DK121189A - 5-substituerede(4,5-c)imidazopyridiner og deres anvendelse ved behandling af paf-formidlede sygdomme - Google Patents

5-substituerede(4,5-c)imidazopyridiner og deres anvendelse ved behandling af paf-formidlede sygdomme

Info

Publication number: DK121189A
Authority: DK; Denmark
Prior art keywords: carbon atoms; alkyl; substituted; group; halogen
Prior art date: 1988-03-14

Application number

DK121189A

Other languages

English (en)

Other versions

DK121189D0 (da

DK169872B1 (da

Inventor

Ish K Khanna

Roger Nosal

Richard Mathias Weier

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-14

Filing date

1989-03-13

Publication date

1989-09-15

1988-03-14 Priority claimed from US07/167,671 external-priority patent/US4914108A/en

1989-03-13 Application filed by Searle & Co filed Critical Searle & Co

1989-03-13 Publication of DK121189D0 publication Critical patent/DK121189D0/da

1989-09-15 Publication of DK121189A publication Critical patent/DK121189A/da

1995-03-20 Application granted granted Critical

1995-03-20 Publication of DK169872B1 publication Critical patent/DK169872B1/da

Links

208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
201000010099 disease Diseases 0.000 title abstract 2
150000005232 imidazopyridines Chemical class 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 23
125000000217 alkyl group Chemical group 0.000 abstract 18
229910052736 halogen Inorganic materials 0.000 abstract 6
150000002367 halogens Chemical class 0.000 abstract 6
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000001246 bromo group Chemical group Br* 0.000 abstract 2
125000001309 chloro group Chemical group Cl* 0.000 abstract 2
125000001153 fluoro group Chemical group F* 0.000 abstract 2
125000004857 imidazopyridinyl group Chemical class N1C(=NC2=C1C=CC=N2)* 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
HVAUUPRFYPCOCA-AREMUKBSSA-N 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP([O-])(=O)OCC[N+](C)(C)C HVAUUPRFYPCOCA-AREMUKBSSA-N 0.000 abstract 1
108010003541 Platelet Activating Factor Proteins 0.000 abstract 1
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
150000001602 bicycloalkyls Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000005343 heterocyclic alkyl group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
125000005358 mercaptoalkyl group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
125000004001 thioalkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK121189A 1988-03-14 1989-03-13 5-Substituerede imidazo[4,5-c]pyridiner, farmaceutiske præparater med disse forbindelser og anvendelse af forbindelserne til fremstilling af farmaceutiske præparater DK169872B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US16767188		1988-03-14
US07/167,671 US4914108A (en)	1988-03-14	1988-03-14	5-substituted(4,5-c)imidazopyridine compounds which have useful platelet activating factor antagonistic activity
US07/317,871 US5019581A (en)	1988-03-14	1989-03-06	5-substituted (4,5-c) imidazopyridine compounds which have useful platelet activating factor antagonistic activity
US31787189		1989-03-06

Publications (3)

Publication Number	Publication Date
DK121189D0 DK121189D0 (da)	1989-03-13
DK121189A true DK121189A (da)	1989-09-15
DK169872B1 DK169872B1 (da)	1995-03-20

Family

ID=26863369

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK121189A DK169872B1 (da)	1988-03-14	1989-03-13	5-Substituerede imidazo[4,5-c]pyridiner, farmaceutiske præparater med disse forbindelser og anvendelse af forbindelserne til fremstilling af farmaceutiske præparater

Country Status (15)

