DK1219594T3 - Nye estere afledt af substituerede phenylcyclohexylforbindelser - Google Patents

Nye estere afledt af substituerede phenylcyclohexylforbindelser

Info

Publication number
DK1219594T3
DK1219594T3 DK02075838T DK02075838T DK1219594T3 DK 1219594 T3 DK1219594 T3 DK 1219594T3 DK 02075838 T DK02075838 T DK 02075838T DK 02075838 T DK02075838 T DK 02075838T DK 1219594 T3 DK1219594 T3 DK 1219594T3
Authority
DK
Denmark
Prior art keywords
substituted
esters derived
novel esters
phenylcyclohexyl
compounds
Prior art date
Application number
DK02075838T
Other languages
Danish (da)
English (en)
Inventor
Castillo Nieto Juan Carlos Del
Freixa Maria Chalaux
Clotet Joan Huguet
Ramon Amat Elisabet De
Mancini Marisabel Mourelle
Original Assignee
Vita Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita Lab filed Critical Vita Lab
Application granted granted Critical
Publication of DK1219594T3 publication Critical patent/DK1219594T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/40Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C219/30Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK02075838T 1998-11-06 1999-11-04 Nye estere afledt af substituerede phenylcyclohexylforbindelser DK1219594T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009802329A ES2141688B1 (es) 1998-11-06 1998-11-06 Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.

Publications (1)

Publication Number Publication Date
DK1219594T3 true DK1219594T3 (da) 2004-04-19

Family

ID=8305698

Family Applications (3)

Application Number Title Priority Date Filing Date
DK99953994T DK1127871T3 (da) 1998-11-06 1999-11-04 Nye estere afledt af substituerede phenylcyclohexylforbindelser
DK02075838T DK1219594T3 (da) 1998-11-06 1999-11-04 Nye estere afledt af substituerede phenylcyclohexylforbindelser
DK02075837T DK1219623T3 (da) 1998-11-06 1999-11-04 Nye estere afledt af substituerede phenylcyclohexylforbindelser

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK99953994T DK1127871T3 (da) 1998-11-06 1999-11-04 Nye estere afledt af substituerede phenylcyclohexylforbindelser

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK02075837T DK1219623T3 (da) 1998-11-06 1999-11-04 Nye estere afledt af substituerede phenylcyclohexylforbindelser

Country Status (39)

Country Link
US (1) US6455585B1 (fr)
EP (3) EP1219594B1 (fr)
JP (1) JP2002529442A (fr)
KR (1) KR100453613B1 (fr)
CN (1) CN1176902C (fr)
AP (1) AP1222A (fr)
AT (3) ATE249418T1 (fr)
AU (1) AU755681B2 (fr)
BG (1) BG105556A (fr)
BR (1) BR9915727A (fr)
CA (1) CA2349245A1 (fr)
CR (1) CR6368A (fr)
CU (1) CU23006A3 (fr)
CZ (1) CZ20011500A3 (fr)
DE (3) DE69911235T2 (fr)
DK (3) DK1127871T3 (fr)
EA (1) EA003742B1 (fr)
EE (1) EE200100246A (fr)
ES (4) ES2141688B1 (fr)
GE (1) GEP20033116B (fr)
HR (1) HRP20010412B1 (fr)
HU (1) HUP0104218A3 (fr)
ID (1) ID29017A (fr)
IL (1) IL142592A0 (fr)
IS (1) IS5934A (fr)
MA (1) MA26765A1 (fr)
MX (1) MXPA01004432A (fr)
NO (1) NO20012234D0 (fr)
NZ (1) NZ511739A (fr)
OA (1) OA11672A (fr)
PL (1) PL347492A1 (fr)
PT (3) PT1219594E (fr)
SI (3) SI1127871T1 (fr)
SK (1) SK284068B6 (fr)
TR (3) TR200200415T2 (fr)
UA (1) UA59477C2 (fr)
WO (1) WO2000027799A1 (fr)
YU (1) YU29601A (fr)
ZA (1) ZA200104026B (fr)

