DK1221950T3 - Synergitisk kombination af en NK1-receptorantagonist og en GABA-strukturanalog - Google Patents

Synergitisk kombination af en NK1-receptorantagonist og en GABA-strukturanalog

Info

Publication number: DK1221950T3
Authority: DK; Denmark
Prior art keywords: receptor antagonist; synergistic combination; structural analog; gaba; gaba structural
Prior art date: 1999-10-07

Application number

DK00966138T

Other languages

English (en)

Inventor

John Hughes

Lakhbir Singh

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-07

Filing date

2000-10-05

Publication date

2004-09-20

2000-10-05 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2004-09-20 Application granted granted Critical

2004-09-20 Publication of DK1221950T3 publication Critical patent/DK1221950T3/da

Links

102000002002 Neurokinin-1 Receptors Human genes 0.000 title 1
108010040718 Neurokinin-1 Receptors Proteins 0.000 title 1
229960003692 gamma aminobutyric acid Drugs 0.000 title 1
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
239000011885 synergistic combination Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Virology (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK00966138T 1999-10-07 2000-10-05 Synergitisk kombination af en NK1-receptorantagonist og en GABA-strukturanalog DK1221950T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US15827199P	1999-10-07	1999-10-07

Publications (1)

Publication Number	Publication Date
DK1221950T3 true DK1221950T3 (da)	2004-09-20

Family

ID=22567369

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00966138T DK1221950T3 (da)	1999-10-07	2000-10-05	Synergitisk kombination af en NK1-receptorantagonist og en GABA-strukturanalog

Country Status (38)

Country	Link
EP (2)	EP1221950B1 (da)
JP (2)	JP2003510356A (da)
KR (1)	KR20020060192A (da)
CN (1)	CN1387434A (da)
AP (1)	AP2002002501A0 (da)
AR (1)	AR029646A1 (da)
AT (1)	ATE269072T1 (da)
AU (2)	AU7663300A (da)
BG (1)	BG106548A (da)
BR (1)	BR0014598A (da)
CA (1)	CA2385930A1 (da)
CO (1)	CO5280195A1 (da)
CR (1)	CR6614A (da)
CZ (1)	CZ20021116A3 (da)
DE (1)	DE60011650T2 (da)
DK (1)	DK1221950T3 (da)
EA (1)	EA004266B1 (da)
EE (1)	EE200200185A (da)
ES (1)	ES2220542T3 (da)
GT (1)	GT200000166A (da)
HR (1)	HRP20020286A2 (da)
HU (1)	HUP0203466A3 (da)
IL (1)	IL148965A0 (da)
IS (1)	IS6318A (da)
MA (1)	MA26826A1 (da)
MX (1)	MXPA02003484A (da)
NO (1)	NO20021625D0 (da)
NZ (1)	NZ517949A (da)
OA (1)	OA12063A (da)
PA (1)	PA8504301A1 (da)
PE (1)	PE20010708A1 (da)
PL (1)	PL357498A1 (da)
PT (1)	PT1221950E (da)
SK (1)	SK4542002A3 (da)
TR (1)	TR200200913T2 (da)
UY (1)	UY26376A1 (da)
WO (2)	WO2001024792A1 (da)
ZA (1)	ZA200202675B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL126999A (en)	1996-07-24	2002-03-10	Warner Lambert Co	Pharmaceutical preparations containing isobutylgaba and its history for use in the treatment of pain
US8048917B2 (en)	2005-04-06	2011-11-01	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
US20030232805A1 (en) *	2002-04-24	2003-12-18	Cypress Bioscience, Inc.	Prevention and treatment of functional somatic disorders, including stress-related disorders
AU2003267732A1 (en) *	2002-10-08	2004-05-04	Ranbaxy Laboratories Limited	Gabapentin tablets and methods for their preparation
WO2004084880A1 (en) *	2003-03-21	2004-10-07	Dynogen Pharmaceuticals, Inc.	METHODS FOR TREATING PAIN USING SMOOTH MUSCLE MODULATORS AND α2δ SUBUNIT CALCIUM CHANNEL MODULATORS
WO2004084881A1 (en) *	2003-03-21	2004-10-07	Dynogen Pharmaceuticals, Inc.	METHODS FOR TREATING FUNCTIONAL BOWEL DISORDERS USING α2δ SUBUNIT CALCIUM CHANNEL MODULATORS WITH SMOOTH MUSCLE MODULATORS
DE602004003172T2 (de) *	2003-03-21	2007-09-27	Dynogen Pharmaceuticals Inc., Waltham	Verfahren zur behandlung von erkrankungen der unteren harnwege mit antimuskarinika und mit modulatoren der alpha-2-delta untereinheit des kalziumkanals
EP1543831A1 (en) *	2003-12-18	2005-06-22	Pfizer GmbH Arzneimittelwerk Gödecke	Pregabalin composition
DE102007019071A1 (de) *	2007-04-23	2008-10-30	Ratiopharm Gmbh	Stabilisierte pharmazeutische Zusammensetzung enthaltend Pregabalin
CA2805371C (en)	2010-07-30	2017-10-31	Toray Industries, Inc.	Therapeutic agent or prophylactic agent for neuropathic pain
WO2012050907A2 (en) *	2010-09-28	2012-04-19	The Regents Of The University Of California	Gaba agonists in the treatment of disorders associated with metabolic syndrome and gaba combinations in treatment or prophylaxis of type i diabetes
DK3946260T3 (da) *	2019-03-26	2026-03-23	Orion Corp	Pregabalinformuleringer og anvendelse deraf
WO2022234110A1 (en) *	2021-05-07	2022-11-10	Plus Vitech, S.L.	Gamma-aminobutyric acid derivatives for use in cancer therapy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5025035A (en) *	1990-10-12	1991-06-18	Warner-Lambert Company	Method of treating depression
US5792796A (en) *	1994-07-27	1998-08-11	Warner-Lambert Company	Methods for treating anxiety and panic
US5510381A (en) *	1995-05-15	1996-04-23	Warner-Lambert Company	Method of treatment of mania and bipolar disorder
DE69736390T2 (de) *	1996-10-07	2007-07-26	Merck Sharp & Dohme Ltd., Hoddesdon	Zns-penetrierende nk-1 rezeptorantagonisten als antidepressivum und / oder anxiolytikum
EP0942734A1 (en) *	1996-12-02	1999-09-22	MERCK SHARP & DOHME LTD.	Use of nk-1 receptor antagonists for treating severe anxiety disorders

