)	2007-10-11	2009-04-16	Reuter Chemischer Apparatebau Kg	Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung
EP2062874B1 (en)	2007-11-20	2014-12-17	KRKA, tovarna zdravil, d.d., Novo mesto	Process and intermediates for the preparation of aliskiren
EP2225200B1 (en) *	2007-12-24	2013-10-16	DSM IP Assets B.V.	Convergent synthesis of renin inhibitors and intermediates useful therein
US20100029774A1 (en) *	2008-05-23	2010-02-04	Nina Finkelstein	Aliskiren monofumarate and processes for preparation thereof
SI2189442T1 (sl)	2008-11-20	2015-03-31	Krka, Tovarna Zdravil, D.D., Novo Mesto	Postopek in intermediati za pripravo aliskirena
EA201190091A1 (ru)	2009-02-05	2012-01-30	Крка, Товарна Здравил, Д. Д., Ново Место	Активируемый влагой способ грануляции
US8203005B2 (en)	2009-10-29	2012-06-19	Carbo Design Llc	Manufacturing process for enantiomerically pure 8-aryloctanoic acids as Aliskiren
CN101774986B (zh)	2010-01-06	2012-03-28	浙江天宇药业股份有限公司	一种制备阿利克伦及其中间体的方法
TR201002256A1 (tr)	2010-03-24	2011-10-21	Sanovel �La� Sanay� Ve T�Caret Anon�M ��Rket�	Stabil aliskiren formülasyonları
US20110268797A1 (en)	2010-04-30	2011-11-03	Sanovel IIac Sanayi Ve Ticaret Anonim Sirketi	Multicoated aliskiren formulations
PT2630118E (pt)	2010-10-19	2015-02-10	Mylan Lab Ltd	Síntese do aliskiren
US8703976B2 (en)	2011-10-02	2014-04-22	Milan Soukup	Manufacturing process for 8-aryloctanoic acids such as Aliskiren
WO2013118138A1 (en)	2011-12-13	2013-08-15	Laboratories Ltd Mylan	Novel process for the preparation of renin inhibitors
EP2814806B1 (en)	2012-02-17	2016-05-25	Mylan Laboratories Ltd.	An improved process for the preparation of aliskiren
WO2013124868A2 (en)	2012-02-21	2013-08-29	Mylan Laboratories Limited	Solid form of aliskiren intermediate
WO2013144979A1 (en)	2012-03-28	2013-10-03	Maylan Laboratories Ltd	Process for the preparation of aliskiren
WO2013171767A1 (en)	2012-05-18	2013-11-21	Mylan Laboratories Limited	An improved process for the preparation of aliskiren
CN103130677B (zh) *	2013-03-12	2015-01-07	博瑞生物医药技术(苏州)有限公司	一种阿利克仑的制备方法
WO2014207206A1 (en) *	2013-06-27	2014-12-31	Dpx Holdings B.V.	Preparation of grignard reagents using a fluidized bed
CN103351300A (zh) *	2013-06-30	2013-10-16	北京万全德众医药生物技术有限公司	一种制备阿利克仑中间体侧链（s）-2-溴代异戊酸甲酯的方法
CN105294478B (zh) *	2014-07-01	2017-06-13	华润双鹤药业股份有限公司	阿利吉仑的一种非对映异构体、其制备方法及用途

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CA2247580A1 (en) *	1997-10-03	1999-04-03	F. Hoffmann-La Roche Ag	Process for preparing chiral succinic acid derivatives

