TR200200416T2 - İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler. - Google Patents

İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler.

Info

Publication number
TR200200416T2
TR200200416T2 TR2002/00416T TR200200416T TR200200416T2 TR 200200416 T2 TR200200416 T2 TR 200200416T2 TR 2002/00416 T TR2002/00416 T TR 2002/00416T TR 200200416 T TR200200416 T TR 200200416T TR 200200416 T2 TR200200416 T2 TR 200200416T2
Authority
TR
Turkey
Prior art keywords
substituted
esters derived
new esters
phenylcyclohexyl
compounds
Prior art date
Application number
TR2002/00416T
Other languages
English (en)
Inventor
Carlos Del Castillo Nieto Juan
Huguet Clotet Joan
De Ramon Amat Elisabet
Chalaux Freixa Maria
Mourella Mancini Marisabel
Original Assignee
Vita-Invest, S. A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita-Invest, S. A. filed Critical Vita-Invest, S. A.
Publication of TR200200416T2 publication Critical patent/TR200200416T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C219/30—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Tramadol' den elde edilen ikame fenil-sikloheksil bilesimlerinden elde edilen yeni esterler, bunlarin elde edilme islemi ve analjezik özelliklere sahip olan ilacin hazirlanmasinda bunlarin kullanimi. Genel formülün (I) bu yeni bilesenleri daha yüksek bir analjezik aktiviteye, daha az toksiteye ve daha uzun bir etkinlik zamanina sahiptir.
TR2002/00416T 1998-11-06 1999-11-04 İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler. TR200200416T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009802329A ES2141688B1 (es) 1998-11-06 1998-11-06 Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.

Publications (1)

Publication Number Publication Date
TR200200416T2 true TR200200416T2 (tr) 2003-01-21

Family

ID=8305698

Family Applications (3)

Application Number Title Priority Date Filing Date
TR2002/00415T TR200200415T2 (tr) 1998-11-06 1999-11-04 İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler.
TR2002/00416T TR200200416T2 (tr) 1998-11-06 1999-11-04 İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler.
TR2001/01160T TR200101160T2 (tr) 1998-11-06 1999-11-04 İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TR2002/00415T TR200200415T2 (tr) 1998-11-06 1999-11-04 İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler.

Family Applications After (1)

Application Number Title Priority Date Filing Date
TR2001/01160T TR200101160T2 (tr) 1998-11-06 1999-11-04 İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler.

Country Status (39)

Country Link
US (1) US6455585B1 (tr)
EP (3) EP1219594B1 (tr)
JP (1) JP2002529442A (tr)
KR (1) KR100453613B1 (tr)
CN (1) CN1176902C (tr)
AP (1) AP1222A (tr)
AT (3) ATE249418T1 (tr)
AU (1) AU755681B2 (tr)
BG (1) BG105556A (tr)
BR (1) BR9915727A (tr)
CA (1) CA2349245A1 (tr)
CR (1) CR6368A (tr)
CU (1) CU23006A3 (tr)
CZ (1) CZ20011500A3 (tr)
DE (3) DE69911235T2 (tr)
DK (3) DK1127871T3 (tr)
EA (1) EA003742B1 (tr)
EE (1) EE200100246A (tr)
ES (4) ES2141688B1 (tr)
GE (1) GEP20033116B (tr)
HR (1) HRP20010412B1 (tr)
HU (1) HUP0104218A3 (tr)
ID (1) ID29017A (tr)
IL (1) IL142592A0 (tr)
IS (1) IS5934A (tr)
MA (1) MA26765A1 (tr)
MX (1) MXPA01004432A (tr)
NO (1) NO20012234D0 (tr)
NZ (1) NZ511739A (tr)
OA (1) OA11672A (tr)
PL (1) PL347492A1 (tr)
PT (3) PT1219594E (tr)
SI (3) SI1127871T1 (tr)
SK (1) SK284068B6 (tr)
TR (3) TR200200415T2 (tr)
UA (1) UA59477C2 (tr)
WO (1) WO2000027799A1 (tr)
YU (1) YU29601A (tr)
ZA (1) ZA200104026B (tr)

