CU23006A3 - Nuevos ésteres derivados de compuestos fenil-ciclonuevos ésteres derivados de compuestos fenil-ciclohexil sustituidos hexil sustituidos - Google Patents

Nuevos ésteres derivados de compuestos fenil-ciclonuevos ésteres derivados de compuestos fenil-ciclohexil sustituidos hexil sustituidos

Info

Publication number
CU23006A3
CU23006A3 CU2001010920010109A CU20010109A CU23006A3 CU 23006 A3 CU23006 A3 CU 23006A3 CU 2001010920010109 A CU2001010920010109 A CU 2001010920010109A CU 20010109 A CU20010109 A CU 20010109A CU 23006 A3 CU23006 A3 CU 23006A3
Authority
CU
Cuba
Prior art keywords
compounds
esters derived
substituted phenyl
new esters
substituted
Prior art date
Application number
CU2001010920010109A
Other languages
English (en)
Inventor
Amat Elisabet De Ramon Amat Elisabet De Ramon
Mancini Marisabel Mourelle Mancini Marisa Mourelle
Clotet Joan Huguet Clotet Joan Huguet
Freixa Maria Chalaux Freixa Maria Chalaux
Nieto Juan Carlos Del Castillo Nieto Juan Castillo
Original Assignee
Vita Invest Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita Invest Sa filed Critical Vita Invest Sa
Publication of CU23006A3 publication Critical patent/CU23006A3/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C219/30—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Nuevos ésteres derivados de compuestos fenil- ciclNuevos ésteres derivados de compuestos fenil- ciclohexil sustituidos, derivados del Tramadol, procedohexil sustituidos, derivados del Tramadol, procedimiento para su obtención y uso de dichos compuestimiento para su obtención y uso de dichos compuestos para la fabricación de un medicamento con propios para la fabricación de un medicamento con propiedades analgésicas. Estos nuevos productos de fórmedades analgésicas. Estos nuevos productos de fórmula general (I) presentan una actividad analgésicaula general (I) presentan una actividad analgésica superior al tramadol, una toxicidad menor y una m superior al tramadol, una toxicidad menor y una mayor duración de acción. ayor duración de acción.
CU2001010920010109A 1998-11-06 2001-05-07 Nuevos ésteres derivados de compuestos fenil-ciclonuevos ésteres derivados de compuestos fenil-ciclohexil sustituidos hexil sustituidos CU23006A3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009802329A ES2141688B1 (es) 1998-11-06 1998-11-06 Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.

Publications (1)

Publication Number Publication Date
CU23006A3 true CU23006A3 (es) 2004-12-17

Family

ID=8305698

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2001010920010109A CU23006A3 (es) 1998-11-06 2001-05-07 Nuevos ésteres derivados de compuestos fenil-ciclonuevos ésteres derivados de compuestos fenil-ciclohexil sustituidos hexil sustituidos

Country Status (39)

Country Link
US (1) US6455585B1 (es)
EP (3) EP1219623B1 (es)
JP (1) JP2002529442A (es)
KR (1) KR100453613B1 (es)
CN (1) CN1176902C (es)
AP (1) AP1222A (es)
AT (3) ATE249418T1 (es)
AU (1) AU755681B2 (es)
BG (1) BG105556A (es)
BR (1) BR9915727A (es)
CA (1) CA2349245A1 (es)
CR (1) CR6368A (es)
CU (1) CU23006A3 (es)
CZ (1) CZ20011500A3 (es)
DE (3) DE69914231T2 (es)
DK (3) DK1127871T3 (es)
EA (1) EA003742B1 (es)
EE (1) EE200100246A (es)
ES (4) ES2141688B1 (es)
GE (1) GEP20033116B (es)
HR (1) HRP20010412B1 (es)
HU (1) HUP0104218A3 (es)
ID (1) ID29017A (es)
IL (1) IL142592A0 (es)
IS (1) IS5934A (es)
MA (1) MA26765A1 (es)
MX (1) MXPA01004432A (es)
NO (1) NO20012234L (es)
NZ (1) NZ511739A (es)
OA (1) OA11672A (es)
PL (1) PL347492A1 (es)
PT (3) PT1127871E (es)
SI (3) SI1127871T1 (es)
SK (1) SK284068B6 (es)
TR (3) TR200200416T2 (es)
UA (1) UA59477C2 (es)
WO (1) WO2000027799A1 (es)
YU (1) YU29601A (es)
ZA (1) ZA200104026B (es)