Country	Link
US (1)	US5019581A (da)
EP (1)	EP0344414B1 (da)
JP (1)	JP2714426B2 (da)
KR (1)	KR890014537A (da)
AT (1)	ATE112774T1 (da)
AU (1)	AU625058B2 (da)
CA (1)	CA1337072C (da)
DE (1)	DE68918755T2 (da)
DK (1)	DK169872B1 (da)
ES (1)	ES2061753T3 (da)
FI (1)	FI91407C (da)
IL (1)	IL89588A0 (da)
NO (1)	NO169965C (da)
NZ (1)	NZ228336A (da)
PH (1)	PH26967A (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5302601A (en) *	1988-03-14	1994-04-12	G. D. Searle & Co.	5-substituted imidazo[4,5-c]pyridines
US5227384A (en) *	1988-03-14	1993-07-13	G. D. Searle & Co.	5-substituted [4,5-c] imidazopyridines and pharmaceutical use thereof
US4990518A (en) *	1989-09-13	1991-02-05	G. D. Searle & Co.	Pharmacologically active heteroaryl substituted imidazo (4,5-c) pyridines
GB9116056D0 (en) *	1991-07-24	1991-09-11	British Bio Technology	Compounds
US5223539A (en) *	1991-11-22	1993-06-29	G. D. Searle & Co.	N,n-di-alkyl(phenoxy)benzamide derivatives
US5208242A (en) *	1992-08-26	1993-05-04	G. D. Searle & Co.	5-substituted-4-phenyl-5H-imidazo[4,5-c]pyridine derivatives
US5262426A (en) *	1993-01-22	1993-11-16	G. D. Searle & Co.	N,N'-cycloalkyl/alkyl carboxamide 4H-imidazo-[4,5-b]pyridine compounds as PAF antagonists
US5360907A (en) *	1993-06-14	1994-11-01	G.D. Searle & Co.	Pyrrolo[3,2-B]pyridinylalkyl benzamide derivatives
US5496855A (en) *	1995-01-27	1996-03-05	Smithkline Beecham Corp.	Anti-inflammatory compounds
GB0215293D0 (en) *	2002-07-03	2002-08-14	Rega Foundation	Viral inhibitors
EP2161273B1 (en) *	2003-12-22	2015-04-15	K.U.Leuven Research & Development	Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment
NZ556624A (en) *	2004-12-21	2010-06-25	Gilead Sciences Inc	5-((3-(2,4-trifluoromethyphenyl)isoxazol-5-yl)methyl)-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine and method of antiviral treatment
TW200808695A (en) *	2006-06-08	2008-02-16	Amgen Inc	Benzamide derivatives and uses related thereto
KR101143596B1 (ko) *	2006-07-07	2012-05-11	길리애드 사이언시즈, 인코포레이티드	신규의 피리다진 화합물 및 이의 용도
UA99466C2 (en)	2007-07-06	2012-08-27	Гилиад Сайенсиз, Инк.	Crystalline pyridazine compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4281005A (en) *	1979-03-05	1981-07-28	Merck & Co., Inc.	Novel 2-pyridylimidazole compounds
DE2927987A1 (de) *	1979-07-11	1981-02-05	Thomae Gmbh Dr K	Neue 2-alkoxyphenyl-imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine, deren herstellung und deren verwendung als arzneimittel
IL68495A0 (en) *	1982-05-03	1983-07-31	Lilly Co Eli	2-phenylimidazo(4,5-c)pyridines
US4804658A (en) *	1986-09-15	1989-02-14	G. D. Searle & Co.	Imidazopyridine derivatives and pharmaceutical compositions

1989
- 1989-03-06 US US07/317,871 patent/US5019581A/en not_active Expired - Lifetime
- 1989-03-13 CA CA000593520A patent/CA1337072C/en not_active Expired - Fee Related
- 1989-03-13 NO NO891058A patent/NO169965C/no unknown
- 1989-03-13 IL IL89588A patent/IL89588A0/xx not_active IP Right Cessation
- 1989-03-13 DK DK121189A patent/DK169872B1/da not_active IP Right Cessation
- 1989-03-14 KR KR1019890003132A patent/KR890014537A/ko not_active Ceased
- 1989-03-14 ES ES89104464T patent/ES2061753T3/es not_active Expired - Lifetime
- 1989-03-14 DE DE68918755T patent/DE68918755T2/de not_active Expired - Fee Related
- 1989-03-14 AU AU31270/89A patent/AU625058B2/en not_active Ceased
- 1989-03-14 PH PH38328A patent/PH26967A/en unknown
- 1989-03-14 EP EP89104464A patent/EP0344414B1/en not_active Expired - Lifetime
- 1989-03-14 JP JP1061979A patent/JP2714426B2/ja not_active Expired - Lifetime
- 1989-03-14 FI FI891200A patent/FI91407C/fi not_active IP Right Cessation
- 1989-03-14 AT AT89104464T patent/ATE112774T1/de active
- 1989-03-14 NZ NZ228336A patent/NZ228336A/en unknown