2000
- 2000-01-05 AP APAP/P/2002/002501A patent/AP2002002501A0/en unknown
- 2000-10-05 TR TR2002/00913T patent/TR200200913T2/xx unknown
- 2000-10-05 HR HR20020286A patent/HRP20020286A2/hr not_active Application Discontinuation
- 2000-10-05 OA OA1200200107A patent/OA12063A/en unknown
- 2000-10-05 CZ CZ20021116A patent/CZ20021116A3/cs unknown
- 2000-10-05 WO PCT/EP2000/009858 patent/WO2001024792A1/en not_active Ceased
- 2000-10-05 JP JP2001527791A patent/JP2003510356A/ja not_active Withdrawn
- 2000-10-05 HU HU0203466A patent/HUP0203466A3/hu unknown
- 2000-10-05 ES ES00966138T patent/ES2220542T3/es not_active Expired - Lifetime
- 2000-10-05 KR KR1020027004462A patent/KR20020060192A/ko not_active Withdrawn
- 2000-10-05 MX MXPA02003484A patent/MXPA02003484A/es active IP Right Grant
- 2000-10-05 DK DK00966138T patent/DK1221950T3/da active
- 2000-10-05 EA EA200200303A patent/EA004266B1/ru not_active IP Right Cessation
- 2000-10-05 AU AU76633/00A patent/AU7663300A/en not_active Abandoned
- 2000-10-05 EP EP00966138A patent/EP1221950B1/en not_active Expired - Lifetime
- 2000-10-05 AT AT00966138T patent/ATE269072T1/de not_active IP Right Cessation
- 2000-10-05 BR BR0014598-0A patent/BR0014598A/pt not_active Application Discontinuation
- 2000-10-05 PT PT00966138T patent/PT1221950E/pt unknown
- 2000-10-05 SK SK454-2002A patent/SK4542002A3/sk unknown
- 2000-10-05 NZ NZ517949A patent/NZ517949A/en unknown
- 2000-10-05 IL IL14896500A patent/IL148965A0/xx unknown
- 2000-10-05 DE DE60011650T patent/DE60011650T2/de not_active Expired - Fee Related
- 2000-10-05 CA CA002385930A patent/CA2385930A1/en not_active Abandoned
- 2000-10-05 EE EEP200200185A patent/EE200200185A/xx unknown
- 2000-10-05 CN CN00813906A patent/CN1387434A/zh active Pending
- 2000-10-05 PL PL00357498A patent/PL357498A1/xx not_active Application Discontinuation
- 2000-10-06 UY UY26376A patent/UY26376A1/es not_active Application Discontinuation
- 2000-10-06 GT GT200000166A patent/GT200000166A/es unknown
- 2000-10-06 PE PE2000001069A patent/PE20010708A1/es not_active Application Discontinuation
- 2000-10-06 CO CO00076105A patent/CO5280195A1/es not_active Application Discontinuation
- 2000-10-06 AR ARP000105296A patent/AR029646A1/es not_active Application Discontinuation
- 2000-10-06 PA PA20008504301A patent/PA8504301A1/es unknown
- 2000-10-09 WO PCT/EP2000/010084 patent/WO2001024791A1/en not_active Ceased
- 2000-10-09 AU AU16962/01A patent/AU1696201A/en not_active Abandoned
- 2000-10-09 JP JP2001527790A patent/JP2003510355A/ja not_active Withdrawn
- 2000-10-09 EP EP00979495A patent/EP1233766A1/en not_active Withdrawn
2002
- 2002-03-21 IS IS6318A patent/IS6318A/is unknown
- 2002-03-22 BG BG106548A patent/BG106548A/xx unknown
- 2002-04-05 CR CR6614A patent/CR6614A/es not_active Application Discontinuation
- 2002-04-05 ZA ZA200202675A patent/ZA200202675B/xx unknown
- 2002-04-05 MA MA26587A patent/MA26826A1/fr unknown
- 2002-04-05 NO NO20021625A patent/NO20021625D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO2001024792A9 (en)	2002-09-06
ZA200202675B (en)	2003-04-15
IL148965A0 (en)	2002-11-10
NO20021625L (no)	2002-04-05
CA2385930A1 (en)	2001-04-12
EE200200185A (et)	2003-04-15
WO2001024791A1 (en)	2001-04-12
JP2003510355A (ja)	2003-03-18
WO2001024792A1 (en)	2001-04-12
TR200200913T2 (tr)	2002-09-23
DE60011650D1 (de)	2004-07-22
CN1387434A (zh)	2002-12-25
KR20020060192A (ko)	2002-07-16
OA12063A (en)	2006-05-03
EP1221950A1 (en)	2002-07-17
AU7663300A (en)	2001-05-10
SK4542002A3 (en)	2003-09-11
HRP20020286A2 (en)	2003-08-31
BG106548A (en)	2002-12-29
CZ20021116A3 (cs)	2003-05-14
JP2003510356A (ja)	2003-03-18
EP1221950B1 (en)	2004-06-16
AP2002002501A0 (en)	2002-06-30
ATE269072T1 (de)	2004-07-15
HUP0203466A3 (en)	2005-03-29
CR6614A (es)	2003-12-04
ES2220542T3 (es)	2004-12-16
CO5280195A1 (es)	2003-05-30
PA8504301A1 (es)	2002-08-26
UY26376A1 (es)	2000-12-29
IS6318A (is)	2002-03-21
NZ517949A (en)	2003-08-29
AR029646A1 (es)	2003-07-10
GT200000166A (es)	2002-03-30
BR0014598A (pt)	2002-06-11
PE20010708A1 (es)	2001-07-27
HUP0203466A2 (hu)	2003-02-28
MA26826A1 (fr)	2004-12-20
EP1233766A1 (en)	2002-08-28
PL357498A1 (en)	2004-07-26
AU1696201A (en)	2001-05-10
DE60011650T2 (de)	2005-07-14
MXPA02003484A (es)	2004-09-10
NO20021625D0 (no)	2002-04-05
EA004266B1 (ru)	2004-02-26
PT1221950E (pt)	2004-08-31
EA200200303A1 (ru)	2002-08-29

