NO961404L - 4-indolylpiperazinyl-derivater - Google Patents

4-indolylpiperazinyl-derivater

Info

Publication number
NO961404L
NO961404L NO961404A NO961404A NO961404L NO 961404 L NO961404 L NO 961404L NO 961404 A NO961404 A NO 961404A NO 961404 A NO961404 A NO 961404A NO 961404 L NO961404 L NO 961404L
Authority
NO
Norway
Prior art keywords
alkyl
indolylpiperazinyl
derivatives
benzyl
phenyl
Prior art date
Application number
NO961404A
Other languages
English (en)
Other versions
NO961404D0 (no
Inventor
John Patrick Yardley
III Horace FLETCHER
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of NO961404D0 publication Critical patent/NO961404D0/no
Publication of NO961404L publication Critical patent/NO961404L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer angstdempende/antidepressive midler med formelen: r R4 R5 x R2-C-CO-N CH2-N l H ¿ R3 1 hvor | R1 er alkyl; : R2 og R3 er alkyl eller er sammen polymetylen; R4 er hydrogen eller alkyl; R5 er fenyl, benzyl, substituert fenyl eller substituert benzyl hvor ! substituentene er hydroksy, halogen, alkoksy, trifluormetyl, nitro, cyano, ; alkoksykarbonyl, amino eller dialkylamino; ; eller et farmasøytisk godtagbart salt derav.
NO961404A 1995-04-10 1996-04-09 4-indolylpiperazinyl-derivater NO961404L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/419,333 US5519025A (en) 1995-04-10 1995-04-10 4-indolylpiperazinyl derivatives

Publications (2)

Publication Number Publication Date
NO961404D0 NO961404D0 (no) 1996-04-09
NO961404L true NO961404L (no) 1996-10-11

Family

ID=23661806

Family Applications (1)

Application Number Title Priority Date Filing Date
NO961404A NO961404L (no) 1995-04-10 1996-04-09 4-indolylpiperazinyl-derivater

Country Status (14)

Country Link
US (1) US5519025A (no)
EP (1) EP0737677A1 (no)
JP (1) JPH08283262A (no)
KR (1) KR960037677A (no)
AU (1) AU5052296A (no)
BR (1) BR9601295A (no)
CA (1) CA2173693A1 (no)
CZ (1) CZ102896A3 (no)
IL (1) IL117858A0 (no)
MX (1) MX9601326A (no)
NO (1) NO961404L (no)
NZ (1) NZ286340A (no)
SK (1) SK45196A3 (no)
ZA (1) ZA962821B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2756283A1 (fr) * 1996-11-27 1998-05-29 Pf Medicament Amines aromatiques d'arylpiperazines, leur preparation et leurs applications comme medicaments
ATE253058T1 (de) 1997-09-02 2003-11-15 Duphar Int Res Piperidin- und piperazin derivate als 5-ht1- rezeptor-agonisten
EP0900792B1 (en) * 1997-09-02 2003-10-29 Duphar International Research B.V Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US6376494B1 (en) 1998-06-15 2002-04-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
BR0015539A (pt) 1999-11-12 2002-07-16 Wyeth Corp Adamantil e noradamantil aril- e aralquilpiperazinas ramificadas com atividade 5-ht1a de serotonina
US6831084B1 (en) 1999-11-12 2004-12-14 Wyeth Branched adamantyl and noradamantyl aryl- and aralkylpiperazines with serotonin 5-HT1A activity
WO2002085871A2 (en) * 2001-04-04 2002-10-31 Wyeth Serotonergic agents with long-acting in vivo effects
US7067518B2 (en) * 2002-09-05 2006-06-27 Wyeth Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641029A (en) * 1970-02-02 1972-02-08 American Cyanamid Co Substituted benzoxazolecarboxamides and benzothiazolecarboxamides
US3646048A (en) * 1970-02-02 1972-02-29 American Cyanamid Co N-(tert-aminoalkyl)-2-indenecarboxamides
IL90279A (en) * 1988-05-24 1995-03-30 American Home Prod Piperazinyl carboxamide derivatives, their preparation and pharmaceutical com¦ositions containing them
IL92544A0 (en) * 1988-12-08 1990-08-31 Duphar Int Res Piperazine derivatives,their preparation and pharmaceutical compositions containing them
GB8909209D0 (en) * 1989-04-22 1989-06-07 Wyeth John & Brother Ltd Piperazine derivatives
US5340812A (en) * 1989-04-22 1994-08-23 John Wyeth & Brother, Limited Piperazine derivatives
KR0173310B1 (ko) * 1989-04-22 1999-02-01 폴 에이 리쳐 피페라진 유도체
GB9411099D0 (en) * 1994-06-03 1994-07-27 Wyeth John & Brother Ltd Piperazine derivatives
US5486518A (en) * 1995-04-10 1996-01-23 American Home Products Corporation 4-indolylpiperazinyl derivatives

Also Published As

Publication number Publication date
CZ102896A3 (en) 1996-10-16
BR9601295A (pt) 1998-01-13
SK45196A3 (en) 1997-04-09
IL117858A0 (en) 1996-08-04
ZA962821B (en) 1997-10-09
MX9601326A (es) 1997-04-30
NO961404D0 (no) 1996-04-09
CA2173693A1 (en) 1996-10-11
EP0737677A1 (en) 1996-10-16
AU5052296A (en) 1996-10-24
US5519025A (en) 1996-05-21
JPH08283262A (ja) 1996-10-29
KR960037677A (ko) 1996-11-19
NZ286340A (en) 1997-06-24

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