2000
- 2000-07-13 PT PT00940108T patent/PT1200390E/pt unknown
- 2000-07-13 AT AT00940108T patent/ATE406346T1/de active
- 2000-07-13 JP JP2001514283A patent/JP4580606B2/ja not_active Expired - Lifetime
- 2000-07-13 EP EP00940108A patent/EP1200390B1/de not_active Expired - Lifetime
- 2000-07-13 EP EP00940109A patent/EP1200384B1/de not_active Expired - Lifetime
- 2000-07-13 AU AU55184/00A patent/AU5518400A/en not_active Abandoned
- 2000-07-13 US US10/048,290 patent/US6777574B1/en not_active Expired - Fee Related
- 2000-07-13 DK DK00940108T patent/DK1200390T3/da active
- 2000-07-13 WO PCT/CH2000/000385 patent/WO2001009079A1/de not_active Ceased
- 2000-07-13 US US10/048,229 patent/US7009078B1/en not_active Expired - Fee Related
- 2000-07-13 PT PT00940109T patent/PT1200384E/pt unknown
- 2000-07-13 DE DE50006271T patent/DE50006271D1/de not_active Expired - Lifetime
- 2000-07-13 AU AU55185/00A patent/AU5518500A/en not_active Abandoned
- 2000-07-13 WO PCT/CH2000/000384 patent/WO2001009083A1/de not_active Ceased
- 2000-07-13 DK DK00940109T patent/DK1200384T3/da active
- 2000-07-13 ES ES00940108T patent/ES2312346T3/es not_active Expired - Lifetime
- 2000-07-13 ES ES00940109T patent/ES2218173T3/es not_active Expired - Lifetime
- 2000-07-13 JP JP2001514287A patent/JP4922521B2/ja not_active Expired - Fee Related
- 2000-07-13 DE DE50015330T patent/DE50015330D1/de not_active Expired - Lifetime
- 2000-07-13 AT AT00940109T patent/ATE265415T1/de active
2005
- 2005-10-21 US US11/254,749 patent/US7132569B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE50015330D1 (de)	2008-10-09
AU5518500A (en)	2001-02-19
WO2001009083A1 (de)	2001-02-08
PT1200384E (pt)	2004-09-30
JP2003506347A (ja)	2003-02-18
US7009078B1 (en)	2006-03-07
WO2001009079A1 (de)	2001-02-08
US20060041169A1 (en)	2006-02-23
DK1200390T3 (da)	2008-12-01
JP4580606B2 (ja)	2010-11-17
ES2218173T3 (es)	2004-11-16
US7132569B2 (en)	2006-11-07
ATE406346T1 (de)	2008-09-15
US6777574B1 (en)	2004-08-17
ATE265415T1 (de)	2004-05-15
JP2003506345A (ja)	2003-02-18
JP4922521B2 (ja)	2012-04-25
EP1200390B1 (de)	2008-08-27
EP1200390A1 (de)	2002-05-02
DE50006271D1 (de)	2004-06-03
ES2312346T3 (es)	2009-03-01
EP1200384B1 (de)	2004-04-28
PT1200390E (pt)	2008-12-05
EP1200384A1 (de)	2002-05-02
AU5518400A (en)	2001-02-19

Publication	Publication Date	Title
DK1200384T3 (da)	2004-08-02	2-Alkyl-5-halogen-pent-4-encarboxylsyrer og deres fremstilling
NL300877I2 (nl)	2017-06-22	obeticholzuur
HUP0301249A2 (hu)	2004-01-28	APO B termelődés gátló benzamid-vegyületek ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
CA2046051A1 (en)	1992-01-06	2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents
HUP0100615A2 (hu)	2001-10-28	Szubsztituált 2-(2,6-dioxo-3-fluoro-piperidin-3-il)-izoindolinok és ezek alkalmazása TNFalfa-szint csökkentésére
HUP9902341A2 (hu)	1999-10-28	Herpeszvírus elleni hatású fenil-tiazol-származékok, előállításuk és alkalmazásuk, a vegyületeket tartalmazó gyógyszerkészítmények
ES2185338T3 (es)	2003-04-16	Derivados de fumagilol y procedimientos para su fabricacion.
CY1110284T1 (el)	2015-01-14	Παραγωγα της 2-αμινο-4-πυριδυλομεθυλο-θειαζολινης και η χρηση τους ως αναστολεις της επαγωγιμης συνθασης νο
HUP0001192A2 (hu)	2000-11-28	Topiramát és származékainak alkalmazása elhízás kezelésére használható gyógyszerkészítmények előállítására
NO894814D0 (no)	1989-12-01	Substituerte 2-pyridoner og pyrid-2-tioner, deres fremstilling og anvendelse i legemidler.
ES2180508T3 (es)	2003-02-16	Metodo para la preparacion de 5-cianoftalida.
KR970707107A (ko)	1997-12-01	산화질소 합성효소 억제제로서 유용한 아미노테트라졸 유도체(aminotetrazole derivatives useful as nitric oxide synthase inhibtors)
UY24802A1 (es)	2001-03-16	Nuevos compuestos
PT918776E (pt)	2004-07-30	Sintese total de acilfulvenos antitumorais
LU92263I2 (fr)	2013-10-07	Imépitoïne et ses dérivés pharmaceutiquement acceptables (PEXION)
ES2191341T3 (es)	2003-09-01	Derivados de la 2-fenoxianilina.
HUP9901621A2 (hu)	1999-08-30	Protein kináz C inhibitor hatású alkil-oxi-amino szubsztituenst tartalmazó fluorenon-származékok, alkalmazásuk, intermedierjeik és ezek előállítása, valamint a vegyületeket tartalmazó gyógyászati készítmények
NO961404L (no)	1996-10-11	4-indolylpiperazinyl-derivater
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