Publication	Publication Date	Title
DK1221950T3 (da)	2004-09-20	Synergitisk kombination af en NK1-receptorantagonist og en GABA-strukturanalog
EP1543034A4 (en)	2006-11-08	TREATMENT AND PROPHYLAXIS WITH 4-1BB BINDING AGENTS
NO20000847L (no)	2000-08-23	Elastiske brønnsementsammensetninger og fremgangsmÕter
IL153834A0 (en)	2003-07-31	N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives
DE60022361D1 (de)	2005-10-06	Paralleler analog-digital-wandler
FR2813407B1 (fr)	2005-06-24	Convertisseur temps/numerique
NO20025640L (no)	2003-01-22	Substituerte 1-aminoalkyl-laktamer og deres anvendelse som muscarin-reseptorantagonister
NO20022645L (no)	2002-08-01	Farmasöytisk superdisintegrerende stoff
DK1121116T3 (da)	2008-05-13	Farmaceutisk præparat af fluvastatin med opretholdt frigivelse
EP1144004A4 (en)	2002-09-04	HER-2 BINDING ANAGONISTS
FI951300A7 (fi)	1995-09-22	Alfutsosiinihydrokloridin hitaan vapautumisen galeenisia muotoja
IS6135A (is)	2001-10-30	Samsett forlyf af amlódipíni og atorvastatíni
NO990786D0 (no)	1999-02-19	Acylaminoalkenylen-amidderivater som NK1 og NK2 antagonister
DK1007024T3 (da)	2003-11-17	Doseringsformer af sertralin med forsinket frigivelse
DE60112000D1 (de)	2005-08-25	Handgelenktotalprothese
DE50006862D1 (de)	2004-07-29	Gerüsttragvorrichtung
EP1223946A4 (en)	2003-05-07	HUMAN NEUROPEPTIDE RECEPTOR
DK1173172T3 (da)	2006-05-15	Synergistiske virkninger af amlodipin og den hydroxylerede metabolit af atorvastatin
FR2798712B1 (fr)	2001-11-16	Volant moteur modulaire
GB9906282D0 (en)	1999-05-12	Fixing units of a foothold
DK1313500T3 (da)	2005-02-14	Associationer af dalfopristin/quinupristin med cefpirom
DK199900093U3 (da)	1999-08-13	Hurtigtvirkende kunstig muskel
NO992687D0 (no)	1999-06-03	Stillasvognarrangement
SK2807U (sk)	2001-03-12	Sústava stavebnicových prvkov
DK1131291T3 (da)	2005-02-28	4-aroyl-piperidin-CCR-3-receptorantagonister III