Also Published As

Publication number	Publication date
EP0344414A1 (en)	1989-12-06
FI891200A0 (fi)	1989-03-14
IL89588A0 (en)	1989-09-10
PH26967A (en)	1992-12-28
FI91407B (fi)	1994-03-15
EP0344414B1 (en)	1994-10-12
NO169965C (no)	1992-08-26
JP2714426B2 (ja)	1998-02-16
CA1337072C (en)	1995-09-19
ATE112774T1 (de)	1994-10-15
FI891200A7 (fi)	1989-09-15
DE68918755D1 (de)	1994-11-17
DK121189D0 (da)	1989-03-13
NO891058L (no)	1989-09-15
DE68918755T2 (de)	1995-03-09
AU625058B2 (en)	1992-07-02
NO891058D0 (no)	1989-03-13
DK169872B1 (da)	1995-03-20
ES2061753T3 (es)	1994-12-16
JPH01316378A (ja)	1989-12-21
NO169965B (no)	1992-05-18
KR890014537A (ko)	1989-10-24
NZ228336A (en)	1992-01-29
US5019581A (en)	1991-05-28
AU3127089A (en)	1989-09-14
FI91407C (fi)	1994-06-27

Legal Events

Date	Code	Title
1989-03-13	A0	Application filed
1995-03-20	B1	Patent granted (law 1993)
1996-11-18	PBP	Patent lapsed

Publication	Publication Date	Title
DK121189A (da)	1989-09-15	5-substituerede(4,5-c)imidazopyridiner og deres anvendelse ved behandling af paf-formidlede sygdomme
DK1583524T3 (da)	2006-12-27	Bis(thiohydrazidamid)-forbindelser til behandling af multilægemiddel-resistent cancer
NO170084C (no)	1992-09-09	Analogifremgangsmaate til fremstilling av terapeutisk aktive dihydropyridinderivater
ATE429229T1 (de)	2009-05-15	Indol-, azaindol- und verwandte heterozyklische amidopiperazin-derivate
CY1108913T1 (el)	2014-07-02	Παραγωγα 4 (φαινυλ-πιπεραζινυλ-μεθυλ) βενζαμιδιου και η χρηση τους για τη θεραπευτικη αντιμετωπιση του πονου, του αγχους ή γαστρεντερικων διαταραχων
BR0211055A (pt)	2004-07-20	Novos compostos como agentes antiinflamatórios, imunomoduladores e anti-proliferativos
FI112485B (fi)	2003-12-15	Uusia 1,4-dihydro-4-okso-1,8-naftyridiinijohdannaisia, menetelmä niiden valmistamiseksi ja kasvaintenvastaisia aineita
DK586588D0 (da)	1988-10-21	Terapeutiske heterocycliske forbindelser
EA200501315A1 (ru)	2006-04-28	8-ЗАМЕЩЁННЫЕ ПРОИЗВОДНЫЕ 6,7,8,9-ТЕТРАГИДРОПИРИМИДО[1,2-a]ПИРИМИДИН-4-ОНА
DE69324403D1 (de)	1999-05-20	Herbizide 2,6-substituierte Pyridine
ATE92486T1 (de)	1993-08-15	Dihydropyridine als antiallergische und entzuendungshemmende mittel.
DE69220048D1 (de)	1997-07-03	Imidazoacridine und ihre antineoplastische anwendung
AR035465A1 (es)	2004-05-26	Compuestos de imidazopiridina, procesos para su preparacion,formulacion farmaceutica, usos de estos compuestos para la fabricacion de medicamentos e intermediarios
AR021826A1 (es)	2002-08-07	COMPUESTOS DE 2- FENILPIRAN-4-ONA, PROCESOS PARA PREPARARLOS, USO DE UN COMPUESTO INTERMEDIARIO EN DICHOS, COMPOSICIoN FARMACÉUTICA QUE LOS COMPRENDE Y USO DE DICHOS COMPUESTOS Y DICHA COMPOSICIoN PARA LA FABRICACIoN DE UN MEDICAMENTO
YU58301A (sh)	2004-05-12	2-aminopiridini koji sadrže supstituente sa kondenzovanim prstenom
ATE205209T1 (de)	2001-09-15	Chinolincarbonsäurederivate und ihre salze
DK0514942T3 (da)	1997-03-24	Hidtil ukendte benzopyranderivater og fremgangsmåder til fremstilling deraf
ATE226196T1 (de)	2002-11-15	Neue cyclische aminophenylessigsäurederivate, ihre herstellung und immunomodulatoren , welche diese als aktiven bestandteil enthalten
NO903230L (no)	1991-01-21	Fremgangsmaate for fremstilling av benzoksazolon-derivater.
DE69523819D1 (de)	2001-12-20	Quinolin-Derivate und diese enthaltende pharmazeutische Zusammensetzungen