NO961404L - 4-indolylpiperazinyl-derivater - Google Patents

4-indolylpiperazinyl-derivater

Info

Publication number
NO961404L
NO961404L NO961404A NO961404A NO961404L NO 961404 L NO961404 L NO 961404L NO 961404 A NO961404 A NO 961404A NO 961404 A NO961404 A NO 961404A NO 961404 L NO961404 L NO 961404L
Authority
NO
Norway
Prior art keywords
alkyl
indolylpiperazinyl
derivatives
benzyl
phenyl
Prior art date
Application number
NO961404A
Other languages
English (en)
Other versions
NO961404D0 (no
Inventor
John Patrick Yardley
III Horace FLETCHER
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of NO961404D0 publication Critical patent/NO961404D0/no
Publication of NO961404L publication Critical patent/NO961404L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer angstdempende/antidepressive midler med formelen: r R4 R5 x R2-C-CO-N CH2-N l H ¿ R3 1 hvor | R1 er alkyl; : R2 og R3 er alkyl eller er sammen polymetylen; R4 er hydrogen eller alkyl; R5 er fenyl, benzyl, substituert fenyl eller substituert benzyl hvor ! substituentene er hydroksy, halogen, alkoksy, trifluormetyl, nitro, cyano, ; alkoksykarbonyl, amino eller dialkylamino; ; eller et farmasøytisk godtagbart salt derav.
NO961404A 1995-04-10 1996-04-09 4-indolylpiperazinyl-derivater NO961404L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/419,333 US5519025A (en) 1995-04-10 1995-04-10 4-indolylpiperazinyl derivatives

Publications (2)

Publication Number Publication Date
NO961404D0 NO961404D0 (no) 1996-04-09
NO961404L true NO961404L (no) 1996-10-11

Family

ID=23661806

Family Applications (1)

Application Number Title Priority Date Filing Date
NO961404A NO961404L (no) 1995-04-10 1996-04-09 4-indolylpiperazinyl-derivater

Country Status (14)

Country Link
US (1) US5519025A (no)
EP (1) EP0737677A1 (no)
JP (1) JPH08283262A (no)
KR (1) KR960037677A (no)
AU (1) AU5052296A (no)
BR (1) BR9601295A (no)
CA (1) CA2173693A1 (no)
CZ (1) CZ102896A3 (no)
IL (1) IL117858A0 (no)
MX (1) MX9601326A (no)
NO (1) NO961404L (no)
NZ (1) NZ286340A (no)
SK (1) SK45196A3 (no)
ZA (1) ZA962821B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2756283A1 (fr) * 1996-11-27 1998-05-29 Pf Medicament Amines aromatiques d'arylpiperazines, leur preparation et leurs applications comme medicaments
DE69819266T2 (de) 1997-09-02 2004-07-29 Duphar International Research B.V. Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
EP0900792B1 (en) * 1997-09-02 2003-10-29 Duphar International Research B.V Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US6376494B1 (en) 1998-06-15 2002-04-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
US6831084B1 (en) 1999-11-12 2004-12-14 Wyeth Branched adamantyl and noradamantyl aryl- and aralkylpiperazines with serotonin 5-HT1A activity
WO2001034586A2 (en) 1999-11-12 2001-05-17 Wyeth Branched adamantyl and noradamantyl aryl- and aralkylpiperazines with serotonin 5-ht1a activity
WO2002085871A2 (en) 2001-04-04 2002-10-31 Wyeth Serotonergic agents with long-acting in vivo effects
US7067518B2 (en) * 2002-09-05 2006-06-27 Wyeth Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641029A (en) * 1970-02-02 1972-02-08 American Cyanamid Co Substituted benzoxazolecarboxamides and benzothiazolecarboxamides
US3646048A (en) * 1970-02-02 1972-02-29 American Cyanamid Co N-(tert-aminoalkyl)-2-indenecarboxamides
CA1340113C (en) * 1988-05-24 1998-11-03 Magid A. Abou-Gharbia Aryl-and heteroaryl piperazinyl carboxamides having central nervous system activity
CA2004670A1 (en) * 1988-12-08 1990-06-08 Jan Hartog Anxiolytically active piperazine derivatives
GB8909209D0 (en) * 1989-04-22 1989-06-07 Wyeth John & Brother Ltd Piperazine derivatives
IL94151A (en) * 1989-04-22 1995-08-31 Wyeth John & Brother Ltd History of piperazine, their preparation and pharmaceutical preparations containing them
US5340812A (en) * 1989-04-22 1994-08-23 John Wyeth & Brother, Limited Piperazine derivatives
GB9411099D0 (en) * 1994-06-03 1994-07-27 Wyeth John & Brother Ltd Piperazine derivatives
US5486518A (en) * 1995-04-10 1996-01-23 American Home Products Corporation 4-indolylpiperazinyl derivatives