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WO2004026291A1 (en) * 2002-08-28 2004-04-01 Shuyi Zhang Oral formulations of ibuprofen and tramadol, methods and preparation thereof
PT1562567T (pt) 2002-11-22 2017-08-24 Gruenenthal Gmbh Combinação de analgésicos selecionados e inibidores da cox-ii
US20040248979A1 (en) * 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102004034619A1 (de) * 2004-07-16 2006-02-23 Grünenthal GmbH Substituierte Aminoverbindungen als 5-HT/NA Uptakehemmer
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
KR101616246B1 (ko) 2008-01-25 2016-05-02 그뤼넨탈 게엠베하 약제학적 투여형
AU2009243681B2 (en) 2008-05-09 2013-12-19 Grunenthal Gmbh Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
WO2011009602A1 (en) 2009-07-22 2011-01-27 Grünenthal GmbH Hot-melt extruded controlled release dosage form
TWI473628B (zh) 2009-07-22 2015-02-21 用於對氧化敏感之類鴉片藥劑之抗破壞劑型
EP2383255A1 (en) 2010-04-28 2011-11-02 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
CA2808219C (en) 2010-09-02 2019-05-14 Gruenenthal Gmbh Tamper resistant dosage form comprising inorganic salt
WO2012028318A1 (en) 2010-09-02 2012-03-08 Grünenthal GmbH Tamper resistant dosage form comprising an anionic polymer
WO2012100423A1 (en) 2011-01-27 2012-08-02 Eli Lilly And Company Analgesic compounds, methods, and formulations
EP2530072A1 (en) 2011-06-03 2012-12-05 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
AU2012289764B2 (en) 2011-07-29 2017-03-02 Grünenthal GmbH Tamper-resistant tablet providing immediate drug release
ES2648129T3 (es) 2011-07-29 2017-12-28 Grünenthal GmbH Pastilla a prueba de manipulación que proporciona una liberación inmediata de un medicamento
US20130225697A1 (en) 2012-02-28 2013-08-29 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
PL2838512T3 (pl) 2012-04-18 2018-12-31 Grünenthal GmbH Farmaceutyczna postać dawkowania odporna na niewłaściwe użycie i odporna na uderzeniowe uwalnianie dawki
WO2013168005A2 (en) * 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of restless leg syndrome and fibromyalgia
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
JP6466417B2 (ja) 2013-05-29 2019-02-06 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 二峰性放出プロファイルを有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形
AU2014273227B2 (en) 2013-05-29 2019-08-15 Grunenthal Gmbh Tamper-resistant dosage form containing one or more particles
JP6449871B2 (ja) 2013-07-12 2019-01-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング エチレン−酢酸ビニルポリマーを含有する改変防止剤形
EP3073994A1 (en) 2013-11-26 2016-10-05 Grünenthal GmbH Preparation of a powdery pharmaceutical composition by means of cryo-milling
EP3142646A1 (en) 2014-05-12 2017-03-22 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
BR112017021475A2 (pt) 2015-04-24 2018-07-10 Gruenenthal Gmbh forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente
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DE1199764B (de) * 1963-04-02 1965-09-02 Gruenenthal Chemie Verfahren zur Herstellung von basisch substituierten Phenolaethern
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
DE19609847A1 (de) * 1996-03-13 1997-09-18 Gruenenthal Gmbh Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe

Also Published As

Publication number Publication date
DE69911235D1 (de) 2003-10-16
EA200100476A1 (ru) 2002-02-28
ID29017A (id) 2001-07-26
DE69914231D1 (de) 2004-02-19
ZA200104026B (en) 2002-05-17
NZ511739A (en) 2002-11-26
SK5842001A3 (en) 2001-12-03
ES2207298T3 (es) 2004-05-16
EP1219594B1 (en) 2004-01-14
EP1219594A1 (en) 2002-07-03
EP1219623B1 (en) 2004-01-14
ES2213731T3 (es) 2004-09-01
HRP20010412A2 (en) 2002-12-31
UA59477C2 (uk) 2003-09-15
CU23006A3 (es) 2004-12-17
PT1219623E (pt) 2004-04-30
MXPA01004432A (es) 2002-09-18
NO20012234L (no) 2001-05-04
TR200200415T2 (tr) 2002-06-21
GEP20033116B (en) 2003-11-25
CN1325377A (zh) 2001-12-05
IS5934A (is) 2001-05-03
CR6368A (es) 2002-04-08
WO2000027799A1 (es) 2000-05-18
TR200101160T2 (tr) 2002-01-21
SI1219594T1 (en) 2004-06-30
YU29601A (sh) 2003-04-30
EP1127871B1 (en) 2003-09-10
SI1219623T1 (en) 2004-06-30
SK284068B6 (sk) 2004-09-08
BR9915727A (pt) 2001-09-04
EA003742B1 (ru) 2003-08-28
BG105556A (en) 2001-12-29
HUP0104218A3 (en) 2002-11-28
KR20010080942A (ko) 2001-08-25
PT1127871E (pt) 2003-12-31
AU1047300A (en) 2000-05-29
KR100453613B1 (ko) 2004-10-20
JP2002529442A (ja) 2002-09-10
CZ20011500A3 (cs) 2001-09-12
DE69914229T2 (de) 2004-12-09
DK1219594T3 (da) 2004-04-19
ATE249418T1 (de) 2003-09-15
HRP20010412B1 (en) 2004-04-30
ATE257837T1 (de) 2004-01-15
US6455585B1 (en) 2002-09-24
AU755681B2 (en) 2002-12-19
SI1127871T1 (en) 2004-02-29
PL347492A1 (en) 2002-04-08
CN1176902C (zh) 2004-11-24
CA2349245A1 (en) 2000-05-18
PT1219594E (pt) 2004-04-30
ES2141688A1 (es) 2000-05-16
NO20012234D0 (no) 2001-05-04
EP1127871A1 (en) 2001-08-29
DE69914229D1 (de) 2004-02-19
DK1127871T3 (da) 2003-11-24
DK1219623T3 (da) 2004-04-19
EE200100246A (et) 2002-12-16
ES2141688B1 (es) 2001-02-01
HUP0104218A2 (hu) 2002-03-28
AP1222A (en) 2003-11-06
ES2213732T3 (es) 2004-09-01
ATE257817T1 (de) 2004-01-15
DE69914231T2 (de) 2004-11-11
OA11672A (en) 2005-01-12
IL142592A0 (en) 2002-03-10
MA26765A1 (fr) 2004-12-20
DE69911235T2 (de) 2004-07-01
EP1219623A1 (en) 2002-07-03

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