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US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
AU2003264311A1 (en) * 2002-08-28 2004-04-08 Jin Wang Oral formulations of ibuprofen and tramadol, methods and preparation thereof
DE50312678D1 (de) 2002-11-22 2010-06-10 Gruenenthal Gmbh Verwendung von (1R, 2R)-3-(3-Dimenthylamino-1-ethyl-2-methyl-propyl)-phenol zur Behandlung von Entzündungsschmerz
US20040248979A1 (en) * 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102004034619A1 (de) * 2004-07-16 2006-02-23 Grünenthal GmbH Substituierte Aminoverbindungen als 5-HT/NA Uptakehemmer
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
TWI454288B (zh) 2008-01-25 2014-10-01 Gruenenthal Chemie 藥物劑型
ES2599031T3 (es) 2008-05-09 2017-01-31 Grünenthal GmbH Proceso para la preparación de una formulación de polvo intermedia y una forma de dosificación solida final utilizando un paso de congelación por pulverización
BR112012001466A2 (pt) 2009-07-22 2020-08-11 Grünenthal GmbH forma de dosagem resistente à falsificação para opioides sensíveis à oxidação, seu processo de fabricação, e embalagem
ES2534908T3 (es) 2009-07-22 2015-04-30 Grünenthal GmbH Forma de dosificación de liberación controlada extruida por fusión en caliente
EP2383255A1 (en) 2010-04-28 2011-11-02 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
WO2012028318A1 (en) 2010-09-02 2012-03-08 Grünenthal GmbH Tamper resistant dosage form comprising an anionic polymer
CA2808219C (en) 2010-09-02 2019-05-14 Gruenenthal Gmbh Tamper resistant dosage form comprising inorganic salt
WO2012100423A1 (en) * 2011-01-27 2012-08-02 Eli Lilly And Company Analgesic compounds, methods, and formulations
EP2530072A1 (en) 2011-06-03 2012-12-05 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
BR112014002022A2 (pt) 2011-07-29 2017-02-21 Gruenenthal Gmbh comprimido resistente à violação proporcionando liberação de fármaco imediata
JP6063462B2 (ja) 2011-07-29 2017-01-18 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 即時薬剤放出を提供するタンパーレジスタント錠剤
BR112014019988A8 (pt) 2012-02-28 2017-07-11 Gruenenthal Gmbh Forma de dosagem resistente a socamento compreendendo um composto farmacologicamente ativo e um polímero aniônico
LT2838512T (lt) 2012-04-18 2018-11-12 GrĆ¼nenthal GmbH Pažeidimui atspari ir dozės atpalaidavimo nuokrypiui atspari farmacinė vaisto forma
US9339484B2 (en) * 2012-05-10 2016-05-17 Cellix Bio Private Limited Compositions and methods for the treatment of restless leg syndrome and fibromyalgia
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
AU2014273227B2 (en) 2013-05-29 2019-08-15 Grunenthal Gmbh Tamper-resistant dosage form containing one or more particles
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WO2015173195A1 (en) 2014-05-12 2015-11-19 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
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DE1199764B (de) * 1963-04-02 1965-09-02 Gruenenthal Chemie Verfahren zur Herstellung von basisch substituierten Phenolaethern
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
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Also Published As

Publication number Publication date
DK1219623T3 (da) 2004-04-19
EE200100246A (et) 2002-12-16
DK1127871T3 (da) 2003-11-24
NO20012234D0 (no) 2001-05-04
ATE257837T1 (de) 2004-01-15
CA2349245A1 (en) 2000-05-18
BG105556A (en) 2001-12-29
SK284068B6 (sk) 2004-09-08
ES2141688B1 (es) 2001-02-01
ZA200104026B (en) 2002-05-17
NZ511739A (en) 2002-11-26
EP1127871A1 (en) 2001-08-29
SI1219594T1 (en) 2004-06-30
CN1325377A (zh) 2001-12-05
ATE257817T1 (de) 2004-01-15
ES2141688A1 (es) 2000-05-16
YU29601A (sh) 2003-04-30
PL347492A1 (en) 2002-04-08
KR100453613B1 (ko) 2004-10-20
DE69911235T2 (de) 2004-07-01
DE69914231T2 (de) 2004-11-11
ES2213731T3 (es) 2004-09-01
IL142592A0 (en) 2002-03-10
PT1127871E (pt) 2003-12-31
EA200100476A1 (ru) 2002-02-28
WO2000027799A1 (es) 2000-05-18
GEP20033116B (en) 2003-11-25
DK1219594T3 (da) 2004-04-19
ID29017A (id) 2001-07-26
KR20010080942A (ko) 2001-08-25
TR200200415T2 (tr) 2002-06-21
NO20012234L (no) 2001-05-04
BR9915727A (pt) 2001-09-04
SK5842001A3 (en) 2001-12-03
SI1219623T1 (en) 2004-06-30
HUP0104218A2 (hu) 2002-03-28
CR6368A (es) 2002-04-08
ATE249418T1 (de) 2003-09-15
PT1219594E (pt) 2004-04-30
OA11672A (en) 2005-01-12
CN1176902C (zh) 2004-11-24
DE69914229D1 (de) 2004-02-19
DE69911235D1 (de) 2003-10-16
JP2002529442A (ja) 2002-09-10
ES2207298T3 (es) 2004-05-16
EP1219594B1 (en) 2004-01-14
US6455585B1 (en) 2002-09-24
HRP20010412A2 (en) 2002-12-31
SI1127871T1 (en) 2004-02-29
MXPA01004432A (es) 2002-09-18
CZ20011500A3 (cs) 2001-09-12
PT1219623E (pt) 2004-04-30
DE69914231D1 (de) 2004-02-19
HRP20010412B1 (en) 2004-04-30
UA59477C2 (uk) 2003-09-15
MA26765A1 (fr) 2004-12-20
EP1219623B1 (en) 2004-01-14
IS5934A (is) 2001-05-03
EP1219623A1 (en) 2002-07-03
ES2213732T3 (es) 2004-09-01
EP1127871B1 (en) 2003-09-10
TR200101160T2 (tr) 2002-01-21
AP1222A (en) 2003-11-06
AU1047300A (en) 2000-05-29
TR200200416T2 (tr) 2003-01-21
AU755681B2 (en) 2002-12-19
EP1219594A1 (en) 2002-07-03
EA003742B1 (ru) 2003-08-28
HUP0104218A3 (en) 2002-11-28
DE69914229T2 (de) 2004-12-09

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