Also Published As

Publication number Publication date
JPH08283262A (ja) 1996-10-29
CZ102896A3 (en) 1996-10-16
CA2173693A1 (en) 1996-10-11
KR960037677A (ko) 1996-11-19
ZA962821B (en) 1997-10-09
MX9601326A (es) 1997-04-30
US5519025A (en) 1996-05-21
BR9601295A (pt) 1998-01-13
IL117858A0 (en) 1996-08-04
NO961404D0 (no) 1996-04-09
AU5052296A (en) 1996-10-24
EP0737677A1 (en) 1996-10-16
NZ286340A (en) 1997-06-24
SK45196A3 (en) 1997-04-09

Similar Documents

Publication Publication Date Title
DK0590919T3 (da) Terapeutiske midler mod Parkinsons sygdom
BG104248A (en) Benzamidoxim derivatives, intermediate products and methods for preparing and using them as fungicides
DE69929689D1 (de) Heterozyclische derivate für die behandlung von herzversagen und andere erkrankungen
DK0464465T3 (da) Substituerede aminoalkylbiphenylderivater, antimykotiske præparater indeholdende disse derivater og mellemprodukter til fremstilling deraf
EE04308B1 (et) Bensimidasooli ühendid, neid ühendeid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine
IT1232252B (it) Derivati della n fenil benzamide ad attivita' antiulcera ed antiallerica e procedimento per la loro preparazione
NO964698D0 (no) Bicykliske aminderivater som inhibitorer av nitrogenoksid-syntetase
FI951555A0 (fi) 5H,10H-imidatso[1,2-a]indeno[1,2-e]pyratsin-4-onijohdannaiset, niiden valmistus ja niitä sisältävät lääkkeet
ES2191341T3 (es) Derivados de la 2-fenoxianilina.
MX9601326A (es) Derivados de 4-indolilpiperazinil.
DK394189A (da) Arylalkylaminer og -amider med antikonvulsive og neurobeskyttende egenskaber
NO995289L (no) Benzimidazol-derivater
BG101601A (bg) Фармацевтични пиперазинови производни
DK0648202T3 (da) Substituerede (arylalkylaminobenzyl)aminopropanamidderivater, fremstilling deraf og anvendelse som anti-epileptiske, neurobeskyttende og antidepressive midler
BG104037A (en) 6-pyrrolidin-2-ylpyrindine derivatives, their preparation and application in therapy
YU68502A (sh) Piridazinil fenil hidrazoni korisni protiv kongestivnog srčanog udara
ATE191465T1 (de) Carbamoylcarbonsäureamide
UA26459C2 (uk) Іhгібітор впливу амілоїдhих білків
TW429147B (en) Pharmaceutical composition for the treatment of CNS disorders
ATE138373T1 (de) N,n',n'-trisubstituierte-5-bisaminomethylen-1,3 dioxan-4,6-dione als acyl-coa:cholesterol- acyltransferasehemmer
MX9204939A (es) Inhibidores 5-bis-aminometilen-1,3-dioxan-4,6-diona n,n',n'-trisubstituidas, de la acil coenzima a: colesterol-aciltransferasa.
MX9605679A (es) 3-fenilpirazoles sustituidos.
UA41868C2 (uk) N-заміщені похідні 3-азабіцикло[3.2.0]гептану