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ES2160534B1 (es) * 1999-12-30 2002-04-16 Vita Invest Sa Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo.
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
WO2004026291A1 (fr) * 2002-08-28 2004-04-01 Shuyi Zhang Formulations orales d'ibuprofene et de tramadol, methodes de preparation de ces dernieres
PT1562567T (pt) 2002-11-22 2017-08-24 Gruenenthal Gmbh Combinação de analgésicos selecionados e inibidores da cox-ii
US20040248979A1 (en) * 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102004034619A1 (de) * 2004-07-16 2006-02-23 Grünenthal GmbH Substituierte Aminoverbindungen als 5-HT/NA Uptakehemmer
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
KR101616246B1 (ko) 2008-01-25 2016-05-02 그뤼넨탈 게엠베하 약제학적 투여형
AU2009243681B2 (en) 2008-05-09 2013-12-19 Grunenthal Gmbh Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
WO2011009602A1 (fr) 2009-07-22 2011-01-27 Grünenthal GmbH Forme galénique extrudée à chaud à libération contrôlée
TWI473628B (zh) 2009-07-22 2015-02-21 用於對氧化敏感之類鴉片藥劑之抗破壞劑型
EP2383255A1 (fr) 2010-04-28 2011-11-02 Lacer, S.A. Nouveaux composés, synthèse et utilisation dans le traitement de la douleur
CA2808219C (fr) 2010-09-02 2019-05-14 Gruenenthal Gmbh Forme pharmaceutique inviolable comportant un sel inorganique
WO2012028318A1 (fr) 2010-09-02 2012-03-08 Grünenthal GmbH Forme pharmaceutique inviolable comportant un polymère anionique
WO2012100423A1 (fr) 2011-01-27 2012-08-02 Eli Lilly And Company Composés analgésiques, procédés, et formulations
EP2530072A1 (fr) 2011-06-03 2012-12-05 Lacer, S.A. Nouveaux composés, synthèse et utilisation dans le traitement de la douleur
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
AU2012289764B2 (en) 2011-07-29 2017-03-02 Grünenthal GmbH Tamper-resistant tablet providing immediate drug release
ES2648129T3 (es) 2011-07-29 2017-12-28 Grünenthal GmbH Pastilla a prueba de manipulación que proporciona una liberación inmediata de un medicamento
US20130225697A1 (en) 2012-02-28 2013-08-29 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
PL2838512T3 (pl) 2012-04-18 2018-12-31 Grünenthal GmbH Farmaceutyczna postać dawkowania odporna na niewłaściwe użycie i odporna na uderzeniowe uwalnianie dawki
WO2013168005A2 (fr) * 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement du syndrome des jambes sans repos et de la fibromyalgie
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
JP6466417B2 (ja) 2013-05-29 2019-02-06 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 二峰性放出プロファイルを有する改変防止(tamper−resistant)剤形
AU2014273227B2 (en) 2013-05-29 2019-08-15 Grunenthal Gmbh Tamper-resistant dosage form containing one or more particles
JP6449871B2 (ja) 2013-07-12 2019-01-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング エチレン−酢酸ビニルポリマーを含有する改変防止剤形
EP3073994A1 (fr) 2013-11-26 2016-10-05 Grünenthal GmbH Préparation de composition pharmaceutique en poudre par cryo-broyage
EP3142646A1 (fr) 2014-05-12 2017-03-22 Grünenthal GmbH Formulation pour capsule à libération immédiate résistant aux manipulations illicites comprenant du tapentadol
BR112017021475A2 (pt) 2015-04-24 2018-07-10 Gruenenthal Gmbh forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente
WO2017042325A1 (fr) 2015-09-10 2017-03-16 Grünenthal GmbH Protection contre un surdosage par voie orale à l'aide de formulations à libération immédiate dissuasives d'abus

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DE1199764B (de) * 1963-04-02 1965-09-02 Gruenenthal Chemie Verfahren zur Herstellung von basisch substituierten Phenolaethern
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
DE19609847A1 (de) * 1996-03-13 1997-09-18 Gruenenthal Gmbh Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe

Also Published As

Publication number Publication date
DE69911235D1 (de) 2003-10-16
EA200100476A1 (ru) 2002-02-28
ID29017A (id) 2001-07-26
DE69914231D1 (de) 2004-02-19
TR200200416T2 (tr) 2003-01-21
ZA200104026B (en) 2002-05-17
NZ511739A (en) 2002-11-26
SK5842001A3 (en) 2001-12-03
ES2207298T3 (es) 2004-05-16
EP1219594B1 (fr) 2004-01-14
EP1219594A1 (fr) 2002-07-03
EP1219623B1 (fr) 2004-01-14
ES2213731T3 (es) 2004-09-01
HRP20010412A2 (en) 2002-12-31
UA59477C2 (uk) 2003-09-15
CU23006A3 (es) 2004-12-17
PT1219623E (pt) 2004-04-30
MXPA01004432A (es) 2002-09-18
NO20012234L (no) 2001-05-04
TR200200415T2 (tr) 2002-06-21
GEP20033116B (en) 2003-11-25
CN1325377A (zh) 2001-12-05
IS5934A (is) 2001-05-03
CR6368A (es) 2002-04-08
WO2000027799A1 (fr) 2000-05-18
TR200101160T2 (tr) 2002-01-21
SI1219594T1 (en) 2004-06-30
YU29601A (sh) 2003-04-30
EP1127871B1 (fr) 2003-09-10
SI1219623T1 (en) 2004-06-30
SK284068B6 (sk) 2004-09-08
BR9915727A (pt) 2001-09-04
EA003742B1 (ru) 2003-08-28
BG105556A (en) 2001-12-29
HUP0104218A3 (en) 2002-11-28
KR20010080942A (ko) 2001-08-25
PT1127871E (pt) 2003-12-31
AU1047300A (en) 2000-05-29
KR100453613B1 (ko) 2004-10-20
JP2002529442A (ja) 2002-09-10
CZ20011500A3 (cs) 2001-09-12
DE69914229T2 (de) 2004-12-09
ATE249418T1 (de) 2003-09-15
HRP20010412B1 (en) 2004-04-30
ATE257837T1 (de) 2004-01-15
US6455585B1 (en) 2002-09-24
AU755681B2 (en) 2002-12-19
SI1127871T1 (en) 2004-02-29
PL347492A1 (en) 2002-04-08
CN1176902C (zh) 2004-11-24
CA2349245A1 (fr) 2000-05-18
PT1219594E (pt) 2004-04-30
ES2141688A1 (es) 2000-05-16
NO20012234D0 (no) 2001-05-04
EP1127871A1 (fr) 2001-08-29
DE69914229D1 (de) 2004-02-19
DK1127871T3 (da) 2003-11-24
DK1219623T3 (da) 2004-04-19
EE200100246A (et) 2002-12-16
ES2141688B1 (es) 2001-02-01
HUP0104218A2 (hu) 2002-03-28
AP1222A (en) 2003-11-06
ES2213732T3 (es) 2004-09-01
ATE257817T1 (de) 2004-01-15
DE69914231T2 (de) 2004-11-11
OA11672A (en) 2005-01-12
IL142592A0 (en) 2002-03-10
MA26765A1 (fr) 2004-12-20
DE69911235T2 (de) 2004-07-01
EP1219623A1 (fr) 2002